Protein Alignment achi and PKNOX2

DIOPT Version :10

• Sequence 1: NP_725183.1
• Gene: achi / 36373
• FlyBaseID: FBgn0033749
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_001369252.1
• Gene: PKNOX2 / 63876
• HGNCID: 16714
• Length: 472
• Species: Homo sapiens
• Alignment Length: 285
• Identity: 71/285 - (24%)
• Similarity: 117/285 - (41%)
• Gaps: 77/285 - (27%)

  Fly     3 SPEQEEVNMVLDRHVRQNIQDMMHEAHVQASLLENEGRGRFHSDSSLDQDSLHADVIVEE----- 62
            ||.|..:|:        :.||::..:....|.:.|..:|.....|:|.|.::....:..:
Human   185 SPNQPSINL--------HSQDLLQNSPNSMSGVSNNPQGIVVPASALQQGNIAMTTVNSQVVSGG 241

  Fly    63 ----------------DQSTEHGANQVQNYHDMMVDSEHHIDINGSL-------RKRRGNLPKTS 104
                            .|:...||.|:||       ::.::|:...|       :.:||.|||.:
Human   242 ALYQPVTMVTSQGQVVTQAIPQGAIQIQN-------TQVNLDLTSLLDNEDKKSKNKRGVLPKHA 299

  Fly   105 VKILKRWLYEHRYNAYPSDAEKFTLSQEANLTVLQVCNWFINARRRILPEMIRREGNDPLHFTIS 169
            ..|::.||::|..:.||::.||..::.:.|||:|||.|||||||||||..|:.....||     :
Human   300 TNIMRSWLFQHLMHPYPTEDEKRQIAAQTNLTLLQVNNWFINARRRILQPMLDASNPDP-----A 359

  Fly   170 RRGKKVSPNCSRSSALGANLTGPNPAHGSPASEVVVGATEEVDGA-GEIHEGIANVLTNFEQYVQ 233
            .:.||:     :|.........||        .:..|..::..|| |...:|..| |.|.:..
Human   360 PKAKKI-----KSQHRPTQRFWPN--------SIAAGVLQQQGGAPGTNPDGSIN-LDNLQSL-- 408

  Fly   234 GPNGQMVKMEPEYEDSVIYSWQQAI 258
                        ..||...:.|||:
Human   409 ------------SSDSATMAMQQAM 421

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
achi	NP_725183.1	Homeobox_KN	112..150	CDD:428673	19/37 (51%)
PKNOX2	NP_001369252.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..62
		PLN02983	<3..>66	CDD:215533
		Meis_PKNOX_N	96..181	CDD:465140
		Homeobox_KN	307..345	CDD:428673	19/37 (51%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	351..371		5/29 (17%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	386..405		6/19 (32%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	422..472		71/285 (25%)