DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fra and Mypn

DIOPT Version :9

Sequence 1:	NP_523716.2	Gene:	fra / 36377	FlyBaseID:	FBgn0011592	Length:	1526	Species:	Drosophila melanogaster
Sequence 2:	NP_001355746.1	Gene:	Mypn / 309760	RGDID:	1308510	Length:	1306	Species:	Rattus norvegicus

Alignment Length:	1278	Identity:	251/1278 - (19%)
Similarity:	407/1278 - (31%)	Gaps:	415/1278 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly   187 LPLPLDKLRMVVLPNGALEIDEVGPSDRGSYQCNVTSGSSSRLSSKTNLNIKKP-SDPGAENSVA 250
            :|:|.|.....:  |.|:|..|....:.........:|.|:..||.::|..::| ..|
  Rat   206 IPIPADSRDNEL--NHAIEQREAKRREAELAAVEAAAGDSTPGSSPSSLYYEEPLGQP------- 261

  Fly   251 PSFLVGPSPKTVREGDTVTLDCVANGVPKPQIKWLRNGMDLDFNDLDSRFSIVGTG---SLQISS 312
            |.|......:.|.||..|.|||:..|:|.||::|...|.:|: |..|  ..||..|   ||.|:.
  Rat   262 PRFTQKLRSREVPEGSRVQLDCIVVGIPPPQVRWYCEGKELE-NSPD--IHIVQAGNLHSLTIAE 323

  Fly   313 AEDIDSGNYQCRASNT--------------VDSLDAQ------------------------ATV- 338
            |.:.|:|.|.|.|||.              |.|.|::                        ||:
  Rat   324 AFEEDTGRYSCFASNIYGTDSTSAEIYIEGVSSSDSEGDPNKEEMNRIQKPNEVSSPPTTSATIP 388

  Fly   339 -------------QVQEP---------------PKFIKAPKDTTAHEKDEPELKCDIWGKPKPVI 375
                         |.|.|               |.|.|..::.:|.|......:|.:.|.|.|.:
  Rat   389 PTVQAQPRVSTIQQCQSPTNYLQGLNGKPIIAAPVFTKMLQNLSASEGQLVVFECRVKGAPSPKV 453

  Fly   376 RWLKNGDLI-----------TPNDYMQLVDGHNLKILGLLNSDAGMFQCVGTNAAGSVHAAARLR 429
            .|.:.|.||           .|....:..:...|.|..:...|:|.|.|..:|..|:|.:.|:|.
  Rat   454 EWYREGTLIEDSPDFRILQKKPRSMAEPEEICTLVIAEVFAEDSGCFTCTASNKYGTVSSIAQLA 518

  Fly   430 VVPQGVKIKKRKSQGHSTKSLQTFDNLTKRRKPFNSGEQLRTKSGGSFPFPDEDDDLDDNDSGTT 494
            |         |.::..|.......||.|  ..|..:.:|         |.|
  Rat   519 V---------RGNEDISDNETLHSDNST--TNPAATEQQ---------PSP-------------- 549

  Fly   495 RLRIPSGKLPKFEQPLNDRRFNIL------NAGSALPLDNQSKSYEDDDDDYDEDDPAKEALLEA 553
                |:.:.|..|||...:...:|      .:.|.:.|.......|||.|            .||
  Rat   550 ----PNPQPPPEEQPPKPKLEGVLVNHNEPRSSSRIGLRVHFNLPEDDKD------------TEA 598

  Fly   554 YKQGEDAHKILDSWQQSKSKKSQQQKQSPASPDSPEQDPSVPHPGGKP-LDSGLQARL------- 610
             ..|........:...|..::...|:...:.|.||.::|  |....|| |||....:|
  Rat   599 -SSGCGMANTSQTRPDSFPERFNGQEARISEPSSPVKEP--PPVLAKPKLDSTQLQQLHNQVLLE 660

  Fly   611 --------PSQPRDLVAQIVKSRFVTLSWVEPLQNAGDVVYYTVYYKMNNSEREQKMVTKSHDDQ 667
                    ||.|::       |.|.|    ..|.:|...|  |:..|.          .||...|
  Rat   661 QLQLHNTSPSSPKE-------SPFNT----SILNSAPPTV--TISSKQ----------VKSPAPQ 702

  Fly   668 QVNIQSLLPGRTYQFRVEANTNFGSGASSAPLEVSTQPEVNIAGPPRNFEGYARSHKEIYVKWEE 732
            ..|:     .|...|...::|      |:|.:..|:.|...::..|:..:   |:..:..:....
  Rat   703 TFNL-----ARPKHFFPASST------STATVSPSSSPVFTLSNTPQTIQ---RTVSKESLLMTH 753

  Fly   733 PTVTNGEILKYRVYYSENDSGADLYHD----STALEAVLT---------ELRPHTDYVISVVPFN 784
            |: |.|          .:..|..:.::    |.|..||.|         :.:||   .:|..|.:
  Rat   754 PS-TQG----------RSPGGLSIQNEPAPPSPAEPAVPTVSYSITSGNQFQPH---CVSPTPVS 804

  Fly   785 RNGMGDSSAEIRVKTFSSTPSEPPNNVTLEVTSSSSITVHWEPP------------------AEE 831
            ..|...:..........|.||.||.|......|:.|:     ||                  ..|
  Rat   805 PTGRIQNPVAFLSSVLPSLPSIPPTNAMGLPKSAPSV-----PPQGLMKKTTKTPQAVSDDYIRE 864

  Fly   832 DRNGQI--TGYKIRYRKFKDAPQVKSTPANIRYFELSNLDRNA--EYQVKIAAMTVNGSGPFTEW 892
            .:|..|  .|.|:.:...:...|         .:::|:.::..  |.:.::....|:.|
  Rat   865 TKNSVILDLGKKVNFSDVRSHQQ---------EYKISSFEQRLMNEIEFRLERTPVDES------ 914

  Fly   893 NRANTLENDLDETQVP-GKPIWISIHPGANNIALHWGPPQHPEIKIRNYVLGWGRGIPDENTIEL 956
                  ::::...::| ||.|.........:..:..|.|.....||        .|||.......
  Rat   915 ------DDEIQHDEIPTGKCIAPIFDKRLKHFRVTEGSPVTFTCKI--------VGIPVPKVYWF 965

  Fly   957 KETERYHILK-----NLESNMDYVVSLRARNVKGD-------------------------GPPIY 991
            |:.::  |.|     .:..:.|...||...:..||                         |.||.
  Rat   966 KDGKQ--ISKRNEHCKMRRDGDGTCSLHIESTHGDDDGNYTIMAANPQGRISCSGHLMVQGFPIR 1028

  Fly   992 DNI-------------KTRDEEPVD----APTPLEVPVGLRA-------ITMSSSSIVVYWIDTM 1032
            :.:             :.||:||:.    .|..|:.|..:.|       :....|.:....:..:
  Rat  1029 NRLSPAGQSHRGRSRMQERDKEPLQERFFRPHFLQAPGDMVAHEGRLCRLDCKVSGLPPPELTWL 1093

  Fly  1033 LNKNQHVTDNRHYTVSYGITGSNRYRYHNTTDLNCMINDLRPNTQ-----YEFAVKVVKGRRESS 1092
            ||....:.|..|..:.            ..|.::.::.|  |.||     |........|:...|
  Rat  1094 LNGQPVLPDASHKMLV------------RETGVHSLLID--PLTQRDAGTYTCVATNKTGQNSFS 1144

  Fly  1093 WSMSVLNSTYQNVPVT--------PPREVTVRLD----EMNPPTVIVQWIPPKHTL--------- 1136
            ..::|:....:..||.        .|....|||:    .|.||  :..|.....|:
  Rat  1145 LELTVVAKEVKKAPVILEKLQNSGVPEGHPVRLEGRVIGMPPP--VFYWKKDNETIPFTRERISM 1207

  Fly  1137 -GQITGYNIYYTTDTTKRDRDW----------------SVEAFAGEETMLMLP-NLKPYTTYYFK 1183
             ...|||.........|.|..|                .::.:|.....:..| :::|..:.|..
  Rat  1208 HQDTTGYVCLLIQPAKKSDAGWYTLSAKNEAGIVSCTARLDIYAQWHQQIPTPISIRPSGSRYGS 1272

  Fly  1184 VQARTTKGANNAPFSALVSYTTSAAVTMQEPDTIAKGIDNEKL 1226
            :   |:||.:  .|||.    :|...||....|....:::::|
  Rat  1273 L---TSKGLD--IFSAF----SSMESTMMYSCTSRSVVESDEL 1306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fra	NP_523716.2	Ig	36..140	CDD:299845
		Ig	<180..222	CDD:299845	7/34 (21%)
		IG_like	257..340	CDD:214653	35/137 (26%)
		IGc2	264..327	CDD:197706	27/65 (42%)
		I-set	344..430	CDD:254352	25/96 (26%)
		Ig	363..428	CDD:299845	19/75 (25%)
		FN3	611..703	CDD:238020	20/91 (22%)
		FN3	711..799	CDD:238020	16/100 (16%)
		FN3	806..897	CDD:238020	17/112 (15%)
		FN3	908..989	CDD:238020	20/111 (18%)
		FN3	1011..1097	CDD:238020	15/97 (15%)
		FN3	1109..1205	CDD:238020	25/126 (20%)
		Neogenin_C	1273..1521	CDD:284094
Mypn	NP_001355746.1	I-set	262..348	CDD:336764	32/88 (36%)
		I-set	422..519	CDD:336764	25/96 (26%)
		I-set	931..1022	CDD:336764	15/100 (15%)
		I-set	1059..1149	CDD:336764	17/103 (17%)
		Ig	1175..1249	CDD:353325	14/75 (19%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR44170
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	2.100