DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fra and Cntn1

DIOPT Version :9

Sequence 1:NP_523716.2 Gene:fra / 36377 FlyBaseID:FBgn0011592 Length:1526 Species:Drosophila melanogaster
Sequence 2:NP_476459.1 Gene:Cntn1 / 117258 RGDID:621300 Length:1021 Species:Rattus norvegicus


Alignment Length:1178 Identity:271/1178 - (23%)
Similarity:447/1178 - (37%) Gaps:340/1178 - (28%)


- Green bases have known domain annotations that are detailed below.


  Fly    17 LSSCL----IFQLIGSSLASQALSF----------TLEPQDAVVPEGHSVLLQCAGTASIGRGGK 67
            |:|||    ..:..|..::.:...|          |:.|::::  || .|.|.|...||      
  Rat    15 LTSCLGEFTWHRRYGHGVSEEDKGFGPIFEEQPINTIYPEESL--EG-KVSLNCRARAS------ 70

  Fly    68 SKSNLPSSVSIRWRGPDGQDLVIVGDTFRTQLKNGSLYISSVEENRGLTGAYQCLLTAEGVGSIL 132
                 |..| .:||..:| |:.:..|  |..:..|:|.|::.::.:. .|.|.| |.:...|.:.
  Rat    71 -----PFPV-YKWRMNNG-DVDLTND--RYSMVGGNLVINNPDKQKD-AGIYYC-LASNNYGMVR 124

  Fly   133 SRPALVAI-VRQPDLNQDFLETYLLPGQTAYFRCMLGEANWQEGVKH-----SVQWLKDDLP--L 189
            |..|.::. ...|...:|..|..:..|:.....|        :...|     |.:||.::.|  :
  Rat   125 STEATLSFGYLDPFPPEDRPEVKVKEGKGMVLLC--------DPPYHFPDDLSYRWLLNEFPVFI 181

  Fly   190 PLDKLRMVVLPNGALEIDEVGPSDRGSYQCNVTSGSSSRLSSKTNLNIKKPSDPGAENSVAPSFL 254
            .:||.|.|...||.|.|..|..||||:|.|.|:|.|    .:|:..:...|..|..|.:..|.  
  Rat   182 TMDKRRFVSQTNGNLYIANVESSDRGNYSCFVSSPS----ITKSVFSKFIPLIPIPERTTKPY-- 240

  Fly   255 VGPSPKTVR-------EGDTVTLDCVANGVPKPQIKWLRNGMDLDFNDLDSRFSIVGTGS-LQIS 311
              |:...|:       .|..|||:|.|.|.|.|.|:|.:     ....:.:...|..:|: |:|.
  Rat   241 --PADIVVQFKDIYTMMGQNVTLECFALGNPVPDIRWRK-----VLEPMPTTAEISTSGAVLKIF 298

  Fly   312 SAEDIDSGNYQCRASNTVDSLDAQATVQVQEPPKFIKAPKDTTAHEKDEPELKCDIWGKPKPVIR 376
            :.:..|.|.|:|.|.|.......||.:.||..|::::...||......:....|...|||.|.||
  Rat   299 NIQLEDEGLYECEAENIRGKDKHQARIYVQAFPEWVEHINDTEVDIGSDLYWPCVATGKPIPTIR 363

  Fly   377 WLKNGDLITPNDYMQLVDGHNLKILGLLNSDAGMFQCVGTNAAGSVHAAARLRVV---------P 432
            |||||......:         |::..:...:|||:||:..||.|:::|.|.|:::         |
  Rat   364 WLKNGYAYHKGE---------LRLYDVTFENAGMYQCIAENAYGTIYANAELKILALAPTFEMNP 419

  Fly   433 QGVKIKKRK--------------------SQG-----HSTK-------SLQTFDNLTK------- 458
            ...||...|                    |:|     :|::       ||: .:|:|:       
  Rat   420 MKKKILAAKGGRVIIECKPKAAPKPKFSWSKGTEWLVNSSRILIWEDGSLE-INNITRNDGGIYT 483

  Fly   459 ------RRK------------------PFNS----GEQLRTKSGGSFPFPDEDDDLDDNDSGTTR 495
                  |.|                  |.|:    ||....:...||     |..||     .|.
  Rat   484 CFAENNRGKANSTGTLVITNPTRIILAPINADITVGENATMQCAASF-----DPSLD-----LTF 538

  Fly   496 LRIPSGKLPKFEQPLND----RRFNILNAGSALPLDNQSKSYEDDDDDYDEDDPAKEALLEAYKQ 556
            :...:|.:..|.:.:.:    |.| :|:|...|.:.|..                   |..|.:.
  Rat   539 VWSFNGYVIDFNKEITNIHYQRNF-MLDANGELLIRNAQ-------------------LKHAGRY 583

  Fly   557 GEDAHKILDSWQQSKSKKSQQQKQSPASPDSPEQDPSVPHPGGKPLDSGLQARLPSQPRDLVAQI 621
            ...|..|:|:              |.||.|...:.|..| |||..::.                 
  Rat   584 TCTAQTIVDN--------------SSASADLVVRGPPGP-PGGLRIED----------------- 616

  Fly   622 VKSRFVTLSWVEPLQNAGDVVYYTVYYK--MNNSEREQKMVTKSHDDQQV---NIQS-----LLP 676
            :::..|.|:|.....|...:..||:..|  :::..::.|      .|..:   |::|     |:|
  Rat   617 IRATSVALTWSRGSDNHSPISKYTIQTKTILSDDWKDAK------TDPPIIEGNMESAKAVDLIP 675

  Fly   677 GRTYQFRVEANTNFGSGASSAPLEVSTQPEVNIAGP---PRNFEGYARSHKEIYVKW----EEPT 734
            ...|:|||.|....|:|..|.|   |.:.:.:.|.|   |.:..|...:::|:.:.|    .|..
  Rat   676 WMEYEFRVVATNTLGTGEPSIP---SNRIKTDGAAPNVAPSDVGGGGGTNRELTITWAPLSREYH 737

  Fly   735 VTN--GEILKYRVYYSEN---------DSGADLYHDSTALEAVLTELRPHTDYVISVVPFNRNGM 788
            ..|  |.|:.::.:..|.         |:|..::.|.|        :.|.|.:.:.|..||..|.
  Rat   738 YGNNFGYIVAFKPFDGEEWKKVTVTNPDTGRYVHKDET--------MTPSTAFQVKVKAFNNKGD 794

  Fly   789 GDSSAEIRVKTFSSTPSEPPNNVTLEVTSSSSITVHWEPPAEEDRNGQITGYKIRYRKFKDAP-- 851
            |..|....:.:....|||.|..|.::|.|||.|:|||:...|:    .:..|:|||....|..  
  Rat   795 GPYSLIAVINSAQDAPSEAPTEVGVKVLSSSEISVHWKHVLEK----IVESYQIRYWAGHDKEAA 855

  Fly   852 ----QVKSTPANIRYFELSNLDRNAEYQVKIAAMTVNGSGPFTEWNRANTLENDLDETQVPGKPI 912
                ||.|...:.|   |.||..:.:|.:::.|....|.||          .:|:.||.....| 
  Rat   856 AHRVQVTSQEYSAR---LENLLPDTQYFIEVGACNSAGCGP----------SSDVIETFTRKAP- 906

  Fly   913 WISIHPGANNIALHWGPPQHPEI--KIRN---YVLGWGR--GIPDENTI---------------E 955
                            |.|.|.|  .:|:   |::.|..  .:.:|:|:               :
  Rat   907 ----------------PSQPPRIISSVRSGSRYIITWDHVVALSNESTVTGYKILYRPDGQHDGK 955

  Fly   956 LKETERYHILKNLESNMDYVVSLRARNVKGDGPPIYDNIKTRDEEPVDAPTPLEVPVGLRAITMS 1020
            |..|.::.|...:..:.:|||.:||.:..|||  :...:|......:.:        ||.::.:.
  Rat   956 LFSTHKHSIEVPIPRDGEYVVEVRAHSDGGDG--VVSQVKISGVSTLSS--------GLLSLLLP 1010

  Fly  1021 SSSIVVYW 1028
            |...:|::
  Rat  1011 SLGFLVFY 1018

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fraNP_523716.2 Ig 36..140 CDD:299845 28/113 (25%)
Ig <180..222 CDD:299845 18/43 (42%)
IG_like 257..340 CDD:214653 25/90 (28%)
IGc2 264..327 CDD:197706 20/63 (32%)
I-set 344..430 CDD:254352 27/85 (32%)
Ig 363..428 CDD:299845 23/64 (36%)
FN3 611..703 CDD:238020 22/101 (22%)
FN3 711..799 CDD:238020 22/105 (21%)
FN3 806..897 CDD:238020 29/96 (30%)
FN3 908..989 CDD:238020 21/102 (21%)
FN3 1011..1097 CDD:238020 4/18 (22%)
FN3 1109..1205 CDD:238020
Neogenin_C 1273..1521 CDD:284094
Cntn1NP_476459.1 IgI_1_Contactin-1 40..134 CDD:409436 27/113 (24%)
Ig strand B 61..65 CDD:409436 2/3 (67%)
Ig strand C 74..78 CDD:409436 1/4 (25%)
Ig strand E 96..100 CDD:409436 2/3 (67%)
Ig strand F 111..116 CDD:409436 2/5 (40%)
Ig strand G 125..128 CDD:409436 1/2 (50%)
Ig2_Contactin-2-like 142..230 CDD:409392 29/99 (29%)
Ig strand B 154..158 CDD:409392 0/3 (0%)
Ig strand C 169..173 CDD:409392 1/3 (33%)
Ig strand E 194..198 CDD:409392 2/3 (67%)
Ig strand F 208..213 CDD:409392 2/4 (50%)
Ig strand G 224..227 CDD:409392 0/2 (0%)
IgI_3_Contactin-1 241..328 CDD:143259 25/91 (27%)
Ig strand B 259..263 CDD:143259 3/3 (100%)
Ig strand C 272..276 CDD:143259 1/3 (33%)
Ig strand E 293..297 CDD:143259 1/3 (33%)
Ig strand F 307..312 CDD:143259 2/4 (50%)
Ig strand G 320..323 CDD:143259 0/2 (0%)
Ig 332..408 CDD:416386 26/84 (31%)
Ig strand A 332..335 CDD:409353 0/2 (0%)
Ig strand A' 339..343 CDD:409353 2/3 (67%)
Ig strand B 347..355 CDD:409353 1/7 (14%)
Ig strand C 361..366 CDD:409353 3/4 (75%)
Ig strand C' 368..371 CDD:409353 1/2 (50%)
Ig strand E 374..379 CDD:409353 1/13 (8%)
Ig strand F 388..395 CDD:409353 3/6 (50%)
Ig strand G 399..408 CDD:409353 3/8 (38%)
Ig5_Contactin-1 413..501 CDD:409438 13/88 (15%)
Ig strand B 432..436 CDD:409438 0/3 (0%)
Ig strand C 445..449 CDD:409438 0/3 (0%)
Ig strand E 467..471 CDD:409438 2/4 (50%)
Ig strand F 481..486 CDD:409438 0/4 (0%)
Ig strand G 494..497 CDD:409438 0/2 (0%)
Ig6_Contactin 503..603 CDD:409359 27/143 (19%)
Ig strand B 522..526 CDD:409359 0/3 (0%)
Ig strand C 537..541 CDD:409359 1/3 (33%)
Ig strand E 568..572 CDD:409359 1/3 (33%)
Ig strand F 582..587 CDD:409359 0/4 (0%)
Ig strand G 595..598 CDD:409359 1/2 (50%)
FN3 612..699 CDD:238020 22/112 (20%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 695..719 7/26 (27%)
FN3 711..803 CDD:238020 21/99 (21%)
fn3 813..895 CDD:394996 28/98 (29%)
FN3 907..991 CDD:238020 20/85 (24%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
11.000

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