DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fra and PRTG

DIOPT Version :9

Sequence 1:	NP_523716.2	Gene:	fra / 36377	FlyBaseID:	FBgn0011592	Length:	1526	Species:	Drosophila melanogaster
Sequence 2:	NP_776175.2	Gene:	PRTG / 283659	HGNCID:	26373	Length:	1150	Species:	Homo sapiens

Alignment Length:	1555	Identity:	340/1555 - (21%)
Similarity:	510/1555 - (32%)	Gaps:	504/1555 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LLSSCLIFQLIGSSLAS----QALSFTLEPQDAVVPEGHSVLLQCAGTASI-------GRGGKSK 69
            :|...|:..|:.|.|..    ..|||..||||..|.....|:|.|.....:       ..|.|..
Human    16 MLLRALLLLLLLSPLPGVWCFSELSFVKEPQDVTVTRKDPVVLDCQAHGEVPIKVTWLKNGAKMS 80

  Fly    70 SNLPSSVSIRWRGPDGQDLVIVGDTFRTQLKNGSLYISSVEENRGL---TGAYQCLLTAEGVGSI 131
            .|....|                      |.|||||||.||..||.   .|.||| |.....|:|
Human    81 ENKRIEV----------------------LSNGSLYISEVEGRRGEQSDEGFYQC-LAMNKYGAI 122

  Fly   132 LSRPALVAIVRQPDLNQDFLETYLLPGQTAYFRCMLGE-----ANWQEGVKHSVQWLKDDLPLPL 191
            ||:.|.:|:..........:.|.:..|..|.|.|.:..     ..|        ::.:..||:.:
Human   123 LSQKAHLALSTISAFEVQPISTEVHEGGVARFACKISSHPPAVITW--------EFNRTTLPMTM 179

  Fly   192 DKLRMVVLPNGALEIDEVGPSDRGSYQCNVTSGSSSRLSSKTNLNIKKPSDPGAENSV--APSFL 254
            |  |:..||.|.|:|.:|...|.|:|:|...:.:..|.|.:.:|.:    .|..|:..  .|:.:
Human   180 D--RITALPTGVLQIYDVSQRDSGNYRCIAATVAHRRKSMEASLTV----IPAKESKSFHTPTII 238

  Fly   255 VGPSPKTVREGDTVTLDCVANGVPKPQIKWLRNGMDLDFNDLD-SRFSIVGTGSLQISSAEDIDS 318
            .||...|.....||.|:|:|.|.|||.|.|.|    ||...:| ....::|.|:|.||......:
Human   239 AGPQNITTSLHQTVVLECMATGNPKPIISWSR----LDHKSIDVFNTRVLGNGNLMISDVRLQHA 299

  Fly   319 GNYQCRAS--NTVDSLDAQATVQVQEPPKFIKAPKDTTAHEKDEPELKCDIWGKPKPVIRWLKNG 381
            |.|.|||:  .|.:...|.||:.|..||.|::.|:..|..........|...|.|.|.:.|||||
Human   300 GVYVCRATTPGTRNFTVAMATLTVLAPPSFVEWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNG 364

  Fly   382 DLITPNDYMQLVDGHNLKILGLLNSDAGMFQCVGTNAAGSVHAAARLRVVPQGVKIKKRKSQGHS 446
            ..|..|..:::.:. .|.|..::..|..::||:..|:.||:.:.|||.||
Human   365 RKIHSNGRIKMYNS-KLVINQIIPEDDAIYQCMAENSQGSILSRARLTVV--------------- 413

  Fly   447 TKSLQTFDNLTKRRKPFNSGEQLRTKSGGSFPFPDEDDDLDDNDSGTTRLRIPSGKLPKFEQPLN 511

Human   414 ----------------------------------------------------------------- 413

  Fly   512 DRRFNILNAGSALPLDNQSKSYEDDDDDYDEDDPAKEALLEAYKQGEDAHKILDSWQQSKSKKSQ 576
                                                        ..||.
Human   414 --------------------------------------------MSEDR---------------- 418

  Fly   577 QQKQSPASPDSPEQDPSVPHPGGKPLDSGLQARLPSQPRDLVAQIVKSRFVTLSWVEPLQNAGDV 641
                                              ||.|.::.|:.:.|..:.|:|..||.|:..|
Human   419 ----------------------------------PSAPYNVHAETMSSSAILLAWERPLYNSDKV 449

  Fly   642 VYYTVYY-KMNNSEREQKMVTKSHDDQQVNIQSLLPGRTYQFRVEANTNFGSGASSAPLEVSTQP 705
            :.|:|:| |......|:..|...:|.....|..|.|...|.|.:.|....|:...|..:..:|..
Human   450 IAYSVHYMKAEGLNNEEYQVVIGNDTTHYIIDDLEPASNYTFYIVAYMPMGASQMSDHVTQNTLE 514

  Fly   706 EVNIAGPPRNFEGYARSHKEIYVKW--EEPTVTNGEILKYRVYY--SENDSGADLYHDSTALEAV 766
            :|.:..|..:..  :||..:|.:.|  .......|:::.||:.:  |..:|...|....|..|.:
Human   515 DVPLRPPEISLT--SRSPTDILISWLPIPAKYRRGQVVLYRLSFRLSTENSIQVLELPGTTHEYL 577

  Fly   767 LTELRPHTDYVISVVPFNRNGMGDSSAEIRVKTFSSTPSEPPNN--VTLEVTSSSSITVHWEPPA 829
            |..|:|.:.|::.:....|.|:|:||.....:|..:|..:.|.:  :.||..:.::|:|.|:...
Human   578 LEGLKPDSVYLVRITAATRVGLGESSVWTSHRTPKATSVKAPKSPELHLEPLNCTTISVRWQQDV 642

  Fly   830 EEDRNGQITGYKIRYRKFKDAPQVKSTPANI----RYFELSNLDRNAEYQVKIAAMTVNGSGPFT 890
            |:  ...|.|||:.|   |:..|.::.|..:    ..:.||.||...:|.|::.|.
Human   643 ED--TAAIQGYKLYY---KEEGQQENGPIFLDTKDLLYTLSGLDPRRKYHVRLLAY--------- 693

  Fly   891 EWNRANTLENDLDETQVPGKPIWISIHPGANNIALHWGPPQHPEIKIRNYVLGWGRGIPDENTIE 955
                     |::|:                                          |...:.|:
Human   694 ---------NNIDD------------------------------------------GYQADQTV- 706

  Fly   956 LKETERYHILKNLESNMDYVVSLRARNVKGDGPPIYDNIKTRDEEPVDAPTPLEVPVGLRAITMS 1020
                           :....||:|.|.|    ||               |.|   |..|.|...:
Human   707 ---------------STPGCVSVRDRMV----PP---------------PPP---PHHLYAKANT 734

  Fly  1021 SSSIVVYWIDTMLNKNQHVTDNRHYTV---SYGITGSNRYRYHNTTDLNCMINDLRPNTQYEFAV 1082
            ||||.::|........|.:    :||:   ..|:..::...|..|::.:.::..|.|||:|||||
Human   735 SSSIFLHWRRPAFTAAQII----NYTIRCNPVGLQNASLVLYLQTSETHMLVQGLEPNTKYEFAV 795

  Fly  1083 KVVKGRRESSWSMSVLNSTYQNVPVTPPREVTVRLDEMNPPTVIVQWIPPKHTLGQITGYNIYYT 1147
            ::...:..|.||..|.:||....|..||..|.|.|.|  ..|.:|.|.||......:|.|.|.|.
Human   796 RLHVDQLSSPWSPVVYHSTLPEAPAGPPVGVKVTLIE--DDTALVSWKPPDGPETVVTRYTILYA 858

  Fly  1148 TDTTKRDRDWSVEAFAGEETMLMLPNLKPYTTYYFKVQARTTKGANNAPFSALVSYTTSAAVTMQ 1212
            :.......:|.|....|..||.:|.||.....|..|:.|....|  ..|||..|.
Human   859 SRKAWIAGEWQVLHREGAITMALLENLVAGNVYIVKISASNEVG--EGPFSNSVE---------- 911

  Fly  1213 EPDTIAKGIDNEKLLYIIIAATAVVLLVVLLGVLLLCRRKPQSSPEHTKKSYQKNNVGVPKPPDL 1277
                                          |.||          |:.|.:|.|:     ||..|.
Human   912 ------------------------------LAVL----------PKETSESNQR-----PKRLDS 931

  Fly  1278 --------WIHHDQMELKNIDKGLH---TVTPVCSDGASSSGALTLPRSVVHSEYEVETPVPGHV 1331
                    :.|.||..:..|..|:.   |...:|.       .:.:.||....
Human   932 ADAKVYSGYYHLDQKSMTGIAVGVGIALTCILICV-------LILIYRSKARK------------ 977

  Fly  1332 TNSLDKRSYVPGYMTTSMNGTMERPQYPRTQYS--HQNRSHMTMEAGLSQQSLTQP--QSNSMAQ 1392
             :|..|         |:.|||.   |.|||..|  ..|.....:|..:..:....|  ..||...
Human   978 -SSASK---------TAQNGTQ---QLPRTSASLASGNEVGKNLEGAVGNEESLMPMIMPNSFID 1029

  Fly  1393 TPEHPYGGYDANFCNAGNAAAGNG-----------CVSTIESSKRGHPLKSFSVPGPPPTGGATP 1446
            ..    ||.|....:.|.....|.           .:...:..:|..|...|..||.
Human  1030 AK----GGTDLIINSYGPIIKNNSKKKWFFFQDSKKIQVEQPQRRFTPAVCFYQPGT-------- 1082

  Fly  1447 VTKHTPAVTIRPQNQSPYKKPSFS------AATPNRLQGGGSVVHSTDEIQRLAPSTSTE 1500
                |..::......||.:..|||      |.|.:.....||  |.|.:..|.:..::.|
Human  1083 ----TVLISDEDSPSSPGQTTSFSRPFGVAADTEHSANSEGS--HETGDSGRFSHESNDE 1136

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fra	NP_523716.2	Ig	36..140	CDD:299845	36/113 (32%)
		Ig	<180..222	CDD:299845	14/41 (34%)
		IG_like	257..340	CDD:214653	31/85 (36%)
		IGc2	264..327	CDD:197706	25/65 (38%)
		I-set	344..430	CDD:254352	26/85 (31%)
		Ig	363..428	CDD:299845	20/64 (31%)
		FN3	611..703	CDD:238020	26/92 (28%)
		FN3	711..799	CDD:238020	22/91 (24%)
		FN3	806..897	CDD:238020	22/96 (23%)
		FN3	908..989	CDD:238020	7/80 (9%)
		FN3	1011..1097	CDD:238020	26/88 (30%)
		FN3	1109..1205	CDD:238020	31/95 (33%)
		Neogenin_C	1273..1521	CDD:284094	51/260 (20%)
PRTG	NP_776175.2	Ig	40..130	CDD:299845	36/112 (32%)
		Ig	139..223	CDD:299845	23/93 (25%)
		IG_like	141..223	CDD:214653	23/91 (25%)
		IG_like	241..323	CDD:214653	31/85 (36%)
		IGc2	250..309	CDD:197706	25/62 (40%)
		I-set	327..412	CDD:254352	26/85 (31%)
		Ig	345..412	CDD:299845	22/67 (33%)
		FN3	419..512	CDD:238020	26/92 (28%)
		FN3	517..610	CDD:238020	22/94 (23%)
		fn3	624..699	CDD:278470	23/139 (17%)
		FN3	726..814	CDD:238020	26/91 (29%)
		FN3	821..911	CDD:238020	30/93 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	981..1002		10/32 (31%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1086..1150		13/53 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4221
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810