DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fra and HMCN2

DIOPT Version :9

Sequence 1:	NP_523716.2	Gene:	fra / 36377	FlyBaseID:	FBgn0011592	Length:	1526	Species:	Drosophila melanogaster
Sequence 2:	NP_001278744.1	Gene:	HMCN2 / 256158	HGNCID:	21293	Length:	5079	Species:	Homo sapiens

Alignment Length:	1969	Identity:	388/1969 - (19%)
Similarity:	603/1969 - (30%)	Gaps:	739/1969 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 SCLIFQLIGSSLA------SQALSFTLEPQDAVVPEGHSVLLQCAGTASIGRGGKSKSNLPSSVS 77
            :|.....:|.:.|      ..|...|..|:|..|..|.|.||.|..|   ||.       |.:|:
Human   764 TCRAVNELGDASAEIQLAVGHAPQLTELPRDVTVELGRSALLACRAT---GRP-------PPTVT 818

  Fly    78 IRWRGPDGQDLVI---VGDTFRT-QLKNGSLYISSVE---------ENRGLTGAYQC----LLTA 125
              ||..|||.|.:   .|...|: |..:|.|:..||.         |.|.:.|..|.    ::|.
Human   819 --WRRGDGQPLGLRLGAGRGSRSRQPDSGVLFFESVAPEDQAPYVCEARNVFGKVQAEARLIVTG 881

  Fly   126 EGVGSILSRPALVAIVRQPDLNQDFLETYLLPGQTAYFRCM------LGEANWQEGVKHSVQWLK 184
            .....|.|....|.:               |.||.....|:      |.|       :|   |||
Human   882 HAPPQIASSAPTVRV---------------LEGQPVSLPCIVLAGRPLPE-------RH---WLK 921

  Fly   185 DDLPLPLDKLRMVVLPNGALEIDEVGPSDRGSYQC--NVTSGSSSR------------------- 228
            |..|||... |..:..:|:|.:|.......|.|.|  ..|:||..|
Human   922 DGRPLPPGS-RHSIRADGSLHLDRALQEHAGRYSCVATNTAGSQHRDVELVVQVPPRIHPTATHH 985

  Fly   229 ---------------------------------------LSSKTNLNIKKPS--DPG-----AEN 247
                                                   :|.:..|.|.:||  |.|     |.|
Human   986 ITNEGVAASLPCVASGVPAPTITWTKETNALTSRGPHYNVSKEGTLLIAQPSAQDAGAYVCTATN 1050

  Fly   248 SVAPS-----FLVGPSPK---------------TVREGDTVTLDCVANGVPKPQIKWLRNGMDLD 292
            :|..|     ..|...|:               |.:.|:.|||||.|.|.|.|.:.|.::...:.
Human  1051 TVGFSSQEMRLSVNTKPRIHMNGSRNADVPLQVTAKAGEEVTLDCEAKGSPPPLVTWTKDSRPVP 1115

  Fly   293 FNDLDSRFSIVGTGSLQISSAEDIDSGNYQCRASNTVDSLDAQATVQVQEPPKFIKAPKDTTAHE 357
              .:.:|:.::.:|||:::..:..|||:|:|.|||...|...:..:.||.||:....|:......
Human  1116 --PITNRYGLLPSGSLRLAQVQVGDSGHYECTASNPAGSASHRYVLGVQVPPQVQPGPRVLKVLV 1178

  Fly   358 KDEPELKCDIWGKPKPVIRWLKNGDLITPNDYMQLVDGH----NLKILGLLNSDAGMFQCVGTNA 418
            .:..:|.|...|.|:|.:.|.|:|         .::.|.    ::....:..||||.::|..:|:
Human  1179 GEALDLNCVAEGNPEPQLSWSKDG---------VVLQGRGPQGSVHFAAIRTSDAGRYRCEASNS 1234

  Fly   419 AGSVHAAARLRVV---------PQGVKIKKRKSQGHS-------TKSLQTFDNLTKRRKPFNSGE 467
            ||.......|||:         ..|: :::...:..|       |...|    :|.|:.|  |.|
Human  1235 AGVDAWEVELRVLEPPHWGADETSGL-LERVAGENASLPCPARGTPKPQ----VTWRKGP--SSE 1292

  Fly   468 QLRTKSG------GSF----PFPDEDDDLD---DNDSGTTRLRIPSGKLPKFEQPL---NDRRFN 516
            .|..:.|      ||.    ..|.:..|.:   .|:.|:|..|   .||..:..|.   :.|:.|
Human  1293 PLHGQPGVAVLEEGSLFLASVSPADSGDYECQATNEVGSTSRR---AKLVVYVPPSIREDGRKAN 1354

  Fly   517 ILN-AGSALPLDNQSKSYEDDDDDYDEDDPAKEA--LLEAY---KQGEDAHKILDSWQQSKSKKS 575
            :.. ||.:|.|:..:..:           |..|.  |.:|.   |.|  .|::||..|.....:.
Human  1355 VSGMAGQSLTLECDANGF-----------PVPEIVWLKDAQLIPKVG--GHRLLDEGQSLHFPRI 1406

  Fly   576 QQQKQSPASPDSPEQ--------------DPSVPHPGGKPLDSGL-------------------- 606
            |:......|..:..|              .|||...|......||
Human  1407 QEGDSGLYSCRAENQAGTAQRDFHLLVLTPPSVLGAGAAQEVLGLAGADVELQCWTSGVPTPQVE 1471

  Fly   607 -----QARLPSQPRDLV---AQIVK---------SRFVTLSWVEPLQNAGDVVYY-----TVYYK 649
                 |..||..|...|   .|:::         .|:..:::....|.|.|....     |::
Human  1472 WTKDRQPVLPGGPHLQVQEDGQVLRITGSHVGDEGRYQCVAFSPAGQQARDFQLRVHAPPTIW-- 1534

  Fly   650 MNNSEREQKMVTKSHDDQQV---------NIQ-----SLLP----------GRTYQ--------- 681
             .::|..:..|.:.|..|.:         ||.     :|||          ||..|
Human  1535 -GSNETGEVAVMEDHLVQLLCEARGVPTPNITWFKDGALLPTSTKVVYTRGGRQLQLGRAQSSDA 1598

  Fly   682 --FRVEANTNFGSGASSAPLEVSTQPEVN-----------IAGPPRNFEGYARSHKEIYVKW--- 730
              :..:|:...|:...:..|:|...|.:.           :||.|...|..||.|....:.|
Human  1599 GVYTCKASNAVGAAEKATRLDVYVPPTIEGAGGRPYVVKAVAGRPVALECVARGHPSPTLSWHHE 1663

  Fly   731 --------EEPTVTNGEILKYRVYYSENDSGADLYH---DSTALEAVLTELRPHTDYVISV-VP- 782
                    |....|:|.:|:..   |..::.:.||.   .|.|.||||       .|.:.| ||
Human  1664 GLPVAESNESRLETDGSVLRLE---SPGEASSGLYSCVASSPAGEAVL-------QYSVEVQVPP 1718

  Fly   783 --FNRNGMGDSSAEIRVKTFSSTPSEPPNNVTLEVTSSSSITVHW---EPPAEEDRNGQITGYKI 842
              ....|:|      :|.|....|.|.|    .:.:.|...|:.|   ..||||....|:..
Human  1719 QLLVAEGLG------QVTTIVGQPLELP----CQASGSPVPTIQWLQNGRPAEELAGVQVAS--- 1770

  Fly   843 RYRKFKDAPQVKSTPANIRYFELSNLDRNAEYQVKIAAMTVNGSGPFT--EWNRANTLENDLDET 905
                       :.|..:|.:.||.:                  ||.|.  ..|.|.|
Human  1771 -----------QGTTLHIDHVELDH------------------SGLFACQATNEAGT-------- 1798

  Fly   906 QVPGKPIWISIHP-------GANNIALHWGPPQHPEIKIRNYVLGWGRGIPD------ENTIELK 957
              .|..:.:|:|.       |..||...:..|    :.::..    |.|:|.      ::.:.|.
Human  1799 --AGAEVEVSVHEFPSVSIIGGENITAPFLQP----VTLQCI----GDGVPTPSLRWWKDGVALA 1853

  Fly   958 ETERYHILKNLESNMDYVVSLRARNVKGDG----------PPIYDNIKTRDEEPVDAPTPLEVPV 1012
            .......::.::...:.:.:..|.|:.|:.          ||   ||   :..||:........|
Human  1854 AFGGNLQIEKVDLRDEGIYTCAATNLAGESKREVALKVLVPP---NI---EPGPVNKAVLENASV 1912

  Fly  1013 GLRAITMSSSSIVVYWIDTMLNKNQHVTDNRHYTVSYG----------ITGSNRYRYHNTTDLNC 1067
            .|..:........|.|    ...:|.|:.....|||..          ::.:..||        |
Human  1913 TLECLASGVPPPDVSW----FKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYR--------C 1965

  Fly  1068 MINDLRPNTQYEFAVKVVKGRRESSWSMSVLNSTYQNVP---VTPPR-------EVTVRL--DEM 1120
            :.:::..:|:..:.::|                   |||   ..||.       ...|||  :..
Human  1966 VASNVAGSTELRYGLRV-------------------NVPPRITLPPSLPGPVLVNTPVRLTCNAT 2011

  Fly  1121 NPPTVIVQW------IPPKHTLGQITGYNIYYTTDTTKRDRDWSVEAFAGEETMLMLPNLKPYTT 1179
            ..|:..:.|      :.|..|.|                     ::.|.|...:
Human  2012 GAPSPTLMWLKDGNPVSPAGTPG---------------------LQVFPGGRVL----------- 2044

  Fly  1180 YYFKVQARTTKGANNAPFSALVSYTTSAAVTMQEPDTIAK-----GIDNEKLLYIIIAATAVVL- 1238
                     |..:..|..|...|....:||.....|.:.:     .|..|:|...::|..:|.|
Human  2045 ---------TLASARASDSGRYSCVAVSAVGEDRQDVVLQVHMPPSILGEELNVSVVANESVALE 2100

  Fly  1239 -------------------LVVLLGVLL--------------------LCRRKPQSSPEHTKKSY 1264
                               |....||.|                    .|....|:.  |::|.|
Human  2101 CQSHAMPPPVLSWWKDGRPLEPRPGVHLSADKALLQVDRADVWDAGHYTCEALNQAG--HSEKHY 2163

  Fly  1265 QKN---------------NV-------------GVPKPPDLWIHHDQMELKNIDKGLHTVTPV-- 1299
            ..|               .|             |||.|...| ..|...|.....||..|:.|
Human  2164 NLNVWVAPVFPLRESHTLTVREGHPTRLSCECRGVPFPKISW-RKDGQPLPGEGAGLQHVSAVGR 2227

  Fly  1300 ------------------CSDGASSSGALTLPRSVVHSEYEVETPVPGHVTNSLDKRSYV----P 1342
                              ||:...:|.          .:.::|..||..:....:..:.|    .
Human  2228 LLYLGQAQLAQEGTYTCECSNVVGNSS----------QDLQLEVHVPPQIAGPREPPTQVSVVQD 2282

  Fly  1343 GYMTTSMNGTMERPQYPRTQYSHQNRSHMTMEAGLSQQSLTQPQSNSMAQTPEHPYGGYDANFCN 1407
            |..|...|.|.:.|  |...:....:. :..|.||..|:..|......||
Human  2283 GVATLECNATGKPP--PTVTWERDGQP-VGAELGLQLQNQGQSLHVERAQ--------------- 2329

  Fly  1408 AGNAAAGNGCVSTIESSKRGHPLKSF--SVPGPPP-TGGATPVTK-----HTP------AVTIRP 1458
                ||..|..|.:..:..|...:.|  ||..||. .|...|:|.     |:|      |:.|.|
Human  2330 ----AAHTGRYSCVAENLAGRAERKFELSVLVPPELIGDLDPLTNITAALHSPLTLLCEAMGIPP 2390

  Fly  1459 ------QNQSPYKKPSFSAATPNRLQGGGSVVHSTD------------------EIQR------- 1492
                  :.:.|     .|......|..||.::..|.                  |.:|
Human  2391 PAIRWFRGEEP-----VSPGEDTYLLAGGWMLKMTQTQEQDSGLYSCLASNEAGEARRNFSVEVL 2450

  Fly  1493 LAPSTSTEELNQEMANLEG 1511
            :.||...|:|.:.:..|:|
Human  2451 VPPSIENEDLEEVIKVLDG 2469

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fra	NP_523716.2	Ig	36..140	CDD:299845	35/120 (29%)
		Ig	<180..222	CDD:299845	14/43 (33%)
		IG_like	257..340	CDD:214653	26/97 (27%)
		IGc2	264..327	CDD:197706	21/62 (34%)
		I-set	344..430	CDD:254352	20/89 (22%)
		Ig	363..428	CDD:299845	17/68 (25%)
		FN3	611..703	CDD:238020	25/143 (17%)
		FN3	711..799	CDD:238020	27/105 (26%)
		FN3	806..897	CDD:238020	19/95 (20%)
		FN3	908..989	CDD:238020	14/103 (14%)
		FN3	1011..1097	CDD:238020	14/95 (15%)
		FN3	1109..1205	CDD:238020	16/110 (15%)
		Neogenin_C	1273..1521	CDD:284094	60/308 (19%)
HMCN2	NP_001278744.1	VWA_2	39..209	CDD:290253
		IG_like	434..513	CDD:214653
		Ig	442..503	CDD:299845
		IG	524..604	CDD:214652
		Ig	534..601	CDD:143165
		I-set	608..692	CDD:254352
		IGc2	621..684	CDD:197706
		IG_like	712..782	CDD:214653	3/17 (18%)
		Ig	715..779	CDD:143165	3/14 (21%)
		Ig	785..869	CDD:299845	30/95 (32%)
		IG	792..879	CDD:214652	30/98 (31%)
		I-set	885..972	CDD:254352	28/112 (25%)
		IGc2	898..962	CDD:197706	21/74 (28%)
		IG	988..1063	CDD:214652	11/74 (15%)
		Ig	995..1062	CDD:299845	11/66 (17%)
		I-set	1079..1161	CDD:254352	25/83 (30%)
		IGc2	1088..1151	CDD:197706	23/64 (36%)
		I-set	1165..1246	CDD:254352	20/89 (22%)
		IGc2	1179..1236	CDD:197706	15/65 (23%)
		IG	1258..1340	CDD:214652	21/91 (23%)
		Ig	1266..1340	CDD:299845	20/82 (24%)
		IG	1354..1433	CDD:214652	18/91 (20%)
		IGc2	1360..1423	CDD:197706	16/75 (21%)
		IG	1446..1527	CDD:214652	12/80 (15%)
		IGc2	1453..1517	CDD:197706	7/63 (11%)
		IG	1540..1620	CDD:214652	14/79 (18%)
		Ig	1540..1620	CDD:299845	14/79 (18%)
		I-set	1632..1716	CDD:254352	23/93 (25%)
		IGc2	1641..1704	CDD:197706	15/65 (23%)
		IG	1727..1807	CDD:214652	25/131 (19%)
		IGc2	1734..1797	CDD:197706	19/98 (19%)
		Ig	1820..1893	CDD:299845	10/80 (13%)
		IG_like	1827..1891	CDD:214653	8/71 (11%)
		I-set	1895..1975	CDD:254352	17/97 (18%)
		Ig	1912..1975	CDD:143165	12/74 (16%)
		I-set	1986..2076	CDD:254352	19/130 (15%)
		IGc2	2001..2066	CDD:197706	15/105 (14%)
		Ig	2079..2169	CDD:299845	16/91 (18%)
		I-set	2080..2167	CDD:254352	15/88 (17%)
		I-set	2171..2261	CDD:254352	15/100 (15%)
		IGc2	2185..2251	CDD:197706	13/66 (20%)
		I-set	2273..2355	CDD:254352	20/103 (19%)
		Ig	2285..2352	CDD:143165	17/88 (19%)
		I-set	2367..2449	CDD:254352	15/86 (17%)
		Ig	2379..2449	CDD:299845	11/74 (15%)
		Ig	2452..2542	CDD:299845	6/18 (33%)
		IG_like	2462..2542	CDD:214653	2/8 (25%)
		IG	2558..2638	CDD:214652
		IGc2	2565..2628	CDD:197706
		IG	2656..2736	CDD:214652
		IGc2	2663..2726	CDD:197706
		IG_like	2770..2847	CDD:214653
		IGc2	2773..2837	CDD:197706
		IG	2862..2942	CDD:214652
		Ig	2868..2942	CDD:299845
		IG_like	2954..3034	CDD:214653
		IGc2	2961..3024	CDD:197706
		I-set	3038..3129	CDD:254352
		IGc2	3056..3119	CDD:197706
		I-set	3133..3221	CDD:254352
		IGc2	3148..3208	CDD:197706
		IG	3234..3318	CDD:214652
		IGc2	3240..3306	CDD:197706
		IG	3329..3410	CDD:214652
IGc2	3336..3400	CDD:197706
IG_like	3424..3499	CDD:214653
IGc2	3430..3489	CDD:197706
I-set	3503..3590	CDD:254352
IGc2	3518..3580	CDD:197706
I-set	3602..3683	CDD:254352
IGc2	3610..3673	CDD:197706
IG	3693..3774	CDD:214652
Ig	3693..3774	CDD:299845
Ig	3777..3859	CDD:299845
IG	3784..3867	CDD:214652
IG_like	3887..3958	CDD:214653
IGc2	3887..3948	CDD:197706
IG	3968..4048	CDD:214652
Ig	3979..4040	CDD:299845
I-set	4052..4139	CDD:254352
IGc2	4065..4129	CDD:197706
I-set	4143..4228	CDD:254352
IGc2	4157..4218	CDD:197706
I-set	4246..4317	CDD:254352
IGc2	4247..4309	CDD:197706
Ig	4322..4405	CDD:299845
I-set	4323..4409	CDD:254352
G2F	4411..4593	CDD:284812
FXa_inhibition	4652..4687	CDD:291342
EGF_CA	4689..4732	CDD:214542
EGF_CA	4733..4774	CDD:284955
EGF_CA	4776..4815	CDD:284955
EGF_CA	4883..4922	CDD:214542
EGF_CA	4923..4963	CDD:214542
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910