DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fra and dcc

DIOPT Version :9

Sequence 1:NP_523716.2 Gene:fra / 36377 FlyBaseID:FBgn0011592 Length:1526 Species:Drosophila melanogaster
Sequence 2:NP_001030157.1 Gene:dcc / 569360 ZFINID:ZDB-GENE-011101-2 Length:1421 Species:Danio rerio


Alignment Length:1618 Identity:471/1618 - (29%)
Similarity:728/1618 - (44%) Gaps:359/1618 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly    35 LSFTLEPQDAVVPEGHSVLLQCAGTASIGRGGKSKSNLPSSVSIRWRGPDGQDLVIVGDTFRTQL 99
            |.|.|:|||.|...|..:.|.|...:..|        :|   ||.|: .||..|..|.|..|.||
Zfish    35 LRFVLQPQDVVTVRGGVLQLDCDALSDQG--------VP---SISWK-KDGVLLSAVVDERRRQL 87

  Fly   100 KNGSLYISSV---EENRGLTGAYQCLLTAEGVGSILSRPALVAI--VRQPDLNQDFLETYLLPGQ 159
            .||||.:.:|   ..:|...|:||||.:.||:|:|:||.|.|.:  ..:..::.:.:..:|  |.
Zfish    88 SNGSLLVQNVMHSRHHRPDEGSYQCLASLEGIGAIVSRTARVTVSGPLRVLVSTESVSAHL--GD 150

  Fly   160 TAYFRC-MLGE----ANWQEGVKHSVQWLKDDLPLPLD-KLRMVVLPNGALEIDEVGPSDRGSYQ 218
            ||..|| :.|:    ..||:.        ::||||..| ..|:|:||:|:|::..|.|.|..:|:
Zfish   151 TALLRCEVTGDPMPVVRWQKN--------REDLPLTFDPDSRVVILPSGSLQVSRVQPPDSATYR 207

  Fly   219 CNVTSGSSSRLSSKTNLNIKKPSDPGAENSVAPSFLVGPSPKTVREGDTVTLDCVANGVPKPQIK 283
            |...:..|:|..:..:|.:.  .:||....:.  ||..|...:|.:|....|:|.|:|.|.|...
Zfish   208 CLAENPGSARTGTDADLRVL--PEPGVSRGLV--FLQRPQKVSVLQGRDAVLECSASGFPNPAFY 268

  Fly   284 WLRNGMDLDFNDLDSRFSIVGTGSLQISSAEDIDSGNYQCRASNTVDSLDAQATVQVQEPPKFIK 348
            ||| |.:| ......::|::...:|.|||..|.|||.|.|.|.|...::.|...:.|..||:|:.
Zfish   269 WLR-GNEL-IQSRSKKYSLLSGSNLLISSVTDDDSGIYTCIAHNKQQNISASCELAVLVPPQFLN 331

  Fly   349 APKDTTAHEKDEPELKCDIWGKPKPVIRWLKNGDLITPNDYMQLVDGHNLKILGLLNSDAGMFQC 413
            .|.:|.|:|..:.|::|.:.|.|:||:||:|||:::.|:||.|:|||.:|:||||:.||.|.:||
Zfish   332 YPSNTYAYESSDIEMECAVTGNPQPVVRWVKNGEVVVPSDYFQIVDGGHLQILGLVRSDEGFYQC 396

  Fly   414 VGTNAAGSVHAAARLRVVPQGVKIKKRKSQGHSTKSLQTFDNLTKRRKPFNSGEQLRTKSGGSFP 478
            :..|.||:..|.|:|                                                  
Zfish   397 IAENEAGNSQAMAQL-------------------------------------------------- 411

  Fly   479 FPDEDDDLDDNDSGTTRLRIPSGKLPKFEQPLNDRRFNILNAGSALPLDNQSKSYEDDDDDYDED 543
                                                                             
Zfish   412 ----------------------------------------------------------------- 411

  Fly   544 DPAKEALLEAYKQGEDAHKILDSWQQSKSKKSQQQKQSPASPDSPEQDPSVPHPGGKPLDSGLQA 608
                 .||:                             |.:|.|                    |
Zfish   412 -----ILLQ-----------------------------PVTPRS--------------------A 422

  Fly   609 RLPSQPRDLVAQIVKSRFVTLSWVEPLQNAGDVVYYTVYYKMNNSEREQKMVTKSHDDQQVNIQS 673
            ..||.|||:...:|.||||.|||..|.:..|.::.|.|:|......||:.:.....:..|:.:.:
Zfish   423 VSPSAPRDVAPVLVSSRFVRLSWRPPEEPRGPILTYGVFYSEEGINRERSVNVTEAESLQLTVSN 487

  Fly   674 LLPGRTYQFRVEANTNFGSGASSAPLEVSTQPEVNIAGPPRNFEGYARSHKEIYVKWEEPTVTNG 738
            |.|..:|.|||.|....|.|.||..:.:|||.|:.:.||..|.:..|.|...|...|:.|...||
Zfish   488 LRPEASYSFRVLAYNEQGPGESSEAIRLSTQAELLVPGPVENLQAEAVSPTSIQASWDPPAPANG 552

  Fly   739 EILKYRVYYSENDSGADLYHDSTALEAVLTELRPHTDYVISVVPFNRNGMGDSSAEIRVKTFSST 803
            .:..||:.::|..||.:...:.......:..|:..|:|.:.|:..||:|.|.|..:..:.|.|..
Zfish   553 PVQSYRLLWTETSSGKEQNVEVVGQSYRMEGLKKFTEYSLRVLAVNRHGPGVSDKDTLITTLSDV 617

  Fly   804 PSEPPNNVTLEVTSSSSITVHWEPPAEEDRNGQITGYKIRYRKFKDAPQVKSTPANIRYFELSNL 868
            ||.||.||:|||..|.||.|.|:||....:||.||||||||||.....:.::...|..::..:.|
Zfish   618 PSSPPQNVSLEVVYSRSIKVSWQPPPANTQNGFITGYKIRYRKTGRRGEQEAIEPNNLWYLFTGL 682

  Fly   869 DRNAEYQVKIAAMTVNGSGPFTEWNRANTLENDLDETQVPGKPIWISIHPGANNIALHWGPPQHP 933
            ::.::|..:::.|||||:||.:||..|.|.||||||:|||.:|..:.:.|..|:|.:.|.||.:|
Zfish   683 EKGSQYSFQVSGMTVNGTGPSSEWLTAETPENDLDESQVPHQPSSLHVRPLPNSIIMSWTPPLNP 747

  Fly   934 EIKIRNYVLGWGRGIPDENTIELKETERYHILKNLESNMDYVVSLRARNVKGDGPPIYDNIKTRD 998
            ...||.|.:|:|.|.|...|:.:...:||:.::|||.:..||:||:|.|..|:|.|:|::..||.
Zfish   748 NTLIRGYTIGYGVGSPYAQTVRVDSKQRYYSIENLEPSSHYVISLKAFNNAGEGVPLYESAVTRS 812

  Fly   999 EEPVDAPTPLEVPVGLRAITMSSSSIVVYWIDTMLNKNQHVTDNRHYTVSY--GITGSNRYRYHN 1061
            ... .:..|:..|||::|:.::|.|:.|.|.|..:.|||..::.|:|:|.:  ..:.|.:::..:
Zfish   813 MTD-SSSAPMIPPVGVQAVALTSDSVRVSWADNSIPKNQKSSEVRYYSVKWRTSHSTSGKHKSAD 876

  Fly  1062 TTDLNCMINDLRPNTQYEFAVKVVKGRRESSWSMSVLNSTYQNVPVTPPREVTVRLDEMNPPTVI 1126
            ||.|:..:..|:|||.|||:|.|.|||:.|:|||:...:||:..|.:.|:::||...|..|..::
Zfish   877 TTALSHTVTGLKPNTMYEFSVMVTKGRKSSTWSMTAHATTYEAAPSSAPKDLTVIGREGRPRAIL 941

  Fly  1127 VQWIPPKHTLGQITGYNIYYTTDTTKRDRDWSVEAFAGEETMLMLPNLKPYTTYYFKVQARTTKG 1191
            :.|.||....|:|||:.:|||.:......||.:|..:|:.....:.:|...|.|||::||:..||
Zfish   942 ISWQPPLEANGRITGFILYYTLEKNLPIDDWVMEPISGDRLTHQVLDLNLDTVYYFRIQAKNAKG 1006

  Fly  1192 ANNAPFSALVSYTTSAAVTMQEPDTIAKG----------------ID------------------ 1222
            .  .|.|..|.|.||   .::.||.:|..                ||                  
Zfish  1007 V--GPLSDPVQYRTS---KVEHPDKMANDQGRHGDGVYWPSDNNPIDMSSLNEAPIGQMRPPHGS 1066

  Fly  1223 -----NEKLLYIIIAATAVVLLVVLLGVLLLCRRKPQSSPEHTKK------SYQKNNVGVPKPPD 1276
                 |..||.||:.:...|.:||:|.|.|:|.|:  ||.:..||      ..:|.:....:|||
Zfish  1067 VTPQKNSNLLVIIVVSVGAVTVVVVLIVALICTRR--SSAQQRKKRATHSAGKRKGSQKDLRPPD 1129

  Fly  1277 LWIHHDQMELKNIDK--------------GLHTVTPV-------------CSDGA----SSSGAL 1310
            |||||::|||||::|              ....:.||             ...||    |||...
Zfish  1130 LWIHHEEMELKNMEKPSGSAPSGRDSPIQSCQEIPPVSHSQSESQMGSKSSHSGADADESSSSIS 1194

  Fly  1311 TLPRSVV---HSEYEVETPVPGHVTN----------SLDKRSYVPGYMTTSMNGTMERPQYPRTQ 1362
            ||.||:.   .:..::..|:....:|          :||...| ||.:.:...|....|::....
Zfish  1195 TLERSLAARRATRTKMMIPMDSQPSNTPVVSAIPVPTLDSSQY-PGILPSPSCGFTAHPKFSLRP 1258

  Fly  1363 YSHQNRSHMTME----AGLSQQSLT----QPQSNSMAQTPEHPYGGYDANFCNAGNAAAGNGCVS 1419
            ...   |.:|:|    :.:|.:..|    |||...:......|....:     ..:.:....|| 
Zfish  1259 MPF---STLTVERSYTSAMSAEGATPMAPQPQPALIPTAQSEPQVSEE-----IPSRSIPTACV- 1314

  Fly  1420 TIESSKRGHPLKSFS---VPGP----------PPTGGATPVTKHTPAVTIRPQNQS-PYKKPSFS 1470
                 :..|||:||:   :|.|          |.|||:.|    .|.|......|: ..:.|...
Zfish  1315 -----RPTHPLRSFTNTLLPPPMGTIEPKVFSPVTGGSLP----KPQVKTASLGQAGKARSPLLP 1370

  Fly  1471 AATPNRLQGGGSVVHSTDEIQRLAPSTST----EELNQEMANLEGLMKDLSAITANEF 1524
            .:.|       :...|.::.|:.....|:    ::|:::||:||||||.|:|||.:.|
Zfish  1371 VSVP-------TAPESAEDGQKPPEDPSSVYEQDDLSEQMASLEGLMKQLNAITGSAF 1421

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fraNP_523716.2 Ig 36..140 CDD:299845 41/106 (39%)
Ig <180..222 CDD:299845 16/42 (38%)
IG_like 257..340 CDD:214653 28/82 (34%)
IGc2 264..327 CDD:197706 24/62 (39%)
I-set 344..430 CDD:254352 40/85 (47%)
Ig 363..428 CDD:299845 32/64 (50%)
FN3 611..703 CDD:238020 32/91 (35%)
FN3 711..799 CDD:238020 24/87 (28%)
FN3 806..897 CDD:238020 39/90 (43%)
FN3 908..989 CDD:238020 30/80 (38%)
FN3 1011..1097 CDD:238020 35/87 (40%)
FN3 1109..1205 CDD:238020 32/95 (34%)
Neogenin_C 1273..1521 CDD:284094 77/317 (24%)
dccNP_001030157.1 Ig 36..131 CDD:299845 41/106 (39%)
IG_like 41..131 CDD:214653 39/101 (39%)
IG_like 142..226 CDD:214653 28/93 (30%)
Ig 152..>212 CDD:299845 22/67 (33%)
I-set 237..323 CDD:254352 30/89 (34%)
Ig 238..323 CDD:299845 30/86 (35%)
I-set 327..412 CDD:254352 40/204 (20%)
Ig 343..413 CDD:299845 34/189 (18%)
FN3 425..517 CDD:238020 32/91 (35%)
FN3 524..613 CDD:238020 24/88 (27%)
FN3 620..711 CDD:238020 39/90 (43%)
FN3 722..810 CDD:238020 32/87 (37%)
FN3 823..916 CDD:238020 35/92 (38%)
FN3 923..1018 CDD:238020 32/96 (33%)
Neogenin_C 1125..1419 CDD:284094 78/319 (24%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 99 1.000 Domainoid score I7020
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 737 1.000 Inparanoid score I585
OMA 1 1.010 - - QHG46607
OrthoDB 1 1.010 - - D118438at33208
OrthoFinder 1 1.000 - - FOG0002773
OrthoInspector 1 1.000 - - otm25378
orthoMCL 1 0.900 - - OOG6_105369
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1863
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
109.880

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