DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment achi and TGIF2

DIOPT Version :9

Sequence 1:	NP_001286352.1	Gene:	achi / 36373	FlyBaseID:	FBgn0033749	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_001186442.1	Gene:	TGIF2 / 60436	HGNCID:	15764	Length:	237	Species:	Homo sapiens

Alignment Length:	181	Identity:	78/181 - (43%)
Similarity:	94/181 - (51%)	Gaps:	45/181 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly    94 RKRRGNLPKTSVKILKRWLYEHRYNAYPSDAEKFTLSQEANLTVLQVCNWFINARRRILPEMIRR 158
            |||||||||.|||||:.|||.||||||||:.||.:||.:.||:|||:||||||||||:||:|:|:
Human    19 RKRRGNLPKESVKILRDWLYLHRYNAYPSEQEKLSLSGQTNLSVLQICNWFINARRRLLPDMLRK 83

  Fly   159 EGNDPLHFTISRRGKKVS----PNCSRSSALGANLTGPN----------PAHG------------ 197
            :|.||..|||||||.|.|    |..|..|.|..::..|.          |.|.
Human    84 DGKDPNQFTISRRGGKASDVALPRGSSPSVLAVSVPAPTNVLSLSVCSMPLHSGQGEKPAAPFPR 148

  Fly   198 ----SPASEVVVGATEEVDGAGEIHEGIANVLTNFEQYVQGPNGQMVKMEP 244
                ||...|..|:|             ..:||..|  ...|.|.:....|
Human   149 GELESPKPLVTPGST-------------LTLLTRAE--AGSPTGGLFNTPP 184

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
achi	NP_001286352.1	Homeobox_KN	111..150	CDD:283551	28/38 (74%)
TGIF2	NP_001186442.1	Homeobox_KN	36..75	CDD:399131	28/38 (74%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	87..106		11/18 (61%)
		Repressive function	103..237		18/97 (19%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	172..193		3/13 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	213..237
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152658
Domainoid	1	1.000	73	1.000	Domainoid score	I9250
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1573375at2759
OrthoFinder	1	1.000	-	-		FOG0002434
OrthoInspector	1	1.000	-	-		mtm8506
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2583
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	9	8.710