DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment achi and Pbx2

DIOPT Version :9

Sequence 1:	NP_001286352.1	Gene:	achi / 36373	FlyBaseID:	FBgn0033749	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_059491.1	Gene:	Pbx2 / 18515	MGIID:	1341793	Length:	430	Species:	Mus musculus

Alignment Length:	311	Identity:	69/311 - (22%)
Similarity:	120/311 - (38%)	Gaps:	76/311 - (24%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ISPEQEEVNMVLDRHVRQNIQDMMH------EAHVQA---------SLLENEGRGRFHSDSSLDQ 51
            :||:    |.:.....|..:..:.|      |.:.||         :||..:.|.|..:...:::
Mouse   150 VSPD----NSIEHSDYRSKLAQIRHIYHSELEKYEQACNEFTTHVMNLLREQSRTRPVAPKEMER 210

  Fly    52 --DSLHADVIVEEDQSTEHGANQVQNYHDMMVDSEHHIDINGSLRKRRGNLPKTSVKILKRWLYE 114
              ..:|......:.|..:.....|.......:|:          |::|.|..|.:.::|..:.|.
Mouse   211 MVSIIHRKFSAIQMQLKQSTCEAVMILRSRFLDA----------RRKRRNFSKQATEVLNEYFYS 265

  Fly   115 HRYNAYPSDAEKFTLSQEANLTVLQVCNWFINARRRILPEM--IRREGNDPLHFTISRRGKKVSP 177
            |..|.|||:..|..|:::..:||.||.|||.|.|.|....:  .:.|.|            ..:.
Mouse   266 HLSNPYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEAN------------IYAV 318

  Fly   178 NCSRSSALGANLTGPNPAHGSPASEVVVGATEEVDGAGEIHEGIANVLTNFEQYVQGPNGQMV-- 240
            ..:.|.|.|.:....:|   :|.|....|.:..:.|:|::..|:..:  |.:.|   |..|:.
Mouse   319 KTAVSVAQGGHSRTSSP---TPPSSAGSGGSFNLSGSGDMFLGMPGL--NGDSY---PASQVESL 375

  Fly   241 --KMEP-EYEDSV----IYS---------WQQAIANNPM-----GFQSLHS 270
              .|.| .|.|::    |||         ||:|:..:.:     |..|:||
Mouse   376 RHSMGPGSYGDNIGGGQIYSPREIRANGGWQEAVTPSSVTSPTEGPGSVHS 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
achi	NP_001286352.1	Homeobox_KN	111..150	CDD:283551	17/38 (45%)
Pbx2	NP_059491.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52
		PBC	50..243	CDD:309062	15/96 (16%)
		homeodomain	245..305	CDD:238039	23/59 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	327..347		5/22 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	375..430		14/52 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167842705
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.840