DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment achi and Irx1

DIOPT Version :9

Sequence 1:	NP_001286352.1	Gene:	achi / 36373	FlyBaseID:	FBgn0033749	Length:	555	Species:	Drosophila melanogaster
Sequence 2:	NP_034703.2	Gene:	Irx1 / 16371	MGIID:	1197515	Length:	480	Species:	Mus musculus

Alignment Length:	247	Identity:	59/247 - (23%)
Similarity:	95/247 - (38%)	Gaps:	45/247 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    96 RRGNLPKTSVKILKRWLYEHRYNAYPSDAEKFTLSQEANLTVLQVCNWFINARRRILPEMIRREG 160
            |..|..:.|...||.||.|||.|.||:..||..|:....:|:.||..||.|||||     :::|.
Mouse   130 RPKNATRESTSTLKAWLNEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFANARRR-----LKKEN 189

  Fly   161 NDPLHFTISRRGKKVSPNCSRSSALGANLTGPNPAHGSPASEVVVGATEEVDGAGEIHEGIANVL 225
            .    .|...|.|.     ....||..:.|..:|.......|:.:.:. ::|...|.....:|
Mouse   190 K----VTWGARSKD-----QEDGALFGSDTEGDPEKAEDDEEIDLESI-DIDQIDERDGDQSN-- 242

  Fly   226 TNFEQYVQGPNGQMVKMEPEYEDSVIYSWQQAI--ANNPMGFQSLHSSLQATMIDKIKNYQMRKA 288
            .:.|...:.|..::.......:.|...|..:.:  .::|:|           ::.::......:.
Mouse   243 EDEEDKAEAPRARVAPPASARDQSSPLSAAETLKSQDSPLG-----------LVKEVSEPGSTRL 296

  Fly   289 AAIGGSAVGSGGAGGSS----SNSSPATSILPYSLFGQLPPEFDDEEKPRPP 336
            .:.|.:|||..||..|.    |.:..|||           |:...:..|.||
Mouse   297 LSPGAAAVGLQGAPHSKPKIWSLAETATS-----------PDGAPKASPPPP 337

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
achi	NP_001286352.1	Homeobox_KN	111..150	CDD:283551	19/38 (50%)
Irx1	NP_034703.2	Homeobox_KN	145..184	CDD:283551	19/38 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	190..285		17/117 (15%)
		SDA1	<194..>252	CDD:283052	11/65 (17%)
		IRO	309..326	CDD:214716	6/27 (22%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	318..354		8/31 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	401..480
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810