DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment achi and MEIS3

DIOPT Version :9

Sequence 1:	NP_001286352.1	Gene:	achi / 36373	FlyBaseID:	FBgn0033749	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	XP_024307380.1	Gene:	MEIS3 / 56917	HGNCID:	29537	Length:	509	Species:	Homo sapiens

Alignment Length:	240	Identity:	58/240 - (24%)
Similarity:	84/240 - (35%)	Gaps:	91/240 - (37%)

- Green bases have known domain annotations that are detailed below.

  Fly    36 ENEGRGRFH---------------SDSSLDQ-DSLHADVIVEEDQSTEHGANQVQNYHDMMVDSE 84
            ::|..|..|               .|:|.|| |.|...|           |:......|..:|.|
Human   294 DHEDSGSVHLGTPGPSSGGLASQSGDNSSDQGDGLDTSV-----------ASPSSGGEDEDLDQE 347

  Fly    85 HHIDINGSLRKRRGNLPKTSVKILKRWLYEH------------------------RY-------- 117
            ..      ..|:||..||.:..|::.||::|                        |:
Human   348 RR------RNKKRGIFPKVATNIMRAWLFQHLSRRSEAPVLPDVCLGLGSPSPGPRWARPWGSDC 406

  Fly   118 --------------NAYPSDAEKFTLSQEANLTVLQVCNWFINARRRILPEMIRREGNDPLHFTI 168
                          :.|||:.:|..|:|:..||:|||.||||||||||:..||.:..........
Human   407 GRPGRQSDSCWWLQHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRTGQGAAF 471

  Fly   169 SRRGKKVSPNCSRSSALGANLTGPNPAHGSPASEVVVGATEEVDG 213
            |..|:.:.         |...|.|:.|...|.|   ||.:..::|
Human   472 SPEGQPIG---------GYTETQPHVAVRPPGS---VGMSLNLEG 504

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
achi	NP_001286352.1	Homeobox_KN	111..150	CDD:283551	22/84 (26%)
MEIS3	XP_024307380.1	Meis_PKNOX_N	184..267	CDD:318653
MEIS3	XP_024307380.1	Homeobox_KN	417..453	CDD:310480	18/35 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152661
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740