DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vis and Irx4

DIOPT Version :9

Sequence 1:	NP_788337.1	Gene:	vis / 36372	FlyBaseID:	FBgn0033748	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_061373.1	Gene:	Irx4 / 50916	MGIID:	1355275	Length:	515	Species:	Mus musculus

Alignment Length:	281	Identity:	73/281 - (25%)
Similarity:	106/281 - (37%)	Gaps:	77/281 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    81 SEHHVDINGSLRK--RRGNLPKSSVKILKRWLYEHRYNAYPSDAEKFTLSQEANLTVLQVCNWFI 143
            |::..|..|::..  ||.|..:.:...||.||.|||.|.||:..||..|:....:|:.||..||.
Mouse   131 SQYPYDRYGTVDSGTRRKNATRETTSTLKAWLQEHRKNPYPTKGEKIMLAIITKMTLTQVSTWFA 195

  Fly   144 NARRRILPEMIRREGNDPLHFTISRRG-----KKVVGATEEVDGAGEIHEGIANVLTNFEQYVQG 203
            |||||     :::|..    .|...|.     |:..|..|| :.|||            |:..:.
Mouse   196 NARRR-----LKKENK----MTWPPRNKCADEKRPYGEGEE-EEAGE------------EESREE 238

  Fly   204 P------NGQMVKMEPEYEDSVIYSWQQAIANNPMGFQSLHSSLQATMIDKIKNYQMRKAAAIGG 262
            |      .|...|.:.|.|.|.:..:      :|:..::....|: |....:.:...|..|:..|
Mouse   239 PLKSAKSEGHAGKDDKELELSDLEDF------DPLDAETSECELK-TPFQSLDSGPERIPASSDG 296

  Fly   263 SAVGS----------GGAGGS--------SSNSSPATSILPYS-------------LFGQ--LPP 294
            ...|.          |.|||:        :.|...:|.::|.|             .|.|  .||
Mouse   297 PGTGKEASTTLRMPLGTAGGAVMDGDLERARNCLRSTVVVPDSGAEGGPPACEAKLTFAQAGAPP 361

  Fly   295 EFDDEEKPRPPKRVRTRTVAA 315
            ..  |.|||......|.|.||
Mouse   362 NL--ETKPRIWSLAHTATAAA 380

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vis	NP_788337.1	Homeobox_KN	109..148	CDD:283551	19/38 (50%)
Irx4	NP_061373.1	Homeobox_KN	161..200	CDD:368670	19/38 (50%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	205..258		14/69 (20%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	278..307		5/28 (18%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	398..425
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0773
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.900