DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment vis and PBX2

DIOPT Version :9

Sequence 1:	NP_788337.1	Gene:	vis / 36372	FlyBaseID:	FBgn0033748	Length:	524	Species:	Drosophila melanogaster
Sequence 2:	NP_002577.2	Gene:	PBX2 / 5089	HGNCID:	8633	Length:	430	Species:	Homo sapiens

Alignment Length:	297	Identity:	61/297 - (20%)
Similarity:	113/297 - (38%)	Gaps:	79/297 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly     2 ISPEQEEVNMVLDRHVRQNIKDLMHEAH--------------VHA-SLLNNEGRDRFHSDSSLDQ 51
            :||:    |.:.....|..:..:.|..|              .|. :||..:.|.|..:...:::
Human   150 VSPD----NSIEHSDYRSKLAQIRHIYHSELEKYEQACNEFTTHVMNLLREQSRTRPVAPKEMER 210

  Fly    52 DSLHAVVGNDLSTEQGANQVQNYHDMMVDSEHHVDINGSLRKRRGNLPKSSVKILKRWLYEHRYN 116
              :.:::....|..|...:......:|:.....:|    .|::|.|..|.:.::|..:.|.|..|
Human   211 --MVSIIHRKFSAIQMQLKQSTCEAVMILRSRFLD----ARRKRRNFSKQATEVLNEYFYSHLSN 269

  Fly   117 AYPSDAEKFTLSQEANLTVLQVCNWFINARRRILPEM--IRREGN---DPLHFTISRRGKKVV-- 174
            .|||:..|..|:::..:||.||.|||.|.|.|....:  .:.|.|   .....::::.|....
Human   270 PYPSEEAKEELAKKCGITVSQVSNWFGNKRIRYKKNIGKFQEEANIYAVKTAVSVTQGGHSRTSS 334

  Fly   175 ---------GATEEVDGAGEIHEGIANVLTNFEQY----------VQGPNGQMVKMEPEYEDSV- 219
                     |.:..:.|:|::..|:..:  |.:.|          ..||.|        |.|::
Human   335 PTPPSSAGSGGSFNLSGSGDMFLGMPGL--NGDSYSASQVESLRHSMGPGG--------YGDNLG 389

  Fly   220 ---IY---------SWQQAIANNPM-----GFQSLHS 239
               :|         |||:|:..:.:     |..|:||
Human   390 GGQMYSPREMRANGSWQEAVTPSSVTSPTEGPGSVHS 426

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
vis	NP_788337.1	Homeobox_KN	109..148	CDD:283551	17/38 (45%)
PBX2	NP_002577.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..52
		PBC	50..243	CDD:397732	14/98 (14%)
		homeodomain	245..305	CDD:238039	23/59 (39%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	326..347		2/20 (10%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..430		14/57 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165152650
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930