DRSC/TRiP Functional Genomics Resources

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Protein Alignment achi and MEIS2

DIOPT Version :10

Sequence 1:NP_725183.1 Gene:achi / 36373 FlyBaseID:FBgn0033749 Length:555 Species:Drosophila melanogaster
Sequence 2:NP_733775.1 Gene:MEIS2 / 4212 HGNCID:7001 Length:477 Species:Homo sapiens


Alignment Length:300 Identity:75/300 - (25%)
Similarity:120/300 - (40%) Gaps:62/300 - (20%)


- Green bases have known domain annotations that are detailed below.


  Fly     5 EQEEVNMVLDRHVRQNIQDMMHEAHVQASLLENEGRGRF--------------HSDSSL----DQ 51
            |.|:|:.:.|....:.|..:..:..:...:.|.:|..:.              |:.||.    |.
Human   160 ELEKVHELCDNFCHRYISCLKGKMPIDLVIDERDGSSKSDHEELSGSSTNLADHNPSSWRDHDDA 224

  Fly    52 DSLHA----------DVIVEEDQSTEHGANQVQNYHDMMVDSEHHIDINGSLRKRRGNLPKTSVK 106
            .|.|:          ......|.|:|.|.....:........:...|.:...:|:||..||.:..
Human   225 TSTHSAGTPGPSSGGHASQSGDNSSEQGDGLDNSVASPGTGDDDDPDKDKKRQKKRGIFPKVATN 289

  Fly   107 ILKRWLYEHRYNAYPSDAEKFTLSQEANLTVLQVCNWFINARRRILPEMIRREGNDPLHFTISRR 171
            |::.||::|..:.|||:.:|..|:|:..||:|||.||||||||||:..||.:.         :|.
Human   290 IMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQS---------NRA 345

  Fly   172 GKKVSPNCSRSSALGANLTGPNPAHGSPASEVVVGATEEVDGAGEIHEGI--ANVLTNFEQYVQ- 233
            |..:.|:.|:.:|..        ..|.|....|:.        |:.|.||  |.:.:....||. 
Human   346 GFLLDPSVSQGAAYS--------PEGQPMGSFVLD--------GQQHMGIRPAGLQSMPGDYVSQ 394

  Fly   234 -GPNGQMVKMEPEYEDSVIYSWQQAIANNPMGFQSLHSSL 272
             ||.| |...:|.|....:......:.:.|    .:||.|
Human   395 GGPMG-MSMAQPSYTPPQMTPHPTQLRHGP----PMHSYL 429

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
achiNP_725183.1 Homeobox_KN 112..150 CDD:428673 20/37 (54%)
MEIS2NP_733775.1 Required for interaction with PBX1. /evidence=ECO:0000250 71..191 5/30 (17%)
Meis_PKNOX_N 110..194 CDD:465140 6/33 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 193..283 15/89 (17%)
Homeobox_KN 295..333 CDD:428673 20/37 (54%)
Interaction with DNA. /evidence=ECO:0000305|PubMed:26550823, ECO:0000305|Ref.16 299..333 18/33 (55%)
Transcriptional activation domain 340..477 24/119 (20%)

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