DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fra and PTPRC

DIOPT Version :9

Sequence 1:	NP_523716.2	Gene:	fra / 36377	FlyBaseID:	FBgn0011592	Length:	1526	Species:	Drosophila melanogaster
Sequence 2:	NP_002829.3	Gene:	PTPRC / 5788	HGNCID:	9666	Length:	1306	Species:	Homo sapiens

Alignment Length:	1061	Identity:	186/1061 - (17%)
Similarity:	312/1061 - (29%)	Gaps:	419/1061 - (39%)

- Green bases have known domain annotations that are detailed below.

  Fly   665 DDQQVNIQSLLPGRTYQFRVE--------------ANTNFGSGASSAPL----EVSTQPEVNIAG 711
            |::::.:::|.|...|:...|              ..|:|||......:    |.:.|..:....
Human   350 DNKEIKLENLEPEHEYKCDSEILYNNHKFTNASKIIKTDFGSPGEPQIIFCRSEAAHQGVITWNP 414

  Fly   712 PPRNFEGYARSHKEIYVKWEEPTVTN--GEILKYRVYYSENDSGADLYHDSTALEAVLTELRPHT 774
            |.|:|..:..    .|:|..|....|  ..::||.                      |..|:|:|
Human   415 PQRSFHNFTL----CYIKETEKDCLNLDKNLIKYD----------------------LQNLKPYT 453

  Fly   775 DYVIS-----VVPFNRNGMGDSSAEIRVKTFSSTPSEPPNNVTLEVTSSSSITVHWEPPAEEDRN 834
            .||:|     :....|||   |:|.....|.|:.||: ..|:|:.:||.:|:.|...||  .|||
Human   454 KYVLSLHAYIIAKVQRNG---SAAMCHFTTKSAPPSQ-VWNMTVSMTSDNSMHVKCRPP--RDRN 512

  Fly   835 GQITGYKIRYRKFKDAPQVKSTPANIRY-------FELSNLDRNAEYQVKIAAMTVNGSGP---- 888
            |....|.:         :|::....:|.       |.:.:|..:.:|..|  |...||..|
Human   513 GPHERYHL---------EVEAGNTLVRNESHKNCDFRVKDLQYSTDYTFK--AYFHNGDYPGEPF 566

  Fly   889 ----FTEWN---------------------------------------RANTLENDLDETQVPGK 910
                .|.:|                                       :...:|.| ||.|:
Human   567 ILHHSTSYNSKALIAFLAFLIIVTSIALLVVLYKIYDLHKKRSCNLDEQQELVERD-DEKQL--- 627

  Fly   911 PIWISIHPGANNIALHWGPPQHPEIKIRNYVLGWGRGIPDENTIELKETE-------RYHI---L 965
                      .|:     .|.|.:|.:..|    .|.|.||..:.|.|.:       ::.|   .
Human   628 ----------MNV-----EPIHADILLETY----KRKIADEGRLFLAEFQSIPRVFSKFPIKEAR 673

  Fly   966 KNLESNMDYVVSL--------RARNVKGDGPPIYDNIKTRD--EEP---VDAPTPLEVPVG--LR 1015
            |....|.:..|.:        ....:.||....|.|....|  :||   :.|..|.:..|.  .|
Human   674 KPFNQNKNRYVDILPYDYNRVELSEINGDAGSNYINASYIDGFKEPRKYIAAQGPRDETVDDFWR 738

  Fly  1016 AITMSSSSIVV---------------YWI----------DTMLNKNQH----------------- 1038
            .|....::::|               ||.          |.::..|||
Human   739 MIWEQKATVIVMVTRCEEGNRNKCAEYWPSMEEGTRAFGDVVVKINQHKRCPDYIIQKLNIVNKK 803

  Fly  1039 --------------------VTDNRHYTV---------------------SYGITGSNRYRYHNT 1062
                                |.::.|..:                     |.|:..:..|
Human   804 EKATGREVTHIQFTSWPDHGVPEDPHLLLKLRRRVNAFSNFFSGPIVVHCSAGVGRTGTY----- 863

  Fly  1063 TDLNCMINDLRPNTQYEFAVKVVKGRRESSWSMSVLNSTY-----QNVPVTPPREVTVRLDEMNP 1122
            ..::.|:..|....:.:....|||.||:....:.| .:.|     ..|......|..|.|.|::|
Human   864 IGIDAMLEGLEAENKVDVYGYVVKLRRQRCLMVQV-EAQYILIHQALVEYNQFGETEVNLSELHP 927

  Fly  1123 PTVIVQWIPPKHTLGQITGYNIYYTTDTTKRD------------------RDWSVEAFAGEE--- 1166
                                   |..:..|||                  |.|..:....:|
Human   928 -----------------------YLHNMKKRDPPSEPSPLEAEFQRLPSYRSWRTQHIGNQEENK 969

  Fly  1167 TMLMLPNLKPYTTYYFKV----QARTTKGAN--------------------NAPFSALVSY-TTS 1206
            :.....|:.||.  |.:|    :...:|.:.                    ||.|  ::|| ...
Human   970 SKNRNSNVIPYD--YNRVPLKHELEMSKESEHDSDESSDDDSDSEEPSKYINASF--IMSYWKPE 1030

  Fly  1207 AAVTMQEP--DTIAKGIDNEKLLYIIIAATAVVLLVVLLGVLLLC------------------RR 1251
            ..:..|.|  :||.   |..::::.......|:|..:..|...:|                  :.
Human  1031 VMIAAQGPLKETIG---DFWQMIFQRKVKVIVMLTELKHGDQEICAQYWGEGKQTYGDIEVDLKD 1092

  Fly  1252 KPQSSP--------EHTKK-------SYQKNNVGVPKPPD--------LWIHHDQMELKNIDKG- 1292
            ..:||.        .|:|:       .||..|..|.:.|.        :.:...::..||..:|
Human  1093 TDKSSTYTLRVFELRHSKRKDSRTVYQYQYTNWSVEQLPAEPKELISMIQVVKQKLPQKNSSEGN 1157

  Fly  1293 -LHTVTPV---CSDGASSSGALTLPRSVVHSEYEVETPVPGHVTNSLDKRSYVPGYMTT------ 1347
             .|..||:   |.||:..:|......:::.|....|......|..:|.|..  ||.::|
Human  1158 KHHKSTPLLIHCRDGSQQTGIFCALLNLLESAETEEVVDIFQVVKALRKAR--PGMVSTFEQYQF 1220

  Fly  1348 ----------SMNGTMERPQYPRTQYSHQNRSHMTMEAGLSQQSLTQPQS-------------NS 1389
                      :.||.:::..:...:....|......:.......|..|:.             .|
Human  1221 LYDVIASTYPAQNGQVKKNNHQEDKIEFDNEVDKVKQDANCVNPLGAPEKLPEAKEQAEGSEPTS 1285

  Fly  1390 MAQTPEHPYGGYDANFCNAGN 1410
            ..:.|||...|..:...|.|:
Human  1286 GTEGPEHSVNGPASPALNQGS 1306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fra	NP_523716.2	Ig	36..140	CDD:299845
		Ig	<180..222	CDD:299845
		IG_like	257..340	CDD:214653
		IGc2	264..327	CDD:197706
		I-set	344..430	CDD:254352
		Ig	363..428	CDD:299845
		FN3	611..703	CDD:238020	10/55 (18%)
		FN3	711..799	CDD:238020	21/94 (22%)
		FN3	806..897	CDD:238020	25/144 (17%)
		FN3	908..989	CDD:238020	17/98 (17%)
		FN3	1011..1097	CDD:238020	22/170 (13%)
		FN3	1109..1205	CDD:238020	23/141 (16%)
		Neogenin_C	1273..1521	CDD:284094	31/180 (17%)
PTPRC	NP_002829.3	PTP_N	7..32	CDD:372119
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	28..163
		PHA03255	81..>231	CDD:165513
		CD45	237..295	CDD:372194
		FN3	392..462	CDD:238020	18/95 (19%)
		FN3	485..565	CDD:238020	25/93 (27%)
		R-PTPc-C-1	707..907	CDD:350405	31/205 (15%)
		Substrate binding. /evidence=ECO:0000250	853..859		2/5 (40%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	993..1014		1/20 (5%)
		R-PTP-C-2	1017..1223	CDD:350406	41/212 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1261..1306		8/44 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910