DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fra and obscnb

DIOPT Version :9

Sequence 1:NP_523716.2 Gene:fra / 36377 FlyBaseID:FBgn0011592 Length:1526 Species:Drosophila melanogaster
Sequence 2:XP_021326058.1 Gene:obscnb / 572412 ZFINID:ZDB-GENE-070119-5 Length:6781 Species:Danio rerio


Alignment Length:1781 Identity:350/1781 - (19%)
Similarity:598/1781 - (33%) Gaps:552/1781 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 SCLIFQLIGSSLASQALSFTLEPQDAVVPEGHSVLLQCAGTASIGRGGKSKSNLPSSVSIRWRGP 83
            :||..:.|      ..||||.|.....|.||.|..|:|            ::::|.: |:.|:  
Zfish  3996 ACLTVRAI------PVLSFTKELTSQEVTEGGSTSLRC------------ETSIPDA-SVTWK-- 4039

  Fly    84 DGQDLVIVGDTFRTQLK-NGSLYI-----SSVEENRGLTGAYQCLLTAEGVGSILSRPALVAIVR 142
              ::.:::.|..:..:| :|:::|     .|||:    .|.|.|....:...:.|:....|.|.|
Zfish  4040 --KNTLVLTDGKKYSIKRDGTIHILEIHKLSVED----AGEYTCEAGEKKSKATLTVKECVKITR 4098

  Fly   143 QPDLNQDFLETYLLPGQTAYFRCMLGEANWQEGVKHSVQWLKDDLPLPLDKLRMVVLPNGALEID 207
                  :..:..::.|:.|.|:|.:.    |:||.:...||                  |:..:.
Zfish  4099 ------ELKDVTVITGEDAIFQCEVS----QKGVTNVEWWL------------------GSNHLQ 4135

  Fly   208 EVGPSDRGSYQCNVTSGSSSRLSSKTNLNIKKPSDPGAENSVAPSFLVGP-----------SPK- 260
            .   :|.....|   .|....|.    |.:..|.|.|   .||  |:|||           .|| 
Zfish  4136 N---NDLNQISC---QGREHSLV----LKMVTPDDSG---DVA--FVVGPMKSVAYLMVQEKPKV 4185

  Fly   261 ---------TVREGDTVTLDCVANGVPKPQIKWLRNGMDLDFNDLDSRFSIV---GTGSLQISSA 313
                     |.:||.||||.|:.:. |:..:.|.:   |.:......|:.:.   ....|:|...
Zfish  4186 VFLEKPLDITAKEGQTVTLSCMTSD-PEAAVAWYK---DEEMIKAGGRYLLYKDRAVHQLRILRV 4246

  Fly   314 EDIDSGNYQCRASNTVDSLDAQATVQVQ-EPPKFIKAPKDTTAHEKDEPELKCDIWGKPKPVIRW 377
            |:.|:|.|.|:..:.    ::.||:.|: :|..|.|..::..|.|.|...|:|:: .||...:.|
Zfish  4247 EEGDAGLYTCKTKDA----ESCATLTVKGQPAYFRKELENQNAIEGDSIILRCEL-SKPVKSVEW 4306

  Fly   378 LKNGDLITPNDYMQL-VDG--HNLKILGLLNSDAGMFQCVG----TNAAGSVHAAARLRVVPQGV 435
            .|.|.::.|:...:| .||  ..|.:..|...|.|.:.|..    |.|:.:|..|..|  :..|:
Zfish  4307 RKGGVVLQPSKKFELKQDGCVLELHVHDLEPEDNGYYTCDAGDQLTTASITVQEAEVL--IVSGI 4369

  Fly   436 KIKKRKSQGHSTKSLQTFDNLTKRRKP----FNSGEQLRTKSGGSFPFPDED------DDLDDND 490
            |.........:..|.|    |::|.|.    :..|.:|...:.......::.      .:|..||
Zfish  4370 KNTDVFVGEQAVFSCQ----LSRRAKGRVQWWLDGTRLENSTFSEISMGEDHVHTLTLRNLSPND 4430

  Fly   491 SGTTRLRIPSGKLPKFEQPL-NDRRFNILNAGSALPLDNQSKSYEDDDDDYDEDDPAKEALLEAY 554
            |||...:  :|.|....:.| .|....:::|              .:|....|..||:...    
Zfish  4431 SGTVLFK--TGALTSSAKLLVKDPNVEVVSA--------------MEDQHVAEKQPAEFIC---- 4475

  Fly   555 KQGEDAHKILDSWQQSKSKKSQQQKQS-PASPDS----PEQDPSVPH---PGGKPLDSGLQA--- 608
                         |.|:..|:..::.. |...|.    .|||.:|..   ...:|.|.|:.:   
Zfish  4476 -------------QYSRPVKAIWKRNGVPVQADGRRVIMEQDWTVARLYISCVEPQDGGIYSCEA 4527

  Fly   609 ---------RLPSQPRDLVAQIVKSRFVTLSWVEPLQNAGDVVYYTVYYKMNNSE----REQKMV 660
                     |:.::|.|::.:        ||.:|.: |.|:.::.....:..|.:    .:.|.|
Zfish  4528 EGTSVVAHLRVQAKPIDILQE--------LSNMETI-NGGEALFECSLSRPENKDCQWLIDGKPV 4583

  Fly   661 TKSHDDQQVNIQSLLPGRTYQFRVE-----ANT--NFGSGASSA---------------PLE--- 700
            .:|.:.:.|:.:|   ||.:...::     .||  .|.:|.||.               |||   
Zfish  4584 KESANVEIVSFES---GRRHLLLLKDLQPCENTRITFQAGTSSTTALLTVKAWQLEVVKPLEDKT 4645

  Fly   701 --VSTQPE----VNIAGPPRNFEGYARSHKEIYVKWEEPTVTNGEILKYRVYYSENDSGADLYHD 759
              |..:.|    :|.|.|......||                ||..|::...::...||:     
Zfish  4646 AIVGQEVEFTCTLNEAVPENEVTWYA----------------NGVELQHNDQWAMRTSGS----- 4689

  Fly   760 STALEAVLTELRPHTDYVISVVPFNRNGMGDSSAEIRVKTFSSTPSEPPNNVTLEVTSSSSITVH 824
            |.:|.....:.:|..:...:.    |:.:  |.|::   |..:.| :||.:..|.....:.||:.
Zfish  4690 SYSLILKKAQAQPTQEITFAA----RDAL--SLAKL---TTIAVP-DPPEDPELVSKGPTFITLS 4744

  Fly   825 WEPPAEEDRNGQITGYKIRYRKFKDAPQV--KSTPANIRYFELSNLDRNAEYQVKIAAMTVNGSG 887
            |..|. .|....|.||::..|.......:  .:.|.....|.:.||...|.|:.::||:...|.|
Zfish  4745 WFTPL-SDGGSPIIGYRVEMRLVDSVLWLPCHTEPVFNTEFLVENLIPGAGYRFRVAAINRAGIG 4808

  Fly   888 PFTEWNRANTLENDLDETQV-------PGKPIWISIHPGANNIALHWGPPQHP-EIKIRNYVLGW 944
            ...:..:..||:..:..|:.       .||.:.:.....|...::.|...... |:.::..::..
Zfish  4809 EPVQLPQTVTLDAPVTMTKKLSTSELHKGKMVRLECELSAEGKSVAWFKDNREIEVGVKYQMVTE 4873

  Fly   945 GRG----IPDENTIE-------LKETERYHILKNLESNMDYVVSLRARN---------VKGD--- 986
            |:.    |.|..|.:       ..|..:..|..|||.: |..:|..|.|         .:||   
Zfish  4874 GKSQVLLIKDFQTTDQGVYSCSASEEAKTSINLNLEGH-DGTLSQDAGNQPKLPPEAASEGDLHA 4937

  Fly   987 ------------GPPIYDNIKTRDEE---------------------PVDAPTPLEVPVGLRAI- 1017
                        ..|..|:|....||                     ||:....:.....|... 
Zfish  4938 LWEAEAKKRRMSREPTLDSISELPEEDGKDKMQKKDEKEPAKEIKVRPVEPGPKITAEPNLYTSS 5002

  Fly  1018 ---TMSSSSIVVYWIDTMLNKNQHVTDNRHYTVSYGITGSNRYRYHNTTDLNCMINDLRP----- 1074
               ::|.:|:|.|...:  :|:....:::..||:    ....|.:...|:.:.....:.|     
Zfish  5003 DEESLSGTSLVSYLKKS--SKSSMTVESQTETVA----SKKLYEHFQMTEQSVTKTSVEPLMEAQ 5061

  Fly  1075 --NTQYEFAVKV---VKGRRESSWSMSVLNSTYQNVPVTPPREVTVRLD---EMNPPTVIVQWIP 1131
              :...|.|||:   .||.:.......|....::.....|  ..|:.|:   |..|..  |:|:.
Zfish  5062 NGDELQEAAVKIQAAFKGYKARKDMRPVFKEVFKEQTKEP--NGTIHLECIVEGKPDK--VRWLK 5122

  Fly  1132 PKHTL--GQITGYNIY-------------------YTTDTTKRDRDWSVEAFAGEETMLMLPN-- 1173
            ....|  |:....:||                   ||.:.|.:   :.|...:|:.|:..|..  
Zfish  5123 DGEPLTDGKHHHIDIYNDGTCSLVVTAATTKDTGVYTCEVTNK---FGVSTHSGKVTVGSLRESV 5184

  Fly  1174 LKPYTT-YYFKVQARTTKGA-------------------------NNAPFSA----------LVS 1202
            .:|.|. |....:|.::.|:                         ...||.:          |.|
Zfish  5185 RRPLTLGYSADSEAESSSGSEMDETLRQASKRLRRLLRTRLPPDVEEEPFVSADEGDLPPQDLQS 5249

  Fly  1203 YTTS----------------AAVTMQEPDTIAKGIDNEKLLYIIIAATAVVLLVV---------- 1241
            |...                |::..||..|. :|:..|..  ||.||.|.|.|.:          
Zfish  5250 YREDDQYIYIRFDNRTEAQVASLRFQEMFTY-QGVPIETA--IIPAAGAKVELRITKMALSEDGS 5311

  Fly  1242 ------------LLGV----LLLCRRKPQSSPEHTKKSYQKNNVGVPKPPDLWI-------HHDQ 1283
                        :.|.    :.:...:.|..|:....|:....||.|.|...|.       .:|.
Zfish  5312 RTPTQDQPMPTFMTGAPAAPVFMTELRSQDVPDGFPVSFDCVIVGKPPPTVKWFKDGKLLEENDH 5376

  Fly  1284 MELKNIDKGLH-----TVTPV------C-----SDGASSSGALTLPRSVVHSEYEVETPVPGHVT 1332
            ..:....:|.|     ||.|.      |     |..|||...|.:..| ..|:|:.       ..
Zfish  5377 YMINEDQEGRHQLIITTVLPTDMGVYRCMAENDSGIASSKAELRVDMS-CSSDYDT-------AA 5433

  Fly  1333 NSLDKRSYV--PGYMTTSMNGTMER----------PQY--------------------------- 1358
            ::.:..|||  .||:::|.:...|.          ||.                           
Zfish  5434 DATETSSYVSAKGYVSSSEHRDTEAFESVAEDELLPQVVDELHDLFLSPGAPIAKMSVRVKGFPT 5498

  Fly  1359 PRTQYSH-----QNRSHMTMEAGLSQQSLTQPQSNSMAQTPEHPYGGYDANFCNAGNAAAGNGCV 1418
            ||..:..     |..|.:.:.....|.||      .:........|.|.|...|...:|..:..:
Zfish  5499 PRVYWFKDGTPLQASSRIVLSTERDQHSL------EILDVKCEDTGEYSAYISNIAGSAYSSARM 5557

  Fly  1419 STIESSKRGHP----LKSFSVPGPPP 1440
            :.:...:|..|    |:...||..||
Zfish  5558 NVLAPGERPTPDQGRLRDSKVPLVPP 5583

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fraNP_523716.2 Ig 36..140 CDD:299845 25/109 (23%)
Ig <180..222 CDD:299845 5/41 (12%)
IG_like 257..340 CDD:214653 24/106 (23%)
IGc2 264..327 CDD:197706 18/65 (28%)
I-set 344..430 CDD:254352 26/92 (28%)
Ig 363..428 CDD:299845 20/71 (28%)
FN3 611..703 CDD:238020 25/122 (20%)
FN3 711..799 CDD:238020 14/87 (16%)
FN3 806..897 CDD:238020 22/92 (24%)
FN3 908..989 CDD:238020 20/116 (17%)
FN3 1011..1097 CDD:238020 17/99 (17%)
FN3 1109..1205 CDD:238020 28/157 (18%)
Neogenin_C 1273..1521 CDD:284094 45/239 (19%)
obscnbXP_021326058.1 I-set 10..99 CDD:254352
I-set 110..199 CDD:254352
I-set 282..362 CDD:333254
I-set 369..452 CDD:333254
I-set 459..>523 CDD:333254
FN3 547..634 CDD:238020
Ig 762..809 CDD:319273
IG 836..901 CDD:214652
I-set 928..997 CDD:333254
I-set 1020..1089 CDD:333254
I-set 1112..1181 CDD:333254
I-set 1204..1273 CDD:333254
I-set 1296..1365 CDD:333254
Ig 1401..1469 CDD:319273
I-set 1483..1552 CDD:333254
Ig 1585..1644 CDD:319273
Ig 1689..1732 CDD:319273
I-set 1750..1833 CDD:333254
I-set 1840..1923 CDD:254352
I-set 1930..1999 CDD:333254
I-set 2018..2091 CDD:333254
I-set 2107..2190 CDD:333254
I-set 2196..2279 CDD:333254
I-set 2285..2368 CDD:333254
I-set 2374..2458 CDD:333254
I-set 2464..2547 CDD:333254
I-set 2553..>2620 CDD:333254
I-set 2643..2725 CDD:333254
I-set 2732..2815 CDD:333254
I-set 2820..2905 CDD:333254
I-set 2912..2995 CDD:333254
IG_like 3007..3084 CDD:214653
I-set 3090..3160 CDD:333254
I-set 3178..3260 CDD:333254
I-set 3266..3349 CDD:333254
IG_like 3389..>3452 CDD:214653
I-set 3471..3541 CDD:333254
I-set 3560..3630 CDD:333254
I-set 3649..3719 CDD:333254
I-set 3739..3808 CDD:333254
I-set 3828..3910 CDD:333254
IG 3926..4000 CDD:214652 2/3 (67%)
I-set 4007..4090 CDD:254352 24/103 (23%)
I-set 4095..>4162 CDD:333254 19/104 (18%)
I-set 4186..4269 CDD:254352 21/90 (23%)
I-set 4275..4358 CDD:333254 23/83 (28%)
IG 4370..4449 CDD:214652 16/84 (19%)
IG_like 4461..4538 CDD:214653 16/93 (17%)
I-set 4636..>4700 CDD:333254 17/84 (20%)
FN3 4725..4818 CDD:238020 23/94 (24%)
I-set 4825..4906 CDD:333254 12/80 (15%)
IQ 5065..5087 CDD:197470 6/21 (29%)
I-set 5104..5177 CDD:254352 15/77 (19%)
I-set 5331..5421 CDD:254352 20/89 (22%)
I-set 5469..5559 CDD:254352 14/95 (15%)
I-set 5583..5678 CDD:333254 1/1 (100%)
SH3_Obscurin_like 5807..5869 CDD:212958
RhoGEF 5899..6075 CDD:321997
PH_Obscurin 6084..6208 CDD:270059
I-set 6216..6308 CDD:254352
I-set 6310..6399 CDD:333254
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.