DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fra and Dcc

DIOPT Version :9

Sequence 1:NP_523716.2 Gene:fra / 36377 FlyBaseID:FBgn0011592 Length:1526 Species:Drosophila melanogaster
Sequence 2:NP_031857.2 Gene:Dcc / 13176 MGIID:94869 Length:1447 Species:Mus musculus


Alignment Length:1685 Identity:487/1685 - (28%)
Similarity:732/1685 - (43%) Gaps:431/1685 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 LIFQLIGSSLAS-------------QALSFTLEPQDAVVPEGHSVLLQCAGTASIGRGGKSKSNL 72
            |.|.|.|:||.|             .:|.|..||.|||...|.:|||.|:        .:|...:
Mouse    13 LAFVLFGASLLSAHLQVTGFQIKPFTSLHFVSEPSDAVTMRGGNVLLNCS--------AESDRGV 69

  Fly    73 PSSVSIRWRGPDGQDLVIVGDTFRTQLKNGSLYISSVEENRGL---TGAYQCLLTAEGVGSILSR 134
            |   .|:|: .||..|.:..|..:.||.||||.|.::..:|..   .|.|||..:....|||:||
Mouse    70 P---VIKWK-KDGLILALGMDDRKQQLPNGSLLIQNILHSRHHKPDEGLYQCEASLADSGSIISR 130

  Fly   135 PALVAI------VRQPDLNQDFLETYLLPGQTAYFRC-MLGE----ANWQEGVKHSVQWLKDDL- 187
            .|.|.:      :.|.:....|:      |.|...:| ::||    .:||:.        :.|| 
Mouse   131 TAKVTVAGPLRFLSQTESITAFM------GDTVLLKCEVIGEPMPTIHWQKN--------QQDLN 181

  Fly   188 PLPLDKLRMVVLPNGALEIDEVGPSDRGSYQCNVTSGSSSRLSSKTNLNIKKPSDPGAENSVAPS 252
            |||.|. |:||||:|||:|..:.|.|.|.|:|:..:.:|.|..::..:.|.  ||||....:  .
Mouse   182 PLPGDS-RVVVLPSGALQISRLQPGDSGVYRCSARNPASIRTGNEAEVRIL--SDPGLHRQL--Y 241

  Fly   253 FLVGPSPKTVREGDTVTLDCVANGVPKPQIKWLRNGMDLDFNDLDSRFSIVGTGSLQISSAEDID 317
            ||..||.....||....|:|..:|.|.|...|||....:...  ..::|::|..:|.||:..|.|
Mouse   242 FLQRPSNVIAIEGKDAVLECCVSGYPPPSFTWLRGEEVIQLR--SKKYSLLGGSNLLISNVTDDD 304

  Fly   318 SGNYQCRASNTVDSLDAQATVQVQEPPKFIKAPKDTTAHEKDEPELKCDIWGKPKPVIRWLKNGD 382
            ||.|.|..:...:::.|.|.:.|..||.|:..|.:..|:|..:.|.:|.:.|||.|.:.|:||||
Mouse   305 SGTYTCVVTYKNENISASAELTVLVPPWFLNHPSNLYAYESMDIEFECAVSGKPVPTVNWMKNGD 369

  Fly   383 LITPNDYMQLVDGHNLKILGLLNSDAGMFQCVGTNAAGSVHAAARLRVVPQGVKIKKRKSQGHST 447
            ::.|:||.|:|.|.||:|||::.||.|.:|||..|.||:..::|:| :||:              
Mouse   370 VVIPSDYFQIVGGSNLRILGVVKSDEGFYQCVAENEAGNAQSSAQL-IVPK-------------- 419

  Fly   448 KSLQTFDNLTKRRKPFNSGEQLRTKSGGSFPFPDEDDDLDDNDSGTTRLRIPSGKLPKFEQPLND 512
                                                                             
Mouse   420 ----------------------------------------------------------------- 419

  Fly   513 RRFNILNAGSALPLDNQSKSYEDDDDDYDEDDPAKEALLEAYKQGEDAHKILDSWQQSKSKKSQQ 577
                                                                             
Mouse   420 ----------------------------------------------------------------- 419

  Fly   578 QKQSPASPDSPEQDPSVPHPGGKPLDSGLQARLPSQPRDLVAQIVKSRFVTLSWVEPLQNAGDVV 642
                ||.|.|                    :.|||.|||::..:|.||||.|||..|.:..|::.
Mouse   420 ----PAIPSS--------------------SILPSAPRDVLPVLVSSRFVRLSWRPPAEAKGNIQ 460

  Fly   643 YYTVYYKMNNSEREQKMVTKSHDDQQVNIQSLLPGRTYQFRVEANTNFGSGASSAPLEVSTQPEV 707
            .:||::......||:.:.|......|:.:.:|.|...|.|||.|...:|.|.||.|::|:||||:
Mouse   461 TFTVFFSREGDNRERALNTTQPGSLQLTVGNLKPEAMYTFRVVAYNEWGPGESSQPIKVATQPEL 525

  Fly   708 NIAGPPRNFEGYARSHKEIYVKWEEPTVTNGEILKYRVYYSENDSGADLYHDSTALEAVLTELRP 772
            .:.||..|....:.|...|.:.||.|...||.:..||::.:|..:|.:...:...|...|..|:.
Mouse   526 QVPGPVENLHAVSTSPTSILITWEPPAYANGPVQGYRLFCTEVSTGKEQNIEVDGLSYKLEGLKK 590

  Fly   773 HTDYVISVVPFNRNGMGDSSAEIRVKTFSSTPSEPPNNVTLEVTSSSSITVHWEPPAEEDRNGQI 837
            .|:|.:..:.:||.|.|.|:.:|.|.|.|..||.||.|::|||.:|.||.|.|.||....:||.|
Mouse   591 FTEYTLRFLAYNRYGPGVSTDDITVVTLSDVPSAPPQNISLEVVNSRSIKVSWLPPPSGTQNGFI 655

  Fly   838 TGYKIRYRKFKDAPQVKSTPANIRYFELSNLDRNAEYQVKIAAMTVNGSGPFTEWNRANTLENDL 902
            ||||||:||.....::::...|..::..:.|::.::|..:::||||||:||.:.|..|.|.||||
Mouse   656 TGYKIRHRKTTRRGEMETLEPNNLWYLFTGLEKGSQYSFQVSAMTVNGTGPPSNWYTAETPENDL 720

  Fly   903 DETQVPGKPIWISIHPGANNIALHWGPPQHPEIKIRNYVLGWGRGIPDENTIELKETERYHILKN 967
            ||:|||.:|..:.:.|..|.|.:.|.||.:|.|.:|.|::|:|.|.|...|:.:...:||:.::.
Mouse   721 DESQVPDQPSSLHVRPQTNCIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRYYSIER 785

  Fly   968 LESNMDYVVSLRARNVKGDGPPIYDNIKTR---------------DEEPVDAP---TPLEVPVGL 1014
            |||:..||:||:|.|..|:|.|:|::..||               |:.|...|   ||:..|||:
Mouse   786 LESSSHYVISLKAFNNAGEGVPLYESATTRSITDPTDPVDYYPLLDDFPTSGPDVSTPMLPPVGV 850

  Fly  1015 RAITMSSSSIVVYWIDTMLNKNQHVTDNRHYTVSY--GITGSNRYRYHNTTDLNCMINDLRPNTQ 1077
            :|:.::..::.|.|.|..:.|||..:|.|.|||.:  ..:.|.:|:..:||.|:.....|:|||.
Mouse   851 QAVALTHEAVRVSWADNSVPKNQKTSDVRLYTVRWRTSFSASAKYKSEDTTSLSYTATGLKPNTM 915

  Fly  1078 YEFAVKVVKGRRESSWSMSVLNSTYQNVPVTPPREVTVRLDEMNPPTVIVQWIPPKHTLGQITGY 1142
            |||:|.|.|.||.|:|||:...:||:..|.:.|:::||...|..|..|||.|.||....|:||.|
Mouse   916 YEFSVMVTKNRRSSTWSMTAHATTYEAAPTSAPKDLTVITREGKPRAVIVSWQPPLEANGKITAY 980

  Fly  1143 NIYYTTDTTKRDRDWSVEAFAGEETMLMLPNLKPYTTYYFKVQARTTKGANNAPFSALVSYTTSA 1207
            .::||.|......||.:|..:|:.....:.:|...|.|||::|||..||.  .|.|..:.:.|  
Mouse   981 ILFYTLDKNIPIDDWIMETISGDRLTHQIMDLSLDTMYYFRIQARNVKGV--GPLSDPILFRT-- 1041

  Fly  1208 AVTMQEPDTIAKG----------------ID-----------------------NEKLLYIIIAA 1233
             :.::.||.:|..                ||                       |..||.|.:..
Mouse  1042 -LKVEHPDKMANDQGRHGDGGYWPVDTNLIDRSTLNEPPIGQMHPPHGSVTPQKNSNLLVITVVT 1105

  Fly  1234 TAVVLLVVLLGVLLLCRRKPQSSPEHTKK------SYQKNNVGVPKPPDLWIHHDQMELKNIDKG 1292
            ..|:.::|::.|.::|.|:  ||.:..||      |.:|.:....:||||||||::||:|||:|.
Mouse  1106 VGVLTVLVVVIVAVICTRR--SSAQQRKKRATHSVSKRKGSQKDLRPPDLWIHHEEMEMKNIEKP 1168

  Fly  1293 LHT--------------VTPVC---------SDGASSSG-------------------------A 1309
            ..|              :|||.         |..||.||                         .
Mouse  1169 TGTDPAGRDSPIQSCQDLTPVSHSQSETQMGSKSASHSGQDTEDAGSSMSTLERSLAARRATRAK 1233

  Fly  1310 LTLPRSVVHSEYEVETPVPGHVTNSLDKRSYVPGYMTTSMNGTMERPQYPRTQYSHQNRSHMTME 1374
            |.:|.....|...|.:.:|   ..:|:...| ||.:.:...|      ||..|::.:.....|:.
Mouse  1234 LMIPMEAQSSNPAVVSAIP---VPTLESAQY-PGILPSPTCG------YPHPQFTLRPVPFPTLS 1288

  Fly  1375 ------AG----LSQQSLTQPQSNSMAQTPEHPYGGYDANFCNAGNAAAGNGCVSTIESSKRGHP 1429
                  ||    :|:...||.|.......||||...      .|.:......||      :..||
Mouse  1289 VDRGFGAGRTQSVSEGPTTQQQPMLPPAQPEHPSSE------EAPSRTIPTACV------RPTHP 1341

  Fly  1430 LKSFSVP-GPPPTGGATPVTKHTPAVTIRPQNQSP--------------YKKPSFSAATPNRLQG 1479
            |:||:.| .|||.....|...:||.:: :|....|              .:.|....:.|.    
Mouse  1342 LRSFANPLLPPPMSAIEPKVPYTPLLS-QPGPTLPKTHVKTASLGLAGKARSPLLPVSVPT---- 1401

  Fly  1480 GGSVVHSTDEIQRLAPSTSTE---------------ELNQEMANLEGLMKDLSAITANEF 1524
                          ||..|.|               :|:::||:||||||.|:|||.:.|
Mouse  1402 --------------APEVSEESHKPTEDPASVYEQDDLSEQMASLEGLMKQLNAITGSAF 1447

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fraNP_523716.2 Ig 36..140 CDD:299845 38/106 (36%)
Ig <180..222 CDD:299845 20/42 (48%)
IG_like 257..340 CDD:214653 25/82 (30%)
IGc2 264..327 CDD:197706 21/62 (34%)
I-set 344..430 CDD:254352 38/85 (45%)
Ig 363..428 CDD:299845 31/64 (48%)
FN3 611..703 CDD:238020 34/91 (37%)
FN3 711..799 CDD:238020 26/87 (30%)
FN3 806..897 CDD:238020 37/90 (41%)
FN3 908..989 CDD:238020 30/80 (38%)
FN3 1011..1097 CDD:238020 36/87 (41%)
FN3 1109..1205 CDD:238020 34/95 (36%)
Neogenin_C 1273..1521 CDD:284094 82/335 (24%)
DccNP_031857.2 Ig1_Neogenin 42..136 CDD:143199 38/105 (36%)
IG_like 46..136 CDD:214653 36/101 (36%)
IG_like 147..224 CDD:214653 30/91 (33%)
IGc2 153..219 CDD:197706 27/80 (34%)
I-set 241..327 CDD:254352 27/87 (31%)
Ig 244..327 CDD:299845 25/84 (30%)
I-set 331..417 CDD:254352 38/86 (44%)
Ig 347..417 CDD:299845 33/70 (47%)
FN3 429..521 CDD:238020 34/91 (37%)
FN3 528..617 CDD:238020 26/88 (30%)
FN3 625..715 CDD:238020 37/89 (42%)
FN3 726..805 CDD:214495 29/78 (37%)
FN3 846..939 CDD:238020 36/92 (39%)
FN3 946..1041 CDD:238020 34/96 (35%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1126..1153 7/26 (27%)
Neogenin_C 1148..1445 CDD:284094 83/337 (25%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1166..1220 10/53 (19%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1291..1329 11/43 (26%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1394..1419 5/42 (12%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 91 1.000 Domainoid score I7671
eggNOG 1 0.900 - - E1_KOG4221
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 710 1.000 Inparanoid score I643
Isobase 00.000 Not matched by this tool.
OMA 1 1.010 - - QHG46607
OrthoDB 1 1.010 - - D118438at33208
OrthoFinder 1 1.000 - - FOG0002773
OrthoInspector 1 1.000 - - otm43150
orthoMCL 1 0.900 - - OOG6_105369
Panther 1 1.100 - - O PTHR44170
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R3265
SonicParanoid 1 1.000 - - X1863
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 1 0.960 - -
1413.870

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