DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment fra and igdcc4

DIOPT Version :9

Sequence 1:	NP_523716.2	Gene:	fra / 36377	FlyBaseID:	FBgn0011592	Length:	1526	Species:	Drosophila melanogaster
Sequence 2:	XP_002662886.2	Gene:	igdcc4 / 100141327	ZFINID:	ZDB-GENE-080327-32	Length:	1246	Species:	Danio rerio

Alignment Length:	1545	Identity:	346/1545 - (22%)
Similarity:	535/1545 - (34%)	Gaps:	485/1545 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 WLLSSCLI-FQLIGSSLASQALSFTLE----PQDAVVPEGHSVLLQCAGTASIGRGGKSKSNLPS 74
            |..  ||: ....|.|:..:.:|..|.    |...|:.....:||.|...||           ..
Zfish     7 WFF--CLLSLGYCGLSVQEKPVSVELSCGAGPVHVVLEPDQPLLLDCHLGAS-----------EP 58

  Fly    75 SVSIRWRGPDGQDLVIVGD--TFRTQLKNGSLYISSVEEN----RGLTGAYQCLLTAEGVGSILS 133
            .:::.|.    :|.|::.:  |.| .|.||||.||:...|    .|:.|.|:| |::...|::.|
Zfish    59 PLNVTWL----RDGVVLSESQTIR-PLPNGSLLISAFSANGPAPAGVEGGYRC-LSSSSAGALTS 117

  Fly   134 RPALVAIVRQPDLNQDFLETYLLP-GQTAYFRCMLGEANWQEGV-KHSVQWLKDDLPLP-----L 191
            |...:.:.......|| .|..::| |.||.|.|      :.:|: ..|:.|.||..|||     |
Zfish   118 RTLSLHLASLSRFLQD-PEPQIVPVGGTARFEC------YVDGLPTPSITWEKDQAPLPAPTESL 175

  Fly   192 DKLRMVVLPNGALEIDEVGPSDRGSYQCNVTSGSSSRLSSKTNLNIKKPSDPGAENSVAPSFLVG 256
            :..|.:.||||.|:|.||...|.|.|:|...:.:..|.|...:|.:    .||.........:..
Zfish   176 EPSRYISLPNGVLQILEVSKEDEGLYRCVAFNSARKRFSQDASLTV----SPGLSQESEVVIVAP 236

  Fly   257 PSPKTVREGDTVTLDCVANGVPKPQIKWLRNGMDLDFNDLDSRFSIVGTGSLQISSAEDIDSGNY 321
            |...||..|....::|:|.|.|||.:.|.|.    |...:.:...::.| :|.|.......:|.|
Zfish   237 PQNSTVVMGRPAVMECMAQGEPKPFVSWSRQ----DGKPIATDVVVLAT-NLVIPDTRSHHAGVY 296

  Fly   322 QCRAS--NTVDSLDAQATVQVQEPPKFIKAPKDTTAHEKDEPELKCDIWGKPKPVIRWLKNGDLI 384
            .|||:  .|.|.:.:.|.::|..||..:::|:..:....:.....|:..|.|.|.:||||||:.:
Zfish   297 VCRANKPKTRDFVSSPAELRVLAPPIILQSPEAVSLSRGNTARFVCNSSGDPPPALRWLKNGEPV 361

  Fly   385 TPNDYMQLVDGHNLKILGLLNSDAGMFQCVGTNAAGSVHAAARLRVVPQGVKIKKRKSQGHSTKS 449
            ..|..::..:...|.|..|...|||.:||:..|:.|:..|.|:|.|:
Zfish   362 QSNARVKTQNPGVLLINQLRLDDAGYYQCIAANSLGTACATAKLSVI------------------ 408

  Fly   450 LQTFDNLTKRRKPFNSGEQLRTKSGGSFPFPDEDDDLDDNDSGTTRLRIPSGKLPKFEQPLNDRR 514

Zfish   409 ----------------------------------------------------------------- 408

  Fly   515 FNILNAGSALPLDNQSKSYEDDDDDYDEDDPAKEALLEAYKQGEDAHKILDSWQQSKSKKSQQQK 579
                                                   .::|
Zfish   409 ---------------------------------------VREG---------------------- 412

  Fly   580 QSPASPDSPEQDPSVPHPGGKPLDSGLQARLPSQPRDLVAQIVKSRFVTLSWVEPLQNAGDVVYY 644
                                          |||.||.:.|....|....|:|..|..|:..::.:
Zfish   413 ------------------------------LPSPPRHVSATPHSSTSALLTWDPPEHNSDQIIGF 447

  Fly   645 TVYYKMNNSEREQKMVTKSHDDQQVNIQSLLPGRTYQFRVEANTNFGSGASSAPLEVSTQPEVNI 709
            :|:|:.          |...|:.:           |||.|..:|.
Zfish   448 SVHYQR----------TAGSDNME-----------YQFAVNNDTT-------------------- 471

  Fly   710 AGPPRNFEGYARSHKEIYVKWEEPTVTNGEILKYRVYYSENDSGADLYHDSTALEAVLTELRPHT 774
                           |::||                                       ||.|||
Zfish   472 ---------------ELHVK---------------------------------------ELLPHT 482

  Fly   775 DYVISVVPFNRNGMGDSSAEIRVKTFSSTPSEPPNNVTLEVTSSSSITVHWEPPAEEDRNGQITG 839
            .|...||.::..|....|..:.|:.....||..| .::|..||.:.|.|.|.|.:.:...|.||.
Zfish   483 AYTFYVVAYSPMGASRPSLPVTVEMLEDVPSASP-QLSLLSTSPTDIRVMWLPLSSQLSRGAITR 546

  Fly   840 YKIRYRKFKDAPQVKSTP--ANIRYFELSNLDRNAEYQVKIAAMTVNGSGPFTEWNRANTLENDL 902
            |:|.||..:....:.|..  .|.....|.:|..|..||::|:|.|..|....:||...:|    .
Zfish   547 YRIDYRALEQVDHIYSVEVGGNETQVTLRDLKPNQAYQLRISAGTRAGFSQSSEWASHHT----P 607

  Fly   903 DETQVPGKPIWISIHPGANNIALHW-GPPQHPEIKIRNYVLGWGRGIPDENT------------- 953
            :.|||...|..:.:....:::.:.| .||.|.:  |..|.|.|.....||.|
Zfish   608 NLTQVLFAPTELKVRAKMHSLHVTWQSPPNHTQ--ITGYKLSWREADGDELTNEEKPVISERIQQ 670

  Fly   954 IELKETERYHILKNLESNMDYVVSLRARNVKGDGPPI--------YDNIKTRDEEPVDAPTPLEV 1010
            |:|::..::|.:..|..:..|.|.:.|.|.:.:|.|.        ...::|.|..|   |.|
Zfish   671 IKLRKRIKHHEVTGLAPDRLYEVRVWAFNKQTEGYPAVWKGRTEKLTRVRTTDSLP---PLP--- 729

  Fly  1011 PVGLRAITMSSSSIVVYWIDTMLNKNQHVTDNR--HYTV---SYGITGSNRYRYHNTTDLNCMIN 1070
            |:.:||...||:||.:.|      :..|.::.|  :||:   ..||..::...|:.::....::.
Zfish   730 PISVRARANSSTSIWLRW------EKPHFSNVRIINYTIRCSPAGIRNASLVSYYTSSSQEILLG 788

  Fly  1071 DLRPNTQYEFAVKVVKGRRESSWSMSVLNSTYQNVPVTPPREVTVRLDEMNPPTVIVQWIPPKHT 1135
            .|:|.|.||.||:.........:|.:|..||..:.|.:|   |.::|..::..:|:|.|.||...
Zfish   789 SLKPFTSYEIAVQSNGADMSGPFSSTVEESTLPDRPSSP---VDMQLSALDSFSVLVSWRPPLEP 850

  Fly  1136 LGQITGYNIYYTTDTTKRDRDWSVEAFAGEETMLMLPNLKPYTTYYFKVQARTTKGANNAPFSAL 1200
            .|.:..|.|.||.:.:..|..|:.....|..|...:|.|...|.||||:.|.|..|.  .|:|.:
Zfish   851 NGVVLTYWILYTPNISHPDYQWTNLTHDGYVTSAEVPGLMSGTRYYFKMGACTEVGV--GPYSPV 913

  Fly  1201 VSYTTSAAVTMQEPDTIAKGIDNEKLLYIIIAATAVVLLVVLLGVL--LLCR----RKPQS---- 1255
            ....|.                 .|...:.|.|...:::.|.||:|  |||.    |..::
Zfish   914 KDVYTP-----------------PKKYELDIHAVTGIIVGVCLGLLCILLCMCISFRNGKTRDVT 961

  Fly  1256 --------SPEHTKKSYQKNNVGVPKP------PDLWIHHDQMELKNIDKGLHTVTPVCSDGASS 1306
                    ||:     |:|.|..||..      ||....|:          |.|:.|  |.....
Zfish   962 GGLDSSSLSPQ-----YRKGNRPVPAASAAAAVPDCSDCHE----------LETLMP--SSAQEP 1009

  Fly  1307 SGALTLPRSVVHS--------EYEVETPVP---GHVTNSLDKRSYVPGYMTT-------SMNGTM 1353
            |..||.| |..||        :..:..|.|   |.|:.:...|  :..|..|       .:||.:
Zfish  1010 SRPLTEP-SEEHSLMGNVGAADDGLAEPKPAWNGSVSRNWANR--ITRYRDTITEDSSALINGAL 1071

  Fly  1354 ERPQYPRTQYSHQNRSHMTMEAGLSQQSLTQPQSNSMAQTPEHPYGGYDANFCNAGNAAAGNGCV 1418
            |.|.....:..|..|.:          ||::.|..  |:...|         ....||....|..
Zfish  1072 EGPPSENNKSGHVERLY----------SLSKNQVE--AEVIVH---------SQLSNATVDQGPQ 1115

  Fly  1419 STIESSKRGHPLKSFSVPGPPPTGGATPVTKHTPAVTIRPQNQSPYKKPS 1468
            |.:|..     |:|.|...|.|...|||.:.|:..   ..:.|||...||
Zfish  1116 SDMELC-----LESPSSQQPSPGEKATPSSPHSED---NHETQSPSPTPS 1157

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
fra	NP_523716.2	Ig	36..140	CDD:299845	30/113 (27%)
		Ig	<180..222	CDD:299845	20/46 (43%)
		IG_like	257..340	CDD:214653	24/84 (29%)
		IGc2	264..327	CDD:197706	18/64 (28%)
		I-set	344..430	CDD:254352	26/85 (31%)
		Ig	363..428	CDD:299845	23/64 (36%)
		FN3	611..703	CDD:238020	19/91 (21%)
		FN3	711..799	CDD:238020	14/87 (16%)
		FN3	806..897	CDD:238020	28/92 (30%)
		FN3	908..989	CDD:238020	21/94 (22%)
		FN3	1011..1097	CDD:238020	23/90 (26%)
		FN3	1109..1205	CDD:238020	29/95 (31%)
		Neogenin_C	1273..1521	CDD:284094	51/220 (23%)
igdcc4	XP_002662886.2	Ig	36..119	CDD:299845	27/99 (27%)
		I-set	129..221	CDD:254352	34/98 (35%)
		IGc2	142..209	CDD:197706	27/72 (38%)
		Ig	237..317	CDD:299845	24/84 (29%)
		IG_like	237..317	CDD:214653	24/84 (29%)
		I-set	321..407	CDD:254352	26/85 (31%)
		Ig	324..407	CDD:299845	25/82 (30%)
		FN3	414..505	CDD:238020	32/185 (17%)
		FN3	512..606	CDD:238020	30/94 (32%)
		FN3	615..709	CDD:238020	22/95 (23%)
		FN3	727..819	CDD:238020	26/100 (26%)
		FN3	824..918	CDD:238020	30/98 (31%)
		SH3-WW_linker	1100..>1205	CDD:293224	20/75 (27%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4221
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR44170
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	3	2.910