DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fra and dcc

DIOPT Version :9

Sequence 1:NP_523716.2 Gene:fra / 36377 FlyBaseID:FBgn0011592 Length:1526 Species:Drosophila melanogaster
Sequence 2:XP_004910421.2 Gene:dcc / 100486082 XenbaseID:XB-GENE-852874 Length:1448 Species:Xenopus tropicalis


Alignment Length:1681 Identity:491/1681 - (29%)
Similarity:744/1681 - (44%) Gaps:422/1681 - (25%)


- Green bases have known domain annotations that are detailed below.


  Fly    21 LIFQLIGSSL--------ASQALSFT-----LEPQDAVVPEGHSVLLQCAGTASIGRGGKSKSNL 72
            |:|.|.|.:|        .||..|||     .||.|||...|.:|:|.|:..:..|         
 Frog    13 LVFLLHGFALLSLNLPVSGSQVRSFTSLWFLSEPSDAVTMRGGNVVLNCSAQSDRG--------- 68

  Fly    73 PSSVSIRWRGPDGQDLVIVGDTFRTQLKNGSLYISSV---EENRGLTGAYQCLLTAEGVGSILSR 134
              :..|:|: .||..|.:..|..|.||.:|||.|.:|   ..:|...|.|||....:|||:|:||
 Frog    69 --APLIKWK-KDGVYLNLAVDDRRQQLPSGSLLIQNVVHSRHHRPDEGFYQCEAFLDGVGTIVSR 130

  Fly   135 PA--LVA----IVRQPDLNQDFLETYLLPGQTAYFRC-MLGE----ANWQEGVKHSVQWLKDDLP 188
            .|  |||    |:.|.:....|:      |.||..:| ::||    .:||..        ::|:.
 Frog   131 TAKVLVAGPLRILSQTESVTAFV------GDTALLKCEIVGEPMPAISWQRN--------EEDVK 181

  Fly   189 LPLDKLRMVVLPNGALEIDEVGPSDRGSYQCNVTSGSSSRLSSKTNLNIKKPSDPGAENSVAPSF 253
            :.....|::|||:|.|:|..:..:|.|.|:|...:..|||:.::..|.|.  |:.|......  |
 Frog   182 VAPGDTRLLVLPSGTLQISRLQTADGGVYRCLAKNPGSSRVGNEAELRIL--SESGLHRQQV--F 242

  Fly   254 LVGPSPKTVREGDTVTLDCVANGVPKPQIKWLRNGMDLDFNDL----DSRFSIVGTGSLQISSAE 314
            |..|......||....|:|..:|.|.|.|.||:.      ::|    ..::|::|..:|.||:..
 Frog   243 LQRPGNVVAVEGQDAVLECAVSGYPTPTIVWLQG------DELVPIRTRKYSVLGGSNLLISNVT 301

  Fly   315 DIDSGNYQCRAS--NTVDSLDAQATVQVQEPPKFIKAPKDTTAHEKDEPELKCDIWGKPKPVIRW 377
            |.|:|.|.|.|:  |...|..|..||.|  ||:|:..|.:..|:|..:.|.:|.:.|||.|.::|
 Frog   302 DDDAGTYTCMATYKNENTSFSADLTVMV--PPRFLNHPANLYAYESMDIEFECAVSGKPSPTVKW 364

  Fly   378 LKNGDLITPNDYMQLVDGHNLKILGLLNSDAGMFQCVGTNAAGSVHAAARLRVVPQGVKIKKRKS 442
            .|||:::.|:||.|:|.|.||:||||:.||.|.:||:..|.||::...|:| ::|          
 Frog   365 TKNGEVVIPSDYFQIVGGSNLRILGLVKSDEGYYQCIAENEAGNIQTYAQL-IIP---------- 418

  Fly   443 QGHSTKSLQTFDNLTKRRKPFNSGEQLRTKSGGSFPFPDEDDDLDDNDSGTTRLRIPSGKLPKFE 507
                                                                             
 Frog   419 ----------------------------------------------------------------- 418

  Fly   508 QPLNDRRFNILNAGSALPLDNQSKSYEDDDDDYDEDDPAKEALLEAYKQGEDAHKILDSWQQSKS 572
                                                                             
 Frog   419 ----------------------------------------------------------------- 418

  Fly   573 KKSQQQKQSPASPDSPEQDPSVPHPGGKPLDSGLQARLPSQPRDLVAQIVKSRFVTLSWVEPLQN 637
                              ||:||.          .:.|||.|||:|..:|.||||.|||..|::.
 Frog   419 ------------------DPAVPS----------SSVLPSAPRDVVPVLVSSRFVRLSWRPPVEP 455

  Fly   638 AGDVVYYTVYYKMNNSEREQKMVTKSHDDQQVNIQSLLPGRTYQFRVEANTNFGSGASSAPLEVS 702
            .|::..||||:....::||:.:.|......|:.:.:|.|..||.|||.|...:|.|.||.|::|.
 Frog   456 RGNIQTYTVYFSKQGAQRERAVNTSQPIALQLTVGNLAPEETYNFRVVAYNEWGPGESSQPVKVG 520

  Fly   703 TQPEVNIAGPPRNFEGYARSHKEIYVKWEEPTVTNGEILKYRVYYSENDSGADLYHDSTALEAVL 767
            ||||:.:.||..|.:..:.:...:.:.||.|...||.:..||::.||..||.:...:...|...|
 Frog   521 TQPELQVPGPVENLQVVSTAPTSVLISWEAPAYANGPVQGYRLFCSETFSGREQNIEVDGLLYRL 585

  Fly   768 TELRPHTDYVISVVPFNRNGMGDSSAEIRVKTFSSTPSEPPNNVTLEVTSSSSITVHWEPPAEED 832
            ..||..|:|.|.|:.:||.|.|.||.|..|.|.|..||..|.||:|||.:|.:|.|.|.||....
 Frog   586 EGLRKFTEYSIRVLAYNRYGPGVSSEEHAVVTLSDVPSAMPQNVSLEVVNSRNIKVSWLPPPSGT 650

  Fly   833 RNGQITGYKIRYRKFKDAPQVKSTPANIRYFELSNLDRNAEYQVKIAAMTVNGSGPFTEWNRANT 897
            :||.|||||||:||......:::...|..::..:.|::.::|..::|||||||:||.::|..|.|
 Frog   651 QNGFITGYKIRHRKTTRRGDLETIEPNNLWYLFTGLEKGSQYSFQVAAMTVNGTGPSSDWYTAET 715

  Fly   898 LENDLDETQVPGKPIWISIHPGANNIALHWGPPQHPEIKIRNYVLGWGRGIPDENTIELKETERY 962
            .||||||:|||.:|..:.:.|...:|.:.|.||.:|.|.:|.|::|:|.|.|...|:.:...:||
 Frog   716 PENDLDESQVPDQPSSLHVRPLTTSIIMSWTPPLNPNIVVRGYIIGYGVGSPYAETVRVDSKQRY 780

  Fly   963 HILKNLESNMDYVVSLRARNVKGDGPPIYDNIKTR-----------------DEEPVDAP---TP 1007
            :.::|||.:..||:||:|.|..|:|.|:|::..||                 |:.|...|   ||
 Frog   781 YSIENLEPSSHYVISLKAFNNAGEGVPLYESATTRSQTDPIDPLEIEFYPFIDDFPTSVPDMSTP 845

  Fly  1008 LEVPVGLRAITMSSSSIVVYWIDTMLNKNQHVTDNRHYTVSY--GITGSNRYRYHNTTDLNCMIN 1070
            :..|||::|:.::..::.|.|.|..:.|||...:.|.||:.:  ..:.|::|:..:||.|:..:.
 Frog   846 MLPPVGVQAVALTHDAVRVSWADNSVIKNQKTAEVRFYTIRWRTSYSASSKYKSADTTSLSHTVT 910

  Fly  1071 DLRPNTQYEFAVKVVKGRRESSWSMSVLNSTYQNVPVTPPREVTVRLDEMNPPTVIVQWIPPKHT 1135
            .|:|||.|||:|.|.||||.|:|||:...:||:..|.:.|:::||...|..|..|||.|.||...
 Frog   911 GLKPNTMYEFSVMVTKGRRSSTWSMTAHATTYETAPTSAPKDLTVITRERKPRAVIVSWQPPIEA 975

  Fly  1136 LGQITGYNIYYTTDTTKRDRDWSVEAFAGEETMLMLPNLKPYTTYYFKVQARTTKGANNAPFSAL 1200
            .|:|..|.::||.|...:..||.:....|:.....:.:|...|.|||::|||..||.  .|.|..
 Frog   976 NGKIIDYILFYTLDKNLQIDDWVMVTITGDRLTHEILDLNLDTAYYFRIQARNAKGL--GPLSDP 1038

  Fly  1201 VSYTTSAAVTMQEPDTIAKG----------------ID-----------------------NEKL 1226
            :::.|.   .::.||.:|..                ||                       |..|
 Frog  1039 ITFRTP---KVEHPDKMANDQGRHGDGGYWSVDTNLIDRSSLNEPPIGQMHPPHGSVTPQKNSNL 1100

  Fly  1227 LYIIIAATAVVLLVVLLGVLLLCRRKPQSSPEHTKK------SYQKNNVGVPKPPDLWIHHDQME 1285
            |.||:.....:.:||::.|.::|.|:  ||.:..||      ..:|.:....:||||||||::||
 Frog  1101 LVIIVVTVGAITIVVVVIVAVICTRR--SSAQQRKKRATHSAGKRKGSQKDLRPPDLWIHHEEME 1163

  Fly  1286 LKNIDK--GLHT------------VTPVC---------SDGASSSG---------ALTLPRSV-- 1316
            :|||:|  |..|            :|||.         |...|.||         ..||.|::  
 Frog  1164 MKNIEKPSGSDTQGRDSPRQSCQDITPVSHSQSESQLGSKSTSHSGPDADEVGSNISTLERTLAA 1228

  Fly  1317 -----------VHSEYEVETPVPGHV-TNSLDKRSYVPGYMTTSMNGTMERPQYPRTQYSHQ--- 1366
                       :.|:.....||...: ..:|:...| ||.:.:...|      ||..|::.:   
 Frog  1229 RRATRAKLMIPMDSQPSSNPPVVSAIPVPTLESAQY-PGILPSPTCG------YPHPQFTLRPVP 1286

  Fly  1367 ----------NRSHMTMEAGLSQQS--LTQPQSNSMAQTPEHPYGGYDANFCNAGNAAAGNGCVS 1419
                      ..|....|...||||  |:.||       |||      ::..:|.:......|| 
 Frog  1287 FPTLSMDRGFGSSRAVTEVPASQQSSVLSHPQ-------PEH------SSSEDAPSRTIPTACV- 1337

  Fly  1420 TIESSKRGHPLKSFSVP-GPPPTGGATPVTKHTPAVT----IRPQNQ---------SPYKKPSFS 1470
                 :..|||:||:.| .|||.....|...:||.::    ..|:.|         ...:.|...
 Frog  1338 -----RPTHPLRSFANPLLPPPMTAMEPKVPYTPLLSQTGASLPKAQVKTASLGLAGKARSPLLP 1397

  Fly  1471 AATPNRLQGGGSVVHSTDEIQRLAPST--STEELNQEMANLEGLMKDLSAITANEF 1524
            .:.|...:........||:     ||:  ..::|:::||:||||||.|:|||.:.|
 Frog  1398 VSVPTAPEVSEESHKHTDD-----PSSVYEQDDLSEQMASLEGLMKQLNAITGSAF 1448

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fraNP_523716.2 Ig 36..140 CDD:299845 42/117 (36%)
Ig <180..222 CDD:299845 12/41 (29%)
IG_like 257..340 CDD:214653 28/88 (32%)
IGc2 264..327 CDD:197706 22/68 (32%)
I-set 344..430 CDD:254352 37/85 (44%)
Ig 363..428 CDD:299845 30/64 (47%)
FN3 611..703 CDD:238020 38/91 (42%)
FN3 711..799 CDD:238020 30/87 (34%)
FN3 806..897 CDD:238020 37/90 (41%)
FN3 908..989 CDD:238020 29/80 (36%)
FN3 1011..1097 CDD:238020 35/87 (40%)
FN3 1109..1205 CDD:238020 32/95 (34%)
Neogenin_C 1273..1521 CDD:284094 84/324 (26%)
dccXP_004910421.2 IgI_1_Neogenin_like 39..136 CDD:409387 36/108 (33%)
Ig strand B 57..61 CDD:409387 2/3 (67%)
Ig strand C 71..75 CDD:409387 1/3 (33%)
Ig strand E 95..99 CDD:409387 3/3 (100%)
Ig strand F 114..119 CDD:409387 3/4 (75%)
Ig strand G 129..132 CDD:409387 2/2 (100%)
Ig_3 141..216 CDD:404760 23/88 (26%)
Ig strand B 157..161 CDD:409353 1/3 (33%)
Ig strand C 170..174 CDD:409353 0/3 (0%)
Ig strand E 195..199 CDD:409353 2/3 (67%)
Ig strand F 209..214 CDD:409353 2/4 (50%)
IG 246..327 CDD:214652 26/86 (30%)
Ig 334..417 CDD:416386 35/83 (42%)
Ig strand A 334..337 CDD:409353 0/2 (0%)
Ig strand A' 339..343 CDD:409353 0/3 (0%)
Ig strand B 346..355 CDD:409353 2/8 (25%)
Ig strand C 360..366 CDD:409353 2/5 (40%)
Ig strand C' 368..371 CDD:409353 1/2 (50%)
Ig strand D 376..380 CDD:409353 2/3 (67%)
Ig strand E 384..388 CDD:409353 2/3 (67%)
Ig strand F 396..404 CDD:409353 3/7 (43%)
Ig strand G 407..417 CDD:409353 3/10 (30%)
FN3 429..521 CDD:238020 38/91 (42%)
FN3 528..617 CDD:238020 30/88 (34%)
FN3 622..715 CDD:238020 39/92 (42%)
FN3 726..805 CDD:214495 28/78 (36%)
FN3 848..941 CDD:238020 35/92 (38%)
FN3 948..1043 CDD:238020 32/96 (33%)
Neogenin_C 1150..1446 CDD:399527 85/326 (26%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 95 1.000 Domainoid score I7285
eggNOG 00.000 Not matched by this tool.
Hieranoid 1 1.000 - -
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 762 1.000 Inparanoid score I547
OMA 1 1.010 - - QHG46607
OrthoDB 1 1.010 - - D118438at33208
OrthoFinder 1 1.000 - - FOG0002773
OrthoInspector 1 1.000 - - otm48286
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1863
SwiftOrtho 1 1.000 - -
TreeFam 00.000 Not matched by this tool.
109.980

Return to query results.
Submit another query.