DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fra and Igdcc3

DIOPT Version :9

Sequence 1:	NP_523716.2	Gene:	fra / 36377	FlyBaseID:	FBgn0011592	Length:	1526	Species:	Drosophila melanogaster
Sequence 2:	NP_001359088.1	Gene:	Igdcc3 / 315759	RGDID:	1307338	Length:	812	Species:	Rattus norvegicus

Alignment Length:	1066	Identity:	222/1066 - (20%)
Similarity:	334/1066 - (31%)	Gaps:	411/1066 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly    32 SQALSFTLEPQDAVVPEGHSVLLQCAGTASIGRGGKSKSNLPSSVSIRWRGPDGQDLVIVGDTFR 96
            |..|:|::||.|.:...|..::|.|          |.:.:.|..||.|..|.:     :..||..
  Rat    49 SAELAFSVEPNDDIANLGQPIMLGC----------KVEGSPPVQVSWRKNGAE-----LPEDTHT 98

  Fly    97 TQLKNGSLYISSVEENRGLT----GAYQCLLTAEGVGSILSRPALVAIVRQPDLNQDFLETYLLP 157
            |.|.||||.|..:...:|.:    |.|:| :.....|.::||.|.:.:....|.:..........
  Rat    99 TLLANGSLLIHHLRLEQGESPSDEGDYEC-VAQNRFGLLVSRKARIQVATMSDFHVHPQAVMGEE 162

  Fly   158 GQTAYFRCMLGEANWQEGV-KHSVQWLKDDLPLPLDKLRMVVLPNGALEIDEVGPSDRGSYQCNV 221
            |..|.|:|.:      .|: |..:.|.|:.:|:..|..|..:||.|.|:|..:...|.|.:.|..
  Rat   163 GGVARFQCQI------HGLPKPLITWEKNRVPIDTDDERYTLLPKGVLQITGLRAEDSGVFHCVA 221

  Fly   222 TSGSSSRLSSKTNLNIKKPSDPGAENSVAPSFLVGPSPKTVREGDTVTLDCVANGVPKPQIKWLR 286
            ::.:|.|:|....|.:   |..|:.....|:.||||...|:....|..|:|||.|.|:|.:.|.|
  Rat   222 SNMASVRVSHGARLTV---SGSGSGTYKEPTILVGPENLTLTVHQTAVLECVATGNPRPIVSWSR 283

  Fly   287 NGMDLDFNDLDSR------FSIVGTGSLQISSAEDIDSGNYQCRAS--NTVDSLDAQATVQVQEP 343
                     ||.|      ..::|||:|.||......||.|.|.|:  .|.....||..:.||.|
  Rat   284 ---------LDGRPIGVEGIQVLGTGNLIISDVTVQHSGVYVCAANRPGTRVRRTAQGRLVVQAP 339

  Fly   344 PKFIKAPKDTTAHEKDEPELKCDIWGKPKPVIRWLKNGDLITPNDYMQLVDGHN-LKILGLLNSD 407
            .:|::.|:..:..........|...|:|.|.:.|||||.::....:::|.:.:: |.|.|:...|
  Rat   340 AEFVQHPQSISRPAGTTAMFTCQAQGEPPPHVTWLKNGQVLGAGGHVRLKNNNSTLSISGVGPED 404

  Fly   408 AGMFQCVGTNAAGSVHAAARLRVVPQGVKIKKRKSQGHSTKSLQTFDNLTKRRKPFNSGEQLRTK 472
            ..::|||..|.|||..|:|||.|:
  Rat   405 EAIYQCVAENIAGSSQASARLTVL----------------------------------------- 428

  Fly   473 SGGSFPFPDEDDDLDDNDSGTTRLRIPSGKLPKFEQPLNDRRFNILNAGSALPLDNQSKSYEDDD 537

  Rat   429 ----------------------------------------------------------------- 428

  Fly   538 DDYDEDDPAKEALLEAYKQGEDAHKILDSWQQSKSKKSQQQKQSPASPDSPEQDPSVPHPGGKPL 602
                                         |.:.
  Rat   429 -----------------------------WAEG-------------------------------- 432

  Fly   603 DSGLQARLPSQPRDLVAQIVKSRFVTLSWVEPLQNAGDVVYYTVYYKMNNSEREQKMVTKSHDDQ 667
                   ||..||::.|..|.|..|.:||.|||.:..:::.|.::            :.|:.|..
  Rat   433 -------LPGPPRNVRAVSVSSTEVRVSWSEPLTHTKEIIGYVLH------------IRKAADSP 478

  Fly   668 QVNIQSLLPGRTYQFRVEANTNFGSGASSAPLEVSTQPEVNIAGPPRNFEGYARSHKEIYVKWEE 732
            ::..|..:...|:|..|.
  Rat   479 KLEYQEAVSKSTFQHLVR----------------------------------------------- 496

  Fly   733 PTVTNGEILKYRVYYSENDSGADLYHDSTALEAVLTELRPHTDYVISVVPFNRNGMGDSSAEIRV 797
                                                :|.|.|.|...:..:...|...:|.....
  Rat   497 ------------------------------------DLEPSTAYSFYIKAYTPRGASLASVPTLA 525

  Fly   798 KTFSSTPSEPPNNVTLEVTSSSSITVHWEP-PAEEDRNGQITGYKIRYRKFKDA----PQVKSTP 857
            .|....|..||.:|.|  ..|||:.:.|:| |.....||   |:|:.||....|    |.:  .|
  Rat   526 STLGEAPVPPPLSVRL--LGSSSLQLLWKPWPRLAQHNG---GFKLFYRPASAASFTGPIL--LP 583

  Fly   858 ANIRYFELSNLDRNAEYQVKIAAMTVNGSG----PFTEWNRAN-----------TLENDLDETQV 907
            ..:..:.||.||.:..|:||:.|...||.|    .|.....|:           ..|...:.|..
  Rat   584 GTVSSYNLSQLDPSTVYEVKLLAYNQNGDGNATVRFVSLKGASERTALTPPCDCRKEEVTNHTST 648

  Fly   908 PGKPIWISIHPGANNIA-----LHWG----------------PPQHPEIKIRNYVL---GWGRGI 948
            .|  |.|.||.|...|.     |.:|                |||.|..:....:|   |..||.
  Rat   649 TG--IVIGIHIGVTCIIFCVLFLLFGQRGRVLLCKDVENQLSPPQGPRSQRDPGILTLNGVNRGE 711

  Fly   949 -----PDENTIELKETERYHILKNLESNMDYVVSLRARNVKGDGPPIYDNIKTRDEEPVDAPTPL 1008
                 .||..::.||.|:.           :..:..|      |.|     .:|..:|. ||||.
  Rat   712 GGQLGRDEKHVDAKELEQL-----------FPTTASA------GQP-----GSRSTDPT-APTPY 753

  Fly  1009 E-------------VPVGLRAITMSS 1021
            |             :..|....||||
  Rat   754 EETQLSMVQLQDFNLAAGRTTETMSS 779

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fra	NP_523716.2	Ig	36..140	CDD:299845	30/107 (28%)
		Ig	<180..222	CDD:299845	13/41 (32%)
		IG_like	257..340	CDD:214653	29/90 (32%)
		IGc2	264..327	CDD:197706	24/70 (34%)
		I-set	344..430	CDD:254352	27/86 (31%)
		Ig	363..428	CDD:299845	23/65 (35%)
		FN3	611..703	CDD:238020	19/91 (21%)
		FN3	711..799	CDD:238020	6/87 (7%)
		FN3	806..897	CDD:238020	32/110 (29%)
		FN3	908..989	CDD:238020	24/109 (22%)
		FN3	1011..1097	CDD:238020	5/11 (45%)
		FN3	1109..1205	CDD:238020
		Neogenin_C	1273..1521	CDD:284094
Igdcc3	NP_001359088.1	Ig	54..145	CDD:386229	30/106 (28%)
		Ig	153..237	CDD:386229	23/89 (26%)
		IG_like	254..336	CDD:214653	29/90 (32%)
		I-set	341..427	CDD:369462	27/85 (32%)
		FN3	434..527	CDD:238020	25/187 (13%)
		fn3	<554..613	CDD:365830	20/63 (32%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44170
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	2.010