DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vis and TGIF2LY

DIOPT Version :9

Sequence 1:	NP_788337.1	Gene:	vis / 36372	FlyBaseID:	FBgn0033748	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_631960.1	Gene:	TGIF2LY / 90655	HGNCID:	18569	Length:	185	Species:	Homo sapiens

Alignment Length:	141	Identity:	55/141 - (39%)
Similarity:	81/141 - (57%)	Gaps:	24/141 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 DMMVDSEHHVDINGSL------RKRRGNLPKSSVKILKRWLYEHRYNAYPSDAEKFTLSQEANLT 134
            |..:.|.::.|....|      :||:||||..|||||:.|:|:||:.||||:.||..||::.||:
Human    29 DTSIMSRNNADTGRVLALPEHKKKRKGNLPAESVKILRDWMYKHRFKAYPSEEEKQMLSEKTNLS 93

  Fly   135 VLQVCNWFINARRRILPEMIRREGNDPLHFTISRRGKKVVGATEEVDGAGEIHEGIANVLTNFEQ 199
            :|::.||||||||||||:|:::..|||:   |..:..|...||.               |.:.|.
Human    94 LLRISNWFINARRRILPDMLQQRRNDPI---IGHKTGKDAHATH---------------LQSTEA 140

  Fly   200 YVQGPNGQMVK 210
            .|...:|.:|:
Human   141 SVPAKSGPVVQ 151

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vis	NP_788337.1	Homeobox_KN	109..148	CDD:283551	22/38 (58%)
TGIF2LY	NP_631960.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..58		8/28 (29%)
		Homeobox_KN	68..107	CDD:310480	22/38 (58%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	166..185
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152668
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D627308at33208
OrthoFinder	1	1.000	-	-		FOG0002434
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	5	4.810