Protein Alignment achi and MEIS1

DIOPT Version :10

• Sequence 1: NP_725183.1
• Gene: achi / 36373
• FlyBaseID: FBgn0033749
• Length: 555
• Species: Drosophila melanogaster
• Sequence 2: NP_002389.1
• Gene: MEIS1 / 4211
• HGNCID: 7000
• Length: 390
• Species: Homo sapiens
• Alignment Length: 245
• Identity: 63/245 - (25%)
• Similarity: 97/245 - (39%)
• Gaps: 62/245 - (25%)

  Fly     5 EQEEVNMVLDRHVRQNIQDMMHEAHVQASLLENEGRGRFHSDSS--------LDQDSLHAD---- 57
            |.|:|:.:.|....:.|..:..:..:...:.:.||..:  |||.        .||.|.:.|
Human   158 ELEKVHELCDNFCHRYISCLKGKMPIDLVIDDREGGSK--SDSEDITRSANLTDQPSWNRDHDDT 220

  Fly    58 ----------------VIVEEDQSTEHGANQVQNYHDMMVDSEHHIDINGSLRKRRGNLPKTSVK 106
                            .....|.|:|.|.....:........:...|.:....|:||..||.:..
Human   221 ASTRSGGTPGPSSGGHTSHSGDNSSEQGDGLDNSVASPSTGDDDDPDKDKKRHKKRGIFPKVATN 285

  Fly   107 ILKRWLYEHRYNAYPSDAEKFTLSQEANLTVLQVCNWFINARRRILPEMIRREGNDPLHFTISRR 171
            |::.||::|..:.|||:.:|..|:|:..||:|||.||||||||||:..||.:.
Human   286 IMRAWLFQHLTHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQS------------ 338

  Fly   172 GKKVSPNCSRSSALGANLTGPNPAHGSPASEVVVGATEEVDGAGEIHEGI 221
                    :|:.:.|   |..|| .|.|....|:.        |:.|.||
Human   339 --------NRAVSQG---TPYNP-DGQPMGGFVMD--------GQQHMGI 368

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
achi	NP_725183.1	Homeobox_KN	112..150	CDD:428673	20/37 (54%)
MEIS1	NP_002389.1	Meis_PKNOX_N	108..192	CDD:465140	5/33 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	190..279		17/90 (19%)
		Homeobox_KN	291..329	CDD:428673	20/37 (54%)
		Interaction with DNA. /evidence=ECO:0000305|PubMed:26550823, ECO:0000305|PubMed:28473536	299..329		18/29 (62%)
		Required for transcriptional activation. /evidence=ECO:0000250	335..390		13/66 (20%)