DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fra and Boc

DIOPT Version :9

Sequence 1:	NP_523716.2	Gene:	fra / 36377	FlyBaseID:	FBgn0011592	Length:	1526	Species:	Drosophila melanogaster
Sequence 2:	NP_766094.1	Gene:	Boc / 117606	MGIID:	2151153	Length:	1110	Species:	Mus musculus

Alignment Length:	910	Identity:	220/910 - (24%)
Similarity:	351/910 - (38%)	Gaps:	197/910 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 ITTNRSSRTLWN--WLL---SSCLIFQLIGSSLASQALSFTLEPQDAVVPEGHSVLLQCAGTASI 62
            :||.|..|.:..  |:|   :.||       :..::....|::|...|...|.:|:|.|...
Mouse     1 MTTCRRERPILTLLWILMATAGCL-------ADLNEVPQVTVQPMSTVQKLGGTVILGCVVE--- 55

  Fly    63 GRGGKSKSNLPSSVSIRWRGPDGQDLVIVGDTFRTQLKNGSLYISSVEENRGLTGAYQCLLTAEG 127
                      |..:::.||. :|::|....|.....:..|:|.|:::  |....|.|||:....
Mouse    56 ----------PPWMNVTWRF-NGKELNGSDDALGVFITRGTLVIAAL--NNHTVGRYQCVARMP- 106

  Fly   128 VGSILSRPALVAIVRQPDLNQDFLETYLL-PGQTAYFRCMLGEANWQEGVKHSV--QWLKDDLPL 189
            .|::.|.||.|.:....|...|......: .|.||...|.|.|::.:..|::||  :||:
Mouse   107 AGAVASVPATVTLANLQDFKLDVQHVIEVDEGNTAVIACHLPESHPKAQVRYSVKQEWLE----- 166

  Fly   190 PLDKLRMVVLPNGALEIDEVGPSDRGSYQCNV---------TSGSSSRLSSKTNLNIKKPSDPGA 245
             ..:...:::|:|.|:|......|.|.|:|..         ||||..||..:.       |...|
Mouse   167 -ASRDNYLIMPSGNLQIVNASQEDEGMYKCAAYNPVTQEVKTSGSGDRLRVRR-------STAEA 223

  Fly   246 ENSVAPSFLVGPSPKTVREGDTVTLDCVANGVPKPQIKWLRNGMDL-DFNDLDSRFSIVGTGSLQ 309
            ...:.|   :......|.:|.::.|:|||:|:|.|::.|.::|..: .:|  .:||.:   .:|.
Mouse   224 ARIIYP---LEAQTVIVTKGQSLILECVASGIPPPRVTWAKDGSSIAAYN--KTRFLL---SNLL 280

  Fly   310 ISSAEDIDSGNYQCRASNTVDSLDAQA---TVQVQEPPKFIKAPKDTTAHEKDEPELKCDIWGKP 371
            |.:..:.|||.|:|.|||.|....|..   .|||.|||:................:|.|::.|.|
Mouse   281 IDTTSEEDSGTYRCMASNGVGDPGAAVILYNVQVFEPPEVTVELSQLVIPWGQSAKLTCEVRGNP 345

  Fly   372 KPVIRWLKNGDLITPNDYMQLVDGHNLKILGLLNSDAGMFQCVGTNAAGSVHAAARLRVVPQGVK 436
            .|.:.||:|...:|.:..::| ....|:::.:...|.|::||:..||.||.||..:||.......
Mouse   346 PPSVLWLRNAVPLTSSQRLRL-SRRALRVVSVGPEDEGVYQCMAENAVGSAHAVVQLRTARPDTT 409

  Fly   437 IKKRKSQGHSTKSLQTFDNLTKRRKPFNSGEQLRTKSGGSFPFPDEDDDLDDNDSGTTRLRIPSG 501
            ::    .|..||.:.....:...| |....:.||.:.|...|             .|:.::..|.
Mouse   410 LR----PGRDTKPIAATPPMPPSR-PSRPDQMLREQPGLVKP-------------PTSSVQPTSL 456

  Fly   502 KLPKFEQPLNDRRFNILNAGSALPLDNQSKSYE--------------------------DDDDDY 540
            |.|..||........||::    |..:::.|||                          :..||:
Mouse   457 KCPGEEQVAPAEAPIILSS----PRTSKTDSYELVWRPRHEGSSRTPILYYVVKHRKVTNSSDDW 517

  Fly   541 DED--------------DPAK--EALLEAYK---QGEDAHKILDSWQQSK-----SKKSQQQKQS 581
            ...              ||..  |..:.||.   :|:.|.....:.::.|     ||:.|.|:..
Mouse   518 TISGIPANQHRLTLTRLDPGSLYEVEMAAYNCAGEGQTAMVTFRTGRRPKPEIVASKEQQIQRDD 582

  Fly   582 PASPDSPEQDPSVPHPGGKPLDSGLQARL--PSQPRDLVAQIVKSRFVTLSWVEPLQNAG-DVVY 643
            |.:.......|          |.|   ||  |..|............|.::|: |..|.| .:..
Mouse   583 PGASLQSSSQP----------DHG---RLSPPEAPDRPTISTASETSVYVTWI-PRGNGGFPIQS 633

  Fly   644 YTVYYKMNNSEREQKMVTKSHDDQQ--VNIQSLLPGRTYQFRVEANTNFGSGASSAPLEVSTQP- 705
            :.|.||......:..:.|.:....:  |.|..|..|.:|:|||.|....|....|||    ::|
Mouse   634 FRVEYKKLKKVGDWILATSAIPPSRLSVEITGLEKGISYKFRVRALNMLGESEPSAP----SRPY 694

  Fly   706 ----------EVNIAGPPRNFEGYARSHKEIYVKW------EEPTVTNGEILKYRVYYSENDSG- 753
                      |..:|||...|.. |.:...|.:||      ...|..:|..:.||...|:|||.
Mouse   695 VVSGYSGRVYERPVAGPYITFTD-AVNETTIMLKWMYIPASNNNTPIHGFYIYYRPTDSDNDSDY 758

  Fly   754 ------ADLYHDSTALEAVLTELRPHTDYVISVVPFNRNGMGDSS----AEIRVKTFSSTPSEPP 808
                  .|.|..|      ::.|:|.|.|.|.:..||..|..:.|    .|.:.:.||..|..||
Mouse   759 KKDMVEGDRYWHS------ISHLQPETSYDIKMQCFNEGGESEFSNVMICETKARKFSGQPGRPP 817

Fly 809 808
Mouse 818 817

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fra	NP_523716.2	Ig	36..140	CDD:299845	26/103 (25%)
		Ig	<180..222	CDD:299845	11/52 (21%)
		IG_like	257..340	CDD:214653	27/86 (31%)
		IGc2	264..327	CDD:197706	21/63 (33%)
		I-set	344..430	CDD:254352	23/85 (27%)
		Ig	363..428	CDD:299845	21/64 (33%)
		FN3	611..703	CDD:238020	24/94 (26%)
		FN3	711..799	CDD:238020	28/104 (27%)
		FN3	806..897	CDD:238020	2/3 (67%)
		FN3	908..989	CDD:238020
		FN3	1011..1097	CDD:238020
		FN3	1109..1205	CDD:238020
		Neogenin_C	1273..1521	CDD:284094
Boc	NP_766094.1	I-set	31..120	CDD:254352	26/105 (25%)
		Ig	35..118	CDD:299845	24/99 (24%)
		IG_like	132..207	CDD:214653	19/80 (24%)
		Ig	138..199	CDD:299845	19/66 (29%)
		Ig	243..301	CDD:299845	22/62 (35%)
		I-set	318..401	CDD:254352	22/83 (27%)
		IGc2	332..393	CDD:197706	17/61 (28%)
		ISET-FN3_linker	404..468	CDD:293231	15/81 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	407..458		11/68 (16%)
		FN3	481..553	CDD:214495	10/71 (14%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	561..610		13/61 (21%)
		FN3	601..692	CDD:238020	24/95 (25%)
		FN3	707..804	CDD:238020	28/103 (27%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	809..828		5/9 (56%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1065..1110
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.910