DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fra and AgaP_AGAP003610

DIOPT Version :9

Sequence 1:	NP_523716.2	Gene:	fra / 36377	FlyBaseID:	FBgn0011592	Length:	1526	Species:	Drosophila melanogaster
Sequence 2:	XP_313369.5	Gene:	AgaP_AGAP003610 / 1274273	VectorBaseID:	AGAP003610	Length:	2338	Species:	Anopheles gambiae

Alignment Length:	1385	Identity:	270/1385 - (19%)
Similarity:	439/1385 - (31%)	Gaps:	455/1385 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly    31 ASQALSFTLEPQDAVVPEGHSVLLQCAGTASIGRGGKSKSNLPSSVSIRWRGPDGQDLVIVGDTF 95
            ||:...:..:..|...|.|.::.|||....             ..|::||...|.|  :......
Mosquito   317 ASRPPLYLTKLTDRSAPAGSTIKLQCTVEG-------------QEVTVRWLKNDQQ--IERTPNL 366

  Fly    96 RTQLKNGSLYISSVEE-NRGLTGAYQCLLTAEGVGSILSRPALVAIVRQPDLNQDFLETYLLPGQ 159
            :|...:| ||..:::. .....|.|:.|....| |.|.|    ||.|:..|..:...:.......
Mosquito   367 QTSAADG-LYTLTIKHLKHSDAGEYKILAKNRG-GEIPS----VAHVKVYDAIKPKCQLPFFVKI 425

  Fly   160 TAYFRCMLG----EAN--WQEGVKHSVQWLKDDLPLPLDKLRMVVLPNG----ALEIDEVGPSDR 214
            ..||...|.    ||.  :|:..:.::.||||..|:.||: |:.....|    .|.|.:..|.|.
Mosquito   426 RDYFHHALNDLVIEARIMFQKEYEPTITWLKDGEPIVLDQ-RIGATFEGEEIFQLNIYDPTPEDS 489

  Fly   215 GSYQC---------------------------NVTSGSSSRLS-------SKTNLNIK------- 238
            |.|.|                           .:|:.....|:       .:..|.||
Mosquito   490 GRYTCIAENEAGRCQMSHTVDFVDKVPYMRLPGITNADRKLLTEEEIEERKREELRIKTEAKERL 554

  Fly   239 -------KPSDPGAENSVAPSFLVGPSPK-----------TVREGDTVTLDCVANGVPKPQIKWL 285
                   :..|...|...:.|:::..|..           |..:|..|.:.|.||| |.|..||.
Mosquito   555 AGGGRTARGGDDVHEPYESESYVIRDSKNKLAWAGQLHNVTTTKGAIVKMTCSANG-PLPMFKWQ 618

  Fly   286 RNGMDLDFNDLDSRFSIVGTGSLQISSAEDIDSGNYQCRASNTVDSLDAQATVQV-------QEP 343
            |||..:||.|.....:....|.:.|:.....|:|.|.|.|.|:.:.:.....::|       ..|
Mosquito   619 RNGRAIDFGDHVKLMNSGAIGQIVINGVTRKDAGEYTCTAKNSHNEIKTTCVLKVITLPSAETTP 683

  Fly   344 PKFIKAPKDTTAHEKDEPELKCDIWGKPKPVIRWLKNGDLIT----------PNDYMQLVDGHNL 398
            ..|.:|.|:......|:..|:.::.|.|||.|.|.|:|:.|.          ||...||.
Mosquito   684 ATFTRAVKEFYDIRADDLVLEVNVHGLPKPTISWQKDGEDIVLGDKLLINREPNGVYQLC----- 743

  Fly   399 KILGLLNSDAGMFQCVGTNAAGSVHAAARLRVVPQGVKIKKRKSQGHSTKSLQTFDNLTKRRKPF 463
             |.....:|.|:::|...|:||:..       |...|....:....| .:.::..|...:|
Mosquito   744 -IHKPAPADCGVYECRAVNSAGTAK-------VSHEVSFTSKDKLIH-VQHIEHADYFKRR---- 795

  Fly   464 NSGEQLRTKSGGSFPFPDEDDDLDDNDSGTTRLRIPSGKLPKFEQPLNDRRFNILNAGSALPLDN 528
                 |..|...|.                                       :|.|....|.|.
Mosquito   796 -----LEEKEAASL---------------------------------------LLTAEPTPPTDQ 816

  Fly   529 QSKSYEDDDDDYDEDDPAKEALLEAYKQGEDA--HKILDSWQQSKSKKSQQQKQSPASPDSPEQD 591
            |.:          :..||.:|..:|.:|.|.|  .:.:...:.::.:..:...::|| |::..|:
Mosquito   817 QQQ----------QQQPASQAQSQAQQQAEPAATGEPVPPVEPAEGEAGEVDTEAPA-PEATAQE 870

  Fly   592 PSV---------PHPGGKPLDSGLQARLPSQPRDLVAQIVKSRFVTLSWVEPLQN----AGDVVY 643
            .:.         ..||.:..:.|     |.:|  .|.:..|:|   |.|...|:|    ||..:.
Mosquito   871 QTAAAAPKPKFKAMPGRRRFEDG-----PVEP--FVIRDSKNR---LMWETKLKNQTVPAGKSIK 925

  Fly   644 YT--------VYYKMNNSE-----REQKMVTKSHDDQQVNIQSLLPGRTYQFRVEANTNFGSGAS 695
            .|        .:..|.|.:     :.....||. :...|.|.......:.::...|..:||....
Mosquito   926 LTCSVTGPQPTWRWMKNGKPLVWSKSVVNATKV-EFGCVRITPTTVADSGEYTAYAKNSFGEIEC 989

  Fly   696 SAPL-------EVSTQP------------------EVNIAGPPRNFEGYARSHKEIYVKWEEPTV 735
            |..:       ::.|.|                  ||::.|.|.....:.|...|...:.:...:
Mosquito   990 SCTVTVFATEKDIETVPTFTRVIDYYDSLVDDLILEVHVRGVPDPKLTWERDGMEFTNETDRVII 1054

  Fly   736 T---NGEILKYR--------------VYYSENDSGAD-LYHDST-----ALEAVLTELRPHTDYV 777
            :   ||   .||              |..::|.:|.: |.|..|     ..::.||....|.|..
Mosquito  1055 SREGNG---VYRLSIHNPEKLDGGKWVVTAKNHAGEEKLKHSVTFKGREFYQSQLTHGIYHADKQ 1116

  Fly   778 ISVVPFNRNGMGDSSAEIRVKTFSSTPS-------EPPNNVTLEVTSSSSITVHWEPPAEEDRNG 835
            |:     |:.........|.::.|..||       ||..:..:|..::...|....|.|.....|
Mosquito  1117 IT-----RSEEDGFVYGTRSRSVSRAPSVAHQAGPEPDISAVVEALAAVEATTEDAPAAGAAAEG 1176

  Fly   836 QITGYKIRYRKFKDA------PQVKSTPANIR-------------------------------YF 863
            .        ....||      |:.|..|...|                               ||
Mosquito  1177 A--------EPAADAADAPEEPKKKKEPKQWRKNLQGLLKGRIPGPIAEEPTKHKVVEVLQKLYF 1233

  Fly   864 E--LSNLDRNAEYQVKIAAMTVNGSGPFTEWNRANTLENDLDETQVPGKPIWISIHPGANNIALH 926
            |  |.|.......|:|:....| |..|..:|.:                          |||.|.
Mosquito  1234 EANLKNQTVAEGSQLKLVCSCV-GPKPTIKWFK--------------------------NNIPLV 1271

  Fly   927 WGPPQHPEIKIRNYVLGWG------RGIPDENTI---------ELKET---------ERYHILKN 967
            |......:.|     :|.|      ..:.|..|.         |::.|         |:.|:..:
Mosquito  1272 WSKNVKNDTK-----MGVGAVHILSAELNDSGTYKCTASNAVGEVETTCKVIVYPVPEKQHVAPS 1331

  Fly   968 LESNM---------DYVVSLRARNVKGDGPPIYDNIK-TRDEEPVDAPT-----PLEVPVGLRAI 1017
            ...|:         |.|:.:   ||:|:..|   .|| .||...:..||     |:..|.|:..:
Mosquito  1332 FVRNVKEHYDIQTNDLVLEV---NVRGNPMP---TIKWLRDGIDLVDPTGEKFFPMREPGGVFKL 1390

  Fly  1018 TM-----------SSSSIVVYWIDTMLNKNQHVTDNR----HYTVSYGITGSNRYRYHNTTDLNC 1067
            |:           :..:..|...|.:.:..:.:.:.:    |.   :||      |||   |.|.
Mosquito  1391 TIHDPQAKDEGQYACEATNVVGKDVLRHAVRRIMERKIAESHV---FGI------RYH---DPNL 1443

  Fly  1068 MINDL-----------RPNTQYEF---AVKVVKGRR-ESSWSMSV---LNSTYQN-VPVTPPREV 1113
            |.:.:           ||:.::.|   ....::|:. |..|....   ..|.|:: |...|..|.
Mosquito  1444 MKHGVYEEPPKPEPAPRPHREFIFLEDGSYYIRGQTPEHLWEWETDTSAPSEYEDYVSPEPEPEP 1508

  Fly  1114 TVRLDEMNPPTVIVQWIPPK 1133
            .|...|..|....|:.:|.:
Mosquito  1509 EVPEPEPEPEPAPVEKVPSR 1528

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fra	NP_523716.2	Ig	36..140	CDD:299845	23/104 (22%)
		Ig	<180..222	CDD:299845	16/72 (22%)
		IG_like	257..340	CDD:214653	26/93 (28%)
		IGc2	264..327	CDD:197706	23/62 (37%)
		I-set	344..430	CDD:254352	25/95 (26%)
		Ig	363..428	CDD:299845	21/74 (28%)
		FN3	611..703	CDD:238020	22/115 (19%)
		FN3	711..799	CDD:238020	21/110 (19%)
		FN3	806..897	CDD:238020	24/129 (19%)
		FN3	908..989	CDD:238020	20/113 (18%)
		FN3	1011..1097	CDD:238020	20/115 (17%)
		FN3	1109..1205	CDD:238020	7/25 (28%)
		Neogenin_C	1273..1521	CDD:284094
AgaP_AGAP003610	XP_313369.5	I-set	321..409	CDD:254352	25/108 (23%)
		Ig	338..401	CDD:143165	17/79 (22%)
		Ig	<450..510	CDD:299845	16/60 (27%)
		I-set	590..673	CDD:254352	25/83 (30%)
		Ig	602..668	CDD:143165	23/66 (35%)
		Ig	701..769	CDD:143165	21/80 (26%)
		Ig	909..995	CDD:299845	16/86 (19%)
		I-set	910..995	CDD:254352	15/85 (18%)
		I-set	1006..1089	CDD:254352	14/85 (16%)
		Ig	1024..1086	CDD:299845	12/64 (19%)
		I-set	1232..1319	CDD:254352	23/118 (19%)
		IGc2	1244..1309	CDD:197706	16/96 (17%)
		Ig	1347..1414	CDD:143165	16/72 (22%)
		I-set	1662..1752	CDD:254352
		Ig	1670..1742	CDD:299845
		Ig	1784..1854	CDD:143165
		IG_like	2068..2151	CDD:214653
		Ig	2078..2146	CDD:143165
		I-set	2165..2263	CDD:254352
		Ig	2184..2258	CDD:143165
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910