DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fra and chl1b

DIOPT Version :9

Sequence 1:	NP_523716.2	Gene:	fra / 36377	FlyBaseID:	FBgn0011592	Length:	1526	Species:	Drosophila melanogaster
Sequence 2:	XP_017212175.2	Gene:	chl1b / 100318566	ZFINID:	ZDB-GENE-091105-1	Length:	1294	Species:	Danio rerio

Alignment Length:	1442	Identity:	295/1442 - (20%)
Similarity:	498/1442 - (34%)	Gaps:	341/1442 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    16 LLSSCLIFQLIGSSLASQALSFTLE-----------------PQDAVV-PEGHSVLLQCAGTASI 62
            ||::||   .:.|...:.||...|:                 |...:. |...|..::|..|.:
Zfish    10 LLAACL---NMSSRYQTNALEIPLDVLERMNMEQLPTITEYSPASLIAFPFEESFPVKCEATGN- 70

  Fly    63 GRGGKSKSNLPSSVSIRWRGPDGQDLVIVGDTFRTQLKNGSLYISSVEENRGLT---GAYQCLLT 124
                       .....||. .:|||.....||....|.:...:|  :.....||   |.|:|..|
Zfish    71 -----------PEPEFRWT-KNGQDFDPYQDTRLITLDDSGTFI--IPNTGNLTEFQGIYRCFAT 121

  Fly   125 AEGVGSILSRPALVAIVRQPDLNQDFLETY-LLPGQTAYFRCMLGEANWQEGVKH-SVQWLKDDL 187
            .: :|:.:|......|...|...::.::.. ::.||:....|     |...|:.. .:.|:...|
Zfish   122 NK-LGTAMSEEIEFIIPNVPKFPKEIIDPIEVMEGQSVILEC-----NPPTGIPPLQIYWMTISL 180

  Fly   188 PLPLDKLRMVVLPNGALEIDEVGPSD-RGSYQC--------NVTSGSSSRLSSKTNLNIKKPSDP 243
            .......|:.|..||.|.......:| |..|.|        .:...::..:..|:| .:.|.|..
Zfish   181 QHIEQDERVSVGLNGNLYFSNTVETDSRRDYCCFAAFPRIRTIVQKTAMSMVVKSN-KLMKDSSS 244

  Fly   244 GAENSVAPSF------LVGP----SPKTVREGDTVTLDCVANGVPKPQIKWLRNGMDLDFNDLDS 298
            |:....|.|.      |:.|    |...:.:|:.:.|:|:|.|.|.|:::|::.|    ||.|..
Zfish   245 GSGRGYANSLLERKPSLLAPTGMESHTRLVKGEDLQLECIAEGFPTPKVEWVKIG----FNKLPE 305

  Fly   299 RFSIVGTGS-LQISSAEDIDSGNYQCRASNTVDSLDAQATVQVQEPPKFIKAPKDTTAHEKDEPE 362
            |..:...|. |.:....:.|.|.|.|||.|....:.....|.|:|||:|...|:........:..
Zfish   306 RVVVESHGKLLTVEMVNEEDEGKYMCRAKNPHGEVVHHFHVTVEEPPEFEIEPQSQLVTIGADVL 370

  Fly   363 LKCDIWGKPKPVIRWLKNGDLI--TPNDYMQLVDGHNLKILGLLNSDAGMFQCVGTNAAGSVHAA 425
            :||.:.|.|:|.:.|..||..:  .|....:::....:.|......::.::||..||..|::.|.
Zfish   371 IKCVVKGNPQPTVGWRVNGRPLNEVPTSNRKILKDGTISIHNANPENSAVYQCEATNKHGTILAN 435

  Fly   426 ARLRVVP-QGVKIKKRKSQGHSTKSLQTFDNLTKRRKPFNS-----------------GEQLRTK 472
            |.:.::. |.:.:.:...|..:.:.    .::....|.|:|                 ||:....
Zfish   436 ANIMIMNIQPLILTENNLQYMAVEG----KSVVMHCKVFSSPASSITWSKADSANAVEGERFTVH 496

  Fly   473 SGGSFPFPD-EDDDLDD------NDSG------TTRLRIPSGKLPKFEQPLNDRRFNILNAGSAL 524
            ..||....: ..:|:.:      |..|      |..::.|:    :...|..|.|   :.||:.:
Zfish   497 QNGSLEIHNVMKEDMGEYSCFAQNTEGKVAIAATLEVKDPT----RIVDPPRDLR---VLAGTTI 554

  Fly   525 PLDNQSKSYEDDDDDYDEDDPAKEALLE----AYKQGEDAHKILDSWQQSKSKKSQQQK------ 579
            ....|.:......||:       |.|.|    |....||...||:.........|...:
Zfish   555 QFSCQPEFDPSFGDDF-------EVLWEKDGIALNGSEDGRYILEDGVLEIINVSFGDQGFYACV 612

  Fly   580 -QSPASPDSPEQDPSVPHPGGKPLDSGLQARLPSQPRDLVAQIVKSRFVTLSWVEPLQNAGDVVY 643
             ::|...|......||             ..:|..|.|::......|.|.|.|.....:...:..
Zfish   613 ARTPVDQDVAVAQLSV-------------VDVPDPPEDVILSEHNGRSVKLQWTPGDDHNSSITE 664

  Fly   644 YTVYYKMNNSE----REQKMVTKSHDDQQVNIQSLLPGRTYQFRVEANTNFGSGASSAPLE---- 700
            :.:.::.:..|    ||...|..:|....:.:...:   .|:|||.|....|.|..|...|
Zfish   665 FVLEFEESQHEPGSWREMMRVPGNHHSAPLKLYGHV---DYRFRVSAINEVGKGRPSQSTERYKT 726

  Fly   701 VSTQPEVNIAGPPRNFEGYARSHKEIYVKWE--EPTVTNGEILKYRVYYSENDSGADLYHDSTAL 763
            .::.|:.|    |.|.:..|....|:.:.||  .|...||..|:|:|.|..:.|..|........
Zfish   727 PASAPDKN----PENIKIEAHLPHEMDINWEPLSPIEHNGPGLEYKVSYRRHGSDEDWTERMVKR 787

  Fly   764 EAVLTELRP-HTDYVISVVPFNRNGMGDSSAEIRVKTFSSTPSEPPNNVTLEVTSSSSITVHWEP 827
            .:.|.:..| ...|.|.:...|..|.|.....|...:....||..|::|.:||.:::.:.|.||.
Zfish   788 HSFLVKNTPTFVLYEIKIQAKNHAGWGPDPKIITAYSGEDFPSAAPDDVAVEVLNNTMVKVRWEH 852

  Fly   828 PAEEDRNGQITGYKIRYRKFKDAPQVKSTPANIRYFELSNLDRN----------AEYQVKIAAMT 882
            ..::..:|.:.||::.:.:.:.....|.|..:......|. :||          :||.:.:.|..
Zfish   853 VHKDKIHGHLGGYRVSWWRLRSLLDSKKTHGDKHTLTFSG-ERNHAVVTGLKPFSEYSLIVMAFN 916

  Fly   883 VNGSGPFTEWNRANTLENDLDETQVPGKPIWISIHPGANNIALH-----WGPPQHPEIKIRNYVL 942
            ..|:||.:......|.|.      |||:....|    |.||..|     |.||......:..|:|
Zfish   917 SRGNGPGSHSVNFKTPEG------VPGQAAAFS----ATNIQKHKVTLTWSPPVDANGVLIGYIL 971

  Fly   943 GWGRGIPDENTIEL---------KETERYHILKNLESNMDYVVSLRARNVKGDGPPIYDNIKTRD 998
            .:..   ..||.||         .::.:.| |:|||:...|...||.....|.||.:       .
Zfish   972 QYQL---INNTEELGPLMTLNISADSNKQH-LENLEALSKYKFYLRCCTRVGCGPAV-------S 1025

  Fly   999 EEPVDAPTPLEVPVGLRAITMSSSSIVVYWIDTMLNKNQHVTDNRHYTVSYGITGSNRYRYHNTT 1063
            ||....|......|....|..|||                                 |:....||
Zfish  1026 EERTTVPEATSTDVASFNIRKSSS---------------------------------RFPPRKTT 1057

  Fly  1064 DLNCMINDLRPNTQYEFAVKVVKGRRESSWSMSVLNSTYQNVPVTPPREVTVRLDEMNPPTVI-- 1126
                    :.|                      |.|:|..::.|            :|..|.:
Zfish  1058 --------VSP----------------------VANATLSSIAV------------LNISTSVSH 1080

  Fly  1127 ----VQWIP-PKHTLGQITGYNIYYTTDTTKRDRDWSV-EAFAGEETMLMLPNLKPYTTYYFKVQ 1185
                :.||| .:.|..::      |......|:.:|.: :.....:|..::..|:|.|.|..::.
Zfish  1081 NYANISWIPGTEQTESEL------YVAFMNNREGNWKISDMLNSSKTFHIIEGLEPGTEYTVRLM 1139

  Fly  1186 ARTTKGANNAPFSALVSYTTSAAVTMQEPDTIAKG-------IDNEKLLYIIIAATAVVLLVVLL 1243
            .:              |:..::::......|.|||       |.|:.....::.|.|::.|:||:
Zfish  1140 TK--------------SWVDNSSIFEDVIRTRAKGLASIHGSISNQGWFIGLMCAIALLTLIVLI 1190

  Fly  1244 --------GVLLLCRRKPQSSP--------EHTKKSYQKNNVGVPKPPDLWIHHDQMELKNIDKG 1292
                    |.....:.|....|        :.|...|..|:   .||.....|....:||..|.|
Zfish  1191 ACFVNRNKGGKYSVKEKEDLHPDLESQGINDDTFCEYSDND---EKPLKSSQHSLNGDLKGGDSG 1252

  Fly  1293 LHTVTPVCSDGA 1304
             .::...|.:.|
Zfish  1253 -DSMVDYCDEDA 1263

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fra	NP_523716.2	Ig	36..140	CDD:299845	23/124 (19%)
		Ig	<180..222	CDD:299845	11/50 (22%)
		IG_like	257..340	CDD:214653	25/87 (29%)
		IGc2	264..327	CDD:197706	21/63 (33%)
		I-set	344..430	CDD:254352	20/87 (23%)
		Ig	363..428	CDD:299845	17/66 (26%)
		FN3	611..703	CDD:238020	21/99 (21%)
		FN3	711..799	CDD:238020	23/90 (26%)
		FN3	806..897	CDD:238020	21/100 (21%)
		FN3	908..989	CDD:238020	26/94 (28%)
		FN3	1011..1097	CDD:238020	9/85 (11%)
		FN3	1109..1205	CDD:238020	15/103 (15%)
		Neogenin_C	1273..1521	CDD:284094	9/32 (28%)
chl1b	XP_017212175.2	Ig	61..135	CDD:325142	19/89 (21%)
		Ig	138..231	CDD:325142	17/97 (18%)
		Ig	279..348	CDD:325142	22/72 (31%)
		Ig	366..438	CDD:325142	17/71 (24%)
		IG	454..533	CDD:214652	12/82 (15%)
		I-set	538..628	CDD:333254	19/99 (19%)
		FN3	632..722	CDD:238020	20/92 (22%)
		FN3	734..815	CDD:238020	22/84 (26%)
		FN3	832..931	CDD:238020	21/99 (21%)
		fn3	942..1022	CDD:306538	23/87 (26%)
		FN3	1070..1142	CDD:214495	15/103 (15%)
		Bravo_FIGEY	1196..1279	CDD:316405	15/72 (21%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.910