DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fra and rig-5

DIOPT Version :9

Sequence 1:	NP_523716.2	Gene:	fra / 36377	FlyBaseID:	FBgn0011592	Length:	1526	Species:	Drosophila melanogaster
Sequence 2:	NP_001251131.1	Gene:	rig-5 / 172791	WormBaseID:	WBGene00004372	Length:	482	Species:	Caenorhabditis elegans

Alignment Length:	454	Identity:	108/454 - (23%)
Similarity:	164/454 - (36%)	Gaps:	137/454 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   141 VRQPDLNQDFLETYLLPGQTAYFRCMLGEANWQEGVKHSVQWLKDDLP---LPLD---------- 192
            ::||.::    ....|.||...|.|::.:..     .|.|.::|.|.|   |..|
Worm    86 IQQPSMS----SAVALLGQDVDFTCIVNDLG-----SHMVAFVKADSPPRLLSFDEKVFRRRNKY 141

  Fly   193 --KLRMVVLPN-GALEIDEVGPSDRGSYQCNVTSGSSSRLSSKTNLNIKKPSDPGAENSVAPSFL 254
              |.|:..|.| ..|.|..|..||||:|.|.:.:...:  .|...|::|.|  |....|.
Worm   142 ELKPRIGDLHNEWVLTIKNVQESDRGNYSCQINTEPIT--LSTGELDVKVP--PVVSRST----- 197

  Fly   255 VGPSPKTVREGDTVTLDCVANGVPKPQIKWLRNGMD-LDFNDLDSRFSIVGTGS-------LQIS 311
              |:...||||:.|:|.|.|:|.|.|.:.|.|.... :.:|      ...|.|:       |.::
Worm   198 --PAAVEVREGNNVSLTCKADGNPTPTVIWRRQDRQIIRYN------GATGFGASVFHGPVLHLT 254

  Fly   312 SAEDIDSGNYQCRASNTVDSLDAQATVQ--VQEPPKFIKAPKDTT-AHEKDEPELKCDIWGKPKP 373
            .........|.|.|||.:.. |...||:  |..|| .::|..:|. |.......:.|.....|:|
Worm   255 KVSRKHMSEYLCVASNGIPP-DESWTVKLLVTFPP-LVQAQSETVQASVGSMARMVCTTEAWPRP 317

  Fly   374 VIRWLKNGDLITPNDYMQL---VDG-----HNLKILGLLNSDAGMFQCVGTNAAGSVHAAARLRV 430
            .:.|.|:|:.:..::.:.:   |.|     |.|:|..:.:|..|:::||..|..|..|:...|..
Worm   318 EMGWEKDGEPVYESNNVAMTHTVSGQYHSVHILEIRNVQSSHFGVYRCVAKNDNGIHHSQVTLNQ 382

  Fly   431 VPQGVKIKKRKSQGHSTKSLQTFDNLTKRRKPFNSGEQLRTKSGGSFPFP---DEDDDLDDNDSG 492
            :          |..|.|.|     ||.    |..||            .|   .|||:.|:.:..
Worm   383 I----------SHNHFTNS-----NLI----PEGSG------------MPRGYSEDDEADEEEDN 416

  Fly   493 TTRLRIPSGKLPKFEQPLNDRRFNILNAGSALPLDNQSKSYEDDDDDYDEDDPAKEALLEAYKQ 556
                                             |:||.       :|.:|:|......||.|.|
Worm   417 ---------------------------------LENQK-------NDSEEEDSQSPPQLEFYSQ 440

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fra	NP_523716.2	Ig	36..140	CDD:299845
		Ig	<180..222	CDD:299845	19/57 (33%)
		IG_like	257..340	CDD:214653	26/92 (28%)
		IGc2	264..327	CDD:197706	18/70 (26%)
		I-set	344..430	CDD:254352	23/94 (24%)
		Ig	363..428	CDD:299845	18/72 (25%)
		FN3	611..703	CDD:238020
		FN3	711..799	CDD:238020
		FN3	806..897	CDD:238020
		FN3	908..989	CDD:238020
		FN3	1011..1097	CDD:238020
		FN3	1109..1205	CDD:238020
		Neogenin_C	1273..1521	CDD:284094
rig-5	NP_001251131.1	IG_like	92..189	CDD:214653	27/107 (25%)
		Ig_3	191..270	CDD:372822	23/91 (25%)
		IG	294..380	CDD:214652	20/85 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910