DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fra and palld

DIOPT Version :9

Sequence 1:	NP_523716.2	Gene:	fra / 36377	FlyBaseID:	FBgn0011592	Length:	1526	Species:	Drosophila melanogaster
Sequence 2:	XP_021324295.1	Gene:	palld / 557660	ZFINID:	ZDB-GENE-041014-252	Length:	1401	Species:	Danio rerio

Alignment Length:	1412	Identity:	254/1412 - (17%)
Similarity:	405/1412 - (28%)	Gaps:	537/1412 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   202 GALEIDEVGPSDRGSYQCNVTSGSSSRLSSK------TNLNIKKPSDPGA--------------- 245
            |:..:|..|..|..|......|..|.||:.:      ::.:..:|...|.
Zfish   196 GSARVDPQGDEDSSSPDSGYLSPKSHRLAMQQAQPPSSSSSSSEPQQEGVLQGQADVGSGELQGG 260

  Fly   246 ----ENSVA-PSFLVGPSPKTVREGDTVTLDCVANGVPKPQIKWLRNGMDLDF---------NDL 296
                :..|| |.|......:.|.||..:.|:|...|.|.|.::|...|.:|..         .||
Zfish   261 GVSLDGPVAPPRFTQKLKSQEVAEGSPIRLECRVTGNPLPLVRWFCEGRELHHCPDIQICRDGDL 325

  Fly   297 DSRFSIVGTGSLQISSAEDIDSGNYQCRASNTVDSLDAQATVQVQ-------------------- 341
            .         :|.|:.|.:.|:|.|.|.|||.:.:.:..|.|.::
Zfish   326 H---------TLVITEAFEDDTGRYTCVASNALGADNTSAEVYIEGASSSDSEGEGSVSKSRSGA 381

  Fly   342 ----------------------------------------------------------EPPKFIK 348
                                                                      .||.|.|
Zfish   382 MPQAQKKTSSVSLTIHTSSPKSPEAQPHRSTLVQPISTTPQRVQSPVSSLYAGDALAKAPPSFTK 446

  Fly   349 APKDTTAHEKDEPELKCDIWGKPKPVIRWLKNGDLITPNDYMQLVDGH-----------NLKILG 402
            ..:|....|.....|:|.:.|.....::|.:.|..|..:...:::...           .|.|..
Zfish   447 VLQDAQPSEGQVVVLECRVRGSLPLRVQWFREGQEIQDSPDFRILQKKPRSAAEPEEICTLVIAE 511

  Fly   403 LLNSDAGMFQCVGTNAAGSVHAAARLRVVPQGVKIKKRKSQGHSTKSLQTFDNLTKRRKPFN--S 465
            ....|.|:|.|..||..|||::.|:|.|.|                        .....|.|  |
Zfish   512 AFPEDGGLFCCTATNEYGSVNSTAQLTVTP------------------------VAEEMPTNGVS 552

  Fly   466 GEQLRTKSGGSFPFPDEDDDLDDNDSGTTRLRIPSGKLPKFEQPLNDRRFNILNAGSALPLDNQS 530
            |::...:...|||.|.............:.|.:|. |.|...:.......:|..:.:|||:...:
Zfish   553 GDESVFEDNQSFPPPPPPLPPPPPPIEISLLEVPP-KTPPSAEAFQINELDIWPSVTALPVQVST 616

  Fly   531 KSYEDDDDDYDEDDPAKEALLEAYKQGEDAHKILDSWQQSKSKKSQQQKQSPASPDSPEQDPSVP 595
                  |...:|..|.|..      |.....|.||....|.|    ..|::.|.|.||....:.|
Zfish   617 ------DKKPEESRPNKPL------QNGQFTKPLDESLSSPS----SVKETAAPPPSPSAVRAPP 665

  Fly   596 HPGGKPLDSGLQARLPSQPRDLVAQIVKSRFVTLSWVEPLQNAGDVVYYTVYYKMNNSEREQKMV 660
                          ||::|:..::.               :.|.||           |.....:.
Zfish   666 --------------LPTKPKPKLSN---------------EQADDV-----------SNERNAVQ 690

  Fly   661 TKSHDDQQVNIQSLLPGRTYQFRVEANTNFGSGASSAPLEVSTQPEVNIAGPPRNFE-------- 717
            .|...||.:..|..||                    ||.|||  |......||.:|:
Zfish   691 LKQLQDQILLEQQQLP--------------------APQEVS--PPSPPLPPPPSFQELESSTMQ 733

  Fly   718 ----GYARSHKEIYVKWEEPTVTNGEILKYRVYYSENDSGADLYHDSTALEAVLTELRPHTDYVI 778
                .|||..:  ::..:.||.:...|    .|.|::.|.:.|        :..|..:|.:.  :
Zfish   734 TSTFNYARPKQ--FIAAQSPTTSGAPI----GYSSQSSSSSPL--------SPTTSHKPFSR--V 782

  Fly   779 SVVPFNRNGMGDSSAEIRVKTFSSTPSEPP-----NNVTL-----------------EVTSS--- 818
            |:.||::..:...|:.:...:..|.|..||     :|::.                 .||||
Zfish   783 SLPPFHQQPLLSKSSSVESPSSPSFPPPPPPFLSSSNLSSPAGLPQEFPLPPPPPPPPVTSSPTR 847

  Fly   819 ------------------SSITVHWEPPAEEDRNGQITGYKIRYRKFKDAPQ------------- 852
                              :|:.....||...:..|...|........|..|:
Zfish   848 SDTSSPFTSTPHSPAGFLASVLPTTPPPPPMNALGLPKGNGTVALPRKTTPRTPRIISDSDIQGS 912

  Fly   853 ----VKSTPANIRYFE--LSNLDRNAEYQVKIAAMTVNGSGPFTEWN------RANTLENDLDET 905
                ::.....:|:.|  |||..:...|:.|:|...:......|.:|      .|||.|...|..
Zfish   913 KDAVIQDLERKLRFKEERLSNGQQRLTYEEKMARRLLGADNAATVFNTQQVEEEANTQEGSADSE 977

  Fly   906 QVPGKPIWISIHPGANNIALHWGPPQHPEIKIRNYVLGWGRGIPDENTIELKETERYHILKNLES 970
            .||.|                       |.|:.::                    ...::..:|.
Zfish   978 SVPQK-----------------------EYKVSSF--------------------EQRLISEIEF 999

  Fly   971 NMDYVVSLRARNVKGDGPPIYDNIKTRDEEPVDAPTPLE-----------VPVGLRAITMSSSSI 1024
            .::     |:...:.|     |:::..::.|.:.....:           :||......|.....
Zfish  1000 RLE-----RSPVEESD-----DDVQHDEDAPGEVAPSFDQKLKHYKVFEGMPVTFSCKVMGDPKP 1054

  Fly  1025 VVYWIDTMLNKNQHVTDNRHYTVSYGITGSNRYRYHNTTDLNCMINDLRPNTQYEFAVKVVKGRR 1089
            .|||..   :..|....:.||.:|....|        |..|:.....|..:..|........||.
Zfish  1055 KVYWFK---DGKQISKRSEHYRISRDPDG--------TCSLHTAAASLDDDGNYTIMAGNPAGRV 1108

  Fly  1090 ESSWSMSV--LNSTYQNVPVTP-----PREVTVRLDEMN---------------PPTVIVQ---- 1128
            ..:..|.|  :|...::...||     ||..:....:.|               |..:|||
Zfish  1109 SCTGRMMVQAVNQRGRSQRSTPGHIRRPRSRSRDSGDENENIQERHFRPHFLQAPGDLIVQEGKL 1173

  Fly  1129 --------WIPPKHTLGQITGYNIYYTTDTTKRDRDWSVEAFAGEETMLMLPN------LKPYTT 1179
                    .:|....:.|:.|..|             ..::|   ..||:..|      ::|.|:
Zfish  1174 CRMDCKVSGLPTPDLIWQLNGQTI-------------RPDSF---HKMLVRENGVHSLVIEPVTS 1222

  Fly  1180 Y---YFKVQARTTKGANNAPFSALVSYTTSAAVTMQEPDTIAKGIDNEKLLYIIIAATAVVLLVV 1241
            .   .:...|....|.|:.....:|     ||..|.:..:..:.:.|..               |
Zfish  1223 RDAGVYTCIASNRAGQNSFNLELIV-----AAKEMHKAPSFIEKLQNTS---------------V 1267

  Fly  1242 LLG--VLLLCRRKPQSSPEHTKKSYQKNNVGVPKPPDLW---------------IHHD------- 1282
            ..|  |.|.||..                 |||.|...|               :|.|
Zfish  1268 AEGHPVRLECRVS-----------------GVPFPQIFWKKENESFTHNTDRISMHQDNFGYLCM 1315

  Fly  1283 --QMELKNIDKGLHTVTPVCSDGASSSGALTLPRSVVHSEY-EVETP 1326
              |..||. |.|.:||:.....|..||.|    |..||::: :..||
Zfish  1316 IIQPALKE-DAGWYTVSAKNEAGIISSTA----RLDVHAQWQQTHTP 1357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fra	NP_523716.2	Ig	36..140	CDD:299845
		Ig	<180..222	CDD:299845	5/19 (26%)
		IG_like	257..340	CDD:214653	25/91 (27%)
		IGc2	264..327	CDD:197706	20/71 (28%)
		I-set	344..430	CDD:254352	24/96 (25%)
		Ig	363..428	CDD:299845	18/75 (24%)
		FN3	611..703	CDD:238020	16/91 (18%)
		FN3	711..799	CDD:238020	19/99 (19%)
		FN3	806..897	CDD:238020	25/158 (16%)
		FN3	908..989	CDD:238020	7/80 (9%)
		FN3	1011..1097	CDD:238020	18/85 (21%)
		FN3	1109..1205	CDD:238020	22/136 (16%)
		Neogenin_C	1273..1521	CDD:284094	20/79 (25%)
palld	XP_021324295.1	I-set	271..358	CDD:254352	26/95 (27%)
		I-set	442..539	CDD:254352	24/96 (25%)
		I-set	1025..1111	CDD:254352	17/96 (18%)
		I-set	1157..1247	CDD:254352	17/105 (16%)
		Ig	1273..1347	CDD:325142	23/95 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44170
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	1.100