DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fra and prtga

DIOPT Version :9

Sequence 1:	NP_523716.2	Gene:	fra / 36377	FlyBaseID:	FBgn0011592	Length:	1526	Species:	Drosophila melanogaster
Sequence 2:	NP_001038495.1	Gene:	prtga / 563834	ZFINID:	ZDB-GENE-061204-4	Length:	1149	Species:	Danio rerio

Alignment Length:	1474	Identity:	329/1474 - (22%)
Similarity:	500/1474 - (33%)	Gaps:	456/1474 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    22 IFQLIGSSLASQALSFTLEPQDAVVPEGHSVLLQCA--GTASIGRGGKSKSNLPSSVSIRWRGPD 84
            :|..|....:...|.|..||.|.......:|:|.|.  |.|.||              |||.
Zfish    14 VFLSISGVWSFSELFFIKEPHDVTAMRRDAVVLDCQAHGEAPIG--------------IRWL--- 61

  Fly    85 GQDLVIVGDTFRT-QLKNGSLYISSVEENRGLT--GAYQCLLTAEGVGSILSRPALVAIVRQPDL 146
             ::.|.:.::.|. .|.||||.||.||..:..:  |.||| |.....|||||:.|.:.|......
Zfish    62 -KNGVTITESERVYSLSNGSLLISEVESRKDKSDEGFYQC-LAQNKYGSILSQRARLTIASLSTF 124

  Fly   147 NQDFLETYLLPGQTAYFRCMLGEANWQEGVKHSVQWLKDDLPLPLDKLRMVVLPNGALEIDEVGP 211
            .|......::.|..|.|.|.:...     ....:.|..:.:.|||...|:.|||:|.|:|..|..
Zfish   125 TQQPASIIVMEGSVARFTCKITAT-----PPPIITWEFNRVTLPLATERITVLPSGVLQIQGVEQ 184

  Fly   212 SDRGSYQCNVTSGSSSRLSSKTNLNIKKPSDPGAENSVAPSFLVGPSPKTVREGDTVTLDCVANG 276
            .|.|||:|...:..|.|.|::..|.:.....|.|..  .|..:.||...||....|..|:|:|:|
Zfish   185 RDAGSYRCVAANIVSRRRSTEATLTVTPAMSPRAPQ--RPRIIAGPQNLTVPAHSTALLECMASG 247

  Fly   277 VPKPQIKWLRNGMDLDFNDLD-SRFSIVGTGSLQISSAEDIDSGNYQCRAS--NTVDSLDAQATV 338
            .|:|.|.|.|    .|...:| .:..::|.|:|.||......:|.|.|||:  .|.:...|.|.:
Zfish   248 NPRPLISWSR----ADHKSIDVHKTKVLGNGNLIISDVNPQHAGIYFCRATTPGTRNYTIAAANI 308

  Fly   339 QVQEPPKFIKAPKDTTAHEKDEPELKCDIWGKPKPVIRWLKNGDLITPNDYMQLVDGHNLKILGL 403
            .|..||..::.|:..|..........|...|.|.|.|.|||||:.:..|..:::.:. .|.|..:
Zfish   309 TVLAPPSLVEWPESVTRPRAGTARFVCTAEGFPTPQITWLKNGEPVRSNGRIKMYNS-KLVINQI 372

  Fly   404 LNSDAGMFQCVGTNAAGSVHAAARLRVVPQGVKIKKRKSQGHSTKSLQTFDNLTKRRKPFNSGEQ 468
            :..|.|::||...|..|||.|.|||.||
Zfish   373 IPEDDGIYQCEAENIQGSVLAMARLIVV------------------------------------- 400

  Fly   469 LRTKSGGSFPFPDEDDDLDDNDSGTTRLRIPSGKLPKFEQPLNDRRFNILNAGSALPLDNQSKSY 533
                                                     ::|.|
Zfish   401 -----------------------------------------MSDNR------------------- 405

  Fly   534 EDDDDDYDEDDPAKEALLEAYKQGEDAHKILDSWQQSKSKKSQQQKQSPASPDSPEQDPSVPHPG 598

Zfish   406 ----------------------------------------------------------------- 405

  Fly   599 GKPLDSGLQARLPSQPRDLVAQIVKSRFVTLSWVEPLQNAGDVVYYTVYY-KMNNSEREQKMVTK 662
                        ||.||::.|..|.|..:.|:|..|..|:..|:.|:|:| |......|:..:..
Zfish   406 ------------PSAPRNIRADTVSSSAIVLAWDRPAYNSEKVIAYSVHYMKAEGLNNEEYQIVI 458

  Fly   663 SHDDQQVNIQSLLPGRTYQFRVEANTNFGSGASSAPLEVSTQPEVNIAGPPRNFEGYARSHKEIY 727
            .:|..:..|..|..||.|.|.:.|....|:...|..:...|..:|.:..|..:..  :||..:|.
Zfish   459 GNDTTRYIIDDLEAGRNYTFYIVAYMPMGASRMSDHVIQHTLEDVPLRAPELSLT--SRSPSDIQ 521

  Fly   728 VKWE--EPTVTNGEILKYRVYYSENDSGADLYHDSTALE-------AVLTELRPHTDYVISVVPF 783
            |.|:  ...::.|.:..||:.|..:..|.     .|.||       .:|..|:|.|.|::.:...
Zfish   522 VSWQPLSHKLSRGRVSAYRLSYRTSSDGT-----LTQLELSAHKTHQLLEGLQPDTTYLLRIAAA 581

  Fly   784 NRNGMGDSSA--EIRVKTFSSTPSEPPNNVTLEVTSSSSITVHWEPPAEEDRNGQITGYKIRYRK 846
            ...|.|:.||  ..|....|||.......:.||..:.:::|:.|..||  ..:..:.|:|:.|.:
Zfish   582 TAVGWGEPSAWSSHRTPKASSTKVPLAPELQLESLNCTTVTLRWHLPA--GSSSGLQGFKLSYHE 644

  Fly   847 --FKDAPQVKSTPANIRYFELSNLDRNAEYQVKIAAMTVNGSGPFTEWNRANTLENDLDET-QVP 908
              ..:|.|.: .|.:.|...:..||...:|.:|:.|.:..|.|            ...|:| ..|
Zfish   645 EGQSEAAQAQ-IPPHHRQHTIGGLDPRKKYHIKLLAFSFMGDG------------YQADQTISTP 696

  Fly   909 GKPIWISIHPGANNIALHWGPPQHPEIKIRNYVLGWGRGIPDENTIELKETERYHILKNLESNMD 973
            |
Zfish   697 G---------------------------------------------------------------- 697

  Fly   974 YVVSLRARNVKGDGPPIYDNIKTRDEEPVDAPTPLEVPVGLRAITMSSSSIVVYWIDTMLNKNQH 1038
             .||:|.|.|    ||               |.|   |..:.|.:.||||:.::|........|.
Zfish   698 -CVSVRDRLV----PP---------------PPP---PHHVYAHSNSSSSVFLHWARPAFTSAQT 739

  Fly  1039 VTDNRHYTV---SYGITGSNRYRYHNTTDLNCMINDLRPNTQYEFAVKVVKGRRESSWSMSVLNS 1100
            :    :|||   ..|:..::...|..|...:.::.||.|||.|||||::......|.||..|..:
Zfish   740 L----NYTVRCNPVGLQNASLVLYLQTAAQSLLVTDLEPNTNYEFAVRLHVDLLSSPWSPVVYQT 800

  Fly  1101 TYQNVPVTPPREVTVRLDEMNPPTVIVQW-IPPKHTLGQITGYNIYYTTDTTKRDRDWSVEAFAG 1164
            |....|...|..|.|.|.|.:  :.:|.| .|...:...:|.|.:.|.|.......||.:....|
Zfish   801 TLPEAPSRAPVGVKVTLIEGD--SALVSWKAPDDRSAAAVTHYTVLYATRRAWAAGDWQMLQREG 863

  Fly  1165 EETMLMLPNLKPYTTYYFKVQARTTKGANNAPFSALVSYT-------------TSAAVTMQEPDT 1216
            ..||.:|.||:|...|..:|.|....|  :.||||.|..|             :.|.|
Zfish   864 SITMALLENLQPGQVYLVQVSASNQMG--DGPFSAAVELTIHTDGHAHRTHGFSHATV------- 919

  Fly  1217 IAKG---IDNEKLLYIIIAATAVVLLVVLLGVLLLCRRKPQSSPEHTKKSYQKNNVGVPKPPDLW 1278
            .:.|   :|...:..|.:.....:..:::..::|.||.|.:.|  .|.||.::  .|...||
Zfish   920 FSDGFYHLDQRSMAGIAVGVCIALTCIIICILILACRSKTRKS--CTTKSIRQ--AGGQTPP--- 977

  Fly  1279 IHHDQMELKNIDKGLHTVTPVCSDGASSSGALTLP------------RSVVHSEYEVETPVPGHV 1331
                            |...:.::.|:.|..:.:|            .:::.:.|   .||..::
Zfish   978 ----------------TAVRLANESAAESVEVMMPMMRDHFIDAKGGTNLIINSY---GPVKPNI 1023

  Fly  1332 TNSLDKR-------------------SYVPGYMTTSMNGTMERPQYPRT-------------QYS 1364
            .....||                   ||.||  ||.:..|...|:.|.|             :.|
Zfish  1024 EKKRRKRWSFFKKNEKEVKKVSSPAYSYHPG--TTLLCYTETSPENPPTTLQGLFGPSGGDSEGS 1086

  Fly  1365 HQNR-SHMTMEAGLSQQSLTQPQSNSMA-----------QTPEH 1396
            |.:. ||.|.::|......|:..:.|:.           |||.|
Zfish  1087 HSSEGSHETSDSGRYSHDDTEATNVSIRSRPASLQDDGNQTPVH 1130

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fra	NP_523716.2	Ig	36..140	CDD:299845	36/108 (33%)
		Ig	<180..222	CDD:299845	17/41 (41%)
		IG_like	257..340	CDD:214653	28/85 (33%)
		IGc2	264..327	CDD:197706	22/65 (34%)
		I-set	344..430	CDD:254352	28/85 (33%)
		Ig	363..428	CDD:299845	23/64 (36%)
		FN3	611..703	CDD:238020	27/92 (29%)
		FN3	711..799	CDD:238020	24/98 (24%)
		FN3	806..897	CDD:238020	20/92 (22%)
		FN3	908..989	CDD:238020	7/80 (9%)
		FN3	1011..1097	CDD:238020	27/88 (31%)
		FN3	1109..1205	CDD:238020	31/109 (28%)
		Neogenin_C	1273..1521	CDD:284094	33/180 (18%)
prtga	NP_001038495.1	immunoglobulin domain	28..118		36/108 (33%)
		Ig1_Neogenin	28..118	CDD:143199	36/108 (33%)
		I-set	29..118	CDD:254352	36/107 (34%)
		immunoglobulin domain	122..211		26/93 (28%)
		I-set	124..210	CDD:254352	26/90 (29%)
		Ig	126..210	CDD:299845	26/88 (30%)
		immunoglobulin domain	222..309		30/90 (33%)
		IG_like	228..310	CDD:214653	28/85 (33%)
		IGc2	237..296	CDD:197706	22/62 (35%)
		immunoglobulin domain	314..384		20/70 (29%)
		IG_like	320..399	CDD:214653	27/79 (34%)
		Ig	332..399	CDD:299845	25/67 (37%)
		FN3	406..499	CDD:238020	27/92 (29%)
		fibronectin type III domain	406..491		26/84 (31%)
		fibronectin type III domain	504..590		21/92 (23%)
		FN3	507..597	CDD:238020	23/96 (24%)
		fibronectin type III domain	606..690		20/98 (20%)
		FN3	606..686	CDD:238020	19/82 (23%)
		fibronectin type III domain	710..794		26/90 (29%)
		FN3	713..801	CDD:238020	27/91 (30%)
		fibronectin type III domain	806..895		27/92 (29%)
		FN3	809..901	CDD:238020	30/95 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1060..1149		16/71 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44170
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	3.010