DRSC/TRiP Functional Genomics Resources

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Protein Alignment fra and unc-40

DIOPT Version :9

Sequence 1:NP_523716.2 Gene:fra / 36377 FlyBaseID:FBgn0011592 Length:1526 Species:Drosophila melanogaster
Sequence 2:NP_491664.1 Gene:unc-40 / 172233 WormBaseID:WBGene00006776 Length:1415 Species:Caenorhabditis elegans


Alignment Length:1647 Identity:432/1647 - (26%)
Similarity:669/1647 - (40%) Gaps:415/1647 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    26 IGSSLASQALSFTLEP-QDAVVPEGHSVLLQCAGTASIGRGGKSKSNLPSSVSIRWRGPDGQDLV 89
            |.:...:....|.:|| ::..|.|..|.||:|:...:..|       |...|.|.|:    :|.|
 Worm    32 IDNDARNLGFQFVMEPRRNVTVMESSSHLLECSYVLAHER-------LVHDVRIEWK----RDGV 85

  Fly    90 IVGDTFRTQLK---NGSLYI---SSVEENRGLTGAYQCLL-------TAEGVGSILSRPALVAIV 141
            ::.:...:::|   ||||:|   ||.||     |.|||.:       ......:.|||.|.:.:.
 Worm    86 LLSERTSSRIKVMSNGSLWIESVSSAEE-----GTYQCAVHVTTKSDQTSDTWTFLSRKATLRLA 145

  Fly   142 RQPDLNQDFLETYLLPGQTAYFRCMLGEANWQEGVKHSVQWLKDDLPLPLDKLRMVVLP-NGALE 205
            .........::..|..||...|.|::........|     ||.:|.|: ::.....:|| :..||
 Worm   146 DLAKFELQAIDRTLAKGQPTAFHCLINSKPTPTAV-----WLHNDEPI-VNGGEYHILPVSNTLE 204

  Fly   206 IDEVGPSDRGSYQCNVTSGSSSRLSSKTNLNIKKPSDPGAENSVAPSFLVGPSPKTVREGDTVTL 270
            |........|:|:|.|......|.|....|.:...:   ..|.:.  |:..|..:.|.:||...|
 Worm   205 ISSTQSRHEGTYRCTVEGAGKRRSSQTARLTVTTET---VSNELV--FITTPRLQVVEQGDEFLL 264

  Fly   271 DCVANGVPKPQIKWLRNGMDLDFNDLDSRFSIVGTGSLQISSAEDIDSGNYQCRASNTVDSLDAQ 335
            :|:...:.:||::||::...:..:.:  |...||..|:.:|.|...|:|.|.|||||..||:|..
 Worm   265 ECLVASLIRPQVRWLKDSRQIIVDGV--RIRRVGVSSILVSRASIEDTGLYTCRASNNDDSIDRA 327

  Fly   336 ATVQVQEPPKFIKAPKDTTAHEKDEPELKC-DIWGKPKPVIRWLKNGDLITPNDYMQLVDGHNLK 399
            .:|:|:.||:....|....|.|..:.||:| ....:|:..:.|.|||:.|..::|. :::.:.|:
 Worm   328 VSVEVRAPPRITTRPTTKVAVETADVELECGTAAARPEARVNWYKNGEAIIGSEYF-VIEPNRLR 391

  Fly   400 ILGLLNSDAGMFQCVGTNAAGSVHAAARLRVVPQGVKIKKRKSQGHSTKSLQTFDNLTKRRKPFN 464
            |||::.:|..::||:..|..||..|:|:|.|                                  
 Worm   392 ILGVVRADQAIYQCIAENDVGSEQASAQLLV---------------------------------- 422

  Fly   465 SGEQLRTKSGGSFPFPDEDDDLDDNDSGTTRLRIPSGKLPKFEQPLNDRRFNILNAGSALPLDNQ 529
                                                                             
 Worm   423 ----------------------------------------------------------------- 422

  Fly   530 SKSYEDDDDDYDEDDPAKEALLEAYKQGEDAHKILDSWQQSKSKKSQQQKQSPASPDSPEQDPSV 594
                                         ||                        |||    .||
 Worm   423 -----------------------------DA------------------------PDS----SSV 430

  Fly   595 PHPGGKPLDSGLQARLPSQPRDLVAQIVKSRFVTLSWVEPLQNAGDVVYYTVYYKMNNSEREQKM 659
            ....|.|:.|       |.|..|.:....|||:.:.|..|:|..|:::.|.::||.|..:|| :|
 Worm   431 AASSGVPMTS-------SAPLGLRSTSSGSRFINVEWDPPVQRNGNIMRYHIFYKDNLIDRE-RM 487

  Fly   660 VTKSHDDQQVNIQSLLPGRTYQFRVEANTNFGSGASSAPLEVSTQPEVNIAGPPRNFEGYARSHK 724
            :..|  .....:.||.|...|..||.|....|.|..|..|:|:|..|..:.|...:....|...:
 Worm   488 INSS--STSATLTSLQPSTMYLIRVTAENEAGMGKFSDSLKVTTNKEQAVPGKVASLTTTATGPE 550

  Fly   725 EIYVKWEEPTVTNGE-ILKYRVYYS----ENDSGADLYHDSTALEAVLTELRPHTDYVISVVPFN 784
            .|.::|..|  :.|: .|:|:::||    |.:....|...||. ...|..:..:|.|.|.:....
 Worm   551 TIDIRWSPP--SGGQPALRYKIFYSHDPLEKNEKETLITTSTT-HYTLHGMDKYTGYQIRIEAEG 612

  Fly   785 RNGMGDSSAEIRVKTFSSTPSEPPNNVTLEVTSSSSITVHWEPPAEEDRNGQITGYKIRYR-KFK 848
            .||.|.||..::|:|.|..||.||.|:..|..||:|:.|.|:.|.||..||:||||:::|: |.:
 Worm   613 SNGSGLSSDTVKVRTQSDEPSAPPVNIQAEADSSTSVRVSWDEPEEESVNGEITGYRLKYKTKAR 677

  Fly   849 DAP-QVKSTPANIRYFELSNLDRNAEYQVKIAAMTVNGSGPFTEWNRANTLENDLDETQVPGKPI 912
            .|. ......|..|.:.:.||:.|.:|.:::|.:..||:|||::|...:|...|.:|..: |.|.
 Worm   678 GAKGNTLVIDATAREYTMGNLEPNTQYLIRMAVVNHNGTGPFSDWVSIDTPGQDKEERTL-GAPR 741

  Fly   913 WISIHPGANNIALHWGPPQHPEIKIRNYVLGWGRGIPDENTIELKETERYHILKNLESNMDYVVS 977
            .|..|.|.:.|.:.|.||...:..:|.|.:|||..:||..||.:..:...:.:..|.|..|||:|
 Worm   742 EIRPHAGIDYILVSWLPPADEQNLVRGYQIGWGLSVPDTETIRVTASTTQYKIARLHSERDYVIS 806

  Fly   978 LRARNVKGDGPPIYDNIKT------------RDEEPVDAPTPLEVPVGLRAITMSSSSIVVYWID 1030
            |||.|..|.|.|||:.::|            .|.:..|..:....|||:||..:|::||.|.|  
 Worm   807 LRAFNNLGSGFPIYETVRTLSRETPSHFNEDSDSDDSDVGSSESTPVGVRAEAISATSIRVMW-- 869

  Fly  1031 TMLNKNQHVTDNRHYTVSYG-ITGSNRYRYHNTTDLNCMINDLRPNTQYEFAVKVVKGRRE-SSW 1093
               .::.....|..|||.|. ....|::||.|:|:....:..|||.|:|||||:.|....: |:|
 Worm   870 ---TESDETAFNTQYTVRYSTAVDGNQHRYVNSTETWATVEGLRPATEYEFAVRAVASNGQLSTW 931

  Fly  1094 SMSVLNSTYQNVPVTPPREVTVRLDEM-NPPTVIVQWIPPKHTLGQITGYNIYYTTDTTKRDRDW 1157
            ||:..|.|....|.:.||::||...|. :|.:..:.|.|||::.|:|..|.::||...:..|:||
 Worm   932 SMATRNRTLAAPPSSAPRDLTVLPAESGDPHSSSLHWQPPKYSNGEIEEYLVFYTDRASLADKDW 996

  Fly  1158 SVEAFAGEETMLMLPNLKPYTTYYFKVQARTTKGANNAPFSALVSYTTSAAVTMQEPD------- 1215
            ::...||::....:.||.|...|:||:|||..||  :.|||::|.||.|....:...|       
 Worm   997 TINYVAGDKLSHQVSNLLPKANYFFKIQARNEKG--HGPFSSVVGYTPSGGAILSGKDRHNARGH 1059

  Fly  1216 -TIAKG------------IDNEKLLYIIIAATAVVLLVVLLGVLLLCRRKPQSSPEHTKKSYQ-- 1265
             :.|.|            :.:..|..|::||.|::|::.|:.:::.|.::  ||....|..||  
 Worm  1060 GSAASGDTVSLVDQLQSLLHSNPLYLILLAAFALILILTLILIIMCCWKR--SSGGGRKNGYQSG 1122

  Fly  1266 -KNNVGVPK----------PPDLWIHHDQMELKNIDKGLHTVTPVCSDGASSSGALTLPRSVVHS 1319
             |.:.|...          |.||||:         ..|.|          ..:||         |
 Worm  1123 KKTSAGAGSGGGIGGLGGPPNDLWIN---------GTGSH----------MRAGA---------S 1159

  Fly  1320 EYEVETPVPGHVTNSLDKRSYVPGYMTTSMNGTMERPQYPRTQYSHQNRSHMTMEAGLSQQSLTQ 1384
            :|.|:.....|:| :.|..|..|.|......||:       |:..||           |.|||..
 Worm  1160 DYMVDGLATAHLT-AADIESPTPRYHHLQGQGTL-------TRSYHQ-----------SSQSLEG 1205

  Fly  1385 PQSNSMAQTP------------------EHPYGGYDANFCNAGNA--------AAGNGCVSTIES 1423
            .|     :||                  |.|||...|    .|:|        |..:|..:.|:.
 Worm  1206 RQ-----RTPQVVYTGTGRHQPIQRIDFESPYGSSSA----IGSASTPPLPMQAPPSGPPTVIDG 1261

  Fly  1424 SK--RGHP--------LKSF-----SVPGPP---------PT-----GGATPVTKHTPAVTIRPQ 1459
            .:  ||.|        |:||     :.|.||         ||     |...||.:.|....:...
 Worm  1262 YRTLRGTPPNSSAANALRSFTQLAGATPPPPHSAASSSSRPTIIAAGGRQVPVGRATAQPRVNVA 1326

  Fly  1460 N-QSPYKKPSFSA-----------------ATPNRLQGGGSVVHSTDEIQ--RLAPSTSTEELNQ 1504
            | .||:...|.|:                 .||.:....||   |..|..  .:.||.|.|:||.
 Worm  1327 NIYSPFASCSASSDAGESDKKSGECMEMRETTPIKSNTAGS---SNGEKMNTNMNPSHSAEDLNA 1388

  Fly  1505 EMANLEGLMKDLSAITAN-EFE 1525
            .:.||:.::.||..:..| .||
 Worm  1389 HLENLDTMLDDLQQLQHNLHFE 1410

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fraNP_523716.2 Ig 36..140 CDD:299845 34/117 (29%)
Ig <180..222 CDD:299845 12/42 (29%)
IG_like 257..340 CDD:214653 28/82 (34%)
IGc2 264..327 CDD:197706 20/62 (32%)
I-set 344..430 CDD:254352 27/86 (31%)
Ig 363..428 CDD:299845 21/65 (32%)
FN3 611..703 CDD:238020 30/91 (33%)
FN3 711..799 CDD:238020 24/92 (26%)
FN3 806..897 CDD:238020 34/92 (37%)
FN3 908..989 CDD:238020 30/80 (38%)
FN3 1011..1097 CDD:238020 34/87 (39%)
FN3 1109..1205 CDD:238020 36/96 (38%)
Neogenin_C 1273..1521 CDD:284094 76/332 (23%)
unc-40NP_491664.1 I-set 42..130 CDD:254352 30/103 (29%)
Ig 43..142 CDD:299845 34/114 (30%)
I-set 149..236 CDD:254352 22/92 (24%)
Ig 158..237 CDD:299845 22/84 (26%)
IG_like 251..332 CDD:214653 28/82 (34%)
IGc2 258..320 CDD:197706 21/63 (33%)
I-set 336..422 CDD:254352 27/86 (31%)
Ig 352..422 CDD:299845 23/70 (33%)
FN3 441..529 CDD:238020 30/90 (33%)
FN3 536..627 CDD:238020 24/93 (26%)
FN3 635..727 CDD:238020 34/91 (37%)
FN3 738..816 CDD:214495 29/77 (38%)
FN3 852..927 CDD:214495 30/79 (38%)
FN3 946..1038 CDD:238020 34/93 (37%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 69 1.000 Domainoid score I6306
eggNOG 1 0.900 - - E1_KOG4221
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 511 1.000 Inparanoid score I711
Isobase 1 0.950 - 0 Normalized mean entropy S5881
OMA 1 1.010 - - QHG46607
OrthoDB 1 1.010 - - D118438at33208
OrthoFinder 1 1.000 - - FOG0002773
OrthoInspector 1 1.000 - - oto18779
orthoMCL 1 0.900 - - OOG6_105369
Panther 1 1.100 - - LDO PTHR44170
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3265
SonicParanoid 1 1.000 - - X1863
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
1514.860

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