DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fra and sdk2b

DIOPT Version :9

Sequence 1:	NP_523716.2	Gene:	fra / 36377	FlyBaseID:	FBgn0011592	Length:	1526	Species:	Drosophila melanogaster
Sequence 2:	XP_009305142.1	Gene:	sdk2b / 564922	ZFINID:	ZDB-GENE-030131-8203	Length:	2256	Species:	Danio rerio

Alignment Length:	1950	Identity:	393/1950 - (20%)
Similarity:	637/1950 - (32%)	Gaps:	673/1950 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 WLLSSCLIFQLIGSSLASQALSFTLEPQDAVVP-----EGHSVLLQCAGTASIGRGGKSKSNLPS 74
            |::...|:...:.|:.......|..||    ||     |.:.::|.|....|            .
Zfish    33 WIVILLLVLLHLASAQDDVPPYFKTEP----VPSQLHLERNRLVLTCMAEGS------------W 81

  Fly    75 SVSIRWRGPDGQDLVIVGDTFRTQLKNGSLY-ISSVEENRGLTGAYQCLLTAEGVGSILSRPALV 138
            .:..:|         |..||..|:......| |.|::  |...|.|:|:: ...||::|.|...|
Zfish    82 PLEFKW---------IHNDTEITRFSLEYRYLIPSLD--RSHAGFYRCIV-RNRVGALLQRRTEV 134

  Fly   139 AIVRQPDLNQDFLETYLLPGQTAY-----FRCMLGEANWQEGVKHSVQWLKDDLPLPLDKLRMVV 198
            .:.......:......:..|:.|.     .||.         .:..|.|.:|...:|......:.
Zfish   135 QVAYMGSFEEGERTQAVSQGEGAVIPAPRIRCF---------PQPQVTWFRDGRKIPPSSRIAIT 190

  Fly   199 LPNGALEIDEVGPSDRGSYQCNVTSGSSSRLSSKTNL-----NIKKPSDPGAENSVAPSFLVGPS 258
            |.|..:.:..|.| |.|.|.....:..:....:..::     |:..|:||     :||:.::.|.
Zfish   191 LDNTLVILSTVAP-DAGRYYVQAVNDKNGENKTGQHITLSVENVGGPADP-----IAPTIVIPPR 249

  Fly   259 PKTVREGDT-VTLDCVANGVP--KPQIKWLRNGMDL--DFNDLDSRFSIVGTGSLQISSAEDIDS 318
            ..:|..|.: ||::||||..|  |..|.|.::|:.:  ..:|.:.|.:::   |..:|     ||
Zfish   250 NTSVISGTSEVTMECVANARPLIKLSISWKKDGVLVRSGLSDFNRRLTVL---SPAVS-----DS 306

  Fly   319 GNYQCRA---SNTVDSLDAQATVQVQEPPKFIKAP-KDTTAHEKDEPELKCDIWGKPKPVIRWLK 379
            |.|:|.|   |::|.::.|.|.:.|.|||:|:|.| |..||..:...::.|...|.|:|.|.|.|
Zfish   307 GFYECEAVLRSSSVPAVSAGAYLHVLEPPQFVKEPEKHITAEMEKVVDIPCQARGVPQPDIVWYK 371

  Fly   380 NGDLITP--NDYMQLVDGHNLKILGLLNSDAGMFQCVGTNAAGSVHAAARLRVVPQGVKIKKRKS 442
            :...|:|  ....:::.|.:|::.|||..|.|||||...|.||.|.....|.|......|....|
Zfish   372 DAVPISPVKTPRYRVLSGGSLQVNGLLPDDTGMFQCFARNQAGEVQTNTYLAVTSIAPNITAGPS 436

  Fly   443 QGHSTKSLQTFDNLTKRRKP-----FNSGEQLRTKSGGSFPFPDEDDDLDDNDSGTTRLRIPSGK 502
            .......:....:......|     :..||  |..:.||...|
Zfish   437 DSTVIDGMSVILHCETSGAPRPAITWQKGE--RVLASGSVQLP---------------------- 477

  Fly   503 LPKFEQPLNDRRFNILNAGSALPLDNQSKSYEDDDDDYDEDDPAKEALLEAYKQG-EDAHKILDS 566
                       ||.:|.:||.|    .|.|:..|...|        ..:.:..:| ::|...|..
Zfish   478 -----------RFTLLESGSLL----ISPSHISDAGTY--------TCMASNSRGIDEASADLVV 519

  Fly   567 WQQSKSKKSQQQ----KQSPASPD-SPEQDPSVP----------------------------H-- 596
            |.:::.....|.    |.:.|:.. ....||||.                            |
Zfish   520 WARTRITNPPQDQSVIKGTKATMTCGVTHDPSVSVRFVWEKDGQVIVTQGLPRLRLDVNGTLHIS 584

  Fly   597 -----------------PGGKPLDSGLQAR-LPSQPRD--LVAQIVKSRFVTLSWVEPLQNAGDV 641
                             .|....::.|:.| ||..|.:  .|....:.|.:.|:|.:|......:
Zfish   585 QTWSGDIGTYTCRVTSVGGNDSRNAHLRVRQLPHAPENPSAVLSSTEKRAINLTWAKPFDGNSPL 649

  Fly   642 VYYTVYYKMNNSEREQKMVTKSHDDQQVNIQSLLPGRTYQFRVEANTNFGSGASSAPLEVSTQPE 706
            :.|.:....||:.....:.....:...|.:..|:|.|:||||:.|..:.|.|..|...:..:.||
Zfish   650 IRYILEVSENNAPWTVLLANIEPESTAVTVNGLIPARSYQFRLCAVNDVGKGQFSKETDRVSLPE 714

  Fly   707 VNIAGPPRNFEGYARSHKEIYVKWEEPT------VTNGEILKYR-------VYYSENDSGADLYH 758
            ...:.||:|.....|:::.|.::|:.|.      :..|.|::||       :.| :|.|..|:
Zfish   715 EPPSAPPQNVIASGRTNQSIMIQWQPPPESHQNGILRGYIIRYRLTGLPVDIQY-KNISNPDV-- 776

  Fly   759 DSTALEAVLTELRPHTDYVISVVPFNRNGMGDSSAEIRVKTFSSTPSEPPNNVTLEVTSSSSITV 823
                ...:|.:|...|:|.|.|..:|..|:|....::...|....|:..|.||..|..:|::|..
Zfish   777 ----TNLLLEDLIIWTNYEIEVAAYNGAGLGVYCHKVTEWTLQGVPTIAPGNVKAEPVNSTTIRF 837

  Fly   824 HWEPPAEEDRNGQITGYKIRYRKFKDAPQVKSTPANIR-YFE-------LSNLDRNAEYQVKIAA 880
            .|..|..:..||...|||:  ..::...:.::|...:| .|:       :..|.:.:||...:..
Zfish   838 TWTAPNPQFINGINQGYKL--LAWEPGKEDETTVVTVRPNFQDSVHVGHIGGLKKFSEYYTSVLC 900

  Fly   881 MTVNGSGP---------------------FT-----------------------------EWNRA 895
            .|..|.||                     ||                             |:||.
Zfish   901 FTTPGDGPRSSPRRLRTHEDTPGAVGHLSFTEILDTSLKVSWREPNEKNGVLTGYRISWEEYNRT 965

  Fly   896 NT-----LENDLDETQV-------------------------------------PGKPI------ 912
            ||     |.|...|.:|                                     ||.|.
Zfish   966 NTRVTHYLPNVTLEYRVTGLTALTTYTIEVAAMTSKGQGQLSSSTISSGVPPELPGPPTNLAISN 1030

  Fly   913 -------------------------------------WISIHPGAN------------------- 921
                                                 |:.:|..||
Zfish  1031 IGPRTVTLQFKPGYDGKTSISRWQVEAQVGVIGENEDWVMVHQRANEPDARSLEVSGLNPYTFYR 1095

  Fly   922 ------NIALHWGPPQHPEIKIR-----------NYVLG-------WGR----------GIPDE- 951
                  || :...||..|..||:           |..|.       |.|          |.||.
Zfish  1096 FRMRQVNI-VGTSPPSQPSRKIQTLQAPPDMAPANVTLRTASETSLWLRWVPLPEWEYNGNPDSV 1159

  Fly   952 -NTIELKET---------------ERYHILKNLESNMDYVVSLRARNVKGDGP---PIYDNIKTR 997
             ..::...|               ||...:::||...:|.|.::|.|..|.||   |:..  :||
Zfish  1160 GYRVQYSRTGAPSKALLHVIADRLEREFTIEDLEEWTEYEVRVQAINGIGAGPWSQPVRG--RTR 1222

  Fly   998 DEEPVDAPTPLEVPVGLRAITMSSSSIVVYWID-----------------------------TML 1033
            :..|...||      .:.|...:||||:|.|.:                             |:.
Zfish  1223 ESVPSCGPT------NVSAFATTSSSILVRWFEVPEPDRNGLILGYKVAYKEKDSDSPLQFWTVE 1281

  Fly  1034 NKNQH----------------------VTDNRHYT------------------------------ 1046
            ....|                      :.|.|..|
Zfish  1282 GNASHSVQLTGLGKYVLYEIQVLAFTRIGDGRPSTPSILERTLDDVPGPPVVILFPEVRTTSVRL 1346

  Fly  1047 ------------VSYGITGSNRYRYHNTTD-------LNC-----MINDLRPNTQYEFAVKVV-- 1085
                        ::|.||    ||.::|..       ||.     .:..|||.:.|.|.::..
Zfish  1347 IWQPPSQPNGIILAYQIT----YRLNSTNSNTATFDVLNSSARQYTVTGLRPESVYVFRIRAQTR 1407

  Fly  1086 KGRRESSWSMSVLNSTYQNVPVTPPREVTVRLDEMNPPTVIVQWIPPKHTLGQITGYNIYYTTDT 1150
            ||..|::.::.|  :|.:.....|....||..:.:...:|::.|.|....|..|.    |||...
Zfish  1408 KGWGEAAEALVV--TTEKRARPQPTSRPTVPQENVQARSVLLSWEPGSDGLSPIR----YYTVQV 1466

  Fly  1151 TK-RDRDWSVE--AFAGEETMLMLPNLKPYTTYYFKVQARTTKGANNAPFSALVSYTTSAAVTMQ 1212
            .: .:::|:|.  :.:.|.:..::..|||:|:|.|:|:|....|.::      .|..:.|..|:|
Zfish  1467 RELPEKNWTVHSASVSHESSSYIVDRLKPFTSYQFRVKATNDIGDSD------YSQESEAITTLQ 1525

  Fly  1213 E-PDTIAKGIDNEKLLYIIIAATAVVLLV-----------VLLGVLLLCRR----KPQSSPEHTK 1261
            : ||      ::..:|.:....|..||:.           :|||..:..|.    :.:|...||.
Zfish  1526 DAPD------ESPTILTVTPHTTTSVLICWQPPPEEKINGILLGFRIRYRELLYDRLRSFSVHTI 1584

  Fly  1262 KS-----------YQKNNVGVPKPPDLWIHHDQMELKNIDKGLHTVTPVCSDGASSSGALTLPRS 1315
            .|           |...|:..|.       ..|.||.|:.|.......:....|...|..:.|:.
Zfish  1585 SSASASWAELTSPYSMRNLSEPS-------LTQYELDNLLKHKRYEIRMSVYNAVGEGPTSSPQE 1642

  Fly  1316 VVHSEYEVETPVPGHVTNSLDKRSYVPGYMTTSMNGTMERP-----------------QYPRTQY 1363
            |...| .|.|..|.:|        .:.....|..:.|.:.|                 :|.|...
Zfish  1643 VFVGE-AVPTAPPQNV--------IIQSATATQFDVTWDPPPLETQNGDIQGYKIFFWEYQRKNE 1698

  Fly  1364 SHQNRSHMTMEAGLSQQSLTQPQSNSMAQTPEHPYGGYDANFCN-AGNAAAGNGCVSTIESSKRG 1427
            :.:.|:....|.|:..::||                ||.....: |...|||:|
Zfish  1699 TEKLRTLFLPEGGVKLKNLT----------------GYTTYMISVAAFNAAGDG----------- 1736

  Fly  1428 HPLKSFSVPGPPPTGGAT-------PVTKHTPAVTIRPQNQSPYKKPSFSAATPNRLQGGGSVVH 1485
                    |..|||.|.|       |...|...:|....|.| :.:|.|    ||.:..|..:::
Zfish  1737 --------PRSPPTRGRTQQAAPSAPSFIHFSELTTTSVNVS-WGEPVF----PNGIIEGYRLIY 1788

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fra	NP_523716.2	Ig	36..140	CDD:299845	26/109 (24%)
		Ig	<180..222	CDD:299845	11/41 (27%)
		IG_like	257..340	CDD:214653	28/90 (31%)
		IGc2	264..327	CDD:197706	22/70 (31%)
		I-set	344..430	CDD:254352	32/88 (36%)
		Ig	363..428	CDD:299845	24/66 (36%)
		FN3	611..703	CDD:238020	22/93 (24%)
		FN3	711..799	CDD:238020	24/100 (24%)
		FN3	806..897	CDD:238020	28/148 (19%)
		FN3	908..989	CDD:238020	33/196 (17%)
		FN3	1011..1097	CDD:238020	28/192 (15%)
		FN3	1109..1205	CDD:238020	24/98 (24%)
		Neogenin_C	1273..1521	CDD:284094	47/237 (20%)
sdk2b	XP_009305142.1	IGc2	69..125	CDD:197706	15/79 (19%)
		IG_like	70..136	CDD:214653	20/89 (22%)
		I-set	147..230	CDD:254352	15/92 (16%)
		Ig	156..230	CDD:299845	14/83 (17%)
		I-set	242..331	CDD:254352	29/96 (30%)
		IGc2	260..313	CDD:197706	20/60 (33%)
		I-set	335..424	CDD:254352	32/88 (36%)
		Ig	357..424	CDD:299845	25/66 (38%)
		I-set	429..519	CDD:254352	22/136 (16%)
		Ig	443..519	CDD:299845	20/122 (16%)
		I-set	524..613	CDD:254352	10/88 (11%)
		Ig	529..613	CDD:299845	10/83 (12%)
		FN3	617..707	CDD:238020	22/89 (25%)
		fn3	720..803	CDD:278470	23/89 (26%)
		FN3	821..917	CDD:238020	23/97 (24%)
		FN3	922..1010	CDD:238020	11/87 (13%)
		FN3	1020..1114	CDD:238020	12/94 (13%)
		fn3	1126..1214	CDD:278470	19/87 (22%)
		FN3	1230..1318	CDD:238020	14/93 (15%)
		FN3	1328..1421	CDD:238020	17/98 (17%)
		FN3	1427..1522	CDD:238020	25/104 (24%)
		FN3	1532..1643	CDD:238020	23/117 (20%)
		FN3	1653..1746	CDD:238020	24/135 (18%)
		FN3	1751..1848	CDD:238020	10/42 (24%)
		fn3	1875..1952	CDD:278470
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910