DRSC/TRiP Functional Genomics Resources

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back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment fra and neo1

DIOPT Version :9

Sequence 1:NP_523716.2 Gene:fra / 36377 FlyBaseID:FBgn0011592 Length:1526 Species:Drosophila melanogaster
Sequence 2:XP_012821597.1 Gene:neo1 / 100170189 XenbaseID:XB-GENE-922578 Length:1451 Species:Xenopus tropicalis


Alignment Length:1618 Identity:500/1618 - (30%)
Similarity:729/1618 - (45%) Gaps:351/1618 - (21%)


- Green bases have known domain annotations that are detailed below.


  Fly    37 FTLEPQDAVVPEGHSVLLQCAGTASIGRGGKSKSNLPSSVSIRWRGPDGQDLVIVGDTFRTQLKN 101
            |..||.|.|...|.:.:|.|:..|.            .:..|.|: .||..|.:|.|..|..|.:
 Frog    49 FLTEPVDTVTLRGFAAVLNCSAYAD------------PTPKIEWK-KDGTFLNLVSDDRRRLLPD 100

  Fly   102 GSLYISSV---EENRGLTGAYQCLLTAEGVGSILSRPALVAIVRQPDLNQDFLETYLLPGQTAYF 163
            |||.|:||   :.|:...|.|||:.|.|.:|||:||.|.:::...|........:.:..|.:...
 Frog   101 GSLLITSVVHSKHNKPDEGIYQCVATVESLGSIVSRTARLSVAGLPRFTSQPESSSVYVGDSIVL 165

  Fly   164 RCMLGEANWQEGVKHSVQWLKDDLPLPLDKLRMVVLPNGALEIDEVGPSDRGSYQCNVTSGSSSR 228
            .|.:...     :...|.|.::.....||. |:.||.||:|.|.....||.|.|:|.|..|||.:
 Frog   166 NCDVSPE-----LVPFVHWEQNKASRELDN-RVAVLLNGSLVISNANESDAGLYRCAVGGGSSIK 224

  Fly   229 LSSKTNLNIKKPSDPGAENSVAPSFLVGPSPKTVREGDTVTLDCVANGVPKPQIKWLRNGMDLDF 293
            .|.:..:.:.:  |.|.|..:.  ||..|.|.|...|.|..|.||.:|.|.|.::|..|..:: .
 Frog   225 YSEEAEIRVLQ--DTGDERPML--FLRQPLPLTRVSGQTALLTCVVSGYPTPSVRWTHNQKEI-L 284

  Fly   294 NDLDSRFSIVGTGSLQISSAEDIDSGNYQCRASNTVDSLDAQATVQVQEPPKFIKAPKDTTAHEK 358
            .:.....:.|..|||||||..:.|||.|.|.|.|...::.|.|.:.:|.||.|...|.:|.|||.
 Frog   285 TENSETLTFVAGGSLQISSVTEEDSGIYTCIADNGNQTIQAHAELSIQVPPIFHVKPSNTHAHES 349

  Fly   359 DEPELKCDIWGKPKPVIRWLKNGDLITPNDYMQLVDGHNLKILGLLNSDAGMFQCVGTNAAGSVH 423
            .:...||::.|||.|.::|:||||::.|:||.::|:.|:|::|||:.||.|.:||:..|..|:|.
 Frog   350 MDIVFKCEVTGKPTPTVKWVKNGDMVIPSDYFKIVEDHDLQVLGLVRSDEGFYQCIAENEVGNVQ 414

  Fly   424 AAARLRVVPQGVKIKKRKSQGHSTKSLQTFDNLTKRRKPFNSGEQLRTKSGGSFPFPDEDDDLDD 488
            |||:|.::..||                                                     
 Frog   415 AAAQLIILEPGV----------------------------------------------------- 426

  Fly   489 NDSGTTRLRIPSGKLPKFEQPLNDRRFNILNAGSALPLDNQSKSYEDDDDDYDEDDPAKEALLEA 553
                    .||:...|...:                                             
 Frog   427 --------TIPTSPTPSLTR--------------------------------------------- 438

  Fly   554 YKQGEDAHKILDSWQQSKSKKSQQQKQSPASPDSPEQDPSVPHPGGKPLDSGLQARLPSQPRDLV 618
                ..||.:                  .|:|..|                     |||.|||:|
 Frog   439 ----ATAHNV------------------AATPGGP---------------------LPSSPRDVV 460

  Fly   619 AQIVKSRFVTLSWVEPLQNAGDVVYYTVYYKMNNSEREQKMVTKSHDDQQVNIQSLLPGRTYQFR 683
            |.:|.:||:.|:|..|....|:.:.|.|||...:..||:...|....:.||.||:|||...|.||
 Frog   461 ASLVSTRFIKLTWRMPADPHGENLTYQVYYSKESMNRERVENTSRPGEMQVTIQNLLPETVYYFR 525

  Fly   684 VEANTNFGSGASSAPLEVSTQPEVNIAGPPRNFEGYARSHKEIYVKWEEPTVTNGEILKYRVYYS 748
            |.|....|:|.||.||:|.|||||.:.||..||:....|...:.|.||.|...||||..|::||.
 Frog   526 VVAQNQNGAGESSLPLKVETQPEVQVPGPAPNFKATPVSPTSVSVSWETPLSGNGEIQSYKLYYM 590

  Fly   749 E----NDSGADLYHDSTALEAVLTELRPHTDYVISVVPFNRNGMGDSSAEIRVKTFSSTPSEPPN 809
            |    |:...|:...|..|..    |:.:|:|...||.||::|.|.|:.::.|:|.|..||..|.
 Frog   591 EKGADNEQDVDVGGHSYTLNG----LKKYTEYTFRVVAFNKHGPGVSTQDVTVRTLSDVPSAAPQ 651

  Fly   810 NVTLEVTSSSSITVHWEPPAEEDRNGQITGYKIRYRKFKDAPQVKS--TPANIRYFELSNLDRNA 872
            |:||||.||.||.|.|:||....:||||.|||:||||.....:...  ..|.:.|. .:.|:|:.
 Frog   652 NLTLEVRSSQSILVQWQPPPIGSQNGQIVGYKVRYRKTTRKSETSEILVDAQLSYL-FTALERDT 715

  Fly   873 EYQVKIAAMTVNGSGPFTEWNRANTLENDLDETQVPGKPIWISIHPGANNIALHWGPP--QHPEI 935
            ||..:..|:|||||||.::|..|.|.|:||||::||..|..:.:.|...||.:.|.||  || ::
 Frog   716 EYSFRAVALTVNGSGPASDWVSAETFESDLDESRVPDVPSSLHVRPLVTNIVVSWTPPENQH-QV 779

  Fly   936 KIRNYVLGWGRGIPDENTIELKETERYHILKNLESNMDYVVSLRARNVKGDGPPIYDNIKTRDE- 999
            .:|.|.:|:|.|.|...|:.:...:||:.:.|||.:..||:||||.|..|:|.|:|::..||.. 
 Frog   780 VVRGYAIGYGLGSPHAQTVRVDHKQRYYTIDNLEPSSHYVISLRAFNNVGEGIPLYESAVTRQHT 844

  Fly  1000 --------------EPVDAPTPLEVPVGLRAITMSSSSIVVYWIDTMLNKNQHVTDNRHYTVSY- 1049
                          .||..|:|:..|||::|..::|.::.:.|.|..|.|||.:||:|:|||.: 
 Frog   845 DPSDVDVFVVHAPYTPVPEPSPMLPPVGVQATIVASDTVRLTWADNSLPKNQKITDSRYYTVRWK 909

  Fly  1050 -GITGSNRYRYHNTTDLNCMINDLRPNTQYEFAVKVVKGRRESSWSMSVLNSTYQNVPVTPPREV 1113
             .|..:.:|:..|:|.|:.::..|:|||.|||:|.|.||||.|:|||:...:|:::||.:||::|
 Frog   910 TNIPANTKYKMANSTTLSYLVTGLKPNTLYEFSVMVTKGRRSSTWSMTAHGTTFESVPSSPPKDV 974

  Fly  1114 TVRLDEMNPPTVIVQWIPPKHTLGQITGYNIYYTTDTTKRDRDWSVEAFAGEETMLMLPNLKPYT 1178
            ||...|..|.|:||.|.||....|:||||.|||:||......||.:|...|......:..|...|
 Frog   975 TVVSKEGKPRTIIVNWQPPSEANGKITGYIIYYSTDAQAELHDWVIEPVIGNRLTHQIQELTLDT 1039

  Fly  1179 TYYFKVQARTTKGANNAPFSALVSYTTSAAVTMQEPDTIAKGID--------------------- 1222
            .||||:|||.:||.  .|.|..|.:.|....:...|:..|..|.                     
 Frog  1040 PYYFKIQARNSKGM--GPMSEAVLFRTPKESSPYMPNDQASSISGKGVRPSDPGSNGGSSLGGSN 1102

  Fly  1223 ---------NEKLLYIIIAATAVVLLVVLLGVLLLCRRKPQSSPEHTKK-----------SYQKN 1267
                     ::.:|..||.:..|:.:::.:.:..:|.|:  ||..|.||           .|:.|
 Frog  1103 SHHGNPTSLDQNMLLTIIVSIGVITVLIAVVIAAICSRR--SSSHHKKKRAASKSVNGSHKYKGN 1165

  Fly  1268 NVGVPKPPDLWIHHDQMELKNIDKGLHTVTPVCSDGASSSGALTLPRS---VVHSEYEVETPVPG 1329
            :..| |||||||||:::|||..||...| .|:.:|       ..||||   :...:...|:.:..
 Frog  1166 SKDV-KPPDLWIHHERLELKPTDKSPET-NPILTD-------TPLPRSPQDLTPGDSTTESSIHQ 1221

  Fly  1330 H------------VTNSLDKRSYVPGYMTTSMNGTMERPQ-----YPRTQYSHQNRSHMTMEAGL 1377
            |            |::...:|...|..|   |....:.||     :|  .:||.|..|.....|.
 Frog  1222 HSNSYRGLESEDSVSSLAGRRGMRPKIM---MPFDSQPPQPVVSAHP--IHSHDNSHHFRSVPGF 1281

  Fly  1378 SQQSLTQP-----------------QSNSMAQT-PEHPYGGYDANFCNAGNAAAGNGCVSTIESS 1424
            ....|..|                 .::|.:|| ||.|    |.:..:....:.....|.::.::
 Frog  1282 MLHVLGGPPQAAESVRHTPSCDTVVAASSSSQTGPEDP----DPSGVSFLPGSLDEDSVPSVPTA 1342

  Fly  1425 --KRGHPLKSFSVPG-PPPTGGATPVTKHTPAVTIRP--QNQSPYK--------------KPSFS 1470
              :..||||||:||. |....||:    :.|::...|  |.|.|..              :|...
 Frog  1343 HIRPSHPLKSFAVPAVPTSASGAS----YEPSLPSSPLLQQQCPTALSVKTASLGTLGRVRPPLP 1403

  Fly  1471 AATP--------NRLQGGGSVVHSTDEIQRLAPSTSTEELNQEMANLEGLMKDLSAIT 1520
            ...|        :|:..|....:..|            ||::|||:||||||||:|||
 Frog  1404 VTVPSAPEPLETSRMLEGSECSYEPD------------ELSKEMAHLEGLMKDLNAIT 1449

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
fraNP_523716.2 Ig 36..140 CDD:299845 37/105 (35%)
Ig <180..222 CDD:299845 16/41 (39%)
IG_like 257..340 CDD:214653 30/82 (37%)
IGc2 264..327 CDD:197706 24/62 (39%)
I-set 344..430 CDD:254352 39/85 (46%)
Ig 363..428 CDD:299845 31/64 (48%)
FN3 611..703 CDD:238020 40/91 (44%)
FN3 711..799 CDD:238020 32/91 (35%)
FN3 806..897 CDD:238020 41/92 (45%)
FN3 908..989 CDD:238020 31/82 (38%)
FN3 1011..1097 CDD:238020 39/87 (45%)
FN3 1109..1205 CDD:238020 41/95 (43%)
Neogenin_C 1273..1521 CDD:284094 83/313 (27%)
neo1XP_012821597.1 Ig1_Neogenin 48..142 CDD:143199 37/105 (35%)
IG_like 152..233 CDD:214653 23/86 (27%)
I-set 245..331 CDD:369462 32/86 (37%)
Ig4_Neogenin 351..421 CDD:212460 32/69 (46%)
FN3 453..545 CDD:238020 40/91 (44%)
FN3 552..641 CDD:238020 32/92 (35%)
FN3 649..740 CDD:238020 41/91 (45%)
FN3 751..831 CDD:214495 30/80 (38%)
FN3 869..962 CDD:238020 39/92 (42%)
FN3 969..1064 CDD:238020 41/96 (43%)
Neogenin_C 1169..1451 CDD:368988 84/315 (27%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 1 1.000 95 1.000 Domainoid score I7285
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 1 1.050 762 1.000 Inparanoid score I547
OMA 00.000 Not matched by this tool.
OrthoDB 1 1.010 - - D118438at33208
OrthoFinder 1 1.000 - - FOG0002773
OrthoInspector 1 1.000 - - otm48286
Panther 1 1.100 - - O PTHR44170
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 1 1.000 - - X1863
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
77.160

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