DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fra and IGSF10

DIOPT Version :9

Sequence 1:NP_523716.2 Gene:fra / 36377 FlyBaseID:FBgn0011592 Length:1526 Species:Drosophila melanogaster
Sequence 2:XP_011511010.1 Gene:IGSF10 / 285313 HGNCID:26384 Length:2695 Species:Homo sapiens


Alignment Length:1052 Identity:210/1052 - (19%)
Similarity:358/1052 - (34%) Gaps:322/1052 - (30%)


- Green bases have known domain annotations that are detailed below.


  Fly    30 LASQALSFTLEPQDAVVPEGHSVLLQCAGTASIGRGGKSKSNLPSSVSIRW-RGPDGQDLVIVGD 93
            :..:|.|||       :|......|.|   .::|      :.||   :|.| |.|.|.||.....
Human  1723 VGGKAASFT-------IPANSDAFLPC---EAVG------NPLP---TIHWTRVPSGLDLSKRKQ 1768

  Fly    94 TFRTQ-LKNGSLYISSVE-ENRGLTGAYQCLLTAEGVGSILSRPALVAIVRQPD--LNQDFLETY 154
            ..|.| |.||:|.|..|| ::||     |.|.:|..:.........:::|..|.  |.:...|..
Human  1769 NSRVQVLPNGTLSIQRVEIQDRG-----QYLCSASNLFGTDHLHVTLSVVSYPPRILERRTKEIT 1828

  Fly   155 LLPGQTAYFRCMLGEANWQEG-VKHSVQWLKDDLPLPLD----KLRMVVLPNGALEIDEVGPSDR 214
            :..|.|...:|.      .|| ...:|.|:..:..:..:    ..:.||..:|.|.:..:...||
Human  1829 VHSGSTVELKCR------AEGRPSPTVTWILANQTVVSESSQGSRQAVVTVDGTLVLHNLSIYDR 1887

  Fly   215 GSYQCNVTSGSSSRLSSKTNLNIKKPSDPGAENSVAPSFLVGPSPKTVRE----------GDTVT 269
            |.|:|                   ..|:||.::|:.....|..:|..:.|          |:::.
Human  1888 GFYKC-------------------VASNPGGQDSLLVKIQVIAAPPVILEQRRQVIVGTWGESLK 1933

  Fly   270 LDCVANGVPKPQIKW-LRNGMD---LDFNDLDSRFSIVGTGSLQISSAEDIDSGNYQCRASNTVD 330
            |.|.|.|.|:|.:.| |.:|.:   |.|.  :|:..:...|:|.|.:....|.|.|:|.|:::..
Human  1934 LPCTAKGTPQPSVYWVLSDGTEVKPLQFT--NSKLFLFSNGTLYIRNLASSDRGTYECIATSSTG 1996

  Fly   331 SLDAQATVQVQEPPKFIKAPKDTTAHEK-------DEPELKCDIWGKPKPVIRWLKNGDLITP-- 386
            |......:.::|.   :.:|:...|.:|       |:..|.|...|:|||.|.|......:..  
Human  1997 SERRVVMLTMEER---VTSPRIEAASQKRTEVNFGDKLLLNCSATGEPKPQIMWRLPSKAVVDQQ 2058

  Fly   387 ---NDYMQLVDGHNLKILGLLNSDAGMFQCVGTNAAGS----VHAAARLRVVPQGVKIKK--RKS 442
               ..::.:....:|.|..:...|:|::.||..|..|.    :|.:.||:  |..:..|:  ||.
Human  2059 HRVGSWIHVYPNGSLFIGSVTEKDSGVYLCVARNKMGDDLILMHVSLRLK--PAKIDHKQYFRKQ 2121

  Fly   443 QGHSTKSLQTFDNLTKRRKPFNSGEQLRTKSGGSFPFPDEDDDLDD----------NDSGTTRLR 497
            ..|.              |.|    |:..|:.|| |.|:....|.|          :|||.    
Human  2122 VLHG--------------KDF----QVDCKASGS-PVPEISWSLPDGTMINNAMQADDSGH---- 2163

  Fly   498 IPSGKLPKFEQPLNDRRFNILNAGSALPLDNQSKSYEDDDDDYDEDDPAKEALLEAYKQ---GED 559
                         ..||:.:.|.|:..               :::...|:|.....|.|   |:|
Human  2164 -------------RTRRYTLFNNGTLY---------------FNKVGVAEEGDYTCYAQNTLGKD 2200

  Fly   560 AHKILDSWQQSKSKKSQQQKQSPASPDSPEQDPSVPHPGGKPLDSG----LQARLPSQPRDLVAQ 620
            ..|:..:...:..:..|..|.:                  |.:.:|    |...:...|:.    
Human  2201 EMKVHLTVITAAPRIRQSNKTN------------------KRIKAGDTAVLDCEVTGDPKP---- 2243

  Fly   621 IVKSRFVTLSWVEPLQNAGDVVYYTVYYKMNNSEREQKMVTKSHDDQQVNIQSLLPGRTYQFRVE 685
                   .:.|:.|   :.|::.:::          .:....::....:|...||....|.  ..
Human  2244 -------KIFWLLP---SNDMISFSI----------DRYTFHANGSLTINKVKLLDSGEYV--CV 2286

  Fly   686 ANTNFGSGASSAPLE-VSTQPEVN-------------IAGPPRNFEGYARSHKEIYVKWEEPTVT 736
            |....|.......|: ||..|.:|             :....::|:..|.......|.|..|   
Human  2287 ARNPSGDDTKMYKLDVVSKPPLINGLYTNRTVIKATAVRHSKKHFDCRAEGTPSPEVMWIMP--- 2348

  Fly   737 NGEILKYRVYYSENDSGADLYHDSTALEAVLTELRPHTDYVISVVPFNRNGMGDSSAEIRVK--- 798
             ..|.....||....:    .|.:..||.....|....|::...    ||..|:|...::::   
Human  2349 -DNIFLTAPYYGSRIT----VHKNGTLEIRNVRLSDSADFICVA----RNEGGESVLVVQLEVLE 2404

  Fly   799 -----TFSSTPSEPPNNVTLEVTSSSSI--TVHWEPPAEEDRNGQITGYKIRYRKFKDAPQVKST 856
                 ||.:..:|   .:..::..|:::  :|...||.|      |........:|.:.||    
Human  2405 MLRRPTFRNPFNE---KIVAQLGKSTALNCSVDGNPPPE------IIWILPNGTRFSNGPQ---- 2456

  Fly   857 PANIRYFELSNLDRNAEYQVKIAAMTVNGS-----------GPF--TEWNRANTLENDLDETQVP 908
                            .||..||:   |||           |.:  ...|:...:|. |...::.
Human  2457 ----------------SYQYLIAS---NGSFIISKTTREDAGKYRCAARNKVGYIEK-LVILEIG 2501

  Fly   909 GKPIWISIHPG------ANNIALH------------WGPP-----QHPEIKIRNYVLGWGRGIPD 950
            .||:.::..||      ..:::||            |..|     ..|:|. ..|:|      .|
Human  2502 QKPVILTYAPGTVKGISGESLSLHCVSDGIPKPNIKWTMPSGYVVDRPQIN-GKYIL------HD 2559

  Fly   951 ENTIELKETERY 962
            ..|:.:||...|
Human  2560 NGTLVIKEATAY 2571

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fraNP_523716.2 Ig 36..140 CDD:299845 30/106 (28%)
Ig <180..222 CDD:299845 11/45 (24%)
IG_like 257..340 CDD:214653 24/96 (25%)
IGc2 264..327 CDD:197706 22/76 (29%)
I-set 344..430 CDD:254352 23/101 (23%)
Ig 363..428 CDD:299845 17/73 (23%)
FN3 611..703 CDD:238020 12/92 (13%)
FN3 711..799 CDD:238020 17/95 (18%)
FN3 806..897 CDD:238020 19/105 (18%)
FN3 908..989 CDD:238020 17/78 (22%)
FN3 1011..1097 CDD:238020
FN3 1109..1205 CDD:238020
Neogenin_C 1273..1521 CDD:284094
IGSF10XP_011511010.1 leucine-rich repeat 111..130 CDD:275380
leucine-rich repeat 131..154 CDD:275380
LRR_8 153..213 CDD:290566
leucine-rich repeat 155..178 CDD:275380
leucine-rich repeat 179..202 CDD:275380
LRR_8 201..267 CDD:290566
leucine-rich repeat 203..226 CDD:275380
leucine-rich repeat 227..250 CDD:275380
leucine-rich repeat 260..282 CDD:275380
LRRCT 291..>309 CDD:214507
IG_like 557..640 CDD:214653
Ig 559..627 CDD:299845
IG_like 654..734 CDD:214653
IGc2 659..724 CDD:197706
IG 1731..1812 CDD:214652 28/104 (27%)
Ig 1740..1812 CDD:299845 26/88 (30%)
IG_like 1825..1909 CDD:214653 21/108 (19%)
Ig 1832..1899 CDD:299845 18/91 (20%)
IG 1929..2005 CDD:214652 22/77 (29%)
IGc2 1929..1996 CDD:197706 21/68 (31%)
IG 2020..2097 CDD:214652 18/76 (24%)
IGc2 2028..2095 CDD:197706 16/66 (24%)
IG_like 2125..2208 CDD:214653 24/133 (18%)
Ig 2132..2208 CDD:299845 21/108 (19%)
I-set 2213..2296 CDD:254352 15/126 (12%)
IGc2 2228..2292 CDD:197706 11/89 (12%)
IG_like 2331..2402 CDD:214653 17/82 (21%)
Ig 2333..2402 CDD:299845 16/80 (20%)
IG 2417..2500 CDD:214652 21/115 (18%)
IGc2 2424..2490 CDD:197706 18/94 (19%)
IG_like 2511..2591 CDD:214653 15/68 (22%)
IGc2 2518..2585 CDD:197706 13/61 (21%)
Ig 2600..2694 CDD:299845
IG_like 2607..2694 CDD:214653
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.910

Return to query results.
Submit another query.