Protein Alignment vis and IRX4

DIOPT Version :10

• Sequence 1: NP_788337.1
• Gene: vis / 36372
• FlyBaseID: FBgn0033748
• Length: 524
• Species: Drosophila melanogaster
• Sequence 2: NP_001265562.1
• Gene: IRX4 / 50805
• HGNCID: 6129
• Length: 545
• Species: Homo sapiens
• Alignment Length: 288
• Identity: 75/288 - (26%)
• Similarity: 105/288 - (36%)
• Gaps: 54/288 - (18%)

  Fly    55 HAVVGNDLSTEQGANQVQNYHDMMVDSEHHVDINGSLRKRRGNLPKSSVKILKRWLYEHRYNAYP 119
            |..:|.||| ..|.:....|..|  ||       |:   ||.|..:.:...||.||.|||.|.||
Human   145 HKGIGLDLS-GLGRSPGSLYGTM--DS-------GT---RRKNATRETTSTLKAWLQEHRKNPYP 196

  Fly   120 SDAEKFTLSQEANLTVLQVCNWFINARRRILPEMIRREGNDPLHFTISRRGKKVVGATEEVDGAG 184
            :..||..|:....:|:.||..||.|||||:..|   .:...|.....:...:......||..|..
Human   197 TKGEKIMLAIITKMTLTQVSTWFANARRRLKKE---NKMTWPPRNKCADEKRPYAEGEEEEGGEE 258

  Fly   185 EIHEGIANVLTNFEQYVQGPNGQMV-KMEPEYEDSVIYSWQQAIANNPM-----GFQSLHSSLQA 243
            |..|         |......|.:.| |.|.|.|.|.:..:....|..|.     .|.||...|:
Human   259 EARE---------EPLKSSKNAEPVGKEEKELELSDLDDFDPLEAEPPACELKPPFHSLDGGLE- 313

  Fly   244 TMIDKIKNYQMRKAAAIGGSAVGSGGAGGSSSNSSPATSILPYSLFGQLP-------PEFDD--- 298
             .:....:..:::|:.....::.:||......:...|.|.|..:..|..|       |:..:
Human   314 -RVPAAPDGPVKEASGALRMSLAAGGGAALDEDLERARSCLRSAAAGPEPLPGAEGGPQVCEAKL 377

  Fly   299 -----------EEKPRPPKRVRTRTVAA 315
                       |.|||......|.|.||
Human   378 GFVPAGASAGLEAKPRIWSLAHTATAAA 405

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
vis	NP_788337.1	Homeobox_KN	110..148	CDD:428673	18/37 (49%)
IRX4	NP_001265562.1	Homeobox_KN	187..225	CDD:428673	18/37 (49%)