DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fra and Dcc

DIOPT Version :9

Sequence 1:NP_523716.2 Gene:fra / 36377 FlyBaseID:FBgn0011592 Length:1526 Species:Drosophila melanogaster
Sequence 2:XP_008770309.2 Gene:Dcc / 25311 RGDID:2492 Length:1447 Species:Rattus norvegicus


Alignment Length:1686 Identity:486/1686 - (28%)
Similarity:732/1686 - (43%) Gaps:433/1686 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 LIFQLIGSSLAS-------------QALSFTLEPQDAVVPEGHSVLLQCAGTASIGRGGKSKSNL 72
            |.|.|.|:||.|             .:|.|..||.|||...|.:|||.|:        .:|...:
  Rat    13 LAFVLFGASLLSAHLQVTGFQIKPFTSLHFVSEPSDAVTMRGGNVLLNCS--------AESDRGV 69

  Fly    73 PSSVSIRWRGPDGQDLVIVGDTFRTQLKNGSLYISSVEENRGL---TGAYQCLLTAEGVGSILSR 134
            |   .|:|: .||..|.:..|..:.||.||||.|.::..:|..   .|.|||..:....|||:||
  Rat    70 P---VIKWK-KDGLILALGMDDRKQQLPNGSLLIQNILHSRHHKPDEGLYQCEASLGDSGSIISR 130

  Fly   135 PALVAI------VRQPDLNQDFLETYLLPGQTAYFRC-MLGE----ANWQEGVKHSVQWLKDDL- 187
            .|.|.:      :.|.:....|:      |.|...:| ::|:    .:||:.        :.|| 
  Rat   131 TAKVMVAGPLRFLSQTESITAFM------GDTVLLKCEVIGDPMPTIHWQKN--------QQDLN 181

  Fly   188 PLPLDKLRMVVLPNGALEIDEVGPSDRGSYQCNVTSGSSSRLSSKTNLNIKKPSDPGAENSVAPS 252
            |:|.|. |:||||:|||:|..:.|.|.|.|:|:..:.:|:|..::..:.|.  ||||....:  .
  Rat   182 PIPGDS-RVVVLPSGALQISRLQPGDSGVYRCSARNPASTRTGNEAEVRIL--SDPGLHRQL--Y 241

  Fly   253 FLVGPSPKTVREGDTVTLDCVANGVPKPQIKWLRNGMDLDFNDLDSRFSIVGTGSLQISSAEDID 317
            ||..||.....||....|:|..:|.|.|...|||....:...  ..::|::|..:|.||:..|.|
  Rat   242 FLQRPSNVIAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLR--SKKYSLLGGSNLLISNVTDDD 304

  Fly   318 SGNYQCRASNTVDSLDAQATVQVQEPPKFIKAPKDTTAHEKDEPELKCDIWGKPKPVIRWLKNGD 382
            ||.|.|..:...:::.|.|.:.|..||.|:..|.:..|:|..:.|.:|.:.|||.|.:.|:||||
  Rat   305 SGTYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECAVSGKPVPTVNWMKNGD 369

  Fly   383 LITPNDYMQLVDGHNLKILGLLNSDAGMFQCVGTNAAGSVHAAARLRVVPQGVKIKKRKSQGHST 447
            ::.|:||.|:|.|.||:|||::.||.|.:|||..|.||:..::|:| :||:              
  Rat   370 VVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQSSAQL-IVPK-------------- 419

  Fly   448 KSLQTFDNLTKRRKPFNSGEQLRTKSGGSFPFPDEDDDLDDNDSGTTRLRIPSGKLPKFEQPLND 512
                                                                             
  Rat   420 ----------------------------------------------------------------- 419

  Fly   513 RRFNILNAGSALPLDNQSKSYEDDDDDYDEDDPAKEALLEAYKQGEDAHKILDSWQQSKSKKSQQ 577
                                                                             
  Rat   420 ----------------------------------------------------------------- 419

  Fly   578 QKQSPASPDSPEQDPSVPHPGGKPLDSGLQARLPSQPRDLVAQIVKSRFVTLSWVEPLQNAGDVV 642
                ||.|.|                    :.|||.|||:|..:|.||||.|||..|.:..|::.
  Rat   420 ----PAIPSS--------------------SILPSAPRDVVPVLVSSRFVRLSWRPPAEAKGNIQ 460

  Fly   643 YYTVYYKMNNSEREQKMVTKSHDDQQVNIQSLLPGRTYQFRVEANTNFGSGASSAPLEVSTQPEV 707
            .:||::......||:.:.|......|:.:.:|.|...|.|||.|...:|.|.||.|::|:||||:
  Rat   461 TFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPEL 525

  Fly   708 NIAGPPRNFEGYARSHKEIYVKWEEPTVTNGEILKYRVYYSENDSGADLYHDSTALEAVLTELRP 772
            .:.||..|....:.|...|.:.||.|...||.:..||::.:|..:|.:...:...|...|..|:.
  Rat   526 QVPGPVENLHAVSASPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKK 590

  Fly   773 HTDYVISVVPFNRNGMGDSSAEIRVKTFSSTPSEPPNNVTLEVTSSSSITVHWEPPAEEDRNGQI 837
            .|:|.:..:.:||.|.|.|:.:|.|.|.|..||.||.||:|||.:|.||.|.|.||....:||.|
  Rat   591 FTEYTLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVSWLPPPSGTQNGFI 655

  Fly   838 TGYKIRYRKFKDAPQVKSTPANIRYFELSNLDRNAEYQVKIAAMTVNGSGPFTEWNRANTLENDL 902
            ||||||:||.....::::...|..::..:.|::.::|..:::||||||:||.:.|..|.|.||||
  Rat   656 TGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDL 720

  Fly   903 DETQVPGKPIWISIHPGANNIALHWGPPQHPEIKIRNYVLGWGRGIPDENTIELKETERYHILKN 967
            ||:|||.:|..:.:.|..|.|.:.|.||.:|.|.:|.|::|:|.|.|...|:.:...:||:.::.
  Rat   721 DESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIER 785

  Fly   968 LESNMDYVVSLRARNVKGDGPPIYDNIKTR---------------DEEPVDAP---TPLEVPVGL 1014
            |||:..||:||:|.|..|:|.|:|::..||               |:.|...|   ||:..|||:
  Rat   786 LESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSGPDVSTPMLPPVGV 850

  Fly  1015 RAITMSSSSIVVYWIDTMLNKNQHVTDNRHYTVSY--GITGSNRYRYHNTTDLNCMINDLRPNTQ 1077
            :|:.::..::.|.|.|..:.|||..:|.|.|||.:  ..:.|.:|:..:||.|:.....|:|||.
  Rat   851 QAVALTHEAVRVSWADNSVPKNQKTSDVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTM 915

  Fly  1078 YEFAVKVVKGRRESSWSMSVLNSTYQNVPVTPPREVTVRLDEMNPPTVIVQWIPPKHTLGQITGY 1142
            |||:|.|.|.||.|:|||:...:||:..|.:.|:::||...|..|..|||.|.||....|:||.|
  Rat   916 YEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAY 980

  Fly  1143 NIYYTTDTTKRDRDWSVEAFAGEETMLMLPNLKPYTTYYFKVQARTTKGANNAPFSALVSYTTSA 1207
            .::||.|......||.:|..:|:.....:.:|...|.|||::|||..||.  .|.|..:.:.|  
  Rat   981 ILFYTLDKNIPIDDWIMETISGDRLTHQIMDLSLDTMYYFRIQARNAKGV--GPLSDPILFRT-- 1041

  Fly  1208 AVTMQEPDTIAKG----------------ID-----------------------NEKLLYIIIAA 1233
             :.::.||.:|..                ||                       |..||.|.:..
  Rat  1042 -LKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVITVVT 1105

  Fly  1234 TAVVLLVVLLGVLLLCRRKPQSSPEHTKK------SYQKNNVGVPKPPDLWIHHDQMELKNIDKG 1292
            ..|:.::|::.|.::|.|:  ||.:..||      |.:|.:....:||||||||::||:|||:|.
  Rat  1106 VGVLTVLVVVIVAVICTRR--SSAQQRKKRATHSASKRKGSQKDLRPPDLWIHHEEMEMKNIEKP 1168

  Fly  1293 LHT--------------VTPVC-SDGASSSGALTLPRSVVHSEYEVETPVPGHVTNSLDK----- 1337
            ..|              :|||. |...|..|:    :|..||..:.|.  .|...::|::     
  Rat  1169 AGTDPAGRGSPIQSCQDLTPVSHSQSESQMGS----KSASHSGQDTEE--AGSSMSTLERSLAAR 1227

  Fly  1338 -------------RSYVPGYMTTSMNGTMERPQY------PRTQYSH------------------ 1365
                         :|..|..::.....|:|..||      |...|.|                  
  Rat  1228 RATRTKLMIPMEAQSNNPAVVSAIPVPTLESAQYPGILPSPTCGYPHPQFTLRPVPFPTLSVDRG 1292

  Fly  1366 --QNRSHMTMEAGLSQQSLTQPQSNSMAQTPEHPYGGYDANFCNAGNAAAGNGCVSTIESSKRGH 1428
              ..||....|...:||....|.:.     ||||...      .|.:......||      :..|
  Rat  1293 FGAGRSQSVSEGPTAQQQPMLPPAQ-----PEHPSSE------EAPSRTIPTACV------RPTH 1340

  Fly  1429 PLKSFSVP-GPPPTGGATPVTKHTPAVTIRPQNQSP--------------YKKPSFSAATPNRLQ 1478
            ||:||:.| .|||.....|...:||.:: :|....|              .:.|....:.|.   
  Rat  1341 PLRSFANPLLPPPMSAIEPKVPYTPLLS-QPGPTLPKTHVKTASLGLAGKARSPLLPVSVPT--- 1401

  Fly  1479 GGGSVVHSTDEIQRLAPSTSTE---------------ELNQEMANLEGLMKDLSAITANEF 1524
                           ||..|.|               :|:::||:||||||.|:|||.:.|
  Rat  1402 ---------------APEVSEESHKPTEDPASVYEQDDLSEQMASLEGLMKQLNAITGSAF 1447

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fraNP_523716.2 Ig 36..140 CDD:299845 38/106 (36%)
Ig <180..222 CDD:299845 19/42 (45%)
IG_like 257..340 CDD:214653 25/82 (30%)
IGc2 264..327 CDD:197706 21/62 (34%)
I-set 344..430 CDD:254352 38/85 (45%)
Ig 363..428 CDD:299845 31/64 (48%)
FN3 611..703 CDD:238020 35/91 (38%)
FN3 711..799 CDD:238020 26/87 (30%)
FN3 806..897 CDD:238020 38/90 (42%)
FN3 908..989 CDD:238020 30/80 (38%)
FN3 1011..1097 CDD:238020 36/87 (41%)
FN3 1109..1205 CDD:238020 34/95 (36%)
Neogenin_C 1273..1521 CDD:284094 81/336 (24%)
DccXP_008770309.2 None


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 92 1.000 Domainoid score I7420
eggNOG 1 0.900 - - E1_KOG4221
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 786 1.000 Inparanoid score I493
OMA 1 1.010 - - QHG46607
OrthoDB 1 1.010 - - D118438at33208
OrthoFinder 1 1.000 - - FOG0002773
OrthoInspector 1 1.000 - - otm45219
orthoMCL 1 0.900 - - OOG6_105369
Panther 1 1.100 - - O PTHR44170
Phylome 1 0.910 - -
SonicParanoid 1 1.000 - - X1863
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1312.880

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