DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fra and neo1a

DIOPT Version :9

Sequence 1:	NP_523716.2	Gene:	fra / 36377	FlyBaseID:	FBgn0011592	Length:	1526	Species:	Drosophila melanogaster
Sequence 2:	XP_009301739.1	Gene:	neo1a / 266983	ZFINID:	ZDB-GENE-021031-1	Length:	1450	Species:	Danio rerio

Alignment Length:	1631	Identity:	497/1631 - (30%)
Similarity:	751/1631 - (46%)	Gaps:	365/1631 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    37 FTLEPQDAVVPEGHSVLLQCAGTASIGRGGKSKSNLPSSVSIRWRGPDGQDLVIVGDTFRTQLKN 101
            |:.||.|.:...|..|||.|:            .:..|...|.|: .||..|.:..|..|..|.:
Zfish    36 FSTEPSDTLAVRGAPVLLNCS------------VHSESPAKIEWK-KDGSFLSLASDERRQVLAD 87

  Fly   102 GSLYISSV---EENRGLTGAYQCLLTAEGVGSILSRPA------LVAIVRQPDL------NQDFL 151
            |||.||||   :.|:...|.|||:.|.:.:|:|:||.|      :...:.||::      :...|
Zfish    88 GSLLISSVVHSKHNKPDEGVYQCVATIDNLGTIISRTARLNVAGIARFLSQPEMASVRVGDSQVL 152

  Fly   152 ETYLLPGQTAYFRCMLGEANWQEGVKHSVQWLKDDLPLPLDKLRMVVLPNGALEIDEVGPSDRGS 216
            ...:.|...::.|       |::. |.:|:         ||. |:..||:|||.|.....:|.|.
Zfish   153 SCEVNPDLVSFIR-------WEQN-KEAVE---------LDH-RVFSLPSGALVISNATETDAGL 199

  Fly   217 YQCNVTSGSSSRLSSKTNLNIKKPSDPGAENSVAPSFLVGPSPKTVREGDTVTLDCVANGVPKPQ 281
            |:|.:.:...::.|.:..|:|.  ::.|.|.::  .||..|...:...|::|.|.||..|.|.|:
Zfish   200 YRCVIDNAGPTKTSEEAQLHIL--TETGEERTL--EFLQEPQHVSKLVGESVLLPCVVTGYPTPE 260

  Fly   282 IKWLRNGMDLDFNDLDSRFSIVGTGSLQISSAEDIDSGNYQCRASNTVDSLDAQATVQVQEPPKF 346
            |.|:..  |....|...||.|:|.|||:|.:..:.|:|.|.|.|.||..|::|||.:.:::.|:|
Zfish   261 ITWMYK--DQLIEDSSGRFEILGGGSLRIFNLTEEDAGVYNCLAENTNGSIEAQAELTLKDSPQF 323

  Fly   347 IKAPKDTTAHEKDEPELKCDIWGKPKPVIRWLKNGDLITPNDYMQLVDGHNLKILGLLNSDAGMF 411
            :|.|.:..|||..:...:|::.|.|.|.|:|:||||.:.|:||.:::...||::|||:.||.|.:
Zfish   324 LKKPVNVFAHEATDVIFECEVSGSPSPTIKWVKNGDAVIPSDYFKIIKEQNLQVLGLVKSDEGFY 388

  Fly   412 QCVGTNAAGSVHAAARLRVVPQGVKIKKRKSQGHSTKSLQTFDNLTKRRKPFNSGEQLRTKSGGS 476
            ||:..|.||:|.::|:|.::.|.|           |..|....:||:
Zfish   389 QCLAENDAGNVQSSAQLVILDQDV-----------TLPLPRPTSLTR------------------ 424

  Fly   477 FPFPDEDDDLDDNDSGTTRLRIPSGKLPKFEQPLNDRRFNILNAGSALPLDNQSKSYEDDDDDYD 541
                           .||...:|..:                  |.|.|
Zfish   425 ---------------ATTDRLMPGSR------------------GGAGP---------------- 440

  Fly   542 EDDPAKEALLEAYKQGEDAHKILDSWQQSKSKKSQQQKQSPASPDSPEQDPSVPHPGGKPLDSGL 606

Zfish   441 ----------------------------------------------------------------- 440

  Fly   607 QARLPSQPRDLVAQIVKSRFVTLSWVEPLQNAGDVVYYTVYYKMNNSEREQKMVTKSHDDQQVNI 671
               .||.|||:||.:|.:||:.|:|..|.:..||.|.|:|||.:..:.||:.:.|....:.||.|
Zfish   441 ---TPSAPRDVVASLVSTRFLKLTWRLPAEPHGDDVTYSVYYSLEGTNRERIVNTSRPGEMQVTI 502

  Fly   672 QSLLPGRTYQFRVEANTNFGSGASSAPLEVSTQPEVNIAGPPRNFEGYARSHKEIYVKWEEPTVT 736
            |:|:|...|.|||.|:...|.|.||.||:|.|||||.:.||..|......|...:.:.|:.|.:.
Zfish   503 QNLMPDTKYAFRVVAHNKNGPGESSVPLKVETQPEVQVPGPAPNLHAVVMSPSTVSLSWDVPLIG 567

  Fly   737 NGEILKYRVYYSEN--DSGADLYHDSTALEAVLTELRPHTDYVISVVPFNRNGMGDSSAEIRVKT 799
            ||||..|::||.|.  ||..||  |...|...:|.|:..|:|...:|.:|::|.|.|:.:|.|:|
Zfish   568 NGEIQNYKIYYMEKGMDSEQDL--DVNTLSYTMTGLKKFTEYSFRLVAYNKHGPGVSTEDISVRT 630

  Fly   800 FSSTPSEPPNNVTLEVTSSSSITVHWEPPAEEDRNGQITGYKIRYRKFKDAPQVKSTPANIRYFE 864
            :|..||.||.|:|:||.:|.|:.:.|:||..:.:||:||||||||||.....:|....:..:.::
Zfish   631 YSDVPSSPPQNMTVEVLNSKSLMIRWQPPPADAQNGEITGYKIRYRKGTRKSEVAEITSGSQLYQ 695

  Fly   865 L-SNLDRNAEYQVKIAAMTVNGSGPFTEWNRANTLENDLDETQVPGKPIWISIHPGANNIALHWG 928
            | ..|.|..||.::::||||||:||.|:|..|.|.|:||||::||..|..:.:....|:|.:.|.
Zfish   696 LIDGLQRGTEYMLRVSAMTVNGTGPATDWTTAETFESDLDESRVPDVPSSLHVRSLVNSIVVSWT 760

  Fly   929 PPQHPEIKIRNYVLGWGRGIPDENTIELKETERYHILKNLESNMDYVVSLRARNVKGDGPPIYDN 993
            ||::.:|.:|.|.:.:|.|.|...||::...:||:.::||..|..||::|:|.|..|:|.|:|::
Zfish   761 PPENQDIVVRGYSISYGIGSPHAQTIKVDYKQRYYTIENLNPNSHYVITLKAFNNVGEGIPVYES 825

  Fly   994 IKTRDEE------------------PVDAPTPLEVPVGLRAITMSSSSIVVYWIDTMLNKNQHVT 1040
            ..||.:.                  ||..|.|:..|||::|..::..:|.|.|.|..|.|||.:|
Zfish   826 AITRPQSDPIDPDVDLYELFHAPYTPVPDPIPMLPPVGVQASVLNQDTIKVTWADNSLPKNQKIT 890

  Fly  1041 DNRHYTVSY--GITGSNRYRYHNTTDLNCMINDLRPNTQYEFAVKVVKGRRESSWSMSVLNSTYQ 1103
            |.|:|||.:  .|..:.:::..|||.|...:..|:|||.|||:|.|.||||.|:|||:...:|::
Zfish   891 DARYYTVRWKTNIPANTKFKVANTTTLFHTVTGLKPNTLYEFSVMVTKGRRTSTWSMTAHGTTFE 955

  Fly  1104 NVPVTPPREVTVRLDEMNPPTVIVQWIPPKHTLGQITGYNIYYTTDTTKRDRDWSVEAFAGEETM 1168
            ::|.:||::|||...|..|.|:||.|.||....|:||||.|||:||......||.:|...|....
Zfish   956 SIPSSPPKDVTVVSKEGRPKTIIVNWQPPSEANGKITGYIIYYSTDVKAEVHDWVIEPVVGNRLT 1020

  Fly  1169 LMLPNLKPYTTYYFKVQARTTKGANNAPFSALVSYTTSAAVTMQ--------------------- 1212
            ..:..|...||||||:|||.:||.  .|.|..|.:.|..|.:..
Zfish  1021 HQIQELTLDTTYYFKIQARNSKGM--GPMSEAVQFRTPKAESSDKMANDQAPGISVKQGRPSAPD 1083

  Fly  1213 -------EPDTIAKGIDNEKLLYIIIAATAVVLLVVLLGVLLLCRR------KPQSSPEHTKKSY 1264
                   :||....|.::..::.||::..|..::||::|..|..||      |.:::.:....|:
Zfish  1084 NGFGSPGKPDMSGTGDNHILVIVIIVSVGAFTIIVVVVGAFLCTRRTTTQQKKKRAACKSANGSH 1148

  Fly  1265 Q-KNNVGVPKPPDLWIHHDQMELKNIDKGLHTVTPVCSDGASSSGALTLPRSVVHSEYEVETPVP 1328
            : |.|....|||||||||:::|||.|||.... .||.:|       ..:||    :..:: |||.
Zfish  1149 KYKGNSKDLKPPDLWIHHERLELKPIDKSPEP-NPVMTD-------TPIPR----TSQDI-TPVD 1200

  Fly  1329 GHVTNSLDKRSYVPGYMTTSMNGTME-----RP--------QYPRTQYS---------HQNRSHM 1371
            |.:...|.:|:...|:.:.....|:.     ||        |.|:...|         |.:..|:
Zfish  1201 GSMDPMLQRRNSYRGHESEDSMSTLAGRRGMRPKMMMPFDAQPPQPVISAHPIHSLDNHHHHYHL 1265

  Fly  1372 TMEAG-----LSQQSLTQ------------PQSNSMAQTPEH---PYGGY----------DANFC 1406
            ...|.     |..||.|:            ..:.|:..||..   |..|.          |.:|
Zfish  1266 GSLASPTRSYLHHQSSTRSIATPISHLDRAESTESVRNTPNAELLPPSGQPSCTTDLSETDISF- 1329

  Fly  1407 NAGNAAAGNGCVSTIESSKR-GHPLKSFSVPGPPPTG-------GATPVTKHTPAVTIRPQNQSP 1463
             ..:||......:|..:..| .||||||:||..|...       .:||:...|          .|
Zfish  1330 -HSSAAEEEPAFATPTAHVRPTHPLKSFAVPAIPAHAMYDSAALPSTPLLSQT----------GP 1383

  Fly  1464 YKKPSFSAATPNRLQGGGSVVHSTDEIQRLAPSTS--------------TEELNQEMANLEGLMK 1514
            :...:.|..|..|.:....|:...      ||..|              |:||::|||:||||||
Zfish  1384 HSVKTASIGTLGRTRTPMPVIVPN------APDVSEGCRLHEDAGSNYETDELSEEMAHLEGLMK 1442

  Fly  1515 DLSAIT 1520
            ||:|||
Zfish  1443 DLNAIT 1448

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fra	NP_523716.2	Ig	36..140	CDD:299845	36/111 (32%)
		Ig	<180..222	CDD:299845	14/41 (34%)
		IG_like	257..340	CDD:214653	32/82 (39%)
		IGc2	264..327	CDD:197706	25/62 (40%)
		I-set	344..430	CDD:254352	36/85 (42%)
		Ig	363..428	CDD:299845	28/64 (44%)
		FN3	611..703	CDD:238020	41/91 (45%)
		FN3	711..799	CDD:238020	31/89 (35%)
		FN3	806..897	CDD:238020	40/91 (44%)
		FN3	908..989	CDD:238020	27/80 (34%)
		FN3	1011..1097	CDD:238020	40/87 (46%)
		FN3	1109..1205	CDD:238020	42/95 (44%)
		Neogenin_C	1273..1521	CDD:284094	88/322 (27%)
neo1a	XP_009301739.1	Ig1_Neogenin	35..129	CDD:143199	36/105 (34%)
		IG_like	40..129	CDD:214653	34/101 (34%)
		IG_like	143..220	CDD:214653	21/94 (22%)
		IGc2	147..207	CDD:197706	19/77 (25%)
		I-set	231..316	CDD:254352	34/86 (40%)
		IGc2	244..307	CDD:197706	27/64 (42%)
		I-set	321..407	CDD:254352	36/85 (42%)
		Ig4_Neogenin	337..407	CDD:212460	29/69 (42%)
		FN3	442..534	CDD:238020	41/91 (45%)
		FN3	541..630	CDD:238020	31/90 (34%)
		FN3	637..729	CDD:238020	40/91 (44%)
		FN3	740..819	CDD:214495	26/78 (33%)
		FN3	860..953	CDD:238020	40/92 (43%)
		FN3	960..1055	CDD:238020	42/96 (44%)
		Neogenin_C	1157..1450	CDD:284094	88/323 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	99	1.000	Domainoid score	I7020
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H1870
Inparanoid	1	1.050	737	1.000	Inparanoid score	I585
OMA	1	1.010	-	-		QHG46607
OrthoDB	1	1.010	-	-		D118438at33208
OrthoFinder	1	1.000	-	-		FOG0002773
OrthoInspector	1	1.000	-	-		otm25378
orthoMCL	1	0.900	-	-		OOG6_105369
Panther	1	1.100	-	-	O	PTHR44170
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1863
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.980