DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fra and cdon

DIOPT Version :9

Sequence 1:	NP_523716.2	Gene:	fra / 36377	FlyBaseID:	FBgn0011592	Length:	1526	Species:	Drosophila melanogaster
Sequence 2:	NP_001075097.1	Gene:	cdon / 280652	ZFINID:	ZDB-GENE-021115-4	Length:	1125	Species:	Danio rerio

Alignment Length:	1087	Identity:	236/1087 - (21%)
Similarity:	401/1087 - (36%)	Gaps:	273/1087 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LLSS--CLIFQLIGSSLASQALSFTLEPQDAVVPEGHSVLLQCAGTASIGRGGKSKSNLPSSVSI 78
            |||:  |:...|:.:.....:.||..||..|::.:|.||.|.|             :..|::..|
Zfish     8 LLSAVLCVCHTLLLNCPTVLSFSFRAEPLSAILKQGSSVHLHC-------------TTHPATARI 59

  Fly    79 RWRGPDGQDLVIVGDTFR---TQLKNGSLYISSVEENRGLTGAYQCLLTAEGVGSILSRPALVAI 140
            .|.. .||.|    |...   .:|...||.:|:::.  .|||:|||...:| .|||:||.|.|.|
Zfish    60 SWLF-QGQPL----DPSHHSGVELSQDSLSLSNLQP--ALTGSYQCSARSE-TGSIISRHARVTI 116

  Fly   141 VRQPDLNQDFLETY-----LLPGQTAYFRCMLGEANWQEGVKHSV--QWLKDDLPLPLDKLRMVV 198
            .   |: ::|.||:     :..|.||...|.|..:|.....:..:  :||:....      ..::
Zfish   117 A---DI-EEFAETHRRSFTVNKGDTAVIECPLPRSNPPALPRFRIRGKWLEQSTD------EYLI 171

  Fly   199 LPNGALEIDEVGPSDRGSYQCNVTSGSSSRLSSK-------TNLNIKKPSDPGAENSVAPSFLVG 256
            ||:|.|:|..|....:|.|:|    |:.:.|:.:       |.|.:|   |..:.:.|...:.:.
Zfish   172 LPSGNLQIVSVSSEHQGMYKC----GAYNPLTRETRVEAHGTKLLVK---DSESSSPVRIVYPIT 229

  Fly   257 PSPKTVREGDTVTLDCVANGVPKPQIKWLRNGMDLDFNDLDSRFSIVGTGSLQISSAEDIDSGNY 321
            |...||.:..::||:||.:|....::||::||.:|   .|.|: .::...:|.::..:..|.|:|
Zfish   230 PRSLTVDQSGSLTLECVVSGSLSSKVKWMKNGAEL---SLSSK-RMLSHSNLVLNDIQPGDGGHY 290

  Fly   322 QCRASNTVDS-LDAQATVQVQEPPKFIKAPKDTTAHEKDEPELKCDIWGKPKPVIRWLKNGDLIT 385
            .|.......: :....||.|......::...|..|.........|...|.|.|.|.||.|...::
Zfish   291 SCSVPTDRGAVVSVNYTVNVLAHVSILRGLSDQAAVAGSSVRFTCAASGNPTPNITWLLNAAPLS 355

  Fly   386 PNDYMQLVDGHNLKILGLLNSDAGMFQCVGTNAAGSVHAAARLRV--VPQGVKIK----KRKSQG 444
            .:..:: :.|.:|.|......|.|::||:..|...|..:..||.:  .||...|.    |.:...
Zfish   356 SSPRLK-ISGTSLLISSTTLQDQGIYQCMFDNGISSAQSTGRLSIQSEPQSSSISAVPVKTQPSV 419

  Fly   445 HSTKSLQTFDNLTKRRKPFNSGEQLRTKSG---------------GSFPFPD------------- 481
            |..:|              :.|::|....|               |..|.|:
Zfish   420 HPIQS--------------DEGDELFLSMGEAALGETVGPPTERIGDRPTPEAPIIISPPQTHKP 470

  Fly   482 -------------------------EDDDLDDNDSGTTRLRIPSGKLPKFEQPLNDRRFNILNAG 521
                                     :.||:.:.......:|:|..:
Zfish   471 NMYDLEWRAGRDWGIAIIAYFVKYRKVDDMGNVVGSWHTVRVPGSE------------------- 516

  Fly   522 SALPLDNQSKSYEDDDDDYDEDDPAK--EALLEAYKQGEDAHKILDSWQQSKSKKSQQQKQSPAS 584
            .:|||              .|.:|:.  |.|:.|.....:....:.:::..|.:         ||
Zfish   517 KSLPL--------------SELEPSSLYEVLMVARSAAGEGQPAMLTFRTGKER---------AS 558

  Fly   585 PD-SPEQDPSVPHPGGKPLDSG--------LQARLPSQP-RDLVAQIVKSRFVTLSWVEPLQNAG 639
            |: :|.:.|.|..|...|.|..        :..|:|..| |..::...:|. |.::|: |..|.|
Zfish   559 PNKNPSKAPIVSLPEKTPEDKTTNTYYGVVIHDRVPEAPDRPTISMATESS-VYVTWI-PRANGG 621

  Fly   640 D-VVYYTVYYKMNNSEREQKMVTKSHDDQQ--VNIQSLLPGRTYQFRVEANTNFG---SGASSAP 698
            . :..:.|.|:......:..:...:....:  |.:::|.||.||:|||.|..|:|   :.|:|.|
Zfish   622 SPITAFRVEYRKQGRNGDWIIAADNISPLKLSVEVRNLEPGSTYRFRVIAMNNYGESPASATSRP 686

  Fly   699 LEV--STQPEVN--IAGPPRNFEGYARSHKEIYVKWEEPTVTNGE--ILKYRVYYSENDSGADLY 757
            .:|  |:.|..|  :.||..:... |.|..:|.::|.....:|..  |..:.:||...||..|..
Zfish   687 YQVSMSSSPVSNRPVTGPHISSTD-AVSDTQILLRWTYTPSSNNNTPIQGFYIYYRPTDSDNDSD 750

  Fly   758 HDSTALEA-----VLTELRPHTDYVISVVPFNRNGMGDSSAEIRVKTFSSTPSEPPNNVTLEVTS 817
            :....:|.     ::.||:|.|.|.|.:..:|..|..:.|   .|....:...:||.     |.|
Zfish   751 YKKDVVEGFKFWHMIGELQPETSYDIKMQCYNDGGESEYS---NVMICETKARQPPG-----VPS 807

  Fly   818 SSSITVHWEPPAEEDRN---------GQITGYKI----------RYRKFKDAPQVKSTPANIRYF 863
            ...||.....||:....         |.:.|..:          .:|..:.....|..|.|..|.
Zfish   808 LRPITPPGFYPADTPSQPGGLLYLIVGCVLGVMVLILLVFIVMCLWRNRQQNSMHKYDPPNYIYQ 872

  Fly   864 ELSNLDRNAEYQVKIAAMTVNGS-----------GPFTEWNRANTLENDLDETQVPGKPIWISIH 917
            .........:|.....:..||||           .|.|..:..:.|.|.|......| .::.:.|
Zfish   873 SAEMNGHVLDYSALPGSSHVNGSVHTGCGHTAPMMPQTCHHLHHKLPNGLALLNGSG-GLYPAGH 936

  Fly   918 PGANNIALHWGPPQHPEIKIRNYVLGWGRGIPDENTIELKETERYHI 964
            |.|::.:||                        :|.:|.:....:|:
Zfish   937 PHAHDTSLH------------------------QNNMEYEHPSPHHL 959

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fra	NP_523716.2	Ig	36..140	CDD:299845	35/106 (33%)
		Ig	<180..222	CDD:299845	11/43 (26%)
		IG_like	257..340	CDD:214653	22/83 (27%)
		IGc2	264..327	CDD:197706	17/62 (27%)
		I-set	344..430	CDD:254352	21/85 (25%)
		Ig	363..428	CDD:299845	17/64 (27%)
		FN3	611..703	CDD:238020	27/100 (27%)
		FN3	711..799	CDD:238020	24/94 (26%)
		FN3	806..897	CDD:238020	22/120 (18%)
		FN3	908..989	CDD:238020	9/57 (16%)
		FN3	1011..1097	CDD:238020
		FN3	1109..1205	CDD:238020
		Neogenin_C	1273..1521	CDD:284094
cdon	NP_001075097.1	Ig	30..116	CDD:299845	35/106 (33%)
		IG_like	35..116	CDD:214653	32/101 (32%)
		IG_like	131..213	CDD:214653	21/91 (23%)
		Ig	139..196	CDD:299845	15/66 (23%)
		IG_like	230..310	CDD:214653	22/83 (27%)
		IGc2	239..294	CDD:197706	17/58 (29%)
		I-set	315..399	CDD:254352	21/84 (25%)
		Ig	317..399	CDD:299845	21/82 (26%)
		FN3	456..552	CDD:238020	13/128 (10%)
		FN3	594..685	CDD:238020	24/92 (26%)
		FN3	700..797	CDD:238020	24/100 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	1	0.910