DRSC/TRiP Functional Genomics Resources

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Protein Alignment fra and ROBO2

DIOPT Version :9

Sequence 1:NP_523716.2 Gene:fra / 36377 FlyBaseID:FBgn0011592 Length:1526 Species:Drosophila melanogaster
Sequence 2:XP_011532283.1 Gene:ROBO2 / 6092 HGNCID:10250 Length:1597 Species:Homo sapiens


Alignment Length:1746 Identity:374/1746 - (21%)
Similarity:583/1746 - (33%) Gaps:542/1746 - (31%)


- Green bases have known domain annotations that are detailed below.


  Fly     4 TTNRSSRTLWN---WLLSSCLIFQLIGSSLASQAL--SFTLEPQDAVVPEGHSVLLQCAGTASIG 63
            |.::.:||.|.   |         ..||.|..:..  .....|.|.:|.:|....|.|       
Human    27 TLSKLTRTPWKGKPW---------KGGSRLRQEDFPPRIVEHPSDVIVSKGEPTTLNC------- 75

  Fly    64 RGGKSKSNLPSSVSIRWRGPDGQDLVIVGD---TFRTQLKNGSLYISSVEENRGL---TGAYQCL 122
                 |:....:.:|.|. .||:.:....|   :.|..|.:|||:...:...|..   .|:|.| 
Human    76 -----KAEGRPTPTIEWY-KDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVC- 133

  Fly   123 LTAEGVGSILSRPAL--VAIVRQPDLNQDFLETYLLPGQTAYFRCMLGEANWQEGVKHSVQWLKD 185
            :....:|..:||.|.  ||::|. |..|:..:..:..|:.|...|.....:    .:.::.|.||
Human   134 VARNYLGEAVSRNASLEVALLRD-DFRQNPTDVVVAAGEPAILECQPPRGH----PEPTIYWKKD 193

  Fly   186 DLPLPLDKLRMVVLPNGALEIDEVGPSDRGSYQCNVTSGSSSRLSSKTNLNIKKPSDPGAENSV- 249
            .:.:. ||...:.:..|.|.|.....||.|.|.|           ..||:..::.||| ||.:| 
Human   194 KVRID-DKEERISIRGGKLMISNTRKSDAGMYTC-----------VGTNMVGERDSDP-AELTVF 245

  Fly   250 -APSFLVGPSPKTVREGDTVTLDCVANGVPKPQIKWLRNGMDLDFNDLDSRFSIVGTGSLQISSA 313
             .|:||..|..:.|.|.:.|...|...|.|:|.::|.::..||.    ..|:.|....:|:|...
Human   246 ERPTFLRRPINQVVLEEEAVEFRCQVQGDPQPTVRWKKDDADLP----RGRYDIKDDYTLRIKKT 306

  Fly   314 EDIDSGNYQCRASNTVDSLDAQATVQVQ----EPPKFIKAPKDTTAHEKDEPELKCDIWGKPKPV 374
            ...|.|.|.|.|.|.|..::|.||:.|:    .||:|:..|:|....:.......|:..|.|:|.
Human   307 MSTDEGTYMCIAENRVGKMEASATLTVRARPVAPPQFVVRPRDQIVAQGRTVTFPCETKGNPQPA 371

  Fly   375 IRWLKNG--DLITPNDYMQ------LVDGHNLKILGLLNSDAGMFQCVGTNAAGSVHAAARLRVV 431
            :.|.|.|  :|:.||...|      :....:|.|..:..||||.:.|.....|||:.|.|:|.|.
Human   372 VFWQKEGSQNLLFPNQPQQPNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLEVT 436

  Fly   432 PQGVKIKKRKSQGHSTKSLQTFDNLTKRRKPF------------NSGEQLRTKSGG--------- 475
                                  |.||.|..|.            :....|:.|:.|         
Human   437 ----------------------DVLTDRPPPIILQGPANQTLAVDGTALLKCKATGDPLPVISWL 479

  Fly   476 --SFPFPDEDDDLDDNDSGTTRLRIPSGKLPKFEQPLNDRRFNILNAGSALPLDNQSKSYEDDDD 538
              .|.||..|......:.||.::                :...|.:.|:...:...|..      
Human   480 KEGFTFPGRDPRATIQEQGTLQI----------------KNLRISDTGTYTCVATSSSG------ 522

  Fly   539 DYDEDDPAKEALLEAYKQGEDAHKILDSWQQSKSKKSQQQKQSPASPDSPEQDPSVPHPGGKPLD 603
                 :.:..|:|:..:.|            :...|:......|..|..|:......:.......
Human   523 -----ETSWSAVLDVTESG------------ATISKNYDLSDLPGPPSKPQVTDVTKNSVTLSWQ 570

  Fly   604 SGLQARLPSQPRDLVAQIVK--SRFVTLSWVEPLQNAGDVVYYTVYYKMNNSEREQKMVTKSHDD 666
            .|....||:.     |.|::  |:.|:.||    |...:.|..|:|                   
Human   571 PGTPGTLPAS-----AYIIEAFSQSVSNSW----QTVANHVKTTLY------------------- 607

  Fly   667 QQVNIQSLLPGRTYQFRVEANTNFGSGASSAPLEVSTQPEVNIAGPPRNFEGYARSHKE------ 725
               .::.|.|...|.|.|.|....|   .|.|..:|.........||.....:.:..||      
Human   608 ---TVRGLRPNTIYLFMVRAINPQG---LSDPSPMSDPVRTQDISPPAQGVDHRQVQKELGDVLV 666

  Fly   726 ------------IYVKW---EEPTVTNGEILKYRVYYSENDSGADLYHD--------STALEAVL 767
                        :.|.|   .:|....|    |||.|.:. ||......        .|...|||
Human   667 RLHNPVVLTPTTVQVTWTVDRQPQFIQG----YRVMYRQT-SGLQATSSWQNLDAKVPTERSAVL 726

  Fly   768 TELRPHTDYVISVVPFNRNGMGDSSAEIRVKTFSSTPSEPPNNVT-LEVTS--SSSITVHWEPPA 829
            ..|:....|.|.|.|:.....|..|....|:|....||.||.:|| |.|.|  |:||:|.|:||.
Human   727 VNLKKGVTYEIKVRPYFNEFQGMDSESKTVRTTEEAPSAPPQSVTVLTVGSYNSTSISVSWDPPP 791

  Fly   830 EEDRNGQITGYKI-------RYRKFKDAPQVKSTPANIRYFELSNLDRNAEYQVKIAAMTVNGSG 887
            .:.:||.|..|||       |:.      ..|:..|.||...:..|....:|:|::||.|..|.|
Human   792 PDHQNGIIQEYKIWCLGNETRFH------INKTVDAAIRSVIIGGLFPGIQYRVEVAASTSAGVG 850

  Fly   888 PFTE-----WNRANTL-----ENDLDE--TQVPGKPIWISIHPGA-------NNIALHWGPPQHP 933
            ..:|     ..|.|.:     .|.:.|  |.|..:|.:|:...||       .:|.|:|...:..
Human   851 VKSEPQPIIIGRRNEVVITENNNSITEQITDVVKQPAFIAGIGGACWVILMGFSIWLYWRRKKRK 915

  Fly   934 EIKIRNYVLGWGRGIPDENTIELKETERYHILKNLESNMDYV------VSLRARNVKGDGPPIYD 992
            .:.  ||.:.:.||  |...  :....|..:|...:.:..::      .||...| ...||....
Human   916 GLS--NYAVTFQRG--DGGL--MSNGSRPGLLNAGDPSYPWLADSWPATSLPVNN-SNSGPNEIG 973

  Fly   993 NIKTRDEEPVDAPTPLEVPVGLRAITMSSSSIVVYWIDTMLNKNQHVTDNRHYTVSYGITGSNRY 1057
            |....|..|   |.|.:   |.:..||.|...:...||        .|....|..|..||.:..|
Human   974 NFGRGDVLP---PVPGQ---GDKTATMLSDGAIYSSID--------FTTKTSYNSSSQITQATPY 1024

  Fly  1058 RYHNTTDLNCMINDLRPNTQYEFAVKVVKGRRESSWSMSVLNSTYQNVPVTPPREVTVRLDEMNP 1122
            .   ||.:      |..|:.:|.||.:    .:..|..|:...|                     
Human  1025 A---TTQI------LHSNSIHELAVDL----PDPQWKSSIQQKT--------------------- 1055

  Fly  1123 PTVIVQWIPPKHTLGQITGYNIYYTTDTTKRDRDWSVEAFAGEETMLMLPNLKPYTTYYFKVQAR 1187
                           .:.|:. |...|..|           |...:|.:|:.            |
Human  1056 ---------------DLMGFG-YSLPDQNK-----------GNNALLYIPDY------------R 1081

  Fly  1188 TTKG-ANNAPFSALVSY-TTSAAVTMQEPDTIAKGIDNEKLLYIIIAATAVVLLVVLLGVLLLCR 1250
            ..:| :|..|.:....: |||:..:.:...:::.|...:|.                       :
Human  1082 LAEGLSNRMPHNQSQDFSTTSSHNSSERSGSLSGGKGGKKK-----------------------K 1123

  Fly  1251 RKPQSSPEHTKKSYQKN------NVGVPKPP-----------------------DLW-------- 1278
            .|..|.|       |||      ||.:|.||                       |.|        
Human  1124 NKNSSKP-------QKNNGSTWANVPLPPPPVQPLPGTELEHYAVEQQENGYDSDSWCPPLPVQT 1181

  Fly  1279 -IHHD-QMELKNIDKGLHT-------VTPVCSDGASSSGALT-LPRSVVHSEYEVETPVPGHV-- 1331
             :|.. :.||:..|..:.|       .:|..|.|..|:..|| .||.      |::..:..|:  
Human  1182 YLHQGLEDELEEDDDRVPTPPVRGVASSPAISFGQQSTATLTPSPRE------EMQPMLQAHLDE 1240

  Fly  1332 -----------------TNSLDKRSYVP--GYMTTSMNGTMERPQYPRTQYSHQNRSHMTMEAGL 1377
                             :|:...:..||  ||::.::...:|      |..:..       :|..
Human  1241 LTRAYQFDIAKQTWHIQSNNQPPQPPVPPLGYVSGALISDLE------TDVADD-------DADD 1292

  Fly  1378 SQQSLTQPQS-NSMAQTPEHPYGGYDANFCNAGNAAAGNGCV-----------STIESSKRGHPL 1430
            .:::|..|:. .::.|||.......|::.  .|:...|.|..           |::.||..|...
Human  1293 EEEALEIPRPLRALDQTPGSSMDNLDSSV--TGSMVNGWGSASDEDRNFSSHRSSVGSSSDGSIF 1355

  Fly  1431 KSFS-----VPGPPPTG---GATPVTKHTPAVTI--RPQNQSPYKKPSFSAAT--------PNRL 1477
            .|.|     |......|   ..|.:|:...|.|.  ||:..||:...|.::|.        |.:.
Human  1356 ASGSFAQALVAAADKAGFRLDGTSLTRTGKAFTSSQRPRPTSPFSTDSNTSAALSQSQRPRPTKK 1420

  Fly  1478 QGGG------SVVH----STDEI-------------QRLAPSTSTEELNQEMANLE 1510
            ..||      ::.|    .||::             |::.||       |:..|:|
Human  1421 HKGGRMDQQPALPHRREGMTDDLPPPPDPPPGQGLRQQIGPS-------QQAGNVE 1469

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fraNP_523716.2 Ig 36..140 CDD:299845 26/111 (23%)
Ig <180..222 CDD:299845 13/41 (32%)
IG_like 257..340 CDD:214653 25/82 (30%)
IGc2 264..327 CDD:197706 18/62 (29%)
I-set 344..430 CDD:254352 28/93 (30%)
Ig 363..428 CDD:299845 23/72 (32%)
FN3 611..703 CDD:238020 20/93 (22%)
FN3 711..799 CDD:238020 26/116 (22%)
FN3 806..897 CDD:238020 35/105 (33%)
FN3 908..989 CDD:238020 18/93 (19%)
FN3 1011..1097 CDD:238020 20/85 (24%)
FN3 1109..1205 CDD:238020 11/97 (11%)
Neogenin_C 1273..1521 CDD:284094 66/353 (19%)
ROBO2XP_011532283.1 Ig1_Robo 53..152 CDD:143317 25/112 (22%)
Ig 160..244 CDD:325142 24/100 (24%)
Ig 265..333 CDD:325142 22/71 (31%)
Ig4_Robo 355..444 CDD:143203 29/110 (26%)
IG 451..532 CDD:214652 14/107 (13%)
FN3 549..642 CDD:238020 26/126 (21%)
FN3 673..758 CDD:238020 22/89 (25%)
FN3 766..859 CDD:238020 34/98 (35%)
PTN13_u3 <1374..>1431 CDD:318742 13/56 (23%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 1 1.100 - - O PTHR44170
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
22.010

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