DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment fra and AgaP_AGAP002832

DIOPT Version :9

Sequence 1:	NP_523716.2	Gene:	fra / 36377	FlyBaseID:	FBgn0011592	Length:	1526	Species:	Drosophila melanogaster
Sequence 2:	XP_003436255.1	Gene:	AgaP_AGAP002832 / 1273129	VectorBaseID:	AGAP002832	Length:	1290	Species:	Anopheles gambiae

Alignment Length:	447	Identity:	121/447 - (27%)
Similarity:	176/447 - (39%)	Gaps:	90/447 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   587 SPE-------QDPSVPHPGGKPLDSGLQARLPSQPRDLVAQIVK--SRFVTLSWV---EPLQNAG 639
            |||       ||  ||.|.|:||                  :|.  ||.|.|||.   :| :||
Mosquito    90 SPEAIVDLLVQD--VPDPPGRPL------------------VVSFTSRSVDLSWAHSQDP-RNA- 132

  Fly   640 DVVYYTVYYKMNNS---EREQKMVTKSHDDQQVNIQSLLPGRTYQFRVEANTNFGSGASS----- 696
            .|..:.:..::..:   |:|..:.|||..... .:..|.|...|.|||.|....|....|
Mosquito   133 PVTNFIIETRIGENGDWEQEPPIHTKSSQAAH-QVTGLQPFTVYSFRVIAVNKLGHSPPSKESYY 196

  Fly   697 ------APLEVSTQPEVNIAGPPRNFEGYARSHKEIYVKWEEPTVTN--GEILKYRVYYSENDSG 753
                  ||           .|.|.....:..|...:|:.|:.|...:  ||.|.||:.|...|..
Mosquito   197 FVTLREAP-----------TGKPVTTIAHNTSATSVYISWKAPPPESILGEFLGYRITYRPRDYH 250

  Fly   754 AD----LY-HDSTALEAVLTELRPHTDYVISVVPFNRNGMGDSSAEIRVKTFSSTPSEPPNNVTL 813
            .|    :| .|||.....:..|..:|.|::|:..||..|:|..:. :.|.|....||.|.|...|
Mosquito   251 TDDVKEIYIRDSTVENHEIHNLETYTQYLVSIQVFNPEGLGPPTT-VLVMTDEGEPSPPQNLTVL 314

  Fly   814 EVTSSSSITVHWEPPAEEDRNGQITGYKIRYRKFKDAP------QVKSTPANIRYFELSNLDRNA 872
            ||| |::|.:.|..|  |..||.|.||::.|.......      ::.....::.::.||||....
Mosquito   315 EVT-STTIKLTWREP--EKANGAIHGYRVYYIHQNQTDLHMPILKLNEMQNSVYHYTLSNLKPFT 376

  Fly   873 EYQVKIAAMTVNGSGPFTEWNRANTLENDLDETQVPGKPIWISIHPGANNIALHWGPPQHPEIKI 937
            ||::.:.|.|....|..:|    .|...|:.....| |.:.::.| ..|.:...|..||.....|
Mosquito   377 EYRILVTAFTKKHDGKPSE----VTQRTDVSGPSAP-KVVNLTCH-SHNALYYGWRIPQTFYNTI 435

  Fly   938 RNYVLGWGRGIPDENTIELKET------ERYHILKNLESNMDYVVSLRARNVKGDGP 988
            ..|::.: |.|......|::.|      |...|:.||.||..|.|.:||.:.....|
Mosquito   436 DLYIISY-RNIAYHEFREIRITVNASIMETSLIIPNLTSNAVYEVKVRAASTSVINP 491

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fra	NP_523716.2	Ig	36..140	CDD:299845
		Ig	<180..222	CDD:299845
		IG_like	257..340	CDD:214653
		IGc2	264..327	CDD:197706
		I-set	344..430	CDD:254352
		Ig	363..428	CDD:299845
		FN3	611..703	CDD:238020	27/110 (25%)
		FN3	711..799	CDD:238020	27/94 (29%)
		FN3	806..897	CDD:238020	27/96 (28%)
		FN3	908..989	CDD:238020	24/87 (28%)
		FN3	1011..1097	CDD:238020
		FN3	1109..1205	CDD:238020
		Neogenin_C	1273..1521	CDD:284094
AgaP_AGAP002832	XP_003436255.1	IG_like	12..99	CDD:214653	3/8 (38%)
		Ig	13..99	CDD:299845	3/8 (38%)
		FN3	103..199	CDD:238020	30/116 (26%)
		FN3	206..300	CDD:238020	27/94 (29%)
		FN3	305..400	CDD:238020	30/101 (30%)
		FN3	405..483	CDD:238020	21/80 (26%)
		PTPc	611..876	CDD:214550
		PTPc	640..876	CDD:238006
		PTPc	900..1151	CDD:214550
		PTPc	928..1134	CDD:238006
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910