DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fra and unc-89

DIOPT Version :9

Sequence 1:NP_523716.2 Gene:fra / 36377 FlyBaseID:FBgn0011592 Length:1526 Species:Drosophila melanogaster
Sequence 2:NP_001020985.1 Gene:unc-89 / 171990 WormBaseID:WBGene00006820 Length:8081 Species:Caenorhabditis elegans


Alignment Length:1665 Identity:327/1665 - (19%)
Similarity:558/1665 - (33%) Gaps:498/1665 - (29%)


- Green bases have known domain annotations that are detailed below.


  Fly    69 KSNLPSSVS----IRWRGPDGQDLVIVGDTFRTQLKNGSLYISSVEENRGLTGAYQCLLT----- 124
            |..:|.::.    |..:|.:|...:::.||                 |....|.|.|..|     
 Worm  3615 KDGVPIAIDNQHVIEKKGENGSHTLVIKDT-----------------NNADFGKYTCQATNKAGK 3662

  Fly   125 AEGVGSI----LSRPALVAIVRQPDLNQDFLETYLLPGQTAYFRCMLGEANWQEGVKHSVQWLKD 185
            .|.||.:    .|.....|...:|...:...||:.:.|.|....|.:.:.:..:     :::.|:
 Worm  3663 DETVGELKIPKYSFEKQTAEEVKPLFIEPLKETFAVEGDTVVLECKVNKESHPQ-----IKFFKN 3722

  Fly   186 DLPLPLDK-LRMVVLPNG--ALEIDEVGPSDRGSYQCNVTSGSSSRLSSKTNLNIKKPSDPGAEN 247
            |.|:.:.: :::.||.:|  .|.|......|.|:|:|...:.:.   .:.||.::|.......|.
 Worm  3723 DQPVEIGQHMQLEVLEDGNIKLTIQNAKKEDVGAYRCEAVNVAG---KANTNADLKIQFAAKVEE 3784

  Fly   248 SV-----------------------------APSFLVGPSPKTVREGDTVTLDCVANGVPKPQIK 283
            .|                             ||.|:......||.|.....|.|...|.|:|:||
 Worm  3785 HVTDESGQLEEIGQFETVGDTASSKTDTGRGAPEFVELLRSCTVTEKQQAILKCKVKGEPRPKIK 3849

  Fly   284 WLRNGMDLDFN-DLDSRFSIVGTGSLQISSAEDIDSGNYQCRASNTVDSLDAQATVQVQ------ 341
            |.:.|.:::.: .:.:.....||.:|...:....|:|.|:|.|.|...|...:..:.|.      
 Worm  3850 WTKEGKEVEMSARVRAEHKDDGTLTLTFDNVTQADAGEYRCEAENEYGSAWTEGPIIVTLEGAPK 3914

  Fly   342 ---EPPKFIKAPKDTTAHEKDEPELKCDIWGKPKPVIRWLKNGDLITPNDYMQ---LVDG-HNLK 399
               |.|.|::..|.......:...|:..|.|||||.::|.|||:.:.|:|.::   |.|| ..|.
 Worm  3915 IDGEAPDFLQPVKPAVVTVGETAVLEGKISGKPKPSVKWYKNGEELKPSDRVKIENLDDGTQRLT 3979

  Fly   400 ILGLLNSDAGMFQCVGTNAAGSVHAAARL------RVVP------QGVKIKKRKSQGHSTKSLQT 452
            :......|...::|..:|..|.|.:...|      :|.|      ..:::|:.::.....|...|
 Worm  3980 VTNAKLDDMDEYRCEASNEFGDVWSDVTLTVKEPAQVAPGFFKELSAIQVKETETAKFECKVSGT 4044

  Fly   453 FDNLTKRRKPFNSGEQLRTKSGGSFPFPD--------EDDDLDD---------NDSGTTRLRIPS 500
            ..::    |.|..|..|:......|...|        ||...||         ||:|....::|.
 Worm  4045 KPDV----KWFKDGTPLKEDKRVHFESTDDGTQRLVIEDSKTDDQGNYRIEVSNDAGVANSKVPL 4105

  Fly   501 GKLP----KFEQPLNDRRFNILNA--------------------GSALPLDNQ-SKSYEDDDDDY 540
            ..:|    |.::.|.|  .|:...                    |:.....:| :|..:..:.:|
 Worm  4106 TVVPSETLKIKKGLTD--VNVTQGTKILLSVEVEGKPKTVKWYKGTETVTSSQTTKIVQVTESEY 4168

  Fly   541 D-EDDPAKEALLEAYK--QGEDAHKILDSWQQSKSKKSQQQKQSPASPDSPEQDPSVPHPGGKPL 602
            . |.:.|:.:...||:  ...|:..:..|...:.:|.:  :|.|..|......|.|||.  |.||
 Worm  4169 KLEIESAEMSDTGAYRVVLSTDSFSVESSATVTVTKAA--EKISLPSFKKGLADQSVPK--GTPL 4229

  Fly   603 DSGLQARLPSQPRDLVAQIVKSRFVTLSWVEPLQNAGDVVYYTVYYKMNNSEREQKMVTKSHDDQ 667
              .|:..:..:|:|            :.|                ||..:..::.|:....:...
 Worm  4230 --VLEVEIEGKPKD------------VKW----------------YKNGDEIKDGKVEDLGNGKY 4264

  Fly   668 QVNIQSLLPGRTYQFRVEANTNFGSGASSAPLEVSTQPE-------------------VNIAGPP 713
            ::.|.........::.|.|....|...|.|.:.||.:||                   |.:.||.
 Worm  4265 RLTIPDFQEKDVGEYSVTAANEAGEIESKAKVNVSAKPEIVSGLVPTTVKQGETATFNVKVKGPV 4329

  Fly   714 RNFEGYARSHKEIYVKWEEPTVTNGEILKYRVYYSENDSGADLYHDSTALEAVLTELRPHTDYVI 778
            :..:.| ::.|||.   :..|..||:                   .|.:||....::....||  
 Worm  4330 KGVKWY-KNGKEIP---DAKTKDNGD-------------------GSYSLEIPNAQVEDAADY-- 4369

  Fly   779 SVVPFNRNGMGDSSAEIRVKTFSSTPSEPPNNVTLEVTSSSSITVHWEPPAEEDRNGQITGYKIR 843
            .||..|..|..||||.:.||    ...:..:.|..|:.|....|.        .:.|:...:.::
 Worm  4370 KVVVSNDAGDADSSAALTVK----LADDGKDKVKPEIVSGLIPTT--------VKQGETATFNVK 4422

  Fly   844 ----------YRKFKDAPQVKSTPANIRYFEL----SNLDRNAEYQVKI----------AAMTVN 884
                      |:..|:.|..|:.......:.|    :.||..|:|:|.:          ||:||.
 Worm  4423 VKGPVKQVKWYKNGKEIPNAKAKDNGDGSYSLEIPNAQLDDTADYKVVVSNDAGDADSSAALTVK 4487

  Fly   885 GSGPFTEWNRANTLENDLDETQVP-GKPIWISIHPGANNIALHW---GPPQHPEIKIRNYVLGWG 945
            ..|        ..:...|::.:|| ||...:.:........:.|   |....|..|.:....|..
 Worm  4488 LPG--------IAIVKGLEDAEVPKGKKAVLQVETNKKPKEIKWYKNGKEITPSDKAQPGSDGDN 4544

  Fly   946 RG---IPDEN-------------------------TIELKETERYHILKNLESNMDYVVSLRARN 982
            :.   |||..                         |::|...|. .|:|.||   |.|||:    
 Worm  4545 KPQLVIPDAGDDDAAEYKVVLTDEDGNTADSSCALTVKLPAKEP-KIIKGLE---DQVVSI---- 4601

  Fly   983 VKGDGPPIYDNIKT------------------------RDEEPVDAPTPLEVPVGLRAIT----- 1018
                |.||...|:|                        :.::..|....||:|..:...|     
 Worm  4602 ----GSPIKLEIETSGSPKTVKWYKNGKELPGAAAKTIKIQKIDDNKYVLEIPSSVVEDTGDYKV 4662

  Fly  1019 ---------MSSSSIVVYWIDTMLN--KNQHVT--DNRHYTVSYG--------------ITGSNR 1056
                     .||..|.|....|.|.  |:|.:|  :|..::|...              |..::|
 Worm  4663 EVANEAGSANSSGKITVEPKITFLKPLKDQSITEGENAEFSVETNTKPRIVKWYKNGQEIKPNSR 4727

  Fly  1057 YRYHNTTDLNCMI---NDLRPNTQ-YEFAVKVVKGRRESSWSMSVLNST---------YQNVPVT 1108
            :.....||....:   |.:|.:.. |:..::...|..|||..::|..:.         .::..|.
 Worm  4728 FIIEQKTDTKYQLVIKNAVRDDADTYKIVLENTAGEAESSAQLTVKKAKAGLCKIVKGLEDQVVA 4792

  Fly  1109 PPREVTVRLDEMNPPTVIVQWIPPKHTLGQITGYNIYYTTDTTKRDRDWSVEAFAGEETMLMLP- 1172
            ...::...:.....|. .|:|:...:.:.......|....|||.|               |::| 
 Worm  4793 KGAKMVFEVKIQGEPE-DVRWLRDANVISAGANAIIEKIDDTTYR---------------LIIPS 4841

  Fly  1173 -NLKPYTTYYFKVQARTTKGANNAPFSALVSYTTSAAVTMQEPDTIAKGIDN-------EKLLYI 1229
             :||....|..:|...:.|..::|...            :.|...|.:|::|       :.:..:
 Worm  4842 ADLKDAGEYTVEVINESGKAKSDAKGE------------VDEKPEIVRGLENIEIPEGDDDVFKV 4894

  Fly  1230 IIAATAVVLLVVLLGVLLLCRR----------KPQSSPEHTKKSYQKNNVGVPKPPDLWIHHDQM 1284
            .::|..              |:          ||.|..|..|       :| ||..:|.|:..|:
 Worm  4895 EVSAPV--------------RQVKWYKNDQEIKPNSHLEAKK-------IG-PKKYELAINRAQL 4937

  Fly  1285 ELKNIDKGLHTVTPVCSDGA---SSSGALTLPRSVV------HSEYEVETPVPGHVTNSLDKRSY 1340
            :    |...:.|  |.|:.|   .||.|||:.:..|      ..:.:||.|.|..:...::.   
 Worm  4938 D----DGADYKV--VLSNAAGDCDSSAALTVVKPNVLKIVDGLKDVDVEEPQPVELKVKVEG--- 4993

  Fly  1341 VPGYMTTSMNGTMERPQYPRTQYSHQNRSHMTMEAGLSQQSLTQPQSNSMAQTPEHPYGGYDANF 1405
            :|..:....||...:|.....::..:..|        .:.|||.|.|....       ||     
 Worm  4994 IPKVIKWYKNGQELKPDADGFKFEEKPES--------GEFSLTIPSSKKSD-------GG----- 5038

  Fly  1406 CNAGNAAAGN-------GCVSTIESSKRGHPLKSFSVPGP 1438
              |.....||       |.|..::|:|...|....:...|
 Worm  5039 --AYRVVLGNDKGEVYSGSVVHVKSAKSSEPTSGANFLSP 5076

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fraNP_523716.2 Ig 36..140 CDD:299845 16/83 (19%)
Ig <180..222 CDD:299845 12/44 (27%)
IG_like 257..340 CDD:214653 22/83 (27%)
IGc2 264..327 CDD:197706 18/63 (29%)
I-set 344..430 CDD:254352 26/95 (27%)
Ig 363..428 CDD:299845 22/68 (32%)
FN3 611..703 CDD:238020 13/91 (14%)
FN3 711..799 CDD:238020 23/87 (26%)
FN3 806..897 CDD:238020 20/114 (18%)
FN3 908..989 CDD:238020 23/112 (21%)
FN3 1011..1097 CDD:238020 24/121 (20%)
FN3 1109..1205 CDD:238020 16/97 (16%)
Neogenin_C 1273..1521 CDD:284094 40/182 (22%)
unc-89NP_001020985.1 SH3 65..124 CDD:302595
RhoGEF 153..328 CDD:238091
PH_unc89 341..455 CDD:270134
Ig 568..634 CDD:143165
I-set <570..638 CDD:254352
I-set 648..737 CDD:254352
Ig 661..728 CDD:299845
I-set 748..837 CDD:254352
IGc2 761..827 CDD:197706
I-set 844..935 CDD:254352
I-set 946..1034 CDD:254352
Ig 954..1034 CDD:299845
I-set 1044..1133 CDD:254352
Ig <1060..1132 CDD:299845
I-set 1140..1237 CDD:254352
Ig 1146..1237 CDD:299845
RCSD 1384..1491 CDD:282963
RCSD 1481..1590 CDD:282963
RCSD 1576..1678 CDD:282963
RCSD 1735..1819 CDD:282963
RCSD 1789..>1860 CDD:282963
I-set 1982..2068 CDD:254352
Ig 2009..2069 CDD:299845
Ig_TrkABC_d4 2075..2164 CDD:143173
I-set 2081..2164 CDD:254352
I-set 2171..2262 CDD:254352
Ig <2198..2262 CDD:299845
I-set 2269..2360 CDD:254352
Ig 2270..2360 CDD:299845
I-set 2367..2456 CDD:254352
IGc2 2380..2446 CDD:197706
I-set 2463..2554 CDD:254352
Ig 2490..2554 CDD:299845
I-set 2563..2652 CDD:254352
Ig 2579..2647 CDD:143165
I-set 2659..2747 CDD:254352
Ig 2667..2747 CDD:299845
I-set 2754..2843 CDD:254352
Ig 2777..2841 CDD:143165
I-set 2887..2981 CDD:254352
Ig 2904..2978 CDD:143165
I-set 2994..3082 CDD:254352
IGc2 3009..3072 CDD:197706
I-set 3087..3183 CDD:254352
Ig 3101..3179 CDD:299845
I-set 3189..3279 CDD:254352
Ig 3206..3276 CDD:299845
I-set 3286..3377 CDD:254352
Ig 3303..3374 CDD:143165
I-set 3384..3472 CDD:254352
Ig 3402..3472 CDD:143165
I-set 3482..3573 CDD:254352
Ig 3501..3570 CDD:143165
I-set 3580..3671 CDD:254352 15/72 (21%)
IGc2 3593..3661 CDD:197706 12/62 (19%)
I-set 3686..3776 CDD:254352 20/97 (21%)
IGc2 3699..3766 CDD:197706 15/71 (21%)
I-set 3817..3902 CDD:254352 24/84 (29%)
Ig 3834..3899 CDD:143165 18/64 (28%)
I-set 3920..4010 CDD:254352 26/89 (29%)
Ig 3921..4010 CDD:299845 25/88 (28%)
I-set 4018..4107 CDD:254352 18/92 (20%)
Ig 4046..4107 CDD:299845 14/64 (22%)
Ig 4108..4201 CDD:299845 15/94 (16%)
I-set 4114..4202 CDD:254352 14/89 (16%)
I-set 4212..4298 CDD:254352 21/117 (18%)
IGc2 4226..4288 CDD:197706 13/91 (14%)
I-set 4302..4388 CDD:254352 25/110 (23%)
Ig 4319..4384 CDD:143165 21/89 (24%)
I-set 4400..4486 CDD:254352 16/93 (17%)
Ig 4417..4482 CDD:143165 10/64 (16%)
I-set 4493..4581 CDD:254352 13/87 (15%)
Ig 4518..>4566 CDD:299845 8/47 (17%)
I-set 4588..4679 CDD:254352 21/102 (21%)
Ig 4599..4679 CDD:299845 15/87 (17%)
I-set 4685..4772 CDD:254352 17/86 (20%)
Ig <4713..4772 CDD:299845 11/58 (19%)
I-set 4781..4869 CDD:254352 17/115 (15%)
Ig 4790..4869 CDD:299845 17/106 (16%)
I-set 4873..4962 CDD:254352 25/116 (22%)
Ig 4891..4960 CDD:299845 20/96 (21%)
I-set 4969..5059 CDD:254352 21/114 (18%)
Ig 4985..5051 CDD:143165 15/90 (17%)
I-set 5073..5161 CDD:254352 1/4 (25%)
Ig 5094..5161 CDD:299845
I-set 5171..5260 CDD:254352
Ig 5189..5255 CDD:143165
I-set 5277..5367 CDD:254352
IGc2 5291..5357 CDD:197706
I-set 5383..5473 CDD:254352
IGc2 5397..5463 CDD:197706
I-set 5487..5577 CDD:254352
IGc2 5501..5567 CDD:197706
I-set 5595..5684 CDD:254352
Ig 5614..5681 CDD:143165
I-set 5701..5791 CDD:254352
IGc2 5714..5781 CDD:197706
I-set 5815..5905 CDD:254352
IGc2 5828..5895 CDD:197706
I-set 5925..6015 CDD:254352
Ig 5939..6015 CDD:299845
I-set 6038..6131 CDD:254352
Ig 6058..6126 CDD:143165
I-set 6150..6240 CDD:254352
Ig 6168..6237 CDD:143165
FN3 6275..6358 CDD:214495
IG_like 6413..6501 CDD:214653
Ig 6427..6499 CDD:143165
I-set 6507..6597 CDD:254352
Ig 6529..6594 CDD:143165
PK_Unc-89_rpt1 6620..6878 CDD:271011
S_TKc 6640..6878 CDD:214567
I-set 7528..7616 CDD:254352
Ig 7546..7616 CDD:299845
FN3 7621..7716 CDD:238020
STKc_Unc-89_rpt2 7781..8035 CDD:271014
S_TKc 7793..8035 CDD:214567
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 58 1.000 Domainoid score I7159
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
32.910

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