DRSC/TRiP Functional Genomics Resources

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Protein Alignment fra and hmcn2

DIOPT Version :9

Sequence 1:NP_523716.2 Gene:fra / 36377 FlyBaseID:FBgn0011592 Length:1526 Species:Drosophila melanogaster
Sequence 2:XP_001920501.5 Gene:hmcn2 / 565032 ZFINID:ZDB-GENE-030131-9765 Length:4212 Species:Danio rerio


Alignment Length:1810 Identity:363/1810 - (20%)
Similarity:580/1810 - (32%) Gaps:640/1810 - (35%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 SCLIFQLIGSSLA------SQALSFTLEPQDAVVPEGHSVLLQCAGTASIGRGGKSKSNLPSSVS 77
            :|:...:.|||.|      ..|.:|:..|.|.....|.::.|.|     |.||      .|:. |
Zfish   766 TCVASNIAGSSSAVVVLQVGAAPTFSESPVDITASVGDNITLPC-----IARG------FPTP-S 818

  Fly    78 IRWRGPDGQDLV--IVGDTFRTQLKNGSLYISSV---EENRGLTGAYQCLLTAEGVGSI--LSR- 134
            :.||..||:.:.  ..|....:||.:|:|.|.||   :|     |.|.|....: .|||  |:| 
Zfish   819 LIWRRQDGRPIFGKSSGHVGTSQLPSGALQIQSVWVDDE-----GVYLCEAKNQ-FGSIKALARV 877

  Fly   135 --------------PALVAIVRQPDLNQDFLETYLLPGQTAYFRCMLGEANWQEGVKHSVQWLKD 185
                          |::..::.|| ||        ||       |.                |.|
Zfish   878 TVTGLEPPLLVQGAPSITTMIAQP-LN--------LP-------CR----------------LLD 910

  Fly   186 DLPLPLDKL------------RMVVLPNGALEIDEVGPSDRGSYQCNVTSGSSSRLSSKTNLNIK 238
            .:||| :::            |:.:..:|:|.:|...|.|.|:|.|...:     ::...|:.:.
Zfish   911 GIPLP-ERIWTHNGKQVRVGGRVFLRSDGSLHVDRAVPEDAGTYVCTAVN-----VAGSANITVT 969

  Fly   239 KPSDPGAENSVAPSFLVGPSPKTVREGDTVTLDCVANGVPKPQIKWLRNGMDLDFNDLDSRFSIV 303
                  .|....|....||...|..||..::|.|.|.|||||.|.|.: |.|.....:.:.|. .
Zfish   970 ------VEVHAPPDIKAGPLHYTASEGTPISLSCEARGVPKPTISWSK-GRDPLNRPVSAPFE-A 1026

  Fly   304 GTGSLQISSAEDIDSGNYQCRASNTVDSLDAQATVQVQEPPKFIKAPKD-----TTAHEKDEPEL 363
            ..|||.|||..:.|:|.|.|.|::.|.....:..:.|...|:.:.|...     ..|....|..|
Zfish  1027 ADGSLYISSPTEEDAGVYICTATSAVGYTSREMHLIVNSKPRIVGADGSQVTVKMAAEVGSEVIL 1091

  Fly   364 KCDIWGKPKPVIRWLKNGDLITP-NDYMQLVDGHNLKILGLLNSDAGMFQCVGTNAAGS------ 421
            .|::.|.|.|::.|.:||..|.| ..:..::...:|||..:...|:.::.|...|.||:      
Zfish  1092 PCEVQGSPTPLVTWSRNGQTIPPVTAWFTMLPSGSLKISDVRVVDSKLYTCSAVNPAGNVSLTYN 1156

  Fly   422 --VHAAARLRVVPQGVKIKKRKS-------QGHSTKSLQTFDNLTKRRKPFNSGEQLRTKSGGSF 477
              |.|..|:...|..:|....::       ||..:..:....|    ..|..|...|:.::    
Zfish  1157 LQVQAKPRIHPAPSTLKALIGQTVVLPCVVQGEPSPQVSWLHN----GLPVASDRMLKIQA---- 1213

  Fly   478 PFPDEDDDLDDNDSGTTR---------------LRIPSGKLPKFEQPLNDRRFNILNAGSALPLD 527
                    :..:||||.|               |.:..|  |.||........::.|:...:|..
Zfish  1214 --------VQHSDSGTYRCVARNSAGEDTIQIVLDVLEG--PYFETNGETVIESVANSKVLIPCP 1268

  Fly   528 NQSKSYEDDDDDYDEDDPAK---------EALLEAYKQG----EDAHKILDSWQQSKS------- 572
            .:.             .||.         |..:|..:.|    ||...::.|...|.|       
Zfish  1269 ARG-------------SPAPQVRWFKNGLEVHMERSEHGVSLAEDGALVIGSASASHSGDFKCVA 1320

  Fly   573 --KKSQQQKQSPASPDSPEQDPSVPHPG---------GKPLDSGLQA-RLPSQPRDLVAQIVKSR 625
              :....::::....:.|   |.:...|         .:||..|..| .:|:.            
Zfish  1321 TNEAGSVERKTRLKVNVP---PEIQDDGQLLNLTVTLKQPLTLGCDAFGIPTP------------ 1370

  Fly   626 FVTLSWVEP----LQNAGDVVYYTVYYKMNNSEREQKMVTKSHDDQQVNIQSLLPGRTYQFRVEA 686
              |:||.:.    |:..|      ||  :.|.:|..|:....||.         .||   |...|
Zfish  1371 --TISWTKDNRPVLETPG------VY--LQNGKRLLKIYRVQHDH---------AGR---FSCTA 1413

  Fly   687 NTNFGSGASSAPLEVSTQP---------EVNI-AGPPRNFEGYARSHKEIYVKWEEPTVTNGEIL 741
            ..:.|.......:||...|         ||.| ||...:.:..........|:|..    :||:|
Zfish  1414 QNSAGEAKREYTIEVQAPPVISGTSGVQEVTIMAGQEVDMQCRVSGRPLPSVEWTH----DGEVL 1474

  Fly   742 KYRVYYSENDSGADLYHDSTALEAVLTELRPHTDY--------VISVVPFNR--------NGMGD 790
                  |.|..                   ||.::        |.||.|.:|        |..|.
Zfish  1475 ------SPNGD-------------------PHVEFLEKGQVLRVKSVRPRDRGLYQCVATNNAGT 1514

  Fly   791 SSAEIRVKTFSSTP----SEPPNNVTL----------EVTSSSSITVHW---------EPPAEED 832
            .:.:.|: |..:.|    |...:.||:          ||......|:.|         .|.....
Zfish  1515 QTRQFRL-TIQAAPLIRDSGEDSEVTVVLGFPAVLHCEVEGIPLPTITWLKDNQPIVSSPQLTYT 1578

  Fly   833 RNGQITGYKIRYRKFKDA-------------------------PQVKSTPANIRYFELSNLDRNA 872
            :.||  ..::...:.:||                         ||::.....:.:       ...
Zfish  1579 QGGQ--SLRVAAARGEDAGAYTCRATNPAGTAHRHYTLRIMVPPQIEGDSTILSF-------GRR 1634

  Fly   873 EYQVKIAAMTVNGS-----------GPFTEW---------------------------------- 892
            |.:|:|     ||:           .|.|:|                                  
Zfish  1635 EEKVRI-----NGTLTLSCLAKGFPEPVTQWFKDGQLLNGNTHSGLSVNSHMLHVDNAMLSHEGQ 1694

  Fly   893 ------NRANTLENDLDET-QVPGKPIWISIHPGANNIAL--HWGPPQHPE-----IKIRNYVLG 943
                  |.|...:.|...| |||  |::..:..||.:..|  ..|..:.|:     ::.|..:||
Zfish  1695 YTCVVSNSAGEDKRDFHLTIQVP--PVFHRVINGAADFTLGEREGDEEDPDSPDGMVERREVLLG 1757

  Fly   944 ------------------W---GRGIPDENTIELKETERYHILK----NLESNMDYVVSLRARNV 983
                              |   ||.:...:.:.|  ....|||:    .||....|  :.:|.|.
Zfish  1758 HSISLSCESNAIPPPRLSWYRQGRQLTSSDGVVL--APGGHILQIPRVQLEDAGKY--TCQAVNE 1818

  Fly   984 KGDG----------PPIYDNIKTRDEEPVDAPTPLEVPVGLRAITMSSSSIVVYWIDTMLNKNQH 1038
            .|:.          ||:...  ..||...|..|.:...|.||.......|..|.||...|   ..
Zfish  1819 AGEDKMHYDLEVLVPPVISG--QTDEFMQDVDTVVNSTVSLRCDVSGHPSPSVSWIKDGL---PL 1878

  Fly  1039 VTDNRHYTVSYGITGSNRYRYHNTTDLNCMINDLRPNTQYEFAVKVVKGRRESSWSMSVLNSTYQ 1103
            .:|:||..:..|         .....:|..::|   ...|:...:...|..|..:|:|:      
Zfish  1879 YSDSRHNILEDG---------KLLEIVNVQVSD---GASYQCVAENKAGAVERLYSLSI------ 1925

  Fly  1104 NVPVTPPREVTVRLDEMNPPTVI----------VQWIPPKHTLGQITGYNIYYTTDTTKRDRDWS 1158
               ..|||.|..|.:||   :|:          ||..||...:....|..:.:||         .
Zfish  1926 ---QVPPRIVGRREEEM---SVVEGHMISLLCDVQAYPPADIIWTKDGQMLEFTT---------G 1975

  Fly  1159 VEAFAGEETMLMLPNLKPYTTYYFKVQARTTKGANNAPFSALVSYTTSAAVTMQEPDTIAKGIDN 1223
            :....|.: ||.:|.                .|..:|.     .|..:|        |.:.|.|.
Zfish  1976 IHILPGGQ-MLQIPR----------------AGQQDAG-----QYVCTA--------TNSAGQDQ 2010

  Fly  1224 EKLLYIIIAATAVV--------LLVVLLGVLLLCRRKPQSSPEHTKKSYQKNNVGVPKPPDLW-- 1278
            :.:|..|.|..|:|        :...|:|..|:.|.:..               |:|||...|  
Zfish  2011 KSILLTIYALPALVPRLESESEVRTPLVGSTLILRCEAN---------------GIPKPEVTWYR 2060

  Fly  1279 ------------IHHDQMELKNI---DKGLHTVTPVCSDGASSSGALTLPRSVVHSEYEVETPVP 1328
                        |...|:|:..:   |.|::|    |.                      .:.:.
Zfish  2061 NGLQLAAGNGLRIERQQLEIVGVQVADGGVYT----CK----------------------VSNIA 2099

  Fly  1329 GHVTNSLDKRSYVPGYMTTSMNGTMERPQYPRTQYSHQN-RSHMTM---EAGLSQQSLTQPQSNS 1389
            |.|..:.....:||..|...::.|:.           || .||:|:   .:|:...::...:..|
Zfish  2100 GQVDRTFRVTVHVPPVMEGPLHETLT-----------QNLGSHITLICEASGIPVPNIAWLKDGS 2153

  Fly  1390 MAQTPEHPYGGYDANFCNAGNAAAGN-GCVSTIESSKRGHPLKSFS--VPGPP-------PTGGA 1444
            ..::.........||....|.....: |..:.|..:..|...|.:|  :..||       |:..:
Zfish  2154 PIESSLQWNWSTRANRLELGPLQLSHAGTYTCIAKNTEGQTQKDYSLTIYAPPSIIDSGHPSEVS 2218

  Fly  1445 TPVTKHTPAVTIRPQNQSPYKKPSFSAATPNRLQGGGSVVHSTDEIQRLAPSTST 1499
            .||.:.. |:..|... ||..|.|:       |:.|.::|:...|...::|..||
Zfish  2219 APVGEEL-ALECRAMG-SPAPKVSW-------LRNGKTLVNGNTEHINISPDGST 2264

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fraNP_523716.2 Ig 36..140 CDD:299845 33/125 (26%)
Ig <180..222 CDD:299845 14/53 (26%)
IG_like 257..340 CDD:214653 29/82 (35%)
IGc2 264..327 CDD:197706 26/62 (42%)
I-set 344..430 CDD:254352 25/99 (25%)
Ig 363..428 CDD:299845 20/73 (27%)
FN3 611..703 CDD:238020 20/95 (21%)
FN3 711..799 CDD:238020 18/103 (17%)
FN3 806..897 CDD:238020 23/185 (12%)
FN3 908..989 CDD:238020 23/122 (19%)
FN3 1011..1097 CDD:238020 18/85 (21%)
FN3 1109..1205 CDD:238020 22/105 (21%)
Neogenin_C 1273..1521 CDD:284094 49/258 (19%)
hmcn2XP_001920501.5 VWA_2 38..208 CDD:290253
IG 441..512 CDD:214652
Ig 441..502 CDD:299845
I-set 516..603 CDD:254352
Ig 533..600 CDD:143165
IG 613..691 CDD:214652
Ig 624..690 CDD:143165
IG 710..784 CDD:214652 5/17 (29%)
Ig 714..781 CDD:143165 5/14 (36%)
IG 794..879 CDD:214652 31/102 (30%)
Ig 794..879 CDD:299845 31/102 (30%)
I-set 885..972 CDD:254352 23/130 (18%)
Ig 904..972 CDD:299845 18/102 (18%)
IG_like 982..1063 CDD:214653 29/82 (35%)
IGc2 989..1053 CDD:197706 26/65 (40%)
IG_like 1083..1159 CDD:214653 20/75 (27%)
Ig 1089..1156 CDD:143165 18/66 (27%)
I-set 1163..1241 CDD:254352 15/93 (16%)
IGc2 1176..1231 CDD:197706 11/70 (16%)
Ig 1244..1327 CDD:299845 16/97 (16%)
IG_like 1258..1335 CDD:214653 12/89 (13%)
Ig 1338..1430 CDD:299845 27/128 (21%)
I-set 1344..1428 CDD:254352 23/117 (20%)
IG_like 1441..1523 CDD:214653 22/111 (20%)
IGc2 1448..1513 CDD:197706 16/93 (17%)
IG_like 1536..1616 CDD:214653 11/81 (14%)
IGc2 1545..1606 CDD:197706 9/62 (15%)
IG_like 1638..1714 CDD:214653 10/80 (13%)
Ig 1644..1711 CDD:143165 6/66 (9%)
IG_like 1753..1830 CDD:214653 15/80 (19%)
Ig 1760..1822 CDD:143165 13/65 (20%)
I-set 1834..1918 CDD:254352 21/100 (21%)
Ig 1851..1925 CDD:299845 18/88 (20%)
IG_like 1937..2017 CDD:214653 22/121 (18%)
IGc2 1943..2007 CDD:197706 16/102 (16%)
IG_like 2031..2110 CDD:214653 18/119 (15%)
IGc2 2039..2100 CDD:197706 15/101 (15%)
I-set 2114..2202 CDD:254352 17/98 (17%)
IGc2 2129..2192 CDD:197706 10/62 (16%)
IG 2214..2295 CDD:214652 16/60 (27%)
IGc2 2222..2287 CDD:197706 13/52 (25%)
I-set 2307..2391 CDD:254352
IGc2 2321..2381 CDD:197706
I-set 2400..2484 CDD:254352
IGc2 2410..2474 CDD:197706
IG_like 2496..2576 CDD:214653
IGc2 2507..2566 CDD:197706
IG 2589..2669 CDD:214652
IGc2 2597..2659 CDD:197706
IG 2679..2760 CDD:214652
IGc2 2687..2750 CDD:197706
I-set 2764..2851 CDD:254352
Ig 2770..2845 CDD:299845
IG 2863..2943 CDD:214652
Ig 2873..2942 CDD:299845
IG_like 2954..3032 CDD:214653
IGc2 2963..3023 CDD:197706
IG_like 3046..3122 CDD:214653
IGc2 3051..3113 CDD:197706
IG_like 3133..3214 CDD:214653
Ig 3144..3213 CDD:299845
IG 3224..3303 CDD:214652
IGc2 3232..3293 CDD:197706
IG_like 3316..3394 CDD:214653
IGc2 3321..3384 CDD:197706
TSP1 3401..3452 CDD:214559
G2F 3455..3636 CDD:284812
EGF_CA 3691..3721 CDD:214542
Furin-like 3728..3857 CDD:279142
EGF_CA 3731..3774 CDD:284955
EGF_CA 3776..3814 CDD:214542
EGF_CA 3816..3849 CDD:238011
EGF_CA 3858..3899 CDD:284955
EGF_CA 3901..3940 CDD:214542
EGF_CA 4005..4044 CDD:214542
EGF_CA 4045..4085 CDD:214542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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