DRSC/TRiP Functional Genomics Resources

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Protein Alignment fra and hmcn1

DIOPT Version :9

Sequence 1:NP_523716.2 Gene:fra / 36377 FlyBaseID:FBgn0011592 Length:1526 Species:Drosophila melanogaster
Sequence 2:XP_005160777.1 Gene:hmcn1 / 559150 ZFINID:ZDB-GENE-041014-322 Length:5623 Species:Danio rerio


Alignment Length:1586 Identity:338/1586 - (21%)
Similarity:534/1586 - (33%) Gaps:491/1586 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 SCLIFQLIGSSL------ASQALSFTLEPQDAVVPEGHSVLLQCAGTASIGRGGKSKSNLPSSVS 77
            :|:.....||:.      ...|..||.:|.|.....|.::.|.|...      |..|..|     
Zfish   763 TCVAVNSAGSAQGYITLDVGSAPQFTKKPSDLSADIGTNITLPCYAQ------GHPKPQL----- 816

  Fly    78 IRWRGPDGQDLVIV--GDTFRTQLKNGSLYISS--VEENRGLTGAYQC-------------LLTA 125
             .||..|...|...  |.:..|...:|.|:|::  ||:.    ..|.|             .:|.
Zfish   817 -SWRREDNIALFTQRHGPSTVTHRMDGGLFITNLWVEDE----ATYVCEAQNHFGRIQVKAKVTV 876

  Fly   126 EGVGS--ILSRPALVAIVRQPDLNQDFLETYLLPGQTAYFRCMLGEANWQEGVKHSVQWLKDDLP 188
            .|:.|  |...|.:|:::..   .|..|...||.|..      |.|.:|..           |..
Zfish   877 TGLVSPLIALSPTVVSVIED---QQVTLPCVLLAGNP------LPERHWLH-----------DNG 921

  Fly   189 LPLDKLRMVVLPNGALEIDEVGPSDRGSYQC---NVTSGSSSRLSSKTNLNIKKPSDPGAENSVA 250
            |......:.|..:|:|.|::|...|.|.|.|   ||. |||:|   .|.||:          .|.
Zfish   922 LVTSSPYVTVRRDGSLHIEQVSQQDGGQYTCLTENVV-GSSNR---TTILNV----------YVM 972

  Fly   251 PSFLVGPSPKTVREGDTVTLDCVANGVPKPQIKWLRNGMDLDFNDLDSRFSIVGTGSLQISSAED 315
            |:...||...:..||..::|.|.|:|||||.|.|.:.|..||.:  .|.||:...|||.|.|...
Zfish   973 PTIQHGPQIFSTIEGTPISLPCRAHGVPKPDITWSKRGELLDLS--GSVFSLTEDGSLHIHSPSG 1035

  Fly   316 IDSGNYQCRASNTV--DSLDAQATVQVQEPPKFIKAPKDTTAHEK------------DEPELKCD 366
            .:||.:.|.|:|..  .|...|.||.|:  || :....:...|:.            |:..|.|:
Zfish  1036 EESGEFVCTATNAAGYSSRKVQLTVYVR--PK-LSGVGEADIHDNSEKLLEMSVIVGDDITLPCE 1097

  Fly   367 IWGKPKPVIRWLKNGDLITPND--YMQLVDGHNLKILGLLNSDAGMFQCVGTNAAGSVHAAARLR 429
            :...|.|:|.|.|:..||:|..  ::||..| :::|.....:|:||:.||.||.||:.....:|.
Zfish  1098 VESVPPPIITWAKDKQLISPFSPRHIQLPSG-SMRITDTRVTDSGMYLCVATNIAGNFSQTVKLS 1161

  Fly   430 V-VPQGVKIKKRKSQ---GHS------TKSL-QTFDNLTKRRKPFNSGEQLRTKSG----GSFPF 479
            | ||..:....|..:   ||:      |:.: :...:..|.......|.:.|...|    .....
Zfish  1162 VLVPPSISAGPRAMKVQIGHAIDLPCVTQGVPEPSVSWLKDGTVLQDGSRYRISDGALTLNQVAL 1226

  Fly   480 PDED------DDLDDNDSGTTRLRIPSGKL-----PKFEQPLNDRRFNILNAGSALPLDNQSKSY 533
            .||.      .::...:....:|.:....:     |.|..||.:|   :.|...|.|.       
Zfish  1227 TDEGIYVCRAVNIAGKEETAIQLHVQVPPVVEVSEPPFNSPLQER---VANQQIAFPC------- 1281

  Fly   534 EDDDDDYDEDDPAK---EALLEAYKQG-------------EDAHKI-------LDSWQQ------ 569
                       |||   |.:::.::.|             ||...:       ||:.:.      
Zfish  1282 -----------PAKGTPEPVIKWFRNGHELTGNEPGVSILEDGTLLILASVSPLDNGEYTCMAVN 1335

  Fly   570 ---SKSKKSQQQKQSPASPDSPEQDPSVPHPGGKPLDSGLQARLP---SQPRDLVAQIVKSRFVT 628
               :..||.|.:...|  ||.              .|:||.:.:.   :||.:||..:..:....
Zfish  1336 DAGTTEKKYQLKVNVP--PDI--------------RDNGLLSNVSVVINQPTNLVCDVTGTPVPV 1384

  Fly   629 LSWVEPLQNAGDVVYYTVYYKMNNSEREQKMVTKSHDDQQVNIQSLLPGRTYQFRVEANTNFGSG 693
            ::|                ||      :...|..|.|     :|.|..|:|.:....|..:.|..
Zfish  1385 ITW----------------YK------DGVEVVPSSD-----VQILQKGKTLKLLKAAVQDAGRY 1422

  Fly   694 ASSAPLEVSTQPEVNIAGP-PRNFEGYARSHKEIYVKWEEPT------------VTNGEI-LKYR 744
            ...|         :||||. .|:|      :.::.|   .||            |.|.|| |:.:
Zfish  1423 ICKA---------INIAGSRERDF------YLDVLV---PPTIIGTVGSRDLSAVLNQEIVLECK 1469

  Fly   745 V---------YYSE------NDSGADLYHDSTALEAVLTELRPHTDYVISVVPFNRNGMGDSSAE 794
            |         :|.:      .|...::.:....|:.....|.....|..|..    |..|..|.:
Zfish  1470 VKGDPFPTIQWYKDRKPVFLGDPNIEVLNRGQQLKIKSARLGDQARYQCSAT----NAAGKQSKD 1530

  Fly   795 IRVKTFSSTPSEPPNNVTLEVT--SSSSITVHWE------PPAEEDRNGQITGYKIRYRKFKDAP 851
            ..:..| ..||....||:.|||  ..:.:|:..|      |.....:||::. ...|..::.|..
Zfish  1531 FNLSIF-VPPSIKGGNVSSEVTVLLGNLVTLECEVRGVPLPAVTWYKNGEVI-LSSRQAQYVDRG 1593

  Fly   852 Q-VKSTPANI----RY-FELSNLDRNAEYQVKI-----AAMTVNGSGPFTEW----NRANTLEND 901
            | :|...|.:    :| ..::::...||..|::     .::|....|| |:.    |::..||.:
Zfish  1594 QFLKILRAQVSDAGQYTCRVTSVAGTAEKVVELDVYVPPSITAGSDGP-TDMKVVLNKSLILECE 1657

  Fly   902 LDETQVPGKPIWISIHPGANNIALHWGPPQHPEIKIRNYVLGWGRGIPDENTIELKETERYHILK 966
            .:.            ||..:...|..|.|......:|  ||..||.|...|.:: .:..||..:.
Zfish  1658 AEG------------HPPPSLTWLKDGSPVAVRESLR--VLDQGRKIEILNALQ-SDAGRYVCVA 1707

  Fly   967 NL---ESNMDYVVSLRARNVKGDGPPIYD-------------NIKTRDEEPVDAPTPL------E 1009
            ..   |..:.|.||:..       ||:.|             ||...:......|||.      .
Zfish  1708 TSVAGEKEIKYDVSVLV-------PPVVDGASDTTDATVILNNILELECYATGRPTPTITWLKDG 1765

  Fly  1010 VPV----GLRAITMSSSSIVV---YWIDTML----NKNQHVTDNRHYTVSYGITGSNRYR----- 1058
            |||    |:| ||.:...:|:   ...||.|    ..|:.....|.:.||..:..:.|..     
Zfish  1766 VPVKHGEGVR-ITSNGRRLVISRAQVSDTALFHCVATNEAGEQEREFKVSVHVPPAIRSTGPAER 1829

  Fly  1059 ---YHNTTDLNCMINDLRP------------NTQYEF--------AVKVVKGRRESSW-----SM 1095
               .|.:..|.|:::.:.|            :|..||        .:.:.|.|.|.:.     :.
Zfish  1830 SVVLHTSISLQCVVSGIPPPSTTWLKDGRPVDTTQEFLKLESAGRVLHIKKARLEDAGKYTCVAT 1894

  Fly  1096 SVLNSTYQNVPVT---PPR----------------EVTVRLDEMNPPTVIVQWIPPKHTLGQITG 1141
            :......|::.::   ||.                ::.::......|...|.|......|....|
Zfish  1895 NAAGEAQQHIRLSVHEPPSIQYAGEMLNETILAGFQIQLKCKATGSPLPAVTWYKDGRPLTSAAG 1959

  Fly  1142 YNIYYTTDTTKRDRDWSVEAFAGEETMLMLPNLKPYTTYYFKVQARTTKGANNAPFSALVSYTTS 1206
            .||.......:.||  :..:.||                ::|..|....|:....:|..| |.  
Zfish  1960 VNILSRGHVLEIDR--AQVSDAG----------------FYKCVAINVAGSTELTYSLQV-YV-- 2003

  Fly  1207 AAVTMQEPDTI-AKGIDNEKLLYIIIAATAVVLLVVLLGVLLLCRRKPQSSPEHTKKSYQKNNVG 1270
                   |.|| :||              .:|.:||...|.|.|...                 |
Zfish  2004 -------PPTISSKG--------------GMVTVVVNDPVRLECEAS-----------------G 2030

  Fly  1271 VPKPPDLWIHH--------DQMELKNIDKGLHTVTPVCSDGASSSGALTLPRSVVHSEYEVETPV 1327
            ||.|...|:..        |.:::.:..:.|..::...||....:..........|.|||:...|
Zfish  2031 VPVPSLTWLKEGSPVSSFSDGIQVLSGGRVLSFISAQVSDAGHYTCVAVNAGGEQHREYELRVYV 2095

  Fly  1328 PGHVTNSLDKRSYVPGYMTTSMNGTM 1353
            |             |..|...:|.|:
Zfish  2096 P-------------PNIMGEEVNNTV 2108

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fraNP_523716.2 Ig 36..140 CDD:299845 29/122 (24%)
Ig <180..222 CDD:299845 12/44 (27%)
IG_like 257..340 CDD:214653 33/84 (39%)
IGc2 264..327 CDD:197706 27/62 (44%)
I-set 344..430 CDD:254352 28/99 (28%)
Ig 363..428 CDD:299845 23/66 (35%)
FN3 611..703 CDD:238020 17/94 (18%)
FN3 711..799 CDD:238020 21/116 (18%)
FN3 806..897 CDD:238020 24/113 (21%)
FN3 908..989 CDD:238020 18/83 (22%)
FN3 1011..1097 CDD:238020 25/129 (19%)
FN3 1109..1205 CDD:238020 19/111 (17%)
Neogenin_C 1273..1521 CDD:284094 16/89 (18%)
hmcn1XP_005160777.1 VWA_2 36..206 CDD:290253
IG_like 443..510 CDD:214653
I-set 514..600 CDD:254352
ig 522..596 CDD:278476
I-set 604..688 CDD:254352
Ig 618..689 CDD:299845
I-set 694..781 CDD:254352 3/17 (18%)
IGc2 708..771 CDD:197706 1/7 (14%)
I-set 785..876 CDD:254352 23/106 (22%)
Ig 789..876 CDD:299845 21/102 (21%)
IG 888..969 CDD:214652 29/104 (28%)
IGc2 895..959 CDD:197706 21/84 (25%)
I-set 973..1060 CDD:254352 33/88 (38%)
Ig 990..1059 CDD:299845 28/70 (40%)
IG 1084..1162 CDD:214652 25/78 (32%)
Ig 1092..1159 CDD:143165 23/67 (34%)
I-set 1166..1251 CDD:254352 11/84 (13%)
IGc2 1179..1241 CDD:197706 9/61 (15%)
I-set 1251..1348 CDD:254352 20/117 (17%)
Ig 1254..1348 CDD:299845 20/114 (18%)
I-set 1360..1441 CDD:254352 23/122 (19%)
IGc2 1367..1431 CDD:197706 19/99 (19%)
I-set 1450..1535 CDD:254352 15/88 (17%)
IGc2 1461..1525 CDD:197706 12/67 (18%)
IG_like 1547..1628 CDD:214653 17/81 (21%)
Ig 1558..1625 CDD:143165 13/67 (19%)
I-set 1641..1722 CDD:254352 22/96 (23%)
Ig 1641..1718 CDD:299845 20/92 (22%)
Ig 1725..1817 CDD:299845 23/92 (25%)
IG 1738..1815 CDD:214652 19/77 (25%)
Ig 1818..1908 CDD:299845 12/89 (13%)
IG 1826..1908 CDD:214652 11/81 (14%)
IG 1922..2001 CDD:214652 15/96 (16%)
Ig 1927..2001 CDD:299845 15/91 (16%)
IG 2014..2093 CDD:214652 19/95 (20%)
IGc2 2019..2083 CDD:197706 12/80 (15%)
Ig 2096..2186 CDD:299845 5/26 (19%)
IG_like 2107..2184 CDD:214653 1/2 (50%)
Ig 2187..2280 CDD:299845
I-set 2197..2277 CDD:254352
Ig 2292..2371 CDD:299845
IG 2292..2369 CDD:214652
I-set 2373..2463 CDD:254352
IGc2 2391..2453 CDD:197706
IG 2476..2556 CDD:214652
IGc2 2484..2546 CDD:197706
IG 2572..2652 CDD:214652
IGc2 2583..2642 CDD:197706
I-set 2670..2751 CDD:254352
IGc2 2678..2741 CDD:197706
IG 2774..2850 CDD:214652
IGc2 2777..2840 CDD:197706
I-set 2864..2945 CDD:254352
Ig 2864..2938 CDD:299845
Ig 2949..3039 CDD:299845
IG_like 2957..3037 CDD:214653
I-set 3051..3132 CDD:254352
IGc2 3059..3122 CDD:197706
I-set 3154..3226 CDD:254352
Ig 3154..3223 CDD:143165
Ig 3229..3323 CDD:299845
I-set 3238..3321 CDD:254352
IG 3335..3415 CDD:214652
Ig 3343..3415 CDD:299845
Ig 3418..3508 CDD:299845
IG 3428..3508 CDD:214652
IG 3520..3601 CDD:214652
Ig <3533..3603 CDD:299845
I-set 3614..3694 CDD:254352
IGc2 3620..3684 CDD:197706
Ig 3697..3787 CDD:299845
IG_like 3704..3785 CDD:214653
Ig 3788..3878 CDD:299845
I-set 3789..3878 CDD:254352
IG_like 3891..3969 CDD:214653
Ig 3899..3968 CDD:299845
IG_like 3979..4060 CDD:214653
Ig 3990..4052 CDD:299845
I-set 4064..4150 CDD:254352
IGc2 4080..4140 CDD:197706
Ig 4161..4241 CDD:299845
IG_like 4161..4241 CDD:214653
I-set 4245..4324 CDD:254352
IGc2 4260..4320 CDD:197706
Ig 4352..4420 CDD:299845
I-set 4425..4511 CDD:254352
Ig 4439..4512 CDD:299845
TSP1 4518..4569 CDD:214559
TSP1 4583..4626 CDD:214559
TSP1 4631..4683 CDD:214559
TSP1 4688..4740 CDD:214559
TSP1 4745..4797 CDD:214559
TSP1 4802..4854 CDD:214559
nidG2 4855..5070 CDD:238158
EGF_CA 5091..5130 CDD:214542
EGF_CA 5131..5174 CDD:284955
EGF_CA 5176..5213 CDD:214542
EGF_CA 5214..5251 CDD:214542
EGF_CA 5256..5297 CDD:284955
EGF_CA 5299..5338 CDD:214542
EGF_CA 5420..5459 CDD:214542
EGF_CA 5460..5496 CDD:214542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
ZFIN 00.000 Not matched by this tool.
10.910

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