DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fra and dig-1

DIOPT Version :9

Sequence 1:NP_523716.2 Gene:fra / 36377 FlyBaseID:FBgn0011592 Length:1526 Species:Drosophila melanogaster
Sequence 2:NP_001366805.1 Gene:dig-1 / 175951 WormBaseID:WBGene00000998 Length:13084 Species:Caenorhabditis elegans


Alignment Length:2035 Identity:376/2035 - (18%)
Similarity:609/2035 - (29%) Gaps:784/2035 - (38%)


- Green bases have known domain annotations that are detailed below.


  Fly    39 LEPQDAV-VPEGHSVLLQCAGTA------------SIGRGGKSKSNLPSSVSIRWRGPDGQDLVI 90
            :|||... |..|.::.:.|...|            .:...|..::.|.:|           .::|
 Worm   309 IEPQGPYEVAPGGNINISCTSVAYPFPDIYWFKNQKVNTDGPDQNTLRAS-----------QILI 362

  Fly    91 VGDTFRTQLKNGSLYISSVEENRGLTGAYQCLLTAEGVGSI-------LSRPALVAIVRQPDLNQ 148
            :.:.:|.:      ..:.|.:|...:......:...|.||.       ..|.:|......|.:..
 Worm   363 IKEIYRNE------EFTCVSDNIHGSANRTVSIVVTGPGSAPHLKSASAGRTSLTVRWEPPSIIN 421

  Fly   149 DFLETYLLPGQTAYFRCMLGEANWQEGVKHSVQWLKDDLPLPLDKLRMVVL-PNGALEI-----D 207
            ..:.||     |.|:     ..|.|:.||:   |.|.::..|..::.:..| |:.|..|     |
 Worm   422 RPITTY-----TLYY-----TNNPQQPVKN---WKKLEVKEPTREVAIPDLRPDTAYYIRVRAND 473

  Fly   208 EVGPSDRGSY------------QCNVTSGSSSRLSSKTNLNIK------------------KPSD 242
            .:||...|:.            ..|:..|...|:...|...|.                  :|.:
 Worm   474 PLGPGKLGNQVQIKTLKPAVRPYVNIVEGDEIRVPPMTAFEIDCNVTRADPVPVLVWLHKGRPLN 538

  Fly   243 PG----------------------AENSVAPS------FLVGPS-PKTVR---EGDTVTLDC--- 272
            .|                      |||....|      .:.||| |:.:|   :||.|||..   
 Worm   539 KGSKTQHIKMKNGGVLESTQFSCVAENEAGKSTKKINVTVTGPSAPERIRYQIDGDKVTLQWEPP 603

  Fly   273 -VANG--------------VPKPQIKWLRNGMDLDFNDLDSR--------------FSIVGTGSL 308
             :.||              :|:.|  |..:.:|    |.::|              |.|||...|
 Worm   604 QITNGPMAGYDVFYTEDPSLPRDQ--WKVHHID----DPNARTTTVLRLNEKTPYTFVIVGRNRL 662

  Fly   309 QISSAEDIDSGNYQCRASNTVDSLDAQATVQVQEPPKFIKAPKDTTAHE--KDEPELKCDIWGKP 371
                ...:.|..:            ...|....:||.....|.:....|  .||..::|...|.|
 Worm   663 ----GPGLPSAPF------------TATTWLAAKPPVVQLEPSEEMTKEPSNDEMIIECGAQGVP 711

  Fly   372 KPVIRWLKNGDLI------------TPNDYMQLVDGHNLKILGLLNSDAGMFQCVGTNAAGSVHA 424
            ||.|.||.:|.||            ||.|..   |....|::....:.:|:..|...|:.||...
 Worm   712 KPKIIWLWSGTLIEDGKEEFRVYDTTPTDAQ---DRTRSKLIAQSTTRSGVATCQAVNSEGSDEK 773

  Fly   425 AARLRVVPQGVKIKKRKSQGHSTKSLQT-FDNLTKRRKPFNSGEQLRTKSGGSFPFPDEDDDLDD 488
            ...::::..|     ....|.:...:.| ||...|..|..|.    |......:...|.|..|.|
 Worm   774 KVPVKILGPG-----SAPLGITPTPMHTGFDVAWKPPKVTNG----RITDYVVYYSKDPDAPLSD 829

  Fly   489 NDSGTTRLRIPSGKLPKFEQPLNDRRFNILNAGSALPLDNQSKSYEDDDDD---------YDEDD 544
            .:|.|                              :|.|.::.:...||:|         ..:|.
 Worm   830 WESKT------------------------------VPADTRNLTVNVDDEDTPYVVKVQARTDDG 864

  Fly   545 PAKEALLEAYKQGEDAHKILDSWQQSKSKKSQQQKQSPASPDSPEQDPSV-PHPG---------- 598
            |.  .:.|||                  :.:..:||.|.|......|||| |..|          
 Worm   865 PG--IISEAY------------------EVTTGRKQVPLSVRLEIADPSVDPSTGETIVEPTQPI 909

  Fly   599 -------GKPLDSGLQARLP-------------------SQP---------------RDLVAQ-- 620
                   |:|:.|...:.||                   |||               |.|:.|  
 Worm   910 HFRCVADGRPMPSVSYSWLPINASESGDEPVPIPIHSDDSQPHHYNSIQVYSTTATKRILLCQAR 974

  Fly   621 ----IVKSRF-----------------------VTLSWVEPLQNAGDVVYYTVYYKMNNS---ER 655
                .|..|.                       ||::|..|....|::..|.||...:.|   ::
 Worm   975 NPDGTVDDRHVFIVNKPGSAPQNPEVIVDPDNRVTITWQPPKYPNGEITSYNVYITGDPSLPVDQ 1039

  Fly   656 EQKMVTKSHDDQQVNIQ--SLLPGRTYQFRVEANTNFGSG----------ASSAPLEVSTQ--PE 706
            .|........|.::.:|  :|.|...|..::.|....|.|          .|.||::..|.  |.
 Worm  1040 WQVFPVDDVTDPKLVLQRGALQPETPYFVKIAAVNPHGEGIHTDPKHFDTVSGAPIDAPTDVLPS 1104

  Fly   707 VNIAGPPRNFEGYARSHKEIYVKWEEPTVTNGEILKYRVY----YSEND------------SGAD 755
            |:|             ...:.:.|..||...|.|..|.||    |.::|            .|||
 Worm  1105 VSI-------------DNTVNITWSPPTQPLGPIKSYTVYFAPEYDDSDFKTWQRISVDAPDGAD 1156

  Fly   756 LYHDSTALEAVLTELRPHTDYVISVVPFNRNGMGDSSAEIR------------------------ 796
              |....|..  .:..|:|.|.|.:...|....|.:|..:|                        
 Worm  1157 --HGEVTLPK--EQFNPNTPYKIRISATNDLSEGPASDPVRFETGSGEIPPTITLDPSNSTYTVE 1217

  Fly   797 ---------------------------------------VKTFSST------------------- 803
                                                   ||..|:|                   
 Worm  1218 PLGAATITCTATGVPQPKVHWIKANGETVDSATLQLYDLVKDTSATCVAENNAGKTQEAVSIQVT 1282

  Fly   804 -PSEPPNNVTLEVTSSSSITVHWEPPAEEDRNGQITGYKIRYRKFKDA-------PQVKSTPANI 860
             |...||.:.|....:..|.|.|..|  ::.|||||.|.|.|.:..:.       .||.....::
 Worm  1283 GPGTAPNEIVLLPMPNQEINVEWTSP--DEVNGQITNYIIHYGEISEDGSEPATWDQVTIARDDV 1345

  Fly   861 RYFELSNLDRNAEYQVKIAAMTVNGSGPFTEWNRANTLENDLDETQVPGKPIWISIHPGANNIAL 925
            .: :|:||:....|.:::.|::..|.|..:......||..   ..|....|| |.:||. |::.:
 Worm  1346 NH-KLANLEPKKTYAIRVQAVSDRGPGVISAPQVIKTLPL---APQAITNPI-IQVHPN-NSVTI 1404

  Fly   926 HWGPPQHPE---IKIRNYVLGWGRG-IPDENTI--ELK-----ETERYHIL----KNLESNMDYV 975
            .:.||..||   .|::::|:.:... .||:.::  |||     :|:...|:    :|...:..|.
 Worm  1405 EFTPPDDPENPGKKVKDFVIQYTTDEEPDDESVWKELKFTDPDDTDDTTIVSIDGENFNPDTKYN 1469

  Fly   976 VSLRARN------------VKGDG-----PPIYDNIKTRDEEPVDAPTPLEVPVG----LRAITM 1019
            ..:.||.            ..|||     .|.: |:.|.|       ..:.||.|    ::.::.
 Worm  1470 TRIIARGEIDSQPNEPTLFATGDGVIAPSQPSF-NVDTED-------GVIRVPAGTDYTIKCVSE 1526

  Fly  1020 SSSSIVVYWIDTMLN---------------------------------------------KNQHV 1039
            ...:..|.|:|:..|                                             :|..:
 Worm  1527 GYPAPDVRWVDSHGNQLSDGPLLRIIDIRKTLNAKCLAENRGGLKETDLTIFVAGPGTAPENIQL 1591

  Fly  1040 TDNRHYTVSY-----GITGSNRYRY---------------------------HNTTDLNCMINDL 1072
            |.|:..|:|.     .|...|..:|                           .|..|:|..:...
 Worm  1592 TANKPTTISVQYEVPSIPNGNISKYIIYYTPLDDQDPDHQLGQVQTKPISDWQNVHDMNDGVEGP 1656

  Fly  1073 R---------PNTQYEFAVKVVKGRRESSWSMSVLNSTYQNVPVTPPREVTVRLDEMNPPTVIVQ 1128
            |         .:|.|...|:.:.......:|......|.......||.|:.|..|...  :.:.|
 Worm  1657 RKVDIKDFVSTDTAYAVVVQAINDDGPGPYSNQYTIRTMSRAREGPPVELRVEPDGQR--SAVAQ 1719

  Fly  1129 W-------IPPKHTLGQITGYNIYYT-------TDTTKRDRDWSVEAFAGEETML--MLPN-LKP 1176
            |       :||       .||.|||.       .|.:....|| ::....:.|.|  .:.| |.|
 Worm  1720 WKEPVTSDVPP-------IGYEIYYVRGDKSVEEDDSAGLNDW-IKISIDDPTKLTHKIQNLLLP 1776

  Fly  1177 YTTYYFKVQARTTKGAN--------------NAPFSALVSYTTSAAVTMQEPDTIAKGIDNEKLL 1227
            .|.|.||::|....|.:              |||:..:              .|...|::....:
 Worm  1777 DTDYVFKMRAIYPDGPSVFSEPCIMKTLPDGNAPYIQI--------------STGDNGVEGSTTI 1827

  Fly  1228 YIIIAATAVVLLVVLLGVLLLCRRKPQSSPEHTKKSYQKNNVGVPKPPDLWIHHDQMELKNIDKG 1292
            .|:..:.          :.:.|                 |..|:|.|...|          |..|
 Worm  1828 QILPGSQ----------MTIAC-----------------NATGIPLPQVKW----------IKAG 1855

  Fly  1293 LHTVTP--VCSDGASSSGALTLPRSVVHSEYEVETPVP-GHVTNSLD-------KRSYVPGYMTT 1347
            .:.:.|  |.:||..:..:|.:......:.:......| ||...:::       :.::...::|:
 Worm  1856 NYEIDPSRVDADGNHAQFSLQVANITEDTTFNCVAQNPLGHANWTINVNLIEGLEPNWRDDFVTS 1920

  Fly  1348 SMNGTM-------ERPQY--PRTQYSHQNRSHMTMEAGLSQQSLTQPQSNSMAQTPEHPYGGYDA 1403
            ..:|..       |.|:|  |..:::.|    .|.:|       .||:.    |....|.||...
 Worm  1921 KSDGGQIVLVFNDELPEYLKPPNEWTIQ----YTDDA-------EQPKD----QWESIPSGGAPL 1970

  Fly  1404 NFCNAGNAAAGNGCVSTIESSKRG--HPLKSFSVPGPP------------------PTGGATPVT 1448
            ......|...|......:::.::|  .|......|.||                  |...:.|:.
 Worm  1971 TRVEVPNMNPGTFYYLVVDNPEKGIQTPTLVVMTPKPPSDIRFGKNNDDEQIVDFKPAVASEPIK 2035

  Fly  1449 KHTPAV--TIRPQNQSPYKKPSFSAATPNRLQGGGSVVHSTD-----EIQRLAPSTSTEELNQEM 1506
            ::|.:|  :..|.|...:..|:...:        |.||...:     .:|..|.....|||..|.
 Worm  2036 EYTISVWPSTDPSNVKKFTTPADVTS--------GVVVDGLEPDTEYNVQVAAEFYEGEELASEP 2092

  Fly  1507 ANLEGLMKDLSAITANEFEC 1526
            ..::...:|:|.      ||
 Worm  2093 VTVKTPPRDVSC------EC 2106

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fraNP_523716.2 Ig 36..140 CDD:299845 19/120 (16%)
Ig <180..222 CDD:299845 12/59 (20%)
IG_like 257..340 CDD:214653 24/118 (20%)
IGc2 264..327 CDD:197706 19/94 (20%)
I-set 344..430 CDD:254352 26/99 (26%)
Ig 363..428 CDD:299845 21/76 (28%)
FN3 611..703 CDD:238020 30/169 (18%)
FN3 711..799 CDD:238020 24/166 (14%)
FN3 806..897 CDD:238020 24/97 (25%)
FN3 908..989 CDD:238020 26/112 (23%)
FN3 1011..1097 CDD:238020 22/175 (13%)
FN3 1109..1205 CDD:238020 31/126 (25%)
Neogenin_C 1273..1521 CDD:284094 52/293 (18%)
dig-1NP_001366805.1 FXa_inhibition 226..262 CDD:405372
ig 311..389 CDD:395002 13/94 (14%)
Ig strand A' 315..319 CDD:409353 1/3 (33%)
Ig strand B 322..330 CDD:409353 1/7 (14%)
Ig strand C 335..341 CDD:409353 0/5 (0%)
Ig strand C' 343..345 CDD:409353 0/1 (0%)
Ig strand D 348..352 CDD:409353 1/3 (33%)
Ig strand E 359..364 CDD:409353 1/4 (25%)
Ig strand F 371..378 CDD:409353 1/6 (17%)
Ig strand G 382..391 CDD:409353 0/8 (0%)
FN3 394..478 CDD:214495 22/96 (23%)
Ig 497..578 CDD:416386 11/80 (14%)
Ig strand C 527..531 CDD:409353 0/3 (0%)
Ig strand F 558..563 CDD:409353 0/4 (0%)
Ig strand G 571..574 CDD:409353 0/2 (0%)
FN3 581..675 CDD:238020 23/115 (20%)
Ig_3 681..766 CDD:404760 24/87 (28%)
FN3 784..876 CDD:238020 24/145 (17%)
FN3 993..1089 CDD:238020 18/95 (19%)
FN3 1096..1196 CDD:238020 27/116 (23%)
Ig_3 1202..1268 CDD:404760 4/65 (6%)
Ig strand A 1203..1206 CDD:409353 0/2 (0%)
Ig strand A' 1212..1216 CDD:409353 0/3 (0%)
Ig strand B 1222..1229 CDD:409353 0/6 (0%)
Ig strand C 1235..1240 CDD:409353 0/4 (0%)
Ig strand E 1249..1253 CDD:409353 0/3 (0%)
Ig strand G 1271..1281 CDD:409353 0/9 (0%)
FN3 1287..1381 CDD:238020 24/96 (25%)
FN3 1585..1694 CDD:238020 16/108 (15%)
FN3 1701..1803 CDD:238020 28/111 (25%)
ig 1824..1903 CDD:395002 17/115 (15%)
Ig strand A' 1828..1831 CDD:409353 1/2 (50%)
Ig strand B 1834..1842 CDD:409353 2/34 (6%)
Ig strand C 1847..1853 CDD:409353 2/15 (13%)
Ig strand C' 1855..1858 CDD:409353 1/2 (50%)
Ig strand D 1861..1865 CDD:409353 1/3 (33%)
Ig strand E 1870..1878 CDD:409353 1/7 (14%)
Ig strand F 1885..1892 CDD:409353 0/6 (0%)
FN3 2005..2097 CDD:238020 19/99 (19%)
vWFA 6583..>6690 CDD:412136
PQQ 11141..11487 CDD:224437
VWA 12151..12302 CDD:214621
vWFA_subfamily_ECM 12363..12522 CDD:238727
EGF_CA 12972..13013 CDD:214542
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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