DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fra and Neo1

DIOPT Version :9

Sequence 1:NP_523716.2 Gene:fra / 36377 FlyBaseID:FBgn0011592 Length:1526 Species:Drosophila melanogaster
Sequence 2:NP_032710.2 Gene:Neo1 / 18007 MGIID:1097159 Length:1492 Species:Mus musculus


Alignment Length:1606 Identity:502/1606 - (31%)
Similarity:741/1606 - (46%) Gaps:303/1606 - (18%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 FTLEPQDAVVPEGHSVLLQCAGTASIGRGGKSKSNLPSSVSIRWRGPDGQDLVIVGDTFRTQLKN 101
            |.:||.|.:...|.||:|.|:..:.            .|.:|.|: .||..|.:..|..|..|.:
Mouse    66 FLVEPVDTLSVRGSSVILNCSAYSE------------PSPNIEWK-KDGTFLNLESDDRRQLLPD 117

  Fly   102 GSLYISSV---EENRGLTGAYQCLLTAEGVGSILSRPALVAIVRQPDLNQDFLETYLLPGQTAYF 163
            |||:||:|   :.|:...|.|||:.|.:.:|:|:||.|.:.:...|........:.:..|.:|..
Mouse   118 GSLFISNVVHSKHNKPDEGFYQCVATVDNLGTIVSRTAKLTVAGLPRFTSQPEPSSVYVGNSAIL 182

  Fly   164 RCMLGEANWQEGVKHSVQWLKDDLPLPLDKLRMVVLPNGALEIDEVGPSDRGSYQCNVTSGSSSR 228
            .|   |.|  ..:...|:|.::..||.||. |:|.||:|.|.|......|.|.|:|.|.||...:
Mouse   183 NC---EVN--ADLVPFVRWEQNRQPLLLDD-RIVKLPSGTLVISNATEGDGGLYRCIVESGGPPK 241

  Fly   229 LSSKTNLNIKKPSDPGAENSVAPSFLVGPSPKTVREGDTVTLDCVANGVPKPQIKWLRNGMDLDF 293
            .|.:..|.:.:  ||  |..|...||:.||......|.:..|.||.:|:|.|.::|::|...|| 
Mouse   242 FSDEAELKVLQ--DP--EEIVDLVFLMRPSSMMKVTGQSAVLPCVVSGLPAPVVRWMKNEEVLD- 301

  Fly   294 NDLDSRFSIVGTGSLQISSAEDIDSGNYQCRASNTVDSLDAQATVQVQEPPKFIKAPKDTTAHEK 358
            .:...|..::..|.|:||...:.|:|.|.|.|.|...:::|||.:.||.||.|:|.|.:..|||.
Mouse   302 TESSGRLVLLAGGCLEISDVTEDDAGTYFCIADNGNKTVEAQAELTVQVPPGFLKQPANIYAHES 366

  Fly   359 DEPELKCDIWGKPKPVIRWLKNGDLITPNDYMQLVDGHNLKILGLLNSDAGMFQCVGTNAAGSVH 423
            .:...:|::.|||.|.::|:||||::.|:||.::|..|||::|||:.||.|.:||:..|..|:..
Mouse   367 MDIVFECEVTGKPTPTVKWVKNGDVVIPSDYFKIVKEHNLQVLGLVKSDEGFYQCIAENDVGNAQ 431

  Fly   424 AAARLRVVPQGVKIKKRKSQGHSTKSLQTFDNLTKRRKPFNSGEQLRTKSGGSFPFPDEDDDLDD 488
            |.|:|.::...|.|                                                   
Mouse   432 AGAQLIILEHDVAI--------------------------------------------------- 445

  Fly   489 NDSGTTRLRIPSGKLPKFEQPLNDRRFNILNAGSALPLDNQSKSYEDDDDDYDEDDPAKEALLEA 553
                                             ..||                            
Mouse   446 ---------------------------------PTLP---------------------------- 449

  Fly   554 YKQGEDAHKILDSWQQSKSKKSQQQKQSPASPDSPEQDPSVPHPGGKPLDSGLQARLPSQPRDLV 618
                                        |.|..|...|...|...|.         |||.|||:|
Mouse   450 ----------------------------PTSLTSATTDHLAPATTGP---------LPSAPRDVV 477

  Fly   619 AQIVKSRFVTLSWVEPLQNA-GDVVYYTVYYKMNNSEREQKMVTKSHDDQQVNIQSLLPGRTYQF 682
            |.:|.:||:.|:|..|..:. ||.:.|:|:|......||:...|....:.||.||:|:|...|.|
Mouse   478 ASLVSTRFIKLTWRTPASDPHGDNLTYSVFYTKEGVARERVENTSQPGEMQVTIQNLMPATVYIF 542

  Fly   683 RVEANTNFGSGASSAPLEVSTQPEVNIAGPPRNFEGYARSHKEIYVKWEEPTVTNGEILKYRVYY 747
            :|.|....|||.|||||.|.|||||.:.||..|...||.|...|.|.||.|...||||..|::||
Mouse   543 KVMAQNKHGSGESSAPLRVETQPEVQLPGPAPNIRAYATSPTSITVTWETPLSGNGEIQNYKLYY 607

  Fly   748 SENDSGADLYHDSTALEAVLTELRPHTDYVISVVPFNRNGMGDSSAEIRVKTFSSTPSEPPNNVT 812
            .|..:..:...|.::....:..|:.:|:|...||.:|::|.|.|:.::.|:|.|..||..|.|::
Mouse   608 MEKGTDKEQDIDVSSHSYTINGLKKYTEYSFRVVAYNKHGPGVSTQDVAVRTLSDVPSAAPQNLS 672

  Fly   813 LEVTSSSSITVHWEPPAEEDRNGQITGYKIRYRKF---KDAPQVKSTPANIRYFELSNLDRNAEY 874
            |||.:|.||.:||:||:...:|||||||||||||.   .|..:...|...:... :..|||..||
Mouse   673 LEVRNSKSIVIHWQPPSSTTQNGQITGYKIRYRKASRKSDVTETLVTGTQLSQL-IEGLDRGTEY 736

  Fly   875 QVKIAAMTVNGSGPFTEWNRANTLENDLDETQVPGKPIWISIHPGANNIALHWGPPQHPEIKIRN 939
            ..::||:||||:||.|:|..|.|.|:|||||:||..|..:.:.|...:|.:.|.||::..|.:|.
Mouse   737 NFRVAALTVNGTGPATDWLSAETFESDLDETRVPEVPSSLHVRPLVTSIVVSWTPPENQNIVVRG 801

  Fly   940 YVLGWGRGIPDENTIELKETERYHILKNLESNMDYVVSLRARNVKGDGPPIYDNIKTRDE----- 999
            |.:|:|.|.|...||::...:||:.::||:.:..||::|:|.|..|:|.|:|::..||..     
Mouse   802 YAIGYGIGSPHAQTIKVDYKQRYYTIENLDPSSHYVITLKAFNNVGEGIPLYESAVTRPHTDTSE 866

  Fly  1000 ----------EPVDAPTPLEVPVGLRAITMSSSSIVVYWIDTMLNKNQHVTDNRHYTVSY--GIT 1052
                      .||..|||:..|||::|..:|..:|.:.|.|..|.|:|.:||:|:|||.:  .|.
Mouse   867 VDLFVINAPYTPVPDPTPMMPPVGVQASILSHDTIRITWADNSLPKHQKITDSRYYTVRWKTNIP 931

  Fly  1053 GSNRYRYHNTTDLNCMINDLRPNTQYEFAVKVVKGRRESSWSMSVLNSTYQNVPVTPPREVTVRL 1117
            .:.:|:..|.|.|:.::..|:|||.|||:|.|.||||.|:|||:...:|::.||.:||::|||..
Mouse   932 ANTKYKNANATTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGATFELVPTSPPKDVTVVS 996

  Fly  1118 DEMNPPTVIVQWIPPKHTLGQITGYNIYYTTDTTKRDRDWSVEAFAGEETMLMLPNLKPYTTYYF 1182
            .|..|.|:||.|.||....|:||||.|||:||......||.:|...|......:..|...|.|||
Mouse   997 KEGKPRTIIVNWQPPSEANGKITGYIIYYSTDVNAEIHDWVIEPVVGNRLTHQIQELTLDTPYYF 1061

  Fly  1183 KVQARTTKGANNAPFSALVSYTTSAAVTMQE-PDTIAKG-------------------------- 1220
            |:|||.:||.  .|.|..|.:.|..|.:..: |:..|.|                          
Mouse  1062 KIQARNSKGM--GPMSEAVQFRTPKADSSDKMPNDQALGSAGKGSRLPDLGSDYKPPMSGSNSPH 1124

  Fly  1221 ------IDNEKLLYIIIAATAVVLLVVLLGVLLLCRRKPQSSPEHTKK----------SYQ-KNN 1268
                  :|:..|| :||.:..|:.:||::.:.:.|.|:..|   |.||          |:: |.|
Mouse  1125 GSPTSPLDSNMLL-VIIVSVGVITIVVVVVIAVFCTRRTTS---HQKKKRAACKSVNGSHKYKGN 1185

  Fly  1269 VGVPKPPDLWIHHDQMELKNIDK---------------GLHTVTPV------------------- 1299
            ....|||||||||:::|||.|||               ....:|||                   
Mouse  1186 CKDVKPPDLWIHHERLELKPIDKSPDPNPVMTDTPIPRNSQDITPVDNSMDSNIHQRRNSYRGHE 1250

  Fly  1300 CSDGASSSGALTLPRSVVHSEYEVETPVP---GHVTNSLDK--RSYVPGYMTTSMNGTMERPQYP 1359
            ..|..|:.......|..:...::.:.|.|   .|..:|||.  ..:....:.:.....:..|..|
Mouse  1251 SEDSMSTLAGRRGMRPKMMMPFDSQPPQPVISAHPIHSLDNPHHHFHSSSLASPARSHLYHPSSP 1315

  Fly  1360 ---RTQYSHQNRSHMTMEAGLSQQSLTQPQSNSMAQTPEH--PYGGYDANFCNAGNAAAGNGCVS 1419
               .|..|..:|::.|.....:..:.|.|.|:|.....:|  |.|...:::. |.:....:|...
Mouse  1316 WPIGTSMSLSDRANSTESVRNTPSTDTMPASSSQTCCTDHQDPEGATSSSYL-ASSQEEDSGQSL 1379

  Fly  1420 TIESSKRGHPLKSFSVPGPPPTGGA--TPVTKHTPAVTIRPQNQSPYKKPSFSAATPNRLQGG-G 1481
            .....:..||||||:||..||.|..  .|....||.::.:..|...:...:.|..|..|.:.. .
Mouse  1380 PTAHVRPSHPLKSFAVPAIPPPGPPLYDPALPSTPLLSQQALNHHIHSVKTASIGTLGRSRPPMP 1444

  Fly  1482 SVVHSTDEIQR----LAPSTST---EELNQEMANLEGLMKDLSAIT 1520
            .||.|..|:|.    |..|.|:   :||.:|||:||||||||:|||
Mouse  1445 VVVPSAPEVQETTRMLEDSESSYEPDELTKEMAHLEGLMKDLNAIT 1490

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fraNP_523716.2 Ig 36..140 CDD:299845 35/105 (33%)
Ig <180..222 CDD:299845 17/41 (41%)
IG_like 257..340 CDD:214653 27/82 (33%)
IGc2 264..327 CDD:197706 21/62 (34%)
I-set 344..430 CDD:254352 37/85 (44%)
Ig 363..428 CDD:299845 29/64 (45%)
FN3 611..703 CDD:238020 40/92 (43%)
FN3 711..799 CDD:238020 30/87 (34%)
FN3 806..897 CDD:238020 43/93 (46%)
FN3 908..989 CDD:238020 27/80 (34%)
FN3 1011..1097 CDD:238020 39/87 (45%)
FN3 1109..1205 CDD:238020 41/95 (43%)
Neogenin_C 1273..1521 CDD:284094 84/302 (28%)
Neo1NP_032710.2 Ig1_Neogenin 65..159 CDD:143199 35/105 (33%)
I-set 65..159 CDD:254352 35/105 (33%)
I-set 163..250 CDD:254352 28/92 (30%)
IGc2 177..236 CDD:197706 23/64 (36%)
I-set 261..348 CDD:254352 29/87 (33%)
IGc2 274..337 CDD:197706 22/63 (35%)
I-set 352..438 CDD:254352 37/85 (44%)
Ig4_Neogenin 368..438 CDD:212460 30/69 (43%)
FN3 470..563 CDD:238020 40/92 (43%)
FN3 570..659 CDD:238020 30/88 (34%)
FN3 667..759 CDD:238020 43/92 (47%)
FN3 770..849 CDD:214495 26/78 (33%)
FN3 887..980 CDD:238020 39/92 (42%)
FN3 987..1082 CDD:238020 41/96 (43%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1072..1128 8/55 (15%)
Neogenin_C 1189..1492 CDD:284094 84/303 (28%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1205..1237 6/31 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1266..1300 6/33 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1321..1399 20/78 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 91 1.000 Domainoid score I7671
eggNOG 1 0.900 - - E1_KOG4221
Hieranoid 1 1.000 - -
Homologene 1 1.000 - - H1870
Inparanoid 1 1.050 710 1.000 Inparanoid score I643
Isobase 1 0.950 - 0 Normalized mean entropy S5881
OMA 1 1.010 - - QHG46607
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 1 1.000 - - FOG0002773
OrthoInspector 1 1.000 - - otm43150
orthoMCL 1 0.900 - - OOG6_105369
Panther 1 1.100 - - O PTHR44170
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3265
SonicParanoid 1 1.000 - - X1863
SwiftOrtho 1 1.000 - -
TreeFam 1 0.960 - -
1615.810

Return to query results.
Submit another query.