DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fra and DCC

DIOPT Version :9

Sequence 1:	NP_523716.2	Gene:	fra / 36377	FlyBaseID:	FBgn0011592	Length:	1526	Species:	Drosophila melanogaster
Sequence 2:	NP_005206.2	Gene:	DCC / 1630	HGNCID:	2701	Length:	1447	Species:	Homo sapiens

Alignment Length:	1699	Identity:	495/1699 - (29%)
Similarity:	738/1699 - (43%)	Gaps:	437/1699 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SSRTLWNWLLSSCLIFQLIGSSL-------------ASQALSFTLEPQDAVVPEGHSVLLQCAGT 59
            |.|.:|    ...|.|.|.|:||             |..||.|..||.|||...|.:|||.|:
Human     4 SLRCVW----VPKLAFVLFGASLFSAHLQVTGFQIKAFTALRFLSEPSDAVTMRGGNVLLDCS-- 62

  Fly    60 ASIGRGGKSKSNLPSSVSIRWRGPDGQDLVIVGDTFRTQLKNGSLYISSVEENRGL---TGAYQC 121
                  .:|...:|   .|:|: .||..|.:..|..:.||.||||.|.::..:|..   .|.|||
Human    63 ------AESDRGVP---VIKWK-KDGIHLALGMDERKQQLSNGSLLIQNILHSRHHKPDEGLYQC 117

  Fly   122 LLTAEGVGSILSRPALVAI------VRQPDLNQDFLETYLLPGQTAYFRC-MLGE----ANWQEG 175
            ..:....|||:||.|.||:      :.|.:....|:      |.|...:| ::||    .:||:.
Human   118 EASLGDSGSIISRTAKVAVAGPLRFLSQTESVTAFM------GDTVLLKCEVIGEPMPTIHWQKN 176

  Fly   176 VKHSVQWLKDDL-PLPLDKLRMVVLPNGALEIDEVGPSDRGSYQCNVTSGSSSRLSSKTNLNIKK 239
                    :.|| |:|.|. |:||||:|||:|..:.|.|.|.|:|:..:.:|||..::..:.|.
Human   177 --------QQDLTPIPGDS-RVVVLPSGALQISRLQPGDIGIYRCSARNPASSRTGNEAEVRIL- 231

  Fly   240 PSDPGAENSVAPSFLVGPSPKTVREGDTVTLDCVANGVPKPQIKWLRNGMDLDFNDLDSRFSIVG 304
             ||||....:  .||..||.....||....|:|..:|.|.|...|||....:...  ..::|::|
Human   232 -SDPGLHRQL--YFLQRPSNVVAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLR--SKKYSLLG 291

  Fly   305 TGSLQISSAEDIDSGNYQCRASNTVDSLDAQATVQVQEPPKFIKAPKDTTAHEKDEPELKCDIWG 369
            ..:|.||:..|.|||.|.|..:...:::.|.|.:.|..||.|:..|.:..|:|..:.|.:|.:.|
Human   292 GSNLLISNVTDDDSGMYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECTVSG 356

  Fly   370 KPKPVIRWLKNGDLITPNDYMQLVDGHNLKILGLLNSDAGMFQCVGTNAAGSVHAAARLRVVPQG 434
            ||.|.:.|:||||::.|:||.|:|.|.||:|||::.||.|.:|||..|.||:...:|:| :||:
Human   357 KPVPTVNWMKNGDVVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQTSAQL-IVPK- 419

  Fly   435 VKIKKRKSQGHSTKSLQTFDNLTKRRKPFNSGEQLRTKSGGSFPFPDEDDDLDDNDSGTTRLRIP 499

Human   420 ----------------------------------------------------------------- 419

  Fly   500 SGKLPKFEQPLNDRRFNILNAGSALPLDNQSKSYEDDDDDYDEDDPAKEALLEAYKQGEDAHKIL 564

Human   420 ----------------------------------------------------------------- 419

  Fly   565 DSWQQSKSKKSQQQKQSPASPDSPEQDPSVPHPGGKPLDSGLQARLPSQPRDLVAQIVKSRFVTL 629
                             ||.|.|     ||               |||.|||:|..:|.||||.|
Human   420 -----------------PAIPSS-----SV---------------LPSAPRDVVPVLVSSRFVRL 447

  Fly   630 SWVEPLQNAGDVVYYTVYYKMNNSEREQKMVTKSHDDQQVNIQSLLPGRTYQFRVEANTNFGSGA 694
            ||..|.:..|::..:||::......||:.:.|......|:.:.:|.|...|.|||.|...:|.|.
Human   448 SWRPPAEAKGNIQTFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGE 512

  Fly   695 SSAPLEVSTQPEVNIAGPPRNFEGYARSHKEIYVKWEEPTVTNGEILKYRVYYSENDSGADLYHD 759
            ||.|::|:||||:.:.||..|.:..:.|...|.:.||.|...||.:..||::.:|..:|.:...:
Human   513 SSQPIKVATQPELQVPGPVENLQAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIE 577

  Fly   760 STALEAVLTELRPHTDYVISVVPFNRNGMGDSSAEIRVKTFSSTPSEPPNNVTLEVTSSSSITVH 824
            ...|...|..|:..|:|.:..:.:||.|.|.|:.:|.|.|.|..||.||.||:|||.:|.||.|.
Human   578 VDGLSYKLEGLKKFTEYSLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNVSLEVVNSRSIKVS 642

  Fly   825 WEPPAEEDRNGQITGYKIRYRKFKDAPQVKSTPANIRYFELSNLDRNAEYQVKIAAMTVNGSGPF 889
            |.||....:||.|||||||:||.....::::...|..::..:.|::.::|..:::||||||:||.
Human   643 WLPPPSGTQNGFITGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPP 707

  Fly   890 TEWNRANTLENDLDETQVPGKPIWISIHPGANNIALHWGPPQHPEIKIRNYVLGWGRGIPDENTI 954
            :.|..|.|.||||||:|||.:|..:.:.|..|.|.:.|.||.:|.|.:|.|::|:|.|.|...|:
Human   708 SNWYTAETPENDLDESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETV 772

  Fly   955 ELKETERYHILKNLESNMDYVVSLRARNVKGDGPPIYDNIKTR---------------DEEPVDA 1004
            .:...:||:.::.|||:..||:||:|.|..|:|.|:|::..||               |:.|...
Human   773 RVDSKQRYYSIERLESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSV 837

  Fly  1005 P---TPLEVPVGLRAITMSSSSIVVYWIDTMLNKNQHVTDNRHYTVSY--GITGSNRYRYHNTTD 1064
            |   ||:..|||::|:.::..::.|.|.|..:.|||..::.|.|||.:  ..:.|.:|:..:||.
Human   838 PDLSTPMLPPVGVQAVALTHDAVRVSWADNSVPKNQKTSEVRLYTVRWRTSFSASAKYKSEDTTS 902

  Fly  1065 LNCMINDLRPNTQYEFAVKVVKGRRESSWSMSVLNSTYQNVPVTPPREVTVRLDEMNPPTVIVQW 1129
            |:.....|:|||.|||:|.|.|.||.|:|||:...:||:..|.:.|:::||...|..|..|||.|
Human   903 LSYTATGLKPNTMYEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSW 967

  Fly  1130 IPPKHTLGQITGYNIYYTTDTTKRDRDWSVEAFAGEETMLMLPNLKPYTTYYFKVQARTTKGANN 1194
            .||....|:||.|.::||.|......||.:|..:|:.....:.:|...|.|||::|||.:||.
Human   968 QPPLEANGKITAYILFYTLDKNIPIDDWIMETISGDRLTHQIMDLNLDTMYYFRIQARNSKGV-- 1030

  Fly  1195 APFSALVSYTTSAAVTMQEPDTIAKG----------------ID--------------------- 1222
            .|.|..:.:.|   :.::.||.:|..                ||
Human  1031 GPLSDPILFRT---LKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTP 1092

  Fly  1223 --NEKLLYIIIAATAVVLLVVLLGVLLLCRRKPQSSPEHTKK------SYQKNNVGVPKPPDLWI 1279
              |..||.||:....|:.::|::.|.::|.|:  ||.:..||      ..:|.:....:||||||
Human  1093 QKNSNLLVIIVVTVGVITVLVVVIVAVICTRR--SSAQQRKKRATHSAGKRKGSQKDLRPPDLWI 1155

  Fly  1280 HHDQMELKNIDKGLHT--------------VTPVC---------SDGASSSG---------ALTL 1312
            ||::||:|||:|...|              :|||.         |...|.||         ..||
Human  1156 HHEEMEMKNIEKPSGTDPAGRDSPIQSCQDLTPVSHSQSETQLGSKSTSHSGQDTEEAGSSMSTL 1220

  Fly  1313 PRSV-VHSEYEVETPVPGHVTNSLDKRSYVPGYMTTSMNGTMERPQY------PRTQYSH----- 1365
            .||: .......:..:|      :|.:|..|..::.....|:|..||      |...|.|
Human  1221 ERSLAARRAPRAKLMIP------MDAQSNNPAVVSAIPVPTLESAQYPGILPSPTCGYPHPQFTL 1279

  Fly  1366 ---------------QNRSHMTMEAGLSQQSLTQPQSNSMAQTPEHPYGGYDANFCNAGNAAAGN 1415
                           ..||....|...:||....|.|.     |||      ::...|.:.....
Human  1280 RPVPFPTLSVDRGFGAGRSQSVSEGPTTQQPPMLPPSQ-----PEH------SSSEEAPSRTIPT 1333

  Fly  1416 GCVSTIESSKRGHPLKSFSVP-GPPPTGGATPVTKHTPAVTIRPQNQSP--------------YK 1465
            .||      :..|||:||:.| .|||.....|...:||.:: :|....|              .:
Human  1334 ACV------RPTHPLRSFANPLLPPPMSAIEPKVPYTPLLS-QPGPTLPKTHVKTASLGLAGKAR 1391

  Fly  1466 KPSFSAATPNRLQGGGSVVHSTDEIQRLAPSTSTE---------------ELNQEMANLEGLMKD 1515
            .|....:.|.                  ||..|.|               :|:::||:||||||.
Human  1392 SPLLPVSVPT------------------APEVSEESHKPTEDSANVYEQDDLSEQMASLEGLMKQ 1438

  Fly  1516 LSAITANEF 1524
            |:|||.:.|
Human  1439 LNAITGSAF 1447

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fra	NP_523716.2	Ig	36..140	CDD:299845	38/106 (36%)
		Ig	<180..222	CDD:299845	19/42 (45%)
		IG_like	257..340	CDD:214653	25/82 (30%)
		IGc2	264..327	CDD:197706	21/62 (34%)
		I-set	344..430	CDD:254352	38/85 (45%)
		Ig	363..428	CDD:299845	31/64 (48%)
		FN3	611..703	CDD:238020	35/91 (38%)
		FN3	711..799	CDD:238020	26/87 (30%)
		FN3	806..897	CDD:238020	38/90 (42%)
		FN3	908..989	CDD:238020	30/80 (38%)
		FN3	1011..1097	CDD:238020	35/87 (40%)
		FN3	1109..1205	CDD:238020	34/95 (36%)
		Neogenin_C	1273..1521	CDD:284094	82/336 (24%)
DCC	NP_005206.2	Ig1_Neogenin	41..136	CDD:143199	38/106 (36%)
		IG_like	46..136	CDD:214653	36/101 (36%)
		IG_like	147..224	CDD:214653	30/91 (33%)
		IGc2	153..219	CDD:197706	26/80 (33%)
		I-set	241..327	CDD:254352	27/87 (31%)
		Ig	244..327	CDD:299845	25/84 (30%)
		I-set	331..417	CDD:254352	38/86 (44%)
		Ig	347..417	CDD:299845	33/70 (47%)
		FN3	429..521	CDD:238020	35/91 (38%)
		FN3	528..617	CDD:238020	26/88 (30%)
		FN3	625..715	CDD:238020	38/89 (43%)
		FN3	726..805	CDD:214495	29/78 (37%)
		FN3	846..939	CDD:238020	35/92 (38%)
		FN3	946..1041	CDD:238020	34/96 (35%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1126..1152		5/25 (20%)
		Neogenin_C	1148..1445	CDD:284094	83/338 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1165..1222		12/56 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1288..1330		11/52 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1394..1419		5/42 (12%)
		Interaction with MYO10. /evidence=ECO:0000269\|PubMed:21642953	1432..1439		6/6 (100%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	96	1.000	Domainoid score	I7351
eggNOG	1	0.900	-	-		E1_KOG4221
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	711	1.000	Inparanoid score	I649
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG46607
OrthoDB	1	1.010	-	-		D118438at33208
OrthoFinder	1	1.000	-	-		FOG0002773
OrthoInspector	1	1.000	-	-		otm41079
orthoMCL	1	0.900	-	-		OOG6_105369
Panther	1	1.100	-	-	O	PTHR44170
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3265
SonicParanoid	1	1.000	-	-		X1863
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	14	13.870