DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fra and AgaP_AGAP010222

DIOPT Version :9

Sequence 1:	NP_523716.2	Gene:	fra / 36377	FlyBaseID:	FBgn0011592	Length:	1526	Species:	Drosophila melanogaster
Sequence 2:	XP_554133.3	Gene:	AgaP_AGAP010222 / 1279645	VectorBaseID:	AGAP010222	Length:	370	Species:	Anopheles gambiae

Alignment Length:	333	Identity:	79/333 - (23%)
Similarity:	116/333 - (34%)	Gaps:	88/333 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   158 GQTAYFRCMLGEANWQEGVKHSVQWLKDDLPLPLDKLRMVVLPN------------GALEIDEVG 210
            |:.|...|::.  |.|   .:.|.||:.|....|.....|:..|            ..|.|.:|.
Mosquito    62 GREAVLTCVIN--NLQ---TYKVAWLRVDTQTILTIQTHVITKNHRMTIAHVEGRAWVLRIRDVK 121

  Fly   211 PSDRGSYQCNVTSGSSSRLSSKTNLNIKKPSDP-----GAENSVAPSFLVGPSPKT---VREGDT 267
            .||:|.|.|.|.                  :||     |..|.|.|..::.....|   ||||..
Mosquito   122 ESDKGWYMCQVN------------------TDPMRNQIGYLNVVVPPNILDYPTSTDMVVREGSN 168

  Fly   268 VTLDCVANGVPKPQIKWLRNGMD-LDFNDLDSRFSIVGTGSL-----QISSAEDIDSGNYQCRAS 326
            |||.|.|:|.|.|.|.|.|.|.: :........:.:|.|.||     .||....:..|.|.|.||
Mosquito   169 VTLKCAASGSPTPSIIWRREGNEPISAGGRTGVYWVVMTTSLNSSTFSISRVNRLHMGAYLCIAS 233

  Fly   327 NTV-DSLDAQATVQVQEPPKFIKAPKDTTAHEKDEPELKCDIWGKPKPVIRWLKNGDLITP---- 386
            |.: .|:..:..:.|..||......:...|.......|:|.....|:.:..|:||..:||.
Mosquito   234 NGIPPSVSKRVMLIVHFPPMIWIQDQLVGAALGQRLTLECQSEAYPRSINYWMKNDTIITQVQTN 298

  Fly   387 -------------------------------NDYMQLVDGHNLKILGLLNSDAGMFQCVGTNAAG 420
                                           |.|..::   .|.|..:..:|.|.::||..|:.|
Mosquito   299 NKHKHDQLTINNERCNIISTGKHFEPSIKEINSYKVVM---KLTIKDINIADFGTYKCVVKNSLG 360

  Fly   421 SVHAAARL 428
            ....:.::
Mosquito   361 ETDGSIKV 368

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fra	NP_523716.2	Ig	36..140	CDD:299845
		Ig	<180..222	CDD:299845	15/53 (28%)
		IG_like	257..340	CDD:214653	30/92 (33%)
		IGc2	264..327	CDD:197706	24/68 (35%)
		I-set	344..430	CDD:254352	20/120 (17%)
		Ig	363..428	CDD:299845	18/99 (18%)
		FN3	611..703	CDD:238020
		FN3	711..799	CDD:238020
		FN3	806..897	CDD:238020
		FN3	908..989	CDD:238020
		FN3	1011..1097	CDD:238020
		FN3	1109..1205	CDD:238020
		Neogenin_C	1273..1521	CDD:284094
AgaP_AGAP010222	XP_554133.3	IG_like	55..148	CDD:214653	25/108 (23%)
		Ig	55..146	CDD:299845	24/106 (23%)
		IG_like	158..248	CDD:214653	30/89 (34%)
		IGc2	165..234	CDD:197706	24/68 (35%)
		IG_like	263..369	CDD:214653	19/109 (17%)
		Ig	269..367	CDD:143165	18/100 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910