DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fra and AgaP_AGAP002707

DIOPT Version :9

Sequence 1:	NP_523716.2	Gene:	fra / 36377	FlyBaseID:	FBgn0011592	Length:	1526	Species:	Drosophila melanogaster
Sequence 2:	XP_312221.5	Gene:	AgaP_AGAP002707 / 1273261	VectorBaseID:	AGAP002707	Length:	499	Species:	Anopheles gambiae

Alignment Length:	468	Identity:	92/468 - (19%)
Similarity:	150/468 - (32%)	Gaps:	163/468 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 SSRTLWNWLLSSCLIFQL---------IGSSLASQALSFTLEPQDAVVPEGHSVLLQCAGTASIG 63
            :|...|:.:.||.....:         :.|||...|.|...:...||.
Mosquito    50 TSAAFWSEMSSSSATLPVTPLHMAAVPLPSSLTVSAESLIRDVTSAVT----------------- 97

  Fly    64 RGGKSKSNLPSSVSIRWRGPDGQDLVIVGDTFRTQLKNGSLY------ISSVEENRGLTGAYQCL 122
              ..|..:||.:|::....|..........:......:|:|.      .:|.....|.:.||...
Mosquito    98 --DASTHSLPEAVAMHGADPGPMVTTHTAPSSARASPSGTLLGGVSSDSASTAAQYGGSNAYNKY 160

  Fly   123 LTAEGVGSILSRPALVAIVRQPDLNQDFLETYLLPGQTAYFRCMLGEANW----QEGVK------ 177
            .|        .||.|:..:  ||:.:..: .:.:|.|:.:..    |.:|    :|.|.
Mosquito   161 TT--------FRPLLIPTL--PDVRRSRI-VHSMPYQSKHHH----ERHWGPFFEEPVNVTSGAA 210

  Fly   178 ----------------------HSVQWLK---DDLPL-----------PLDKLRMVVLPNGALEI 206
                                  .:|.|::   |.:.|           |..|::.....|..|.|
Mosquito   211 LQVGYHLSTEAILNCRVGMLKDKTVMWIRRTTDKVSLLTVGNNTYSGDPRIKVKFQYPNNWRLHI 275

  Fly   207 DEVGPSDRGSYQCNVTSGSSSRLSSKTNLNIKKPS-----DPGAENS---------------VAP 251
            :.:...|.|.|.|.|::......:  |||.:.:|:     :.|.|.|               |:.
Mosquito   276 NPIKSDDAGLYMCQVSTHPPRVFA--TNLTVLEPAVRIVDEMGYEFSDRYYKLGSTIEISCQVST 338

  Fly   252 SFL--VGPSPK----------------------TVREGDTVTLD--CVANGVPKPQIKWLRNGMD 290
            |:|  :.||||                      |.:.|...|.|  .:::...:..|.|.::|.:
Mosquito   339 SYLATLPPSPKSAGQQQRSKTSPVGASANALDETAKTGSKATKDDNKLSDSTERGLISWTKDGAE 403

  Fly   291 LDFNDLDSRFSIVGT-----GSLQISSAEDIDSGNYQCRASNTVDSLDAQATVQVQ----EPPKF 346
            |   ..|.:.|..||     ..|.|..|..:.:|.|.|    ||....:|| .|||    |.|
Mosquito   404 L---PKDVKMSFSGTKQWLISRLSILQANRVHNGVYNC----TVAGKQSQA-AQVQVLNGETP-- 458

  Fly   347 IKAPKDTTAHEKD 359
             .|.:....|.|:
Mosquito   459 -AAVQHNFGHRKE 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fra	NP_523716.2	Ig	36..140	CDD:299845	18/109 (17%)
		Ig	<180..222	CDD:299845	13/55 (24%)
		IG_like	257..340	CDD:214653	26/111 (23%)
		IGc2	264..327	CDD:197706	17/69 (25%)
		I-set	344..430	CDD:254352	4/16 (25%)
		Ig	363..428	CDD:299845
		FN3	611..703	CDD:238020
		FN3	711..799	CDD:238020
		FN3	806..897	CDD:238020
		FN3	908..989	CDD:238020
		FN3	1011..1097	CDD:238020
		FN3	1109..1205	CDD:238020
		Neogenin_C	1273..1521	CDD:284094
AgaP_AGAP002707	XP_312221.5	IG_like	221..304	CDD:214653	17/84 (20%)
		Ig	<237..305	CDD:299845	16/69 (23%)
		Ig	<395..443	CDD:299845	16/54 (30%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910