DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fra and IGDCC4

DIOPT Version :9

Sequence 1:	NP_523716.2	Gene:	fra / 36377	FlyBaseID:	FBgn0011592	Length:	1526	Species:	Drosophila melanogaster
Sequence 2:	XP_016877937.1	Gene:	IGDCC4 / 57722	HGNCID:	13770	Length:	1264	Species:	Homo sapiens

Alignment Length:	1569	Identity:	349/1569 - (22%)
Similarity:	546/1569 - (34%)	Gaps:	505/1569 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 WLLSSCLIFQ--LIGSSLASQALSFTLEPQDAVVPEGHSVLLQCA-GTASIGRGGKSKSNLPSSV 76
            |:....|:.|  .:..|.....|...|.|:.|.|       |.|: |.|:.|.        |:.|
Human    34 WVRGELLLPQETTVELSCGVGPLQVILGPEQAAV-------LNCSLGAAAAGP--------PTRV 83

  Fly    77 SIRWRGPDGQDLVIVGDTFRTQLKNGSLYIS----------SVEENRG-LTGAYQCLLTAEG-VG 129
            :  | ..|| |.::..|.... |.||||::|          ||.|..| :.|.|.||  |.| :|
Human    84 T--W-SKDG-DTLLEHDHLHL-LPNGSLWLSQPLAPNGSDESVPEAVGVIEGNYSCL--AHGPLG 141

  Fly   130 SILSRPALVAIVRQPDLNQDFLETYLLPGQTAYFRCMLGEANWQEGVKHS-VQWLKDDLPLPLDK 193
            .:.|:.|:|.:....|.:.......:....||.|.|.:      ||:... :.|.||.:.|| ::
Human   142 VLASQTAVVKLATLADFSLHPESQTVEENGTARFECHI------EGLPAPIITWEKDQVTLP-EE 199

  Fly   194 LRMVVLPNGALEIDEVGPSDRGSYQCNVTSGSSSRLSSKTNLNIKKPSDPGAENSVAPSFLVGPS 258
            .|::|||||.|:|.:|..||.|.|:|..|:.:....|.:..|::.......:........:..|.
Human   200 PRLIVLPNGVLQILDVQESDAGPYRCVATNSARQHFSQEALLSVAHRGSLASTRGQDVVIVAAPE 264

  Fly   259 PKTVREGDTVTLDCVANGVPKPQIKWLRNGMDLDFNDLDSRFSIVGTGSLQISSAEDIDSGNYQC 323
            ..||..|.:|.::|||:..|.|.:.|:|.    |...:.:...::|..:|.|::|:...||.|.|
Human   265 NTTVVSGQSVVMECVASADPTPFVSWVRQ----DGKPISTDVIVLGRTNLLIANAQPWHSGVYVC 325

  Fly   324 RAS--NTVDSLDAQATVQVQEPPKFIKAPKDTTAHEKDEPELKCDIWGKPKPVIRWLKNGDLITP 386
            ||:  .|.|...|.|.::|...|...:||:..:..........|...|:|:|.:|||.||..:.|
Human   326 RANKPRTRDFATAAAELRVLAAPAITQAPEALSRTRASTARFVCRASGEPRPALRWLHNGAPLRP 390

  Fly   387 NDYMQLVDGHNLKI---LGLLNSDAGMFQCVGTNAAGSVHAAARLRVVPQGVKIKKRKSQGHSTK 448
            |..:::..|....:   :||  .|||.:|||..|:||...|||.|.||
Human   391 NGRVKVQGGGGSLVITQIGL--QDAGYYQCVAENSAGMACAAASLAVV----------------- 436

  Fly   449 SLQTFDNLTKRRKPFNSGEQLRTKSGGSFPFPDEDDDLDDNDSGTTRLRIPSGKLPKFEQPLNDR 513

Human   437 ----------------------------------------------------------------- 436

  Fly   514 RFNILNAGSALPLDNQSKSYEDDDDDYDEDDPAKEALLEAYKQGEDAHKILDSWQQSKSKKSQQQ 578
                                                    .::|
Human   437 ----------------------------------------VREG--------------------- 440

  Fly   579 KQSPASPDSPEQDPSVPHPGGKPLDSGLQARLPSQPRDLVAQIVKSRFVTLSWVEPLQNAGDVVY 643
                                           |||.|..:.|..:.|..|.::|..|..::..::.
Human   441 -------------------------------LPSAPTRVTATPLSSSAVLVAWERPEMHSEQIIG 474

  Fly   644 YTVYYK----MNNSEREQKMVTKSHDDQQVNIQSLLPGRTYQFRVEANTNFGSGASSAPLEVSTQ 704
            ::::|:    |:|.|                         |||.|.
Human   475 FSLHYQKARGMDNVE-------------------------YQFAVN------------------- 495

  Fly   705 PEVNIAGPPRNFEGYARSHKEIYVKWEEPTVTNGEILKYRVYYSENDSGADLYHDSTALEAVLTE 769
                                                                 :|:|.|:  :.:
Human   496 -----------------------------------------------------NDTTELQ--VRD 505

  Fly   770 LRPHTDYVISVVPFNRNGMGDSSAEIRVKTFSSTPSEPPNNVTLEVTSSSSITVHWEPPAEEDRN 834
            |.|:|||...||.:::.|...:|....|.|....||..| .::|...:.|.|.|.|.|......|
Human   506 LEPNTDYEFYVVAYSQLGASRTSTPALVHTLDDVPSAAP-QLSLSSPNPSDIRVAWLPLPPSLSN 569

  Fly   835 GQITGYKIRYRKFKDAPQVKSTP--ANIRYFELSNLDRNAEYQVKIAAMTVNGSGPFTEW--NRA 895
            ||:..|||.|...|: .|:.||.  .|.....|::|..|..|:|:|:|.|..|.|..::|  :|.
Human   570 GQVVKYKIEYGLGKE-DQIFSTEVRGNETQLMLNSLQPNKVYRVRISAGTAAGFGAPSQWMHHRT 633

  Fly   896 NTLENDLDETQVPGKPIWISIHPGANNIALHWGPPQHPEIKIRNYVLGW---------------- 944
            .::.|   ::.||..|..:.:.....::.:.|.||.|| .:|..|.|.|
Human   634 PSMHN---QSHVPFAPAELKVQAKMESLVVSWQPPPHP-TQISGYKLYWREVGAEEEANGDRLPG 694

  Fly   945 GRGIP--DENTIELKETERYHILKNLESNMDYVVSLRARNVKGDGPPIYDNIKTR----DEEPVD 1003
            |||..  |...:.||:..:.:.|..|.....|.|.|.|.|...||.......||.    .:.|:.
Human   695 GRGDQAWDVGPVRLKKKVKQYELTQLVPGRLYEVKLVAFNKHEDGYAAVWKGKTEKAPAPDMPIQ 759

  Fly  1004 APTPLEVPVGLRAITMSSSSIVVYWIDTMLNKNQHVTDNR--HYTVSY---GITGSNRYRYH-NT 1062
            ...||. |..:.|.:.||:||.:.|      |....|..:  :|||.:   |:..::...|: ::
Human   760 RGPPLP-PAHVHAESNSSTSIWLRW------KKPDFTTVKIVNYTVRFSPWGLRNASLVTYYTSS 817

  Fly  1063 TDLNCMINDLRPNTQYEFAVKVVKGRRESSWSMSVLNSTYQNVPVTPPREVTVRLDEMNPPTVIV 1127
            :..:.:|..|:|.|:|||||:......:..:...|..||..:.|.|||.:  :||..:.|.||.:
Human   818 SGEDILIGGLKPFTKYEFAVQSHGVDMDGPFGSVVERSTLPDRPSTPPSD--LRLSPLTPSTVRL 880

  Fly  1128 QWIPPKHTLGQITGYNIYYTTDTTKRDRDWSVEAFAGEETMLMLPNLKPYTTYYFKVQARTTKGA 1192
            .|.||....|:|..|.|.|:::.|:.:..|::....|......:..|:..|.|:||:.|||..|.
Human   881 HWCPPTEPNGEIVEYLILYSSNHTQPEHQWTLLTTQGNIFSAEVHGLESDTRYFFKMGARTEVGP 945

  Fly  1193 NNAPFSALVSYTTSAAVTMQEPDTIAKGIDNEKLLYIIIAATAVVLLVVLLGVLLL----C---R 1250
              .|||.|     ...:|:||  .::..:|...:..||:.        |.||:|.|    |   |
Human   946 --GPFSRL-----QDVITLQE--KLSDSLDMHSVTGIIVG--------VCLGLLCLLACMCAGLR 993

  Fly  1251 RKP--QSSPEHTKKS-------YQKNNVGVPKPPDLWIHHDQMELKNIDKGLHTVTPVCSDGASS 1306
            |.|  :|.|..:..:       |.:..:|.|.||                ..|.:
Human   994 RSPHRESLPGLSSTATPGNPALYSRARLGPPSPP----------------AAHEL---------- 1032

  Fly  1307 SGALTLPRSVVHSEYEVETPVPGHVTNSLDKRSYVPGYMTTSMNGTMERPQYPRTQYSHQNRSHM 1371
                   .|:||...:..:|.|..|.:..:..|.:.|.::                   :.|||.
Human  1033 -------ESLVHPHPQDWSPPPSDVEDRAEVHSLMGGGVS-------------------EGRSHS 1071

  Fly  1372 TMEAGLSQQS-LTQPQSNSMAQTPEH-----------PYGG-----------YDANFCNAGNAAA 1413
            ..:...:|.| |:...|.:..:.|:.           |..|           ||        |..
Human  1072 KRKISWAQPSGLSWAGSWAGCELPQAGPRPALTRALLPPAGTGQTLLLQALVYD--------AIK 1128

  Fly  1414 GNG-------CVSTIESSKRGHPLKSFSVPGPPPTGGATPVTKHTPAVTIRPQNQSPYKKPSFSA 1471
            |||       |.:.:|:....|  ..||.....|......:....|.....|...|....|...|
Human  1129 GNGRKKSPPACRNQVEAEVIVH--SDFSASNGNPDLHLQDLEPEDPLPPEAPDLISGVGDPGQGA 1191

  Fly  1472 ATPNRLQGG 1480
            |..:|..||
Human  1192 AWLDRELGG 1200

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fra	NP_523716.2	Ig	36..140	CDD:299845	36/116 (31%)
		Ig	<180..222	CDD:299845	19/41 (46%)
		IG_like	257..340	CDD:214653	27/84 (32%)
		IGc2	264..327	CDD:197706	20/64 (31%)
		I-set	344..430	CDD:254352	30/88 (34%)
		Ig	363..428	CDD:299845	26/67 (39%)
		FN3	611..703	CDD:238020	16/95 (17%)
		FN3	711..799	CDD:238020	13/87 (15%)
		FN3	806..897	CDD:238020	31/94 (33%)
		FN3	908..989	CDD:238020	26/98 (27%)
		FN3	1011..1097	CDD:238020	23/91 (25%)
		FN3	1109..1205	CDD:238020	31/95 (33%)
		Neogenin_C	1273..1521	CDD:284094	42/238 (18%)
IGDCC4	XP_016877937.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4221
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR44170
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.910