DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG8569 and zmynd11

DIOPT Version :9

Sequence 1:	NP_610795.1	Gene:	CG8569 / 36376	FlyBaseID:	FBgn0033752	Length:	608	Species:	Drosophila melanogaster
Sequence 2:	NP_001096471.1	Gene:	zmynd11 / 100125090	XenbaseID:	XB-GENE-960939	Length:	604	Species:	Xenopus tropicalis

Alignment Length:	677	Identity:	156/677 - (23%)
Similarity:	235/677 - (34%)	Gaps:	245/677 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 SLSVKNATERGILVARAGGGRSKRLALAFCQKVSRLPSSPI-------DPFCFECHLPGAVKKCI 99
            ||:||:    |::|.....| .|.......|:...||...|       |.:|||||.||.|..|.
Frog    57 SLAVKD----GLIVETLTVG-CKGSKAGIEQEGYWLPGDEIDWETETHDWYCFECHSPGEVMMCD 116

  Fly   100 SCHRSFHENCQRQDPEKPNYSVPSDKGQPYQFPVNELDNQPLNNTQNLETPQTPTPLLDHNSNIN 164
            .|.|.:|..|           :|.|
Frog   117 QCFRVYHPKC-----------LPDD---------------------------------------- 130

  Fly   165 QTLLATTDFLKHENIEWDDDVFFVCEQKGARQRKLPRIKDELQSSLDSDEGSDLERCTHCRLLAL 229
               |...|...|    |                                      :|..|:  ::
Frog   131 ---LRLRDSSNH----W--------------------------------------QCPVCK--SM 148

  Fly   230 AALHNPPQLDKQELGCLLKYSWDQHHSWISMDVAKYMAKHWNERDK----ALVKRLLFKTKILGL 290
            ...:|    .|||:|..:::         .:...|..|...|::.|    .:.:||:..|  :.:
Frog   149 KKKNN----TKQEMGKYMRF---------IVSRMKERAIELNKKGKDSKHPMYRRLVHTT--IDV 198

  Fly   291 GDIERNIAAAKYTYLTEFLMDLLDLQHNMAVFFGQKSVEYNATKWLMRDVTHDIREIRRCPDCYR 355
            ..|...:...||....||..|...|.||..:|:|..|.:.:..|.|.:|..|::.|::.|.:|:.
Frog   199 STINEKVTEGKYKSYDEFKADAQLLLHNTIIFYGDDSEQADVAKVLYKDTCHELDELQLCKNCFY 263

  Fly   356 YSNEASLSDLWFAKPCLQRHELVFAKQVGSPPWPAKVMSVSKRQPIKYDVRFFGGTHSRALISER 420
            .||  :..:.||..||:..||||:||..|...||||||   :::..:.||||||..|.||.|...
Frog   264 LSN--ARPENWFCYPCIPNHELVWAKMKGFGFWPAKVM---QKEDNQVDVRFFGHHHQRAWIPSD 323

  Fly   421 DITPIESDI-QSHIKPRNSRALSAAIKELQCHMML---SHYSASLFGFHADPTVAENLIKVALSH 481
            :|..|..:: |.|:|  .|.....|..||..|...   ..:..|. |.......||:.|.
Frog   324 NIQEITVNVHQLHVK--RSMGWKKACDELDLHQRFLREGRFWKSK-GEEKGEEEAESSIS----- 380

  Fly   482 CTESTETSAS----GKRGR---------------------------PPTP------------ATP 503
            .|.:.:..||    .|:||                           ||.|            ..|
Frog   381 STSNDQHKASQEPRAKKGRRNQNVEPKKEEQEPEPETEAVSSSQEIPPVPPPVEKVSVCTQTKKP 445

  Fly   504 GAAKNRRLNNTTSNTSSPVPIR------------------GIPDS--------VAYDSLTAEI-- 540
            .|...|.|:.:| .|::.:..:                  |:.:.        .|.|.|..|:
Frog   446 SAPSPRMLHRST-QTNNDLACQNMCHDKYSKIFNEYKERVGVDNKRETERVVREALDKLRVEMEE 509

  Fly   541 ------------LQAHNDLL------NCRRELSATQRKLA--------EVKRKQWCYHCLDEAVF 579
                        .||..|..      .|:.|.....:|||        :.|:|||||:|.:||::
Frog   510 EKRQAVSKAVSNAQAEMDRKCKQVKEKCKEEFLEEIKKLAAQHKQLISQTKKKQWCYNCEEEAMY 574

  Fly   580 NCCFTASYCSVECQRRD-KRRHQASCK 605
            :||:..||||::||:.. ...|:.:|:
Frog   575 HCCWNTSYCSIKCQQEHWHAEHKRTCR 601

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG8569	NP_610795.1	PHD_SF	85..120	CDD:304600	13/34 (38%)
		Bromo_ZMYND11	243..350	CDD:99924	25/110 (23%)
		BS69_related	366..451	CDD:99902	36/85 (42%)
		zf-MYND	570..604	CDD:280009	14/34 (41%)
zmynd11	NP_001096471.1	PHD_BS69	102..145	CDD:277012	20/138 (14%)
		Bromo_ZMYND11	158..258	CDD:99924	25/110 (23%)
		BS69_related	272..353	CDD:99902	36/85 (42%)
		AtpF	472..>562	CDD:223783	14/89 (16%)
		zf-MYND	565..600	CDD:366792	14/34 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	200	1.000	Inparanoid score	I3661
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D183667at33208
OrthoFinder	1	1.000	-	-		FOG0006060
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR46379
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3824
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	6	6.190