DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment vis and MEIS3

DIOPT Version :9

Sequence 1:	NP_788337.1	Gene:	vis / 36372	FlyBaseID:	FBgn0033748	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	XP_024307380.1	Gene:	MEIS3 / 56917	HGNCID:	29537	Length:	509	Species:	Homo sapiens

Alignment Length:	201	Identity:	53/201 - (26%)
Similarity:	75/201 - (37%)	Gaps:	74/201 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 RFHSDSSLDQDSLH-----------AVVGNDLSTEQG-------ANQVQNYHDMMVDSEHHVDIN 88
            |.|.||.    |:|           |....|.|::||       |:......|..:|.|..
Human   293 RDHEDSG----SVHLGTPGPSSGGLASQSGDNSSDQGDGLDTSVASPSSGGEDEDLDQERR---- 349

  Fly    89 GSLRKRRGNLPKSSVKILKRWLYEH------------------------RY-------------- 115
              ..|:||..||.:..|::.||::|                        |:
Human   350 --RNKKRGIFPKVATNIMRAWLFQHLSRRSEAPVLPDVCLGLGSPSPGPRWARPWGSDCGRPGRQ 412

  Fly   116 --------NAYPSDAEKFTLSQEANLTVLQVCNWFINARRRILPEMIRREGNDPLHFTISRRGKK 172
                    :.|||:.:|..|:|:..||:|||.||||||||||:..||.:..........|..|:.
Human   413 SDSCWWLQHPYPSEEQKKQLAQDTGLTILQVNNWFINARRRIVQPMIDQSNRTGQGAAFSPEGQP 477

  Fly   173 VVGATE 178
            :.|.||
Human   478 IGGYTE 483

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vis	NP_788337.1	Homeobox_KN	109..148	CDD:283551	22/84 (26%)
MEIS3	XP_024307380.1	Meis_PKNOX_N	184..267	CDD:318653
MEIS3	XP_024307380.1	Homeobox_KN	417..453	CDD:310480	18/35 (51%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152662
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.740