DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fra and Prtg

DIOPT Version :9

Sequence 1:	NP_523716.2	Gene:	fra / 36377	FlyBaseID:	FBgn0011592	Length:	1526	Species:	Drosophila melanogaster
Sequence 2:	NP_780694.3	Gene:	Prtg / 235472	MGIID:	2444710	Length:	1191	Species:	Mus musculus

Alignment Length:	1506	Identity:	332/1506 - (22%)
Similarity:	511/1506 - (33%)	Gaps:	454/1506 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    35 LSFTLEPQDAVVPEGHSVLLQCAGTASIGRGGKSKSNLPSSVSIRWRGPDGQDLVIVGDTFRTQ- 98
            |.|..|||||.|.....|:|.|   .:.|.|         .:.:.|. .:|..|   .:..|.|
Mouse    33 LFFMKEPQDATVTRKDPVVLDC---QAHGEG---------PIKVTWL-KNGAKL---SENKRIQV 81

  Fly    99 LKNGSLYISSVEENRGL---TGAYQCLLTAEGVGSILSRPALVAIVRQPDLNQDFLETYLLPGQT 160
            |.|||||||.||..||.   .|.||| |.....|:|||:.|.:.:..........:.|.:..|..
Mouse    82 LSNGSLYISEVEGRRGEQSDEGFYQC-LAVNKYGAILSQKAHLTLSTISAFEVHPVSTEVHEGGV 145

  Fly   161 AYFRCMLGEA-----NWQEGVKHSVQWLKDDLPLPLDKLRMVVLPNGALEIDEVGPSDRGSYQCN 220
            |.|.|.:...     .|        ::.:..||..:|  |:..||:|.|:|.:|||.|.|:|:|.
Mouse   146 ARFSCKISSTPPAVITW--------EFNRTALPTTMD--RVTALPSGVLQIYDVGPEDAGNYRCV 200

  Fly   221 VTSGSSSRLSSKTNLNIKKPSDPGAENSVAPSFLVGPSPKTVREGDTVTLDCVANGVPKPQIKWL 285
            ..:.:..|.|.:.:|.|...::  ..:...|:.:..|...|.....||.|:|:|.|.|:|.|.|.
Mouse   201 AATIAHKRKSMEASLTIVAANE--TRSFYMPTIIASPQNVTASLHQTVVLECMATGYPRPIISWS 263

  Fly   286 RNGMDLDFNDLD-SRFSIVGTGSLQISSAEDIDSGNYQCRAS--NTVDSLDAQATVQVQEPPKFI 347
            |    ||...:| ....::|.|:|.||..:...:|.|.|||:  .|.:...|.||:.|..||.|:
Mouse   264 R----LDHKSIDVFNTRVLGNGNLIISDVKLQHAGVYVCRATTPGTRNFTVAMATLTVLAPPSFV 324

  Fly   348 KAPKDTTAHEKDEPELKCDIWGKPKPVIRWLKNGDLITPNDYMQLVDGHNLKILGLLNSDAGMFQ 412
            :.|:..|..........|...|.|.|.:.|||||..|..|..:::.:. .|.|..::..|..::|
Mouse   325 EWPESLTRPRAGTARFVCQAEGIPSPKMSWLKNGRRIHSNGRIKMYNS-KLVINQIIPEDDAIYQ 388

  Fly   413 CVGTNAAGSVHAAARLRVVPQGVKIKKRKSQGHSTKSLQTFDNLTKRRKPFNSGEQLRTKSGGSF 477
            |:..|:.|||.:.|||.||
Mouse   389 CMAENSQGSVLSRARLTVV---------------------------------------------- 407

  Fly   478 PFPDEDDDLDDNDSGTTRLRIPSGKLPKFEQPLNDRRFNILNAGSALPLDNQSKSYEDDDDDYDE 542

Mouse   408 ----------------------------------------------------------------- 407

  Fly   543 DDPAKEALLEAYKQGEDAHKILDSWQQSKSKKSQQQKQSPASPDSPEQDPSVPHPGGKPLDSGLQ 607
                         ..||.
Mouse   408 -------------MSEDR----------------------------------------------- 412

  Fly   608 ARLPSQPRDLVAQIVKSRFVTLSWVEPLQNAGDVVYYTVYY-KMNNSEREQKMVTKSHDDQQVNI 671
               ||.|.::.|:.:.|..:.|:|..||.|:..|:.|:|:| |......|:..|...:|.....|
Mouse   413 ---PSAPYNVHAETMSSSAILLAWERPLYNSDKVIAYSVHYMKAEGLNNEEYQVVLGNDTTHYII 474

  Fly   672 QSLLPGRTYQFRVEANTNFGSGASSAPLEVSTQPEVNIAGPPRNFEGYARSHKEIYVKWEEPTVT 736
            ..|.|...|.|
Mouse   475 DDLEPDSNYTF------------------------------------------------------ 485

  Fly   737 NGEILKYRVYYSENDSGADLYHDSTALEAVLTELRPHTDYVISVVPFNRNGMGDSSAEIRVKTFS 801
                                                   |:::.:|...:.|.|   .:...|..
Mouse   486 ---------------------------------------YIVAYMPLGASQMSD---HVTQNTLE 508

  Fly   802 STPSEPPNNVTLEVTSSSSITVHWEPPAEEDRNGQITGYKIRYR-KFKDAPQVKSTPANIRYFEL 865
            ..|..|| .::|...|.:.|.|.|.|...:.|.||:..|::.:| ..::|.||...|..:..:.|
Mouse   509 DVPLRPP-EISLTSRSPTDILVSWLPIPAKYRRGQVVLYRLSFRLSTENAIQVVELPGTVHEYLL 572

  Fly   866 SNLDRNAEYQVKIAAMTVNGSGPFTEWNRANTLENDLDETQVPGKPIWISIHP-GANNIALHWGP 929
            ..|..::.|.|:|.|.|..|.|..:.|....|.:  ....:.|..| .:.:.| ....|::.|..
Mouse   573 EGLKPDSVYLVRITAATRVGLGESSVWTSHRTPK--ATSVKAPKSP-ELHLEPLNCTTISVRWLQ 634

  Fly   930 PQHPEIKIRNYVLGW-GRGIPDENTIELKETERYHILKNLESNMDYVVSLRARNVKGDGPPIYDN 993
            .......||.|.|.: ..|..:...|.|...:..:.|..|:....|.|.|.|.|...:|......
Mouse   635 DTEDPAAIRGYKLFYKEEGQQEHGPIFLDTGDLLYTLSGLDPRRKYHVRLLAYNNMEEGYQADQT 699

  Fly   994 IKT------RDEEPVDAPTPLEVPVGLRAITMSSSSIVVYWIDTMLNKNQHVTDNRHYTV---SY 1049
            :.|      || ..|..|.|   |..|.|...:||||.::|........|.:    :||:   ..
Mouse   700 VSTPGCVSVRD-RMVPPPPP---PHHLYAKANTSSSIFLHWRRPAFTTAQVI----NYTIRCNPV 756

  Fly  1050 GITGSNRYRYHNTTDLNCMINDLRPNTQYEFAVKVVKGRRESSWSMSVLNSTYQNVPVTPPREVT 1114
            |:..::...|..|::.:.::..|.|||:|||||::...:..|.||..|.:||....|..||..|.
Mouse   757 GLQNASLVLYLQTSETHMLVQGLEPNTKYEFAVRLHVDQLSSPWSPVVYHSTLPEAPTGPPVGVK 821

  Fly  1115 VRLDEMNPPTVIVQWIPPKHTLGQITGYNIYYTTDTTKRDRDWSVEAFAGEETMLMLPNLKPYTT 1179
            |.|.|  ..|.:|.|.||......:|.|.|.|.:.......:|.|....|..||.:|.||.....
Mouse   822 VTLIE--DDTALVSWKPPDGPETVVTRYTILYASRKAWIAGEWQVLHREGAITMALLENLVAGNV 884

  Fly  1180 YYFKVQARTTKGANNAPFSALVSYTT---SAAVTMQEPDTIAKGID-------------NEKLLY 1228
            |..|:.|....|  ..|||..|....   .|:.:.|.|    |.:|             ::|.:.
Mouse   885 YIVKISASNEVG--EGPFSNSVELAVLPKDASESNQRP----KRLDSSNAKVYSGYYHLDQKSMT 943

  Fly  1229 IIIAATAVVLLVVLLGVLLLCRRKP--QSSPEHTKKS----YQKNNVGVPKPPDLWIHHDQMELK 1287
            .|.....:.|..:|:.||:|..|..  :||...|.:|    ..:.:..|....|:.        |
Mouse   944 GIAVGVGIALTCILICVLILIYRSKARKSSASKTAQSGTQPLSQASASVAAGSDMG--------K 1000

  Fly  1288 NIDKGLHTVTPVCSDGASSSGALTLPRSVVHSEYEVETPVPGH---VTNSLDKR----------- 1338
            |:::...|         :.|....:|.|.:.::...:..:..:   :.|:..|:
Mouse  1001 NLERATET---------AESLVPMMPSSFIDAKGGTDLIINSYGPIIKNNTKKKWLFFQDTKKIK 1056

  Fly  1339 -------------SYVPGYMTTSMNGTMERP-------QYPR--------TQYS-HQNRSHMTME 1374
                         .|.||  ||.:....:.|       .:||        |::| :...||.|.:
Mouse  1057 VEQTQRRFTQAVCFYQPG--TTVLISDEDSPGSPGQTASFPRPFGATALDTEHSANSEGSHETGD 1119

  Fly  1375 AG-LSQQSLTQPQ-SNSMAQTP--EHPYGGYDANFCNAGNAAAGNGCVSTIESSKRG---HPLKS 1432
            :| .|.:|..:.. |:.::.||  .:|..|.|::    |:||          ..|.|   .||.:
Mouse  1120 SGRFSHESNDEIHLSSVISSTPPTSNPLAGGDSD----GDAA----------PKKHGDPAQPLPA 1170

  Fly  1433 FSVPGPPPTGG 1443
            .....|..:.|
Mouse  1171 EQTSAPQTSAG 1181

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fra	NP_523716.2	Ig	36..140	CDD:299845	39/107 (36%)
		Ig	<180..222	CDD:299845	16/41 (39%)
		IG_like	257..340	CDD:214653	30/85 (35%)
		IGc2	264..327	CDD:197706	24/65 (37%)
		I-set	344..430	CDD:254352	27/85 (32%)
		Ig	363..428	CDD:299845	21/64 (33%)
		FN3	611..703	CDD:238020	23/92 (25%)
		FN3	711..799	CDD:238020	4/87 (5%)
		FN3	806..897	CDD:238020	27/91 (30%)
		FN3	908..989	CDD:238020	20/82 (24%)
		FN3	1011..1097	CDD:238020	26/88 (30%)
		FN3	1109..1205	CDD:238020	31/95 (33%)
		Neogenin_C	1273..1521	CDD:284094	40/221 (18%)
Prtg	NP_780694.3	Ig	34..124	CDD:299845	39/106 (37%)
		I-set	35..125	CDD:254352	39/106 (37%)
		IG_like	135..217	CDD:214653	25/91 (27%)
		Ig	146..201	CDD:143165	20/64 (31%)
		IG_like	235..317	CDD:214653	30/85 (35%)
		IGc2	244..303	CDD:197706	24/62 (39%)
		I-set	321..406	CDD:254352	27/85 (32%)
		Ig	339..406	CDD:299845	23/67 (34%)
		FN3	413..506	CDD:238020	27/188 (14%)
		FN3	511..604	CDD:238020	28/93 (30%)
		FN3	613..693	CDD:238020	19/80 (24%)
		FN3	720..808	CDD:238020	26/91 (29%)
		FN3	815..905	CDD:238020	30/93 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	975..1010		7/51 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1079..1191		26/117 (22%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4221
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810