DRSC/TRiP Functional Genomics Resources

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Protein Alignment fra and AgaP_AGAP002737

DIOPT Version :9

Sequence 1:NP_523716.2 Gene:fra / 36377 FlyBaseID:FBgn0011592 Length:1526 Species:Drosophila melanogaster
Sequence 2:XP_312188.5 Gene:AgaP_AGAP002737 / 1273231 VectorBaseID:AGAP002737 Length:6685 Species:Anopheles gambiae


Alignment Length:1852 Identity:343/1852 - (18%)
Similarity:604/1852 - (32%) Gaps:610/1852 - (32%)


- Green bases have known domain annotations that are detailed below.


  Fly    19 SCLIFQLIGSSLASQALSFTLEPQDAVVPE---GHSVLLQCAGTASIGRGGKSKSNLPSSVSIRW 80
            ||....|:|..:.|..|:..: |:....||   ....:|...||.|:    :.|.....:..:||
Mosquito   101 SCQAENLLGKCVCSGQLTVRV-PETYKAPEFVDELRAILTSQGTISL----ECKVIGYPTPELRW 160

  Fly    81 RGPDGQDLVIVGDTFRTQLKNGSLYISSVEENRGLTGAYQCLLTAEGVGSILSRPALVAIVRQPD 145
            ...:.:  :..||.|...:..|.|         ...|.|.|:.|        :...|:....:..
Mosquito   161 YKDEKE--IKAGDMFGLSINGGDL---------ASLGVYTCVAT--------NCNGLIEANEKYS 206

  Fly   146 LNQDFLETYLLPGQTAYFRCMLGEANWQEGVKHSVQWLKDDL------------------PLPLD 192
            :.:|.|..:|:....|.. |..||  |:     .|...||.|                  |..::
Mosquito   207 IFEDGLGCFLVDINAAEL-CDAGE--WK-----CVITCKDGLIGITTNVVELDVPRNYRAPRFME 263

  Fly   193 KLRMVVLPNGALEID------------------EVGPSD---------RGSYQCNVTSGSSSRLS 230
            .|:.|:...|.:..:                  |:.|.|         .||| |.|...|....|
Mosquito   264 GLKAVMTDEGLVSFECKVIGFPTPILRWYKDGRELKPGDVYHLTGVNSLGSY-CCVARNSLGEAS 327

  Fly   231 SKTNLNIKKPSDPGA-----------ENSVAPSFLVGPSPKTVREGDTVTLDCVANGVPKPQIKW 284
            |.|.|::   :|..|           :.:.||.|..|.:.:.|...:...|..|.:.|.||.:.|
Mosquito   328 STTFLSV---NDIKAQLNEEEWLNLLQVNQAPVFKQGLNSRDVNIAEPFRLTVVVSSVSKPTVCW 389

  Fly   285 LRNGMDLDFNDL------DSRFSIVGTGSLQISSAEDIDSGNYQCRASNTVDSLDAQATVQVQEP 343
            .::.:.:|.:|.      ||.:    |..|.:..|:..|.|.::|.|||..........|::..|
Mosquito   390 YKDDLVVDGSDNCKLTADDSTY----TYHLDVVVAQLDDQGEWKCVASNEFGQAGTSCFVKLIIP 450

  Fly   344 -----PKFIKAPK-----DTTAHEKDEPELKCDIWGKPKPVIRWLKNGDLITPNDYMQLVDGHNL 398
                 |||::..|     |.|.:      |:|.:.|.|:||::|.|:|..:.|.|..:::.|.:.
Mosquito   451 KHYRKPKFLENLKAVMLRDGTVN------LECKVIGVPQPVLKWYKDGTELKPGDIHRIITGQDG 509

  Fly   399 KILGLLNSDAGMFQCVGTNAAGSVHAAARLR----------VVPQGVK----IKKRK-SQGHSTK 448
            |..      .|.:.|...|..|||.:.|.|.          :.|:|..    :|... |..|..:
Mosquito   510 KCC------LGTYTCEAVNCMGSVSSTASLHGYDGIADEGPLPPEGAAAGPLVKDASLSTIHEER 568

  Fly   449 SLQTFDNLTKRRKPFNSGEQLRTKSGGSFPFPDEDDDLD-------DNDSGTTRLRIPSGKLPKF 506
            :.|.||.........::|     :...||.|..::..:.       .||..   |:|......:.
Mosquito   569 TSQMFDTAASYESAASNG-----RGEISFTFDGKEVSVSLYETPELTNDEA---LQIVQMFADQL 625

  Fly   507 EQPLNDRRFNILNAGSA--------------------LPLDNQSKSYEDD-DDDYDEDDPAKEAL 550
            .|.:|:.. |:.:..|.                    :|:...|..:||| ..|:|.|:...|..
Mosquito   626 HQNINENE-NVTSLPSLRFVKETSTSGQLVMEALVIDVPVVEDSNVFEDDRRTDFDIDEMHDENT 689

  Fly   551 LEAYKQGEDAHKILDSWQQSKSKKSQQQKQSPASPDSPEQD-----------PSVPHP------G 598
            . .::.|..:.|: .:.:||..::.:.:..:|:.....|||           |.:..|      |
Mosquito   690 F-TFESGIASSKV-RTHRQSSGEQDEFRSMTPSDHSDLEQDVMMSILSRDSLPVLTSPAKTTDGG 752

  Fly   599 GKPLDSGLQARLPSQPRDLVAQIVKSRFVTLSWVEPLQNAGDVVYYTVYYKMNNSEREQKMVT-- 661
            |....:....||.|....:|..:...|       |.::|..|:.....:.     ||.:|::.  
Mosquito   753 GASGGADTAERLLSLVETVVFHLASIR-------EEVRNQTDLAMTPSFL-----ERSEKILADI 805

  Fly   662 --------KSHDDQQVNIQSLLP---------------------GRTYQFRVEANTNFGSG---- 693
                    |....:.|.::|||.                     .||:.:|.......|.|    
Mosquito   806 LYPVQQLHKQLAGRPVVLESLLGPVEHLARGLSVVEKCVQIGGYSRTFVYRTSVCIVEGCGKQIL 870

  Fly   694 --ASSAPLEVSTQPEVNIAGPPRNFEGYARSHKEIY---------VKWEEPTVTNGEILKYRVYY 747
              .:...|....|||.:..           :.::||         ::..:.::.:..||:     
Mosquito   871 NCLTDMRLLAGQQPEADFV-----------TQQKIYMALLEVQTSIESAQESIQSQRILQ----- 919

  Fly   748 SENDSGADLYHDSTALEAVLT--ELRPHTDYV----------------ISVVPFNRN-------- 786
             |.||.|.:..    |.:::|  .:....|::                |:|:.|.::        
Mosquito   920 -EADSVAAMQD----LSSIVTNRSIFEDIDFILKADEPIGGLQIKNLQITVLEFEKSLATILTIV 979

  Fly   787 GMGDS-SAEIRVKTFSSTPSEPPNNVTLEVTSSSSITVHWEPPAEEDRNGQITGYKIRYRKFKDA 850
            ...|| :....:..|..|      .|.||:.:.:.:.:   ..:.|.|..:|...:::       
Mosquito   980 SQSDSCNVRSEIARFGLT------EVLLELKNKTEVLL---VQSAEQRQQRIVAEEMK------- 1028

  Fly   851 PQVKSTPANIRYFELSNL----DRNAEYQVKIAAMTVNGSGPFTEWNRA-NTLENDLDETQVPGK 910
            |.|.         |||:|    :.:|.|...|..:. :...|..|...| :.|.::|  ..||.:
Mosquito  1029 PAVT---------ELSSLVELVEASASYAEVITCLN-DMFVPLEEMKAALSKLSSEL--RHVPER 1081

  Fly   911 PIWISIHPGANNIALHWGPPQHPEIKIRNYVLGWGRGIPDENTIELKE---------TERYHILK 966
            ..       ::|.||        |.:|..:.         |..:.|||         |....:..
Mosquito  1082 EY-------SSNQAL--------EQQIEEFY---------EMIVHLKEEIQRTSKEYTRNGDVFV 1122

  Fly   967 NLESNMDYVVSLRARNVKGDGPPIYDNIKTRDEE-----------PVDAPTPLEVPVGLRAITMS 1020
            .||..::.:..:...          |:|.  |||           .::..|.||:.:..:    |
Mosquito  1123 RLEDCLNRLFCIHTA----------DSID--DEECARMEIVLIQLLMNHLTKLELALQEK----S 1171

  Fly  1021 SSSIVVYWIDTMLNKNQHVTDN-RHYTVSYGITGSNRYRYHNTTDLNCMINDLRPNTQYEFAVKV 1084
            ...::.|.....||    |.|| :|:  ||                      :|.|.:||     
Mosquito  1172 EQEMLSYMSTAFLN----VHDNLQHF--SY----------------------MRSNNKYE----- 1203

  Fly  1085 VKGRRESSWSMSVLNSTYQNVPVTPPREVTVRLDEMNPPTVIVQWIPPKHTLGQITGYNIYYTTD 1149
             |.|::      :|....:.|.....||.:|...|..           :..:.:|..::|:  .|
Mosquito  1204 -KIRQD------ILQHARKMVFFLIERESSVTATEER-----------RKAIYEIALFSIH--ND 1248

  Fly  1150 TTKR----DRDWSV---EAFAGEETMLMLPNLKPYTTYYFKVQARTTKGANNAPFSALVSYTTSA 1207
            :.:.    ::|:..   :|.:....:..|.......|...|...::....|.|.|::|:...|:.
Mosquito  1249 SARMREGLEKDFFELLGDADSAHRLLKCLHEFDECATLCLKTHEQSVFADNEAAFASLLKLATAM 1313

  Fly  1208 AVTMQ--EPDTIAKGIDNEKLL------------YIIIAATAVVLLVVLLG-----VLLLCRRKP 1253
            ..:.:  |...:....|:.|:|            |.......:.||...|.     :::.|:||.
Mosquito  1314 RQSCETVEDQIMNNSFDHCKVLTSLEFLHGAADDYSQSNENGMALLCQNLCEDLNLLIMTCKRKQ 1378

  Fly  1254 QSSPE------------------HTKKSYQ--KNNVGVPKP--------PDLWIHHDQME----- 1285
            ..|.:                  ..:|:.|  .:.:.:.:|        .:|...|.|::     
Mosquito  1379 VKSTDISETVSTSTLDSLKTSVIEIRKTMQAKSSTLNIEQPLSALECTINELVDQHMQLDSVELV 1443

  Fly  1286 -------------LKNID-KGLHTVTPVCSDGASSSGALTLPRSVVHSEYEVETPVPGHVTNSLD 1336
                         ||||| :..|....|..:........:|.::  .||:.:|....|.|.:.| 
Mosquito  1444 NAIATPIAKVTETLKNIDLQSAHVEPTVVMEDCLLQMCESLEKA--QSEHSLEQAKEGTVHSKL- 1505

  Fly  1337 KRSYVPGYMTTSMNGTMERPQYPRTQYSHQNRSHMTME----AGLSQ------QSLTQPQSN--S 1389
                            :|..    |...|..|..:.:|    |..||      :||.|..|:  .
Mosquito  1506 ----------------LETV----THVQHDIRECIQLEKDTRAKASQMQQGALESLKQSLSDVQQ 1550

  Fly  1390 MAQTP------EHPYGGYDANFCNAGNAAAGNGCVSTIESSKRGHPLKSFSVPGPPPTGGATPVT 1448
            :.||.      ..|....:                ||| :...|.|:|..|:  ......|||:.
Mosquito  1551 LIQTEIVVKEVSKPLFALE----------------STI-NELVGQPMKLESI--ELVNAIATPIA 1596

  Fly  1449 KHT--------------PAVTI------------RPQNQSPYKKPSFSAATPNRLQGGGSVVHST 1487
            |.|              |.|.:            :.|::...::..........|:....|.|..
Mosquito  1597 KVTETLKNIDLQSAHVEPTVVMEDCLLQMCESLEKAQSEHSLEQAKEGTVHSKLLETVTHVQHDI 1661

  Fly  1488 DEIQRLAPSTSTEELNQEMANLEGLMKDLSAI 1519
            .|..::...|..:....:...||.|.:.||.:
Mosquito  1662 RECIQMEKDTRAKASQMQQGALESLKQSLSDV 1693

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fraNP_523716.2 Ig 36..140 CDD:299845 20/106 (19%)
Ig <180..222 CDD:299845 15/86 (17%)
IG_like 257..340 CDD:214653 21/88 (24%)
IGc2 264..327 CDD:197706 17/68 (25%)
I-set 344..430 CDD:254352 27/100 (27%)
Ig 363..428 CDD:299845 20/64 (31%)
FN3 611..703 CDD:238020 20/128 (16%)
FN3 711..799 CDD:238020 16/123 (13%)
FN3 806..897 CDD:238020 18/95 (19%)
FN3 908..989 CDD:238020 13/89 (15%)
FN3 1011..1097 CDD:238020 16/86 (19%)
FN3 1109..1205 CDD:238020 16/102 (16%)
Neogenin_C 1273..1521 CDD:284094 58/318 (18%)
AgaP_AGAP002737XP_312188.5 I-set 1..119 CDD:254352 6/17 (35%)
IGc2 142..194 CDD:197706 15/74 (20%)
Ig 258..328 CDD:299845 13/70 (19%)
I-set 259..334 CDD:254352 17/75 (23%)
I-set 356..446 CDD:254352 23/93 (25%)
Ig 374..442 CDD:143165 19/71 (27%)
I-set 456..534 CDD:254352 26/89 (29%)
Ig 472..532 CDD:143165 19/71 (27%)
SCP-1 <1004..1540 CDD:114219 114/673 (17%)
sbcc 1630..2405 CDD:129705 11/64 (17%)
sbcc <2202..2840 CDD:129705
LPLAT <4497..4682 CDD:302626
I-set 4819..4907 CDD:254352
IGc2 4835..4897 CDD:197706
I-set 5227..5315 CDD:254352
Ig 5244..5312 CDD:143165
I-set 5493..5578 CDD:254352
Ig 5504..5572 CDD:143165
Ig 5609..5680 CDD:299845
I-set 5825..5914 CDD:254352
Ig 5942..6009 CDD:143165
I-set 6080..6168 CDD:254352
IGc2 6092..6158 CDD:197706
IG_like 6269..6342 CDD:214653
IGc2 6276..6337 CDD:197706
Ig 6375..6437 CDD:143165
I-set 6470..6557 CDD:254352
Ig 6498..6554 CDD:143165
IG_like 6578..6661 CDD:214653
Ig 6588..6659 CDD:299845
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
SonicParanoid 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
10.910

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